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BACKGROUND: Our previous studies found that the polypeptide of Cornus cervi Colla can promote bone growth, which has a good application prospect in the treatment of bone diseases. However, how Cornus cervi Colla works in the body and the principle are not clear. OBJECTIVE: To study the in vivo distribution and tracing of Cornus cervi Colla using fluorescence labeling and tracer technique. METHODS: Cornus cervi Colla was fluorescently labeled using fluorescein isothiocyanate, and the labeling results were detected by fluorescence imaging and UV spectral scanning. Successfully labeled Cornus cervi Colla was injected into mice by gavage, and the absorption of Cornus cervi Colla into blood was detected by laser confocal microscopy, and the distribution of Cornus cervi Colla in mice was detected by small animal in vivo imager. The distribution of Cornus cervi Colla in the mice was detected by laser confocal microscopy. Samples were taken from serum and bone at the time of the strongest fluorescence, and gel electrophoresis was carried out on serum and bone tissue protein solutions, and the components of Cornus cervi Colla absorbed into target organs were determined by secondary mass spectrometry. RESULTS AND CONCLUSION: The fluorescent markers were successfully separated by dextran gel chromatography, and the fluorescence imaging and ultraviolet spectrum scanning proved that the labeling was successful, and the fluorescence substitution degree of FITC-labeled Cornus cervi Colla was 0.953%. The fluorescence intensity of the components of Cornus cervi Colla in the blood showed that Cornus cervi Colla was most distributed in serum after oral administration for 2 hours. The fluorescence images of mice at different times were the same as those of bilateral femur and tibia, indicating that Cornus cervi Colla could play a role by entering the bone. Compared with UniProt database, secondary mass spectrometry showed that the peptide was a characteristic fragment of decorin. It is proved that decorin in Cornus cervi Colla can enter the bone to play a therapeutic role. [ABSTRACT FROM AUTHOR]

Objective To explore the correlation between CT perfusion and DSA collateral compensation and the risk factors affecting cerebral hemisphere perfusion in patients with Moyamoya disease. Methods A total of 115 adult Moyamoya disease patients with 230 cerebral hemispheres were enrolled in this study, and their DSA and CT perfusion data were collected. The ASPECTS was used to divide the brain regions and score four perfusion hemodynamic indicators including time to peak (TTP), mean transit time (MTT), cerebral blood flow (CBF), and cerebral blood volume (CBV), and to score the cerebrovascular collateral compensation displayed by DSA. Spearman correlation analysis and multiple linear regression analysis were performed on the four perfusion hemodynamic indicators and the DSA collateral compensation score. Results In 115 patients with Moyamoya disease, MTT score (r=0.41, P<0.01) was positively correlated with the DSA collateral compensation score. The DSA collateral compensation score (β=0.31, P=0.02), gender (β=1.20, P=0.01), clinical type (β=2.94, P<0.01), and history of stroke (β=-1.19, P=0.02) were independent influencing factors for cerebral perfusion changes. Female patients had better perfusion than male patients (P=0.02), hemorrhagic patients had better perfusion than ischemic patients (P=0.01), and patients without a history of stroke had better perfusion than those with a history of stroke (P=0.03). Conclusions The DSA collateral compensation score was correlated with the MTT score. Moreover, the DSA collateral compensation score, gender, clinical type, and history of stroke were independent influencing factors for cerebral hemisphere perfusion. CT perfusion should be considered when evaluating bypass vessels, neovascularization, and postoperative prognosis. [ABSTRACT FROM AUTHOR]

Roughage plays an important role in maintaining ruminant health and improving performance. Roughage is fermented and degraded by microorganisms in the rumen into substances that can be absorbed and utilized, which can maintain the normal life activities of the body. Rumen health can be maintained by stimulating rumination, saliva secretion, and rumen development in animals. Inadequate roughage intake can lead to gastrointestinal damage, nutrient deficiencies, reduced performance, and behavioral abnormalities in ruminants. The differences in tissue structure and nutrient composition of different roughages will affect the nutrient digestion, nitrogen utilization and metabolism of ruminants. Therefore, different roughage sources in the diet are key factors affecting rumen function and performance. In this paper, the quality of roughage from different sources and its effects on ruminant microorganisms, body metabolism, and production performance were reviewed, and the mechanism of action was elaborated, so as to provide a reference for the rational utilization of roughage in ruminants. [ABSTRACT FROM AUTHOR]

The river chief governance system is a complex system project, and exploring the governance mechanisms of this system is an important part of developing water resource governance theory with Chinese characteristics. Therefore, from the perspective of system theory and based on social-ecological system theory, we constructed a systematic analysis framework for the governance of the river chief system, and utilized this analysis framework with the data related to water resources and the river chief system of 52 prefecturallevel cities and provinces in four provinces, namely, Jiangxi, Anhui, Fujian, and Yunnan provinces, from 2011 to 2020, to empirically analyze the effects of policy instruments and hydro-engineering on the effectiveness of water resources governance. The study found that: ① The river chief system did have a certain system governance effect, and its system governance effect was realized with the help of policy instruments and two types of hydro-engineering governance tools ('soft' and 'hard'), through indirectly changing the behavior of water resource users to take, use, or discharge water, or directly changing the state of the water resource system. ② The sum of the policy instruments would lead to water conservation behaviors by all water users, the regulatory policy instruments would lead to farmers' choice of conservation irrigation behavior, and the hybrid policy instruments would lead to enterprises' choice of pollutant discharge behavior related to industrial structure upgrading. ③ The hybrid policy instruments would increase the scale of hydro-engineering construction. ④ Voluntary policy instruments could only be effective through participatory governance if there were fewer external pressures on the water system. ⑤ The scale of hydro-engineering construction showed an inverted U-shaped relationship with the effectiveness of system governance, and only when the scale of hydro-engineering construction was in the moderate range would hydro-engineering have the role of enhancing the effectiveness of system governance. With the improvement of hydraulic technology, the vertex of this inverted U-shaped curve would be lowered, and the moderate construction scale of hydro-engineering would also be decreased. Through the method of diagnosing the complex regional river chief governance system, this study believes that the river chief system can be optimized in terms of such aspects as adjusting the utilization ratio of voluntary policy instruments, understanding the behavioral patterns of resource users anywhere in taking, using, or discharging water, supporting the development of hydro-engineering technologies, and scientifically controlling the construction scale of hydro-engineering. [ABSTRACT FROM AUTHOR]

Given that Chinese society is currently undergoing a comprehensive transitional phase characterized by intensifying stratification and conflicting interests among social classes, which has led to the increase of self-initiated events aimed at interest maintenance. The ensuing collective behaviors consequently pose considerable challenges to maintaining social order and stability in China. With the aim of adequately mitigating and forestalling potentially deleterious collective behavior. It is of great significance to study the evolutionary logic of collective behaviors under different circumstances, and thus provide a scientific reference for effectively controlling and preventing the malignant events of collective behaviors. The evolution of collective behaviors is a complex public-administration problem with nonlinear characteristics. Domestic scholars have put forward a series of explanatory frameworks for grassroots populace involvement in collective behaviors by integrating western theories with Chinese context.However, traditional methodologies of social science research can hardly understand the emergence characteristics and the overall structure of collective behaviors from the perspective of microcosmic units, and it is difficult to accurately analyze the specific social mechanism. Based on the existing theories and research of collective behaviors,and leveraging computational sociological thinking and approaches in an innovative manner,we firstly constructed a comprehensive interpretation framework generalizing the evolution of collective behavior into different dimensions of the rational-irrational and independent-influenced ones, and reconstructs the evolutionary logic of collective behaviors in theory combining with the discussion of information receiving and processing mechanism. Four kinds of the information diffusion mechanisms including the global-complete, local-complete, global-incomplete and local-incomplete evolutions were then formed. The complex network theory and information diffusion models in the field of social computing were further introduced, and the process of the evolved behaviors with the modeling and mathematical expression was built, and then a strong operational overall framework for systematically analyzing collective behaviors was formed. Secondly, under the guidance of the overall framework, the analysis framework and evolution models under different dimensions and diffusion mechanisms were constructed, and their specific process was also analyzed mathematically. The result shows that significant social influence and time limitation were identified as environmental constraints that prevent such self-correction and lead to unpredictability and path dependence of the system. In structured crowds, sparse networks facilitate the dissipation of collective behavior, while scale-free networks enhance the self-reinforcement of social influence. Based on the simulation of computer-generated parameters and the investigation data of migrant workers, the mechanisms of both generalization and specialization of collective behaviors were discussed. The scale-free network structure and formal network structure of migrant workers manifest similar characteristics in collective behavior evolution. Migrant workers at critical positions in the formal network have major impacts on the initiation of collective behavior.The research provides targeted perspectives for government agencies to develop contingency plans for collective behaviors as well as construct a modernized governance system led by the government with multi-stakeholder participation from enterprises, social organizations and citizens. [ABSTRACT FROM AUTHOR]

Objective To understand the influencing factors of stigma in patients with premature ejaculation, and construct its nomogram risk prediction model. Methods Using convenience sampling method, 212 patients with premature ejaculation in a class A tertiary hospital in Taiyuan were investigated by general situation questionnaire and social impact scale. The data were analyzed by single factor and multi-factor Logistic regression with SPSS 26. 0 statistical software, and the risk prediction model of nomogram was constructed with R software. Results The incidence of stigma in the patients with premature ejaculation was 67%. Education, economic burden of diseases, complicated diseases, knowledge of diseases, partner s satisfactory sexual life and sexual health knowledge were the influencing factors of stigma of premature ejaculation patients. The area under ROC curve of nomogram to predict the risk of stigma in premature ejaculation patients was 0. 860 (95% CI: 0. 813 ~0. 952), and the consistency of the calibration curve and the goodness of fit of Hosmer-Lemeshow were all good (丸$ = 2. 704, P 二 0. 259); The analysis of decision curve (DC A) showed that the model had a high level of net income and better clinical practical value. Conclusion Stigma frequently occurs in premature ejaculation patients which is influenced by many factors. The established nomogram risk prediction model has good discrimination, calibration and clinical practical value, which can provide reference for clinical medical staff to evaluate and screen high-risk patients with stigma and take targeted intervention measures. [ABSTRACT FROM AUTHOR]

Objective: To analyze the quantitative constitutive relationship between the median-inhibitory concentration (IC50) of halobenzoquinones (HBQs) to the human hepatocellular carcinoma HepG2 cells and structural parameters, and to explore the structural parameters that may affect the cytotoxicity of HBQs. Methods: The HepG2 cells were cultured in vitro and cultured with different contentrations of HBQs solutions, at the same time, blank control group [10% fetal bovine serum (FBS) +DMEM culture medium] and negative control group [ (10% FBS+DMEM culture medium +1. 33% methanol (MeOH) ] were set up. The action concentrations of HBQs were comfirmed with MTS and neural red uptake (NRU) methods, respectively. The survival rates of cells in various groups were detected by MTS and NRU methods, and the IC50 of HBQs was calculated. The quantum chemical calculation module MOPAC was used to calculate the structural parameters of every kind of HBQs. Single-factor linear regression analysis was used to construct the quantitative structure-toxicity relationship (QSTR) models based on the IC50 and structural parameters of the HBQs. Results: The MTS method determination results showed that the action concentrations of 2, 6-dichloro-1, 4-benzoquinone (2, 6-DCBQ) were 75, 100, 125, 150, 175, 200, 225, and 250 μmol·L-1, the action concentrations of 2, 6-dichloro-3-methyl-1, 4-benzoquinone (DCMBQ) were 175, 200, 225, 250, 275, 300, and 325 μmol·L-1, the action concentrations of 2, 3, 6- trichlorocyclohexa-1, 4- benzoquinone (TCBQ) were 200, 225, 250, 275, 300, and 325 μmol·L-1, the action concentrations of 2, 5-dibromo-1, 4-benzoquinone (2, 5-DBBQ) were 75, 100, 125, 150, 175, and 200 μmol·L-1, and the action concentrations of 2, 6-dibromo-1, 4-benzoquinone (2, 6-DBBQ) were 200, 225, 250, 275, 300, 325 μmol·L-1 . The NRU method determination results showed that the action concentrations of 2, 6-DCBQ were 25, 50, 75, 100, and 125 μmol·L-1, the action concentrations of DCMBQ were 125, 150, 175, 200, 225, and 250 μmol·L-1, the action concentrations of TCBQ were 175, 200, 225, 250, 275, and 300 μmol·L-1, the action concentrations of 2, 5-DBBQ were 75, 100, 125, 150, and 175 μmol·L-1, the action concentrations of 2, 6-DBBQ were 125, 150, 175, 200, 225, and 250 μmol·L-1 . The survival rates of HepG2 cells in various groups were significantly decreased with the increase of HBQs concentration, showing a dose-response relationship. The cytotoxic effects of HBQs on the HepG2 cells detected by MTS method were 2, 6-DCBQ>2, 5-DBBQ>DCMBQ>TCBQ>2, 6-DBBQ; and the cytotoxic effects of HBQs on HepG2 cells detected by NRU method were 2, 6-DCBQ>2, 5-DBBQ> DCMBQ>2, 6-DBBQ>TCBQ. The single-factor multiple linear regression analysis results showed that the correlation analysis between IC50 and structural parameters of the HBQs detected by MTS and NRU methods had no statistically significant differences (P>0. 05). Conclusion: The substitution position, type and number of halogen atoms can affect the toxic effects of HBQs, and there is a trend that the more halogen substitution, the less toxic it is. [ABSTRACT FROM AUTHOR]

Objective To understand the disease perception level and influencing factors of patients with erectile dysfunction （ED）, and provide reference for adjusting their disease perception level and formulating intervention strategies. Methods Total of 220 ED patients were selected by Convenience sampling method in Taiyuan first class hospitals from December 2021 to June 2022. The general demographic data questionnaire and the simplified version of the disease perception questionnaire were used for cross-section investigation. Results The total score of disease perception in the patients with ED was 41.90 ± 7.33. Univariate analysis demonstrated that marital status, occupational status, family monthly income per capita, treatment cycle, and the number of related underlying diseases were the influencing factors of disease perception in ED patients (P <0.05). Regression analysis showed that the treatment cycle and the number of related underlying diseases were the important influencing factors of disease perception in ED patients (all P < 0.05), which explained 8.6% of the total variation in disease perception. Conclusion Patients with ED have both a moderately high level of disease perception and negative emotional experience. Medical Staff should take personalized intervention measures in clinic to guide the ED patient' s positive emotions, improve sexual arousal and sexual desire disorders, and reduce negative disease perception, and improve the life quality of patients. [ABSTRACT FROM AUTHOR]

Objective: To investigate the correlation of serum interleukin-6 (IL-6), procalcitonin (PCT), cathepsin S (CatS), Cgalactoagglutinin 3 (Gal-3) with glycolipid metabolism, insulin resistance and cardiac function in patients with type 2 diabetes mellitus (T2DM) complicated with coronary heart disease. Methods: 102 patients with T2DM who were admitted to our hospital from February 2019 to February 2021 were selected, and they were divided into simple T2DM group (n=62) and T2DM complicated with coronary heart disease group (n=40) according to whether had coronary heart disease. Another 50 healthy physical examination personnel in the same period were taken as the control group. The levels of serum IL-6, PCT, CatS and Gal-3 in the three groups were compared. The differences of glucose and lipid metabolism, insulin resistance and cardiac function indexes between simple T2DM group and T2DM complicated with coronary heart disease group were compared, and the correlation between serum IL-6, PCT, CatS and Gal-3 and the above indexes was analyzed. Results: The levels of serum IL-6, PCT, CatS and Gal-3 in simple T2DM group and T2DM complicated with coronary heart disease group were higher than those in the control group, and the levels of the above indexes in T2DM complicated with coronary heart disease group were higher than those in simple T2DM group (P<0.05) . The levels of fasting plasma glucose (FPG), low density lipoprotein cholesterol (LDL-C) and insulin resistance index (HOMA-IR) in T2DM complicated with coronary heart disease group were higher than those in simple T2DM group (P<0.05), but there were no significant differences in the levels of 2 h postprandial blood glucose (2hPG), glycosylated hemoglobin (HbA1c), triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C) and fasting insulin (FINS) between the two groups (P>0.05) . The left ventricular ejection fraction (LVEF), left ventricular end systolic volume (LVESV) and left ventricular end diastolic volume (LVEDV) in T2DM complicated with coronary heart disease group were lower than those in simple T2DM group (P<0.05) . Pearson correlation analysis showed that the levels of serum IL-6, PCT, CatS and Gal-3 in patients with T2DM complicated with coronary heart disease were positively correlated with the levels of LDL-C and HOMA-IR, but negatively correlated with LVEF, LVESV and LVEDV (P<0.05). Conclusions: The levels of serum IL-6, PCT, CatS and Gal-3 in patients with T2DM complicated with coronary heart disease are abnormally high, and are closely related to glucose and lipid metabolism, insulin resistance and cardiac function. It has a certain auxiliary evaluation value for the condition of patients. [ABSTRACT FROM AUTHOR]

Under the context of China's carbon peak and carbon neutrality, the treatment of municipal solid waste (MSW) is facing new challenge to reduce carbon emission. This study suggests that significant carbon emission reduction and dual cycle of mass and energy can be realized, under the context of MSW classification, by the collaborative treatment of multi-source solid waste in Eco-Industrial Park. Results showed that in 2020, the incineration and landfilling of MSW in China reduced 5.18 million tons of CO2 emission, at the same year, 15 million tons of CO2 emission could have been reduced if the wet waste was treated in Eco-Industrial Park rather than separate treatment. Waste-toenergy (WtE) plant is the core of the Eco-industrial Park, the adoption of larger grate, higher steam parameter, and thermoelectric cogeneration technologies in WtE plant contributes 0.95 million tons of CO2 reduction, annually. It was suggested that multi-source solid wastes should be treated in the Eco-industrial Park to maximize the benefits of carbon emission reduction. At the same time, in response to the national "one belt one road" initiative, the Eco-industrial Park was recommended to be applied in developing counties in Southeast Asia, contributing China's solutions to the carbon emission reduction of global solid waste treatment. [ABSTRACT FROM AUTHOR]

Acid mine drianage (AMD) is mainly caused by pyrite corrosion in the tailings leaching solution to produce acid ions. Sunlight is an important factor that cannot be ignored. The photocorrosion process of pyrite will increase the risk of AMD leaching. Sodium triethylenetetraamine dithiocarbamate (DTC-TETA) forms a covalent passivation coating on the surface of pyrite. Under light illumination condition, the total iron leaching inhibition rate is 99. 6%. Fe 3+ leaching inhibition rate reaches 100%. Scanning electron microscope-energy dispersive X-ray spectroscopy (SEM-EDS), X-ray diffraction spectroscopy (XRD) and Transmission electron microscope (TEM) characterization show that DTC-TETA improves the structural stability of pyrite itself in photochemical reactions. DTC-TETA consumes the photoactived radicals oxygen species (ROS, ·OH) in the AMD leaching solution through the electron-donating properties of N-containing groups on the surface of pyrite. The ROS generation rate first increases at short time and then decreases within 10 h. It slows down the photochemical corrosion reaction of metal semiconductor tailings. [ABSTRACT FROM AUTHOR]

Natural forage has been widely compressed into the blocks ideal for long-term food storage in modern agriculture. The mechanical behavior of forage during compression can be directly related to the density of blocks and the compression energy consumption. In this study, a systematic investigation was made on the stress transfer, force chain structure, and evolution of crushed alfalfa in the process of vibration compression using a discrete element method (DEM), in order to clarify the mechanical behavior of forage and the mechanism of vibration compression. A DEM model of crushed alfalfa was also established to determine the stress change during compression. A physical experiment was conducted to verify the DEM model. It was found that the variation trend of compressive force after simulation was consistent with the experimental data. There was no significant difference between the simulated and experimental data at the significance level of α = 0.05. A simulation analysis was performed on the force chain structure and evolution during compression using the DEM model. The research results were as follows. The distribution and evolution of the force chain in compressed alfalfa were different in the process of compression with/without vibration. Once alfalfa was compressed without vibration, the axial force chain was transmitted from the top to the bottom, and the distribution density of the strong chain decreased layer by layer as well. The number of strong contact points was 39 258 in alfalfa block. Once alfalfa was compressed by vibration, the axial force chain was transmitted from the bottom to the top in the early stage of compression, and the upper and lower ends were transmitted to the middle layer at the later stage. At the end of compression, the force chain in the block was distributed evenly, where the number of strong contact points was 38 079. The more strong the contact points were, the greater the compression force was, and the more difficult the material was to be compressed. Once the crushed alfalfa was compressed whether with or without vibration, a strong chain appeared around the center, and the outward transmission was gradually enhanced, as the compression stroke increased in the radial direction. At the same time, the distribution density and the strength of the strong chain generated in the material during vibration compression were less than those without vibration. Furthermore, there was a small porosity in the upper and lower layers at the end of the compression stroke without vibration, and a large porosity in the middle layer, where the absolute difference was 3.65 pecentage points between the porosity of the sparse and dense layers. Once alfalfa was compressed by vibration, the porosity of each layer basically maintained a decreasing trend from the top to the bottom, where the absolute difference of porosity was 2.71 pecentage points between the sparse and dense layers. It infers that the vibration was conducive to homogenizing the block density. The mechanical properties of biomass in the vibration compression were also analyzed at the microscopic scale. The finding can also provide a new way to explore the mechanism of vibration compression in forage production. [ABSTRACT FROM AUTHOR]

Objective: To study the clinical effect of bromocriptine in the treatment of non-emergency prolactin-type pituitary adenomas. Methods: From January 2016 to December 2019, 120 patients with non-emergency prolactin-type pituitary adenoma who were admitted to the Department of Neurosurgery and Obstetrics and Gynecology of the Third Affiliated Hospital of Inner Mongolia Medical University were randomly divided into two groups. The control group was given surgical treatment, and the observation group was treated with bromocriptine orally on the basis of the control group. The daily dose was 2.5 mg at the beginning. After 3-5 days of administration, the daily dose was gradually increased to 7.5 mg, divided into 2～ Take 3 times and maintain the administration for 3 months. Compare the two groups before treatment, 1 month and 3 months, compare the serum prolactin levels and symptom scores of the two groups, and observe the psychological, social, environmental and physiological scores of the two groups. Results: The effective rate of the observation group was significantly higher than that of the control group (P<0.05); after 1 month and 3 months of treatment, the serum prolactin levels of the two groups of patients with non-emergency prolactin-type pituitary adenoma decreased significantly (P<0.05). 0.05), and the serum prolactin level of the observation group was significantly lower than that of the control group (P<0.05); after 1 month and 3 months of treatment, the symptom scores of prolactin-type pituitary adenomas in both groups were significantly reduced (P<0.05), And the symptom score of prolactin-type pituitary adenoma in the observation group was significantly lower than that in the control group (P<0.05); after treatment, the scores in the psychological, social, environmental, and physiological fields of the two groups were significantly increased (P<0.05), And the scores of the psychological, social, environmental and physiological fields of the observation group were significantly higher than those of the control group (P<0.05). Conclusion: Combined use of bromocriptine after tumor resection can better improve the symptoms of patients with non-emergency prolactin-type pituitary adenomas, reduce serum prolactin levels, and improve the quality of life. It is worthy of promotion. [ABSTRACT FROM AUTHOR]

Objective: To explore the correlation and diagnostic value of serum phthalate ester chemicals (PAEs), carbohydrate antigen 125 (CA125), and retinol binding protein-4 (RBP-4) with ovarian reserve function in patients with ovarian cysts. Methods: A total of 150 ovarian cyst patients admitted to our hospital from January 2020 to December 2022 were selected as the observation group, and another 150 healthy volunteers with physical examination in the same period were selected as the matched group. Compare the expression levels of serum PAEs (diethyl phthalate (DEP), dibutyl phthalate (DBP), and 2-ethylhexyl phthalate (di(2-ethylhexyl)) (Di (2-ethylhexyl) phthalate (DEHP)}, CA125, RBP-4, and ovarian function related indicators between two groups of subjects. Use Pearson's test to analyze the expression levels of serum PAEs The correlation between CA125 and RBP-4 and ovarian reserve function in patients with ovarian cysts, and the establishment of receiver operating characteristic (ROC) curves to analyze the diagnostic value of serum PAES, CA125, and RBP-4 for ovarian cysts. Result: The total levels of serum PAEs, CA125, DEP, DBP, DEHP, and PAEs in the observation group were higher than those in the matched group (P<0.05); The levels of follicle stimulating hormone (FSH) and luteinizing hormone (LH) in the observation group were higher than those in the matched group, while the levels of estradiol (E2) were lower than those in the matched group(P<0.05); PAES, CA125, and RBP-4 were positively correlated with FSH and LH, and negatively correlated with E₂ (P<0.05); The area under the curve (AUC) from high to low is joint diagnosis (0.864), RBP-4 (0.721), CA125 (0.698), and PAEs (0.641). The combination of PAES, CA125, and RBP-4 has higher diagnostic sensitivity and specificity for ovarian cysts compared to a single diagnosis of the three. Conclusion: There is a significant relationship between serum PAEs, CA125, and RBP-4 levels and ovarian reserve function in patients with ovarian cysts. The higher the levels of these three, the worse the ovarian reserve function in patients with ovarian cysts. In addition, the combination of PAES, CA125, and RBP-4 has high diagnostic sensitivity and specificity for ovarian cysts, which can provide reliable basis for clinical diagnosis and disease judgment of ovarian cysts. [ABSTRACT FROM AUTHOR]

Objective To investigate the effect of differentiation inhibitory factor 3（ID3） on the chemosensitivity of doxorubicin（DOX） in hepatocellular carcinoma（HCC） and its possible mechanism.Methods HepG2 cells and adriamycin（ADM）-resistant HepG2 cells（HepG2/ADM cell） were cultured in vitro.The expression of ID3 mRNA in these two kinds of cells was detected by qRT-PCR. HepG2/ADM cells were selected, and were randomly divided into the control group and experimental group, which were transfected with Oe-NC and oe-ID3, respectively. After 24 hours of transfection, the expression of ID3 mRNA was detected. The IC50 value of DOX was detected after adding different concentrations of DOX. TUNEL apoptotic staining and flow cytometry were used to detect the apoptotic rate. Western blotting was used to detect the expression of PI3 K/AKT signaling pathway related proteins（pPI3 K, pAKT, and Bcl-2）.Results The relative expression of ID3 mRNA was 0.24±0.04 in the HepG2/ADM cells, and 1.00±0.11 in the HepG2 cells, with significant difference（P<0.05）. The relative expression levels of ID3 mRNA in the experimental group and the control group were 13.54±2.33 and 1.00±0.00, with significant difference（P<0.05）. The IC50 value of DOX in the experimental group was（0.12±0.03）μg/mL, while that in the control group was（0.25±0.04）μg/mL, with significant difference between the two groups（P<0.05）. The apoptotic rate of the experimental group was higher than that of the control group（P<0.05）. The relative protein expression of pPI3 K, pAKT and Bcl-2 in the experimental group was lower than that in the control group（all P<0.05）.Conclusion Overexpression of ID3 can increase the sensitivity of HCC to DOX by inhibiting the expression of PI3 K/AKT signaling pathway-related proteins, thus increasing the sensitivity of HCC to DOX. [ABSTRACT FROM AUTHOR]

Objective: To investigate the relationship between serum levels of brain natriuretic peptide(BNP), carbohydrate antigen 125(CA125), thyroid hormone(TH) and cardiac function in patients with chronic heart failure(CHF). Methods: A total of 120 patients with CHF, who were treated in Affiliated Hospital of Inner Mongolia Medical University from December 2015 to December 2017,were selected as the subjects. The cardiac function grading of the patients was New York Heart Association(NYHA) I/II with 51 cases;NYHA III with 39 cases, NYHA IV with 30 cases. Another 40 healthy volunteers, who were received physical examination in this hospital during the same period, were selected as control group. The levels of serum BNP, CA125 and TH were measured in all subjects, and their relationship with left ventricular ejection fraction(LVEF) and left ventricular end-diastolic diameter(LVEDD) was analyzed. Results: The levels of serum BNP and CA125 in the patients with different cardiac functions were significantly higher than those in the control group,and the levels of BNP and CA125 were increased with the increasing of NYHA grading(P<0.05). The level of serum T3 in the patients with NYHA III and NYHA IV was significantly lower than that in the control group, and level of T3 was gradually decreased with the increasing of NYHA grading, the difference was statistically significant among all groups(P<0.05). Pearson analysis showed that levels of serum BNP and CA125 were negatively correlated with LVEF(P<0.05), and there were positively correlated with LVEDD(P<0.05). The level of serum T3 was positively correlated with LVEF(P<0.05), and there was negatively correlated with LVEDD(P<0.05). Conclusion:Serum BNP, CA125 and T3 levels in the patients with CHF are closely related to cardiac function, and the combined detection of the three elements has great value in the clinical diagnosis and condition judgement of CHF. [ABSTRACT FROM AUTHOR]

Wastewater treatment plays an important role in water environmental protection, but it is also one of the most important sources of energy consumption and carbon emission in the world.Therefore, promoting the reduction of pollution and carbon emissions in sewage treatment and achieving green development in the sewage treatment industry has garnered widespread attention in academia.This study constructed an evaluation index system for the green efficiency of urban sewage treatment that covered both pollution reduction and carbon reduction targets.The super-efficieny SBM-DEA model, including non-desired outputs, Kernel density estimation, traditional and spatial Markov transfer probability matrix, was used to measure the green efficiency of urban wastewater treatment in 30 provinces（cities and autonomous regions） in China from 2013 to 2020.Also, the spatial and temporal evolution characteristics were analyzed and empirical research was conducted using the Tobit model.The result showed that during the study period, the green efficiency of urban sewage treatment in China showed a fluctuating downward trend, and the efficiency gradually stabilized into the distribution pattern of “East-Middle-West” decreasing step after 2016.The results of Markov probability transfer matrix showed that the efficiency had a certain degree of stability, and there was a “club convergence” phenomenon.Geographical factors playedan important role.From the regression results, there was a significant positive relationship between the cumulative completed investment in wastewater treatment plants, GDP per capita, pipe network density, employment, population density, number of green invention patent applications, precipitation and green efficiency of wastewater treatment in China.On the other hand, the length of combined rainwater and sewage pipes, average industry wages, industrial structure, environmental regulations, and per capita water resources had a significant inhibitory effect on the green efficiency of urban sewage treatment in China.The degree and conditions of each influencing factor were highly territorial. [ABSTRACT FROM AUTHOR]

Based on eastern slope constructing dump at an open-pit mine in Xinjiang Uygur Autonomous Region, using the orthogonal method to establish an experiment program, this paper performed a basal contact friction experiment to simulate slope failure, and the experiment of four typical production model fully reflected the failure process of composite slope. Experiments show the 21 st coal floor is the key factor of slope failure. By analyzing the displacement of monitoring point, there are four kinds of potential sliding surface including line, straight line, broken line and circular arcs and two kinds of failure classified into subsidence and creep-crack. The paper discusses the effect of weak layer, time and dump on slope, points out the improvement for basal contact friction experiment, and proposes a reasonable reinforcement time for stability and the importance of reasonable making model. Overlying dump have dual influences on slope stability, which controls the scale of potential sliding mass together with weak layer. The research can be applied to the prevention of multi-seam and soft rock slope in open pits. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To investigate the secondary prevention of medication compliance in patients with ischemic stroke and to analyze the effect factors of medication compliance, so as to provide a certain basis for standardization of clinical medication and prevention. METHODS: 190 patients with ischemic stroke admitted into Luohe the Sixth People’s Hospital from Oct. 2015 to Mar. 2017 were extracted, retrospective analysis was conducted for patients’ medication compliance, and single factor and multi-factor Logistic regression analysis was conducted for effect factors of medication compliance, effects of application of different drugs for secondary prevention was evaluated. RESULTS: Ages, marital status, drug costs, whether to take the medicine on their own, daily dose times and daily dose amount were closely connected with medication compliance. Patients with long-term application of antithrombotic drugs, antiplatelet drugs and other Chinese medicine had higher medication compliance. Patients with lower total cholesterol and LDL at admission examination indicators had higher medication compliance. Patients with recurrent ischemic stroke had lower medication compliance. According to Logistic regression model, the effect factors related to medication compliance were marital status and drug costs. Compared with unmarried, divorced and widowed, married patients had higher medication compliance, patients with drug costs <500 yuan had lower medication compliance. As for the 61 cases with higher medication compliance, the incidence of positive events in patients with blood lipids and antithrombotic drugs was significantly lower than that of patients without these drugs, with statistically significant difference (P <0.05). CONCLUSIONS: The medication compliance for secondary prevention in patients with ischemic stroke is poorer, it is necessary to strengthen the propaganda and education of knowledge of disease and medication for patients and family members, so as to improve the medication compliance and improve the outcomes. [ABSTRACT FROM AUTHOR]

[Objective] Effects of nitrogen diposition on soil mineralization and nigrification were studied in the present paper. [Method]The salinity soil in Erkusack village, Shufu County, Kashgar areas was taken as the research material and laboritory simulation methods were a-dopted. [Result]The soil mineral nitrogen content in surface soil was the highest (0-20 cm). After the settlement of nitrogen deposition each soil mineral nitrogen content was higher than that without nitrogen deposition, showing that the nitrogen deposition increased the soil mineral nitrogen content. With the increase of training days, after nitrogen deposition soil net nitrogen nitrification rate increased gradually, while for that without nitrogen diposition, in turn, the soil net nitrogen nitrification rate gradually reduced. [Conclusion] The settlement of nitrogen speeds up the original soil nitrogen nitrification. After nitrogen deposition its net nitrogen mineralization rate change regularity was not strong. [ABSTRACT FROM AUTHOR]

Entropy can effectively reflect the network structure heterogeneity of complex systems. For the question of applicability of entropy indices to describe the global heterogeneity of the network, the benchmark networks for the evaluation are still lacking. On the foundation of previous study, this paper introduces a Caveman network and its evolution rules, which provides a new way of thinking for measurement of network complexity. The theoretical analysis and simulation experiments indicate that the Caveman network can effectively evaluate the sensitivity of different structure entropies on evolution process of Caveman network, and reflect the difference of ability to identify the properties of network complex of entropy indices. Besides that, Caveman network can promote exploration in information space and resist network attacks, shedding new light on designing system structure with high robustness and efficiency. [ABSTRACT FROM AUTHOR]

Based on the current situation and construction plan of the experimental center of our college, and in order to make the students majored in electricity to adapt to the current status of industrial development and demands, training objectives of engineering undergraduates have been designed as follows; having the ability to analyze and solve engineering problems independently, having the potential to carry out research of science, having competitive compared with students at home and abroad; having strong sense of identity with alma mater and teachers and having to be not slaves of utilitarianism. The four-year university practice learning process is analyzed and a good learning curve is designed. Lab layout and process management methods are also planned and designed to achieve ideal cultivation goal. [ABSTRACT FROM AUTHOR]

Objective　To observe the clinical efficacy of of mouse nerve growth factor and Safflower Flavin on elderly diabetic patients safflower flavin cerebral infarction. Methods 80 elderly diabetic patients with cerebral infarction were randomly divided into treatment group and control group．The control group was treated with oxygen，dehydrating agent，controlling blood sugar，maintaining electrolyte balance，aspirin and injecting safflower flavin. On the basis of control group，the treatment group was given rat nerve growth factor. Before and after treatment two weeks，clinical symptoms and neurological function of patients were estimated. Results There were statistical significant differences in the clinical symptoms and neurological function of patients before and after treatment．Conclusion　It is an effective treatment with mouse nerve growth factor and safflower flavin on elderly diabetic patients with cerebral infarction and it is worthy of spreading in the clinic. [ABSTRACT FROM AUTHOR]

On the basis of electromagnetic transient software PSCAD/EMTDC, this paper deduces the mathematical model of the Shanghai Nanhui integrated wind farm and VSC-HVDC on d—p coordinate system, proposes the control strategy for both ends of VSC-HVDC integrating with wind farm，and designs the control system. The simulation result shows that the designed control system enjoys great effect which realizes the independence and flexible regulation of VSC power transmission [ABSTRACT FROM AUTHOR]

On the basis of electromagnetic transient software PSCAD/EMTDC，this paper deduces the mathematical model of the Shanghai Nanhui integrated wind farm and VSC - HVDC on d —p coordinate system，proposes the control strategy for both ends of VSC - HVDC integrating with wind farm，and designs the control system. The simulation result shows that the designed control system enjoys great effect which realizes the independence and flexible regulation of VSC power transmission. [ABSTRACT FROM AUTHOR]

Promoting high-quality development of new urbanization is the necessary way to realize Chinese style modernization. The long-term development mode of urbanization is characterized as “land-based urbanization” in which tremendous agricultural land transferring to non-agricultural land regardless of human's development. Accordingly, rural people hardly benefit from economic and social development equally, which is not conducive to the integrated development of urban and rural areas, or to the realization of social equity and justice. As an outcome of capital-guided population flow, the old-style urbanization ignores people's needs and becomes the crux of inadequate and unbalanced development between urban and rural areas and between different regions. The high-quality development of new urbanization faces unprecedented challenges. Low fertility, aging and gender imbalance have become the new normal of the population. The burden of elderly care in central and western rural China is heavy, and the male marriage squeeze is also concentrated in the central and western rural China. The emerging trend of family-oriented rural-urban migration brings about a strong demand of rural migrants for public services such as employment, childbearing, childcare, education, elderly care and medical care. The outflow of labor force is weakening the function of rural families. Under the circumstances of frequent external socio-economic risks, it is urgent to strengthen the resilience of individuals, families and society. In central and western China, the issue of rural hollowing is serious and industrial development of small and medium-sized towns lag behind which induces a weaker ability to absorb agricultural transfer population. Urbanization in central and western China is the important and difficult point. To promote the national strategy of new urbanization, it is urgent to deeply study the family function and sustainable development of the agricultural transfer population in central and western China. Family is not only the basis of individual survival and development, but also the main carrier of social policies. Family function and sustainable development of the agricultural transfer population is one of the key issues of “human-centered new urbanization”. The level and operation efficiency of family function affect the quality of life and development of each family member. To better focus this problem, family functions are divided into two categories: economic functions, i.e. sustainable livelihoods of rural households; Non-economic functions, including family reproduction function(marriage formation), reproduction function(fertility), childcare and old-age care function. Family development includes sustainable development of above family functions. The family development ability of agricultural transfer population is the comprehensive ability of families, given a certain livelihood capital and population endowment, rationally choosing family strategies and gradually realizing family sustainable development by using the rights and opportunities given by urbanization policies and equalization of public services. To conduct a scientific and systematic study on family function and development of agricultural transfer population in central and western China, it is necessary to construct a multidisciplinary research framework with a logical line of “macro analysis of socio-demographic and economic environment→ current situation and mechanism research → policy innovation research”, and make a comprehensive analysis from multiple perspectives such as region, generation, gender and life course. The main research contents include trend of urbanization development, family economic function and livelihood transformation of agricultural transfer population, family non-economic functions and family development, policy response, cost calculation and optimization of new-type urbanization at county level. [ABSTRACT FROM AUTHOR]

The productivity of ruminants is mainly driven by rumen microorganisms, including functional microbial communities such as bacteria, methanogens, fungi, and protozoa. Rumen microorganisms can decompose and ferment plant-based feed to produce nutrients such as volatile fatty acids, microbial proteins, and vitamins. From the early stages of animal life to each important node of life, the rumen microbial community undergoes drastic changes. At present, early regulation of rumen microbiota in ruminants is one of the hot topics in the field of animal husbandry research. Therefore, understanding the colonization status of rumen microorganisms is of great significance for the healthy of animal bodies. The paper reviewed the common microbial flora in rumen, its main functions and colonization process, in order to understand the rumen microflora of ruminants and provide reference for further research. [ABSTRACT FROM AUTHOR]

Objective: To introduce experience of application of alar cartilage three tripod structure reconstruction in comprehensive nasal tip rhinoplasty. Methods: From September 2012 to February 2015, primary comprehensive nasal tip plasty in 84 cases were performed in our institute. 3 cases were men and 81 cases were women. From 20 to 45 years old, with an average age of 31.7 years. 65 cases have hypertrophy noses with low dosum, who have been performd with alar cartilage suture+alar cartilage resection+prosthesis implantation+autologous bonnet cartilage transplantation operation. 19 cases have hypertrophy nasal tip and low dorsum combined with short columella, who have been performed with autogenous cartilage for columella support+alar cartilage resection+alar cartilage suture+prosthesis implantation+autologous bonnet cartilage transplantation. Results: The 84 patients were followed up for 1 months-2years, except 1 case had dissatisfied nasal tip shape because of preoperative hypertrophy noses. Other cases had obvious change of nasal tip angle, cases with short columella also had obvious length change of columella, the scars and complications were not obvious. Conclusion: For different condition of alar cartilage development of the patients, using personalized alar cartilage tripod structural remodeling of nasal tip comprehensive surgery can achieve better clinical effect, this should be chosen according to the different characteristics of the patients. [ABSTRACT FROM AUTHOR]

Objective To study the changes and correlation of serum interleukin-17， -6 and -8 （IL-17， IL-6 and IL-8），c-reactive protein （CRP），tumor necrosis factor alpha （TNF-α） of patients with chronic obstructive pulmonary diseases （COPD）， and discuss the role and clinical significance of these factors in the occurrence and development of COPD. Methods 100 COPD patients were selected （COPD group），and 50 healthy elderly people in the same period in outpatient medical examination were served as control （control group） . The levels of IL-17， IL-6 and IL-8，CRP， TNF-α in serum were detected with ELISA method. Results The serum levels of IL-17， IL-6，IL-8，CRP and TNF-α of patients in COPD group were higher than those in the control group （ < 0.01），and of patients with acute aggravating period were higher than those of patients with stable period （ < 0.05 or < 0.01） . Pearson correlation analysis showed there were positive correlations among IL-17，IL-6， IL-8， CRP and TNF-α （ < 0.05） . Conclusion The serum levels of IL-17， IL-6， IL-8， CRP and TNF-α of COPD patients have abnormal increased， and will increase with the rise of the illness severity. The above factors may be involved in the airway in patients with acute inflammatory reaction and the development process. [ABSTRACT FROM AUTHOR]

BACKGROUND: Osteonecrosis of the femoral head is a common and disabling disease, which is mainly characterized by microcirculation disorders and bone cell metabolism disorders. Luzhongjiangu decoction was developed by Shandong Academy of Chinese Medicine and used in the form of soup in the clinic, which has good efficacy in the treatment of osteonecrosis of the femoral head. However, its mechanism of action has not been clarified. OBJECTIVE: To study the effect mechanism of Luzhongjiangu decoction on intestinal flora in rats with osteonecrosis of the femoral head based on 16S rDNA sequencing technique. METHODS: The model of osteonecrosis of the femoral head was established in Wistar rats by intragastric administration of retinoic acid. The therapeutic effect of Luzhongjiangu decoction was evaluated by serum hormone, bone histopathology and serum hormone levels. 16s rDNA sequencing technique was used to detect the intestinal flora of rats in the blank control group, model group and middle-dose Luzhongjiangu decoction group. The corresponding library was constructed and OTU clustering and microbial community diversity and abundance analysis were carried out to determine the composition of intestinal flora and the changes of species and diversity among groups. RESULTS AND CONCLUSION: Luzhongjiangu decoction could significantly increase the expression of osteocalcin, osteopontin and other osteogenic related factors, alleviate the destruction of bone trabeculae, increase bone mineral density, and had a significant therapeutic effect on osteonecrosis of the femoral head, of which the middle dose group showed the most significant effect. The results of intestinal flora sequencing showed that Luzhongjiangu decoction improved the flora disorder of rats with osteonecrosis of the femoral head to some extent, and screened out different colonies such as Bacillus, Desulfurizans, Desulfurization, Isobacteria, Bifidobacterium and so on; it could up-regulate the abundance of beneficial bacteria such as Bifidobacterium, down-regulate the abundance of harmful bacteria such as Desulfovibrio, and improve the structure of intestinal flora. Functional prediction analysis indicated that Luzhongjiangu decoction could mainly affect amino acid metabolism and energy metabolism. Correlation analysis showed that the differential bacteria of Bifidobacterium and Intestinimonas in the middle dose group of Luzhongjiangu decoction were positively correlated with vitamin D3, estradiol and calcitonin, and negatively correlated with prostaglandin E2. In the model group, Escherichia-Shigella, Desulfovibrio, Globicatella and Streptococcus were positively correlated with prostaglandin E2 and negatively correlated with vitamin D3, estradiol and calcitonin. To conclude, Luzhongjiangu decoction may play a role in the treatment of osteonecrosis of the femoral head by regulating the structure of intestinal flora, up-regulating the abundance of beneficial bacteria and affecting the secretion of vitamin D3, estradiol, calcitonin and prostaglandin E2. [ABSTRACT FROM AUTHOR]

目的 探讨血乳酸、第1天呼吸指数、血百草枯中毒（PQ）浓度、血乳酸联合血PQ浓度等指标预测血液灌 流治疗急性百草枯中毒14 d预后的临床价值。方法 回顾性分析60例急性百草枯中毒患者临床资料，根据14 d预 后情况分为生存组和死亡组，动态观察两组24 h血糖、血乳酸、碱剩余、呼吸指数、动静脉氧分压差变化，比较两组血 PQ浓度、百草枯中毒严重指数（SIPP）、口服 PQ剂量、24 h乳酸清除率、24 h血糖清除率、血乳酸联合血 PQ浓度、血 PQ浓度×中毒至灌流时间、血PQ浓度×入院至灌流时间等指标的差异，进行主成分分析KMO检验、相关性分析、Lo⁃ gistic回归分析筛选预测死亡的独立危险因子，通过受试者工作特征（ROC）曲线及拟合曲线进行分辨度和校准度检 验，比较各指标预测能力。结果 死亡组口服 PQ 剂量、血乳酸、血 PQ 浓度、血糖、呼吸指数、24 小时乳酸清除率、 SIPP、血PQ浓度×中毒至灌流时间、血PQ浓度×入院至灌流时间等指标高于生存组（P均<0. 05）；死亡组肺泡动脉氧 分压比和碱剩余水平低于生存组（P均<0. 05）。主成分分析：研究最终提取前两位主成分，提取后主成分累计解释 56. 38% 的数据变异。相关性分析：血乳酸、血 PQ浓度×血乳酸、血 PQ浓度、呼吸指数与患者 14 d死亡呈正相关（γ 分别为 0. 68、0. 69、0. 48、0. 36，P均<0. 05）。Logistic回归分析：血乳酸优势比（OR）=1. 831，95%CI为1. 26~2. 66，P< 0. 05；第1天呼吸指数OR=117. 62，95%CI为2. 96～4677. 99，P<0. 05，提示血乳酸及第1天呼吸指数是预测患者14 d 预后的独立危险因子。血 PQ浓度×血乳酸、血乳酸、第 1天呼吸指数、血 PQ浓度预测 14 d预后的 ROC曲线下面积 （AUC）和95%CI分别为0. 90（0. 82~0. 98）、0. 89（0. 81~0. 98）、0. 76（0. 63~0. 89）、0. 77（0. 66~0. 89），不同指标预测14 d 患者预后的AUC比较：入院时乳酸或血乳酸×血PQ浓度>血PQ浓度，差异有统计学意义（Z分别为2. 17、0. 09，P均< 0. 05）。通过Hosmer-Lemeshow拟合优度检验，乳酸、第1天呼吸指数均有较好的校准度（χ²分别为5. 15、7. 23，P均> 0. 05），用乳酸、第1天呼吸指数预测急性PQ中毒14 d死亡概率曲线与实际死亡率曲线相吻合。结论 血乳酸水平、 血乳酸联合血PQ浓度、第1天呼吸指数、血PQ浓度预测血液灌流治疗急性百草枯中毒患者14 d预后的临床价值较 高，血乳酸及第1天呼吸指数是预测死亡的独立危险因素，血乳酸的预测准确性更高. [ABSTRACT FROM AUTHOR]

This paper introduces two networking modes， hvac and flexible DC，for offshore wind farm and their ad vantages and disadvantages. Through the example，the paper analyzes the relation between investment and distance of 100，500 and 1000 MW offshore wind farm， and compares the economy of HVAC and flexible DC two transmission modes. On the basis of the characteristics of transmission modes and relevant operation，the paper also evaluates the cost of equipment investment ， operation and maintenance，which proves that flexible hvdc is more economic for offshore wind farm. [ABSTRACT FROM AUTHOR]

【Objective】 Analyze the species, density, biomass, diversity and other community characteristics of plankton in combination with the assess of dominant plankton and water quality physical and chemical indicators to evaluate the water quality of Juyan Lake. 【Methods】 From November 2020 to September 2021,13 physical and chemical indicators of water quality as well as plankton resources in the Juyan Lake were sampled and analyzed in accordance with Handbook of Fishery Natural Resources Investigation in Inland Waters and Technical Specification for Freshwater Plankton Investigation （SC/T 9402—2010）. 【Results】 In the survey duration, the transparency of Juyan Lake water body was 0.45-1.08 m, the total nitrogen was 0.97-2.48 mg/L,and the total phosphorus and nitrogen nutritional status indices were 33.79-35.09 and 54.01-69.92 respectively. 6 phyla and 63 species of phytoplankton were identified, including 16 dominant species with densities of 236 500 to 392 600 per liter, biomass of 0.30 to 1.04 mg/L, Shannon-Wiener diversity index of 2.53 to 2.88 and the richness indices of 2.64 to 3.08. 2 phyla and 22 species of zooplankton were identified, including 17 dominant species, with densities of 35.98 to 131.95 per liter,biomass of 0.27 to 1.12 mg/L,Shannon-Wiener diversity index of 2.80 to 3.23,and the richness indices of 2.35 to 2.93. Two species of α-polysaprobic zone indicator organisms and two species of β-polysaprobic zone indicator organisms, nine species of α-mesosaprobic zone indicator organisms and eight species of β-mesosaprobic zone indicator organisms and two species of oligosaprobic zone indicator organisms were detected. 【Conclusion】 The physical and chemical indicators of Juyan Lake revealed that the water body was in eutrophic state, mainly manifested as nitrogen levels far over the standard. Plankton biomass showed that Juyan Lake′s water was in oligotrophic state. The density of phytoplankton indicated that the aquatic body was in oligotrophic to mesotrophic state. Dominating plankton species, pollution indicator organisms, and Shannon-Wiener diversity index all showed that Juyan Lake was in mesotrophic or medium eutrophic state. Comprehensive analysis revealed that Juyan Lake′s water quality was mesotrophic. [ABSTRACT FROM AUTHOR]

BACKGROUND: The research group has found that the small molecule peptides of antler gum are rich in peptide chains that promote bone growth, proliferation and ossification of bone marrow mesenchymal stem cells. The specific mechanism and target of antler glue in the treatment of avascular necrosis of the femoral head are still unclear, which needs further studies. OBJECTIVE: To explore the mechanism of antler glue in the treatment of femoral head necrosis based on proteomics. METHODS: Thirty-six female Wistar rats, SPF grade, were randomized into a blank group, a model group, and an antler glue group. The rats in the latter two groups were given retinoic acid 70 mg/kg once a day for 8 weeks to establish a rat model of femoral head necrosis, while the rats in the blank group were not treated. At 8 weeks after modeling, the rats in the antler glue group were given antler glue 0.35 g/kg, and those in the model and blank groups were given the same volume of 0.9% sodium chloride solution, once a day by gavage for 8 weeks. Pathological examination of bone tissue was used for verifying the successful modeling and the repair effect of antler glue on the femoral head. Non-standard (Label-free) proteome quantification technology was used to detect differential genes among groups. Biological function of differential proteins and signaling pathways involved were enriched based on GO and KEGG database analyses. STRING database was used to construct the target protein-protein interaction network diagram. The study protocol was approved by the Animal Experiment Ethics Committee of Shandong Academy of Traditional Chinese Medicine. RESULTS AND CONCLUSION: The pathological sections of bone tissue showed that antler glue could effectively repair the necrotic femoral head. A total of 1 457 kinds of proteins were identified, including 353 kinds of common differential proteins between blank group and model group as well as between model group and antler glue group. In the model group, 97 kinds of differential proteins that increased or decreased showed a significant callback after intervention with antler glue. The mechanism of antler glue in the treatment of femoral head necrosis involves blood circulation, energy metabolism, inflammatory reaction and immune process. Protein disulfide isomerase (P4HB), cadherin 2 (CDH2), annexin A2 (ANXA2), proprotein convertase subtilisin/kexin type 9 (PCSK9), milk fat globule epidermal growth factor 8 (MFGE8), and bone morphogenetic protein may be important targets of antler glue. Antler glue may treat femoral head necrosis by regulating transforming growth factor β, glycolysis/gluconeogenesis, and PI3K-Akt signaling pathways. [ABSTRACT FROM AUTHOR]

BACKGROUND: Osteonecrosis due to drugs is a serious adverse reaction occurring after the application of such drugs. Increasing evidence suggests that the gut microbiota composition is associated with osteonecrosis due to drugs. However, the causal relationship of the gut microbiota to osteonecrosis due to drugs is still unclear. OBJECTIVE: To evaluate the potential causal relationship between the gut microbiota and the risk of osteonecrosis due to drugs using the Mendelian randomization method. METHODS: A two-sample Mendelian randomization study was performed using the summary statistics of gut microbiota from the largest available genomewide association study meta-analysis (n=13 266) conducted by the MiBioGen consortium as well as the summary statistics of osteonecrosis due to drugs obtained from the FinnGen consortium R9 release data (264 cases and 377 013 controls). Inverse variance weighted, MR-Egger, weighted median, weighted model and simple model were used to examine the causal association between gut microbiota and osteonecrosis due to drugs. Sensitivity analysis was used to test whether the results of the Mendelian randomization analysis were reliable. Reverse Mendelian randomization analysis was performed on all the bacteria as an outcome for effect analysis and sensitivity analysis. RESULTS AND CONCLUSION: Inverse variance weighted estimates suggested that Lentisphaerae (phylum), Lentisphaeria (class), Melainabacteria (class), Gastranaerophilales (order), Rhodospirillales (order), Victivallales (order) and Bifidobacterium (genus) had protective causal effects on osteonecrosis due to drugs. Methanobacteria (class), Bacillales (order), Methanobacteriaceae (family), Lachnospiraceae (family), Methanobacteriales (order), Holdemania (genus), Holdemania (UCG010 group) (genus), Odoribacter (genus) and Tyzzerella3 (genus) had negative causal effects on osteonecrosis due to drugs. According to the results of reverse Mendelian randomization analysis, Clostridiaceae1 (family), Peptostreptococcaceae (family), Streptococcaceae (family), Clostridiumsensustricto1 (genus) and Streptococcus (genus) showed negative causal effects on osteonecrosis due to drugs. However, Eisenbergiella (genus) showed protective causal effects on osteonecrosis due to drugs. None of the bidirectional sensitivity analysis revealed heterogeneity or horizontal pleiotropy. When gut microbiota were used as exposure and osteonecrosis due to drugs as the outcome, Mendelian randomization analysis found that seven bacterial traits were positively correlated to osteonecrosis due to drugs, nine bacterial traits were negatively related to osteonecrosis due to drugs. When osteonecrosis due to drugs were used as exposure and gut microbiota as the outcome, reverse Mendelian randomization analysis found a negative correlated relationship with five bacterial traits and a positive causal relationship with one bacterial trait. By changing the diversity and composition of gut microbiota, it is expected to improve the incidence and prognosis of osteonecrosis due to drugs, providing new ideas for the study of orthopedic diseases. [ABSTRACT FROM AUTHOR]

In this study, 18 melon resources were used as the experimental materials, and the randomized block design was adopted. Agronomic characters such as phenology, leaf, vine, flower and yield of 18 muskmelon resources were investigated and analyzed. The diversity of agronomic characters was studied and cluster analysis was carried out. The results showed that the phenological variation coefficient ranged from 5. 24% to 15.43%, the variation coefficient of leaf agronomic characters ranged from 9.86% to 21.06%, the variation coefficient of vine agronomic characters ranged from 9.56% to17.47%, the variation coefficient of flower agronomic characters ranged from 13. 12% to 27. 17% and the yield variation coefficient ranged from 65.42% to 66.75% in these melon resources. The results of the cluster analysis showed that the 18 melon resources could be divided into five categories by phenological phase clustering, of which the first category resources had the longest female flowering period and the shortest growth period, the fifth category resources had the longest growth period. 18 melon resources could be divided into three categories by clustering the leaf and vine agronomic characters, of which the second category were robust and had strong branches. The flowering agronomic characters and yield clustering showed that the 18 melon resources could be divided into four categories, of which the second category was weak in fruit setting ability and the fourth type had high yield with an average fruit weight of 2.58 kg. Resources No. 3, No. 7 and No. 8 could be preferred as parent materials when new varieties of melon that were suitable for facility cultivation and early maturing were breeded. And when new varieties of melon that were suitable for facility cultivation, late maturing and high yield were breeded, No. 10 resources could be preferred as parent materials. [ABSTRACT FROM AUTHOR]

Acute respiratory distress syndrome (ARDS) is a severe critical respiratory disease characterized by refractory hypoxemia, which is caused by intrapulmonary and extrapulmonary factors. It has a rapid onset, and high morbidity and mortality. With the global prevalence and mutation of respiratory viruses, the diagnosis and treatment of ARDS have become more complicated, requiring exploration into the molecular mechanisms and effective therapeutic methods of the occurrence and development of ARDS in clinical practice. Researchers have found that the pathogenesis of ARDS involves the interaction of multiple factors, including imbalances in inflammatory responses and redox reactions, dysregulation of endothelial cells, disruption of alveolar-capillary barrier and abnormalities in coagulation function. Although advancements in molecular biology techniques such as genomics and proteomics have provided new insights into the pathogenesis of ARDS, there is still a lack of early diagnostic biomarker and effective drugs targeted for ARDS. At present, more comprehensive and in-depth basic and clinical research is still needed. Increasing evidence suggests that transient receptor potential vanilloid-1 (TRPV1), also known as the capsaicin receptor, plays a crucial role in respiratory system diseases. TRPV1 is widely distributed in the upper respiratory tract, airway smooth muscle, alveoli and pulmonary blood vessels, participating in mediating airway dilation and constriction, cough reflex, and release of inflammatory mediators related to inflammation and pain, as well as sensing and transmitting various biological signals related to temperature, chemical substances and mechanical stress stimuli in the respiratory system. The widespread distribution and diverse physiological functions of TRPV1 make it a research hotspot in the occurrence and development of respiratory system diseases such as pneumonia, pulmonary edema, cough, asthma and acute lung injury. This article reviews the correlation and molecular mechanisms between ARDS caused by sepsis, traumatic brain injury and respiratory viruses with TRPV1, aiming to summarize the positive effects of regulating TRPV1 expression on the pathogenesis of ARDS and provide reference for strengthening early diagnosis and effective intervention measures for ARDS. [ABSTRACT FROM AUTHOR]

目的：观察完整结肠系膜切除术（CME）治疗右半结肠癌的短期效果及安全性。方法选择右半结肠癌患者96例，随机分为CME组和传统手术组各48例，比较两组手术时间、术中出血量、淋巴结清扫数目、患者住院天数及术后并发症发生情况。结果两组均完整地切除了癌灶和系膜组织。两组手术时间、术中出血量、住院天数及术后并发症发生率比较，P均＞0．05；CME组术中淋巴结清扫数目为（17．7±1．9）枚，传统手术组为（15．8±2．4）枚，P＜0．05。结论 CME可以完整地切除癌灶和系膜组织，实现淋巴结清扫的最大化，且不增加手术风险及术后并发症发生率。 [ABSTRACT FROM AUTHOR]

[Objective] GPAT is the first enzyme in the plant glycerolipid synthetic pathway, which may play an important role in oil quality improvement and biomass energy.[Methord] Based on the GPATs obtained from GenBank, ESTs of Gossypium were selected to obtain the cDNA sequence of GbGPAT2 gene by RT-PCR from Haizi 8, which was a homozygous line of Gossypium barbadease. [Result]The full length cDNA of GbGPAT2 was 1294 bp, containing an open reading frame(ORF) of 1113 bp, which encoded a protein of 370 amino acids. Its molecular weight was about 42.4 kDa, and pI 8.72.GbGPAT2 contained a typical conserved LPLAT-LPCAT1-like domain and a NAT-SF superfamily domain.GbGPAT2 putative protein shared 87%-92 % identity with Jatropha curcas and Arabidopsis, respectively.GbGPAT2 shared only 8 % identity with GhGPAT(ADK23938.1, cloned from upland cotton without further information). The bioinformatics analysis of the membranes and subcellular localization showed that GbGPAT2 might be located in the cytoplasm membrane or the chloroplast membrane, with two transmembrane domain(TMD) structures, subcellular localization analysis showed that GbGPAT2-GFP fusion protein was distributed specifically in membranes. The embryo specific expression analysis by using quantitative RT-PCR assay indicated that the expression level of GbGPAT2 reached a peak in the stage 25 days post anther(DPA). [Conclusion] As a result, GbGPAT2 may play an important role in the Gossypium barbadense seed oil synthesis. [ABSTRACT FROM AUTHOR]

Objective To explore the correlation between Tp-Te interval, Tp-Te / QT ratio and other ECG indexes, and the occurrence of ventricular arrhythmias in patients with breast cancer first treated by anthracyclinebased chemotherapy, and to investigate the predictive value of these ECG indexes. Methods A total of 150 females diagnosed with breast cancer were enrolled. All patients were treated by anthracycline chemotherapy. According to the occurrence of ventricular arrhythmias after treatment, these patients were divided into three groups: non-ventricular arrhythmia group (n = 90), ventricular tachycardia group (n = 26) and premature ventricular contraction (PVC) group (n = 34). The general clinical data (including age, smoking history, diabetes history, hypertension history, Hb, TC, TG, HDL-C, LDL-C, K+, Na+ and Ca2+), and ECG related indexes ( including QT interval, Tp-Tec and Tp-Te / QT ) before and after treatment were compared among groups. Correlation analysis and receiver operating characteristic curve (ROC curve) were used to analyze the predictive value of ECG related indexes on the occurrence of ventricular tachycardia and PVC in patients with breast cancer after treatment. Results After treatment, the values of QTc, Tp-Tec and Tp-Te / QT in patients of the ventricular tachycardia group and the PVC group are all significantly increased (P<0. 05); these values are all higher than those in the normal controls(P<0. 05). Patients in the ventricular tachycardia group have the most obvious increase of ECG related indexes (P<0. 05). Spearman correlation analysis shows that QT interval, Tp-Tec and Tp-Te / QT are all significantly positively correlated with the occurrences of ventricular tachycardia and PVC in patients with breast cancer after treatment. ROC curve analysis indicates that the predictive value of Tp-Tec on the occurrences of ventricular tachycardia and PVC in patients with breast cancer is significantly higher than that of QTc and Tp-Te / QT; the best cut-off values are 93. 54 and 83. 07 ms, respectively. Conclusion QT interval, Tp-Te interval and Tp-Te / QT ratio have certain predictive value on the occurrence of ventricular arrhythmias in patients with breast cancer first treated by anthracycline-based chemotherapy, and the predictive value of Tp-Te interval is the highest. In the future, it may be used as an important ECG index to make early prediction and evaluation of the risk of ventricular arrhythmias in breast cancer patients undergoing chemotherapy, and provide theoretical basis for its early prevention and treatment. [ABSTRACT FROM AUTHOR]

Ｏｂｊｅｃｔｉｖｅ 　Ｔｏ ｅｘｐｌｏｒｅ ｔｈｅ ｂｅｓｔ ｓｕｒｇｉｃａｌ ｔｉｍｉｎｇ ａｆｔｅｒ ｎｅｏａｄｊｕｖａｎｔ ｃｈｅｍｏｒａｄｉａｔｉｏｎ ｆｏｒ ａｄｖａｎｃｅｄ ｒｅｃｔａｌ ｃａｎｃｅｒ ｐａｔｉｅｎｔｓ． Ｍｅｔｈｏｄｓ 　Ａｃｃｏｒｄｉｎｇ ｔｏ ｔｈｅ ｔｉｍｅ ｉｎｔｅｒｖａｌ ｂｅｔｗｅｅｎ ｎｅｏａｄｊｕｖａｎｔ ｃｈｅｍｏｒａｄｉａｔｉｏｎ ａｎｄ ｓｕｒｇｅｒｙ，１１７ ｐａｔｉｅｎｔｓ ｗｉｔｈ ａｄｖａｎｃｅｄ ｒｅｃｔａｌ ｃａｎｃｅｒ ｗｅｒｅ ｄｉｖｉｄｅｄ ｉｎｔｏ ｓｈｏｒｔ ｉｎｔｅｒｖａｌ ｇｒｏｕｐ （≤７ ｗｅｅｋｓ， ｎ ＝ ５４） ａｎｄ ｌｏｎｇ ｉｎｔｅｒｖａｌ ｇｒｏｕｐ （＞７ ｗｅｅｋｓ， ｎ ＝ ６４）． Ｔｈｅ ｅｎｄｐｏｉｎｔｓ ｉｎｃｌｕｄｅｄ ｐｏｓｔｏｐｅｒａｔｉｖｅ ｐａｔｈｏｌｏｇｙ， ｓｈｏｒｔ⁃ｔｅｒｍ ｅｆｆｉｃａｃｙ， ｔｕｍｏｒ ｒｅｃｕｒｒｅｎｃｅ ａｎｄ ｐａｔｉｅｎｔ ｓｕｒｖｉｖａｌ ｂｅｔｗｅｅｎ ｔｈｅ ｔｗｏ ｇｒｏｕｐｓ． Ｒｅｓｕｌｔｓ　Ｔｈｅｒｅ ｗｅｒｅ ８ ｃａｓｅｓ ＰＣＲ ｉｎ ｓｈｏｒｔ ｉｎｔｅｒｖａｌ ｇｒｏｕｐ ａｎｄ ２０ ｃａｓｅｓ ｉｎ ｌｏｎｇ ｉｎｔｅｒｖａｌ ｇｒｏｕｐ（Ｐ ＝ ０．４１５）． Ｔｈｅｒｅ ｗｅｒｅ ２３ ｃａｓｅｓ ｏｆ Ｔ ｄｏｗｎｇｒａｄｅ ｉｎ ｓｈｏｒｔ ｉｎｔｅｒｖａｌ ｇｒｏｕｐ ａｎｄ ４０ ｃａｓｅｓ ｉｎ ｔｈｅ ｌｏｎｇ ｉｎｔｅｒｖａｌ ｇｒｏｕｐ， ｗｈｉｃｈ ｈａｓ ｓｉｇｎｉｆｉｃａｎｔ ｄｉｆｆｅｒｅｎｃｅ （Ｐ ＝０．０３９）． Ｔｈｅｒｅ ｗｅｒｅ ２１ ｃａｓｅｓ ｏｆ Ｎ ｄｏｗｎｇｒａｄｅ ｉｎ ｓｈｏｒｔ ｉｎｔｅｒｖａｌ ｇｒｏｕｐ ａｎｄ ３８ ｃａｓｅｓ ｉｎ ｌｏｎｇ ｉｎｔｅｒｖａｌ ｇｒｏｕｐ， ｗｈｉｃｈ ｈａｓ ｓｉｇｎｉｆｉｃａｎｔ ｄｉｆｆｅｒｅｎｔ （Ｐ ＝０．０３３）． Ｔｈｅ ｓｈｏｒｔ⁃ｔｅｒｍ ｇｒｏｕｐ ｗａｓ ｅｆｆｅｃｔｉｖｅ ｉｎ ２８ ｃａｓｅｓ， ｓｔａｂｌｅ ｉｎ ２０ ｃａｓｅｓ， ａｎｄ ｐｒｏｇｒｅｓｓｅｄ ｉｎ ５ ｃａｓｅｓ． Ｉｎ ｓｈｏｒｔ ｔｅｒｍ ｅｆｆｉｃａｃｙ ｃｏｍｐａｒｉｓｏｎ， ｔｈｅ ｃａｓｅｓ ｏｆ ｃｏｍｐｌｅｔｅ ｒｅｓｐｏｎｓｅ， ｓｔａｂｌｅ ｄｉｓｅａｓｅ ａｎｄ ｐｒｏｇｒｅｓｓｉｖｅ ｄｉｓｅａｓｅ ｉｎ ｓｈｏｒｔ ｉｎｔｅｒｖａｌ ｇｒｏｕｐ ｗａｓ ２８ ｃａｓｅｓ， ２０ ａｎｄ ５， ｌｏｎｇ ｉｎｔｅｒｖａｌ ｇｒｏｕｐ ｗａｓ ４７ ｃａｓｅｓ， １４ ｃａｓｅｓ ａｎｄ ３ ｃａｓｅｓ， ｗｈｉｃｈ ｈａｓ ｎｏ ｓｉｇｎｉｆｉｃａｎｔ ｄｉｆｆｅｒｅｎｃｅ（Ｐ ＝０．０６８）． Ｔｈｅ ３⁃ｙｅａｒ ｌｏｃａｌ ｒｅｃｕｒｒｅｎｃｅ ｒａｔｅ ｏｆ ｓｈｏｒｔ ｉｎｔｅｒｖａｌ ｇｒｏｕｐ ａｎｄ ｌｏｎｇ ｉｎｔｅｒｖａｌ ｇｒｏｕｐ ｗａｓ １７．０％ ａｎｄ ４．７％， ｒｅｓｐｅｃｔｉｖｅｌｙ， ａｎｄ ｔｈｅ ｄｉｆｆｅｒｅｎｃｅ ｗａｓ ｓｔａｔｉｓｔｉｃａｌｌｙ ｓｉｇｎｉｆｉｃａｎｔ（Ｐ ＝ ０．０２９）． Ｔｈｅ ｉｎｃｉｄｅｎｃｅ ｏｆ ｒｅｃｕｒｒｅｎｃｅ ｉｎ ３ ｙｅａｒｓ ｏｆ ｓｈｏｒｔ ｉｎｔｅｒｖａｌ ｇｒｏｕｐ ａｎｄ ｌｏｎｇ ｉｎｔｅｒｖａｌ ｇｒｏｕｐ ｗａｓ ６４．２％ ａｎｄ ７９．７％， ｒｅｓｐｅｃｔｉｖｅｌｙ， ａｎｄ ｔｈｅ ｄｉｆｆｅｒｅｎｃｅ ｗａｓ ｎｏｔ ｓｉｇｎｉｆｉｃａｎｔ （Ｐ ＝ ０． ０６１）． Ｔｈｅ ｈｉｇｈｅｓｔ ＰＣＲ ｒａｔｅ ｗａｓ ｒｅａｃｈｅｄ ｉｎ ｔｈｅ １０ｔｈ ａｎｄ １１ｔｈ ｗｅｅｋ ａｆｔｅｒ ｎｅｏａｄｊｕｖａｎｔ ｃｈｅｍｏｒａｄｉｏｔｈｅｒａｐｙ． Ｏｆ ｔｈｅ １２ ａｎｄ ８ ｐａｔｉｅｎｔｓ ｗｈｏ ｕｎｄｅｒｗｅｎｔ ｓｕｒｇｅｒｙ， ３ （２５．０％） ａｎｄ ２ （２５．０％） ａｃｈｉｅｖｅｄ ＰＣＲ， ｒｅｓｐｅｃｔｉｖｅｌｙ． Ｃｏｎｃｌｕｓｉｏｎ　ＰＣＲ ａｎｄ ｌｏｃａｌ ｒｅｃｕｒｒｅｎｃｅ ｒａｔｅ ｍｉｇｈｔ ｂｅ ｉｍｐｒｏｖｅｄ ｂｙ ｔｉｍｅ ｉｎｔｅｒｖａｌ ｂｅｔｗｅｅｎ ｎｅｏａｄｊｕｖａｎｔ ｃｈｅｍｏｒａｄｉａｔｉｏｎ ａｎｄ ｓｕｒｇｅｒｙ ｗａｓ ｍｏｒｅ ｔｈａｎ ７ ｗｅｅｋｓ． [ABSTRACT FROM AUTHOR]

Objective To understand the progress of fear disease in patients with erectile dysfunction and explore its influencing factors. Methods From March 2022 to June 2022, 134 patients with erectile dysfunction in a third-class hospital in Taiyuan were selected by convenient sampling method, and the general situation questionnaire, the simplified scale of fear disease progression, anxiety and depression scale were investigated, and the relevant data were statistically analyzed by SPSS 26.0・ Results The total score of fear disease progression of erectile dysfunction patients was 28. 50 ±4・ 77, the score of physiological health dimension was 14.37 ±2. 65, and the score of social family dimension was 14. 13 ± 3.41 ・ Among the patients, 32 （23・ 9% ） had a fear disease progression score of m34. The results of multiple stepwise regression analysis showed that education background, personality type, complicated diseases, anxiety and depression were the main influencing factors for the progress of fear disease in patients with erectile dysfunction. Conclusion The progress of fear disease in patients with erectile dysfunction is at a medium level・ Medical staff should actively take measures to control the progress of fear disease in patients with erectile dysfunction and improve their life quality. [ABSTRACT FROM AUTHOR]

In order to isolate and screen the growth-promoting strains that can promote the growth of typical local pastures from the soil of the degraded grassland in the northern part of the Qinghai-Tibet Plateau (abbreviated as northern Tibet), to promote the restoration of vegetation in northern Tibet. The results showed that: (1) Two low-temperature-tolerant bacteria TS22 and TS27 were successfully screened from Tibetan soil, and they were identified as Brevibacterium sp. by 16SrRNA gene. And Bacilusmycoides. (2) The results of in vitro evaluation of the growth-promoting properties of the two isolates showed that the strains TS22 and TS27 both have the ability to produce IAA, SID and ACC-deaminase activity, and TS222 has a higher ACC-deaminase activity. Aminase activity (264.69nmol.α-KBmg-1.h-1), TS27 shows a strong ability to produce IAA[(7.52±3.85)mg.L-1] and SID(92%). (3) The pot experiment showed that the effects of strains TS22 and TS27 on the growth of bluegrass and sagegrass in a low temperature environment of 10 ℃ vary with the difference of plants and strains. Strain TS22 has differences in plant height, root length, ground and underground dryness. In terms of major aspects, the growth of Poa pratensis was significantly promoted, and the growth-promoting ability was better than TS27. The results of this study provide a good bacterial resource and practical basis for the use of plant-microbial technology in vegetation restoration in alpine regions of northern Tibet. [ABSTRACT FROM AUTHOR]

第36 卷 第12 期 农 业 工 程 学 报 Vol.36 No.12 89 2020 年 6 月 Transactions of the Chinese Society of Agricultural Engineering Jun. 2020 “Pools and raised-beds” mode of storage and diversion of water improving water and salt movement and increasing cotton yield in Bohai Rim saline-alkali land Feng Guoyi, Qi Hong, Zhang Qian, Lei Xiaopeng, Liang Qinglong, Wang Shulin, Wang Yan, Dong Ming, Liu Xu, Du Haiying, Lin Yongzeng※ (Key Laboratory of Biology and Genetic Improvement of Cotton in Huanghuaihai Semiarid Area, Ministry of Agriculture/Cotton Research Institute, Hebei Academy of Agricultural and Forestry Sciences, Shijiazhuang 050051, China) Abstract: The photosynthetic production and yield of crops are seriously affected by the stress of saline-alkali, drought and waterlogging in Bohai Rim land. Traditionally, pools and raised-beds are built to alleviate the adversity stress in this area. However, the pools and raised-beds are separately functional so that the effects are not well. In this study, a “shallow pools and raised-beds” system for storage and diversion of water, an improved system of traditional system, was established in coastal farmland. In this system, water collected in pools could be used for irrigating crops on the raised-beds. The purpose of this study was to investigate the effects of the system on water-salt movement of saline-alkali fields and cotton production. The system was constructed in 2014 at the state-owned Haixing Farm, Cangzhou City, Hebei Province, China, which was located in 38°21′N and 117°31′E. The experiment was carried out in 2017 and 2018. This system was constituted of three types of fields: raised-bed field (A), shallow groundwater extracted field (B) and salt-restriction and water drained field (C). The field without using this system was considered as control (CK) to clarifying the mechanisms of water-salt movement in fields in this system. Cotton was planted in same pattern in these four types of fields. Soil samples at 0-200 cm depth of four types of cotton fields were collected during the period from April to October of 2017 and 2018 for determination of soil moisture, salt content and pH values. The photosynthesis index (leaf area, SPAD value, net apparent photosynthesis rate, canopy apparent photosynthesis rate and photosynthetic accumulation characteristics) and yield (including its components) of cotton were measured or calculated during the whole growth period of cotton in 2017 and 2018. The effects of their spatial distribution characteristics on the photosynthesis and yield of cotton were also analyzed. Results showed that the soil moisture in the four types of fields was the highest in July and August and the lowest from April to June. Among the four types of fields, the soil moisture was the highest in the CK and the lowest in the field A. In the soil layers of 0-40 cm, the soil moistures of fields A and C were both lower than 20%. Compared to CK, the soil moisture was decreased by 13.0%-46.6% in the field A, 1.9%-23.0% in the field B, and 0.3%-44.0% in the field C, respectively. Similarly, the salt content of field A, B and C was also decreased by 21.1%-77.6% compared to CK. Compared to CK, the pH values of field A and B were both decreased in June and August. Soil salt in cotton field of A and B decreased to about 3.0 g/kg. Soil salt content in cotton field C was below 5.0 g/kg, and soil pH values in July and August were below 8.0. Cotton field A showed the lowest soil moisture, soil salt content and pH value. The seed cotton yield of field A, B and C was 3 500, 3 000 and 2 500 kg/hm2, respectively. The “shallow pools and raised-beds” model of storage and diversion of water greatly changed water-salt movement in cotton field, which was beneficial to cotton production and thus increased the cotton yield in Bohai Rim saline-alkali land. This research provided a scientific model for the efficient exploitation and utilization of coastal saline-alkali land. [ABSTRACT FROM AUTHOR]

Objective: To explore the therapeutic effect of diffeent doses of rosuvastatin combined with Tongxinluo capsule on patients with coronary heart disease complicated with hyperlipidemia. Methods: According to the random number table method, 120 patients with coronary heart disease and hyperlipidemia admitted to the Affiliated Hospital of Inner Mongolia Medical University from April 2017 to May 2018 were divided into low-dose combination group (5 mg rosuvastatin + Tongxinluo capsule), medium-dose combination group (10 mg rosuvastatin + Tongxinluo capsule), high-dose combination group (20mg rosuvastatin + Tongxinluo capsule). There were 40 cases in each group. The three groups were treated for 12 weeks. The blood lipid indexes, therapeutic effect, serum inflammatory factor levels in the three groups were compared. The adverse reactions during the three groups were observed. Results: The total effective rates in the high-dose, medium-dose combination group were higher than that in the low-dose combined group (P<0.05). After treatment, the levels of total cholesterol (TC), triglyceride (TG) and low density lipoprotein cholesterol (LDL-C) in the high-dose combination group and the medium-dose combination group were lower than those in the low-dose combination group, and the levels of high density lipoprotein cholesterol (HDL-C) were higher than those in the low-dose combination group (P<0.05). After treatment,the levels of serum high sensitivity C reactive protein (hs-CRP), tumor necrosis factor-γ(TNF-γ) and interferon-α(IFN-α) in the three groups decreased with the increase of dosage (P<0.05). There were no significant differences in the incidence of adverse reactions in the low-dose, medium-dose and high-dose combination group (P>0.05). Conclusion: 10 mg and 20 mg of rosuvastatin combined with Tongxinluo capsule in the treatment of coronary heart disease with hyperlipidemia is effective, can effectively improve blood lipid levels, there is no serious adverse reactions, and the improvement of inflammatory factors is dose dependent, physicians can choose the dosage according to clinical practice. [ABSTRACT FROM AUTHOR]

High performance ITO ceramic targets are manufactured by adjusting the sintering pressure during the sintering process. The ITO films were grown by magnetron sputtering and were characterized by X-ray diffraction (XRD), UV-visible spectrophotometer, atomic force microscope (AFM) and scanning electron microscope. The surface nodulation of ITO ceramic targets were observed. The results show that nodulation of ITO ceramic targets have been greatly improved when sintering pressure is more than standard atmosphere pressure. The ITO films which are fabricated by magnetron sputtering are amorphous. The roughness values for ITO films reduce from 0.35nm to 0.28nm. The average optical transmittance of ITO films is higher than 84% which a glass substrate is used as a reference sample. In addition, the ITO films have little etching residue after the improvement of the sintering pressure. In generally, changing the sintering pressure by control the pressure of atmosphere can improve the quality of the ITO ceramic targets effectively and enhance the performance of the transparent conductive films. [ABSTRACT FROM AUTHOR]

Objective To summarize bone mineral density test results of middle-aged and older people in Zibo，Shandong Province，and to investigate the incidence of osteoporosis in this population． Methods Between 18 May 2013 to 29 June 2014， middle-aged and older people living in Zibo，Shandong Province were randomly sampled according to age groups for bone mineral density measurement and investigation of osteoporosis incidence． Using ALOKA AOS － 100NW ultrasound bone mineral densitometer ( made in Japan) ，SOS and T-score were obtained and used for osteoporosis evaluation． Participants were grouped by age at steps of 10 years，and the mean of each group was calculated and compared in men and women． Graphs were also produced． The percentages of participants with T-score ≤ － 1SD and ＞ － 2. 5SD persons and ≤ － 2. 5SD were calculated． Ｒesults In total 605 people participated in the study，with an age range of 40 － 90 years ( mean 57. 29 ± 14. 25 years) ． The mean value of SOS was total sample 1547. 92 ± 217. 97 m /sec; male 1576. 19 ± 370. 42 m /sec; female 1532. 77 ± 25. 87 m /sec; there was significant difference ( P = 0. 034) between men and women． The mean of T-score was － 0. 24334 ± 4. 278 SD for total sample; male 0. 54926 ± 7. 121859 SD; female － 0. 64765 ± 1. 169555 SD; there were no significant differences ( P = 0. 206) between normal range，men and women． There were 160 participants with T-score between － 1SD and － 2. 5SD，representing 26. 45% of the study population，and the average value of T-score was － 1. 57875 ± 0. 402595SD． There were 25 participants ( 4. 13%) with T-score ≤ 2. 5SD，and the average value of T-score was － 2. 84240 ± 0. 347662SD． There were 185 people ( 30. 58%) who had T-score ≤ － 1SD，and the average value of T-score was － 1. 74591 ± 0. 586059 SD． Conclusion Women's average bone mass was significantly lower than that of men． Bone mass in men although declining with increased age，the differences between age groups were not statistically significant． In women there was a significant decrease in bone mass with increase in age． [ABSTRACT FROM AUTHOR]