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The experiment aims to evaluate the nutritional value of fermented pleurotus eryngii residue in yellow-feather broilers. 45 healthy male yellow-feather broilers (Tuhuang No.6) weighing (2.04±0.14) kg at 60 days old were randomly divided into 3 groups. Control group was fed with basal diet, groups A and B with basal diets + 20% and 30% fermented pleurotus eryngii residue, respectively. At the end of the experiment, the average daily feed intake (ADFI), energy metabolism and nutrient metabolism were measured. The experiment lasted for 13 days. The results showed as follows: the ADFI was significantly increased in groups A and B (P<0.05). The groups A and B with different substitution ratios of fermented fungus residue had a significant difference in the metabolic rates of calcium, phosphorus, and crude fiber calculated by the substitution method (P<0.05), while no significant differences were found in the metabolizable energy and nutrient metabolizable rates (P>0.05). The AME (TME) and AMEN (TMEN) of fermented fungus residue in groups A and B were 4.87, 5.21 MJ/kg (5.01, 5.39 MJ/kg) and 4.77, 5.14 MJ/kg (4.92, 5.32 MJ/kg), respectively. The total energy metabolism rate and nitrogen metabolism rate were 32.88%, 33.77% and 22.86%, 18.31%, respectively. The apparent (true) metabolic rates of DM, CP, EE, NDF, and ADF were 24.24%, 22.67% (26.37%, 24.55%), 22.86%, 18.31% (31.91%, 27.45%), 58.39%, 48.92% (59.02%, 49.58%), 19.20%, 25.44% (18.99%, 25.44%), and 62.67%, 58.51% (62.38%, 58.48%), respectively. It is concluded that the substitution ratio of untested raw materials may affect the metabolic rate of calcium, phosphorus, and crude fiber calculated by the substitution method, while metabolizable energy and other nutrient metabolizable rates can be used as a data reference for the application of fermented pleurotus eryngii residue in yellow-feather broilers. [ABSTRACT FROM AUTHOR]

Objective To discuss the role of ETS1 in development and progression of lung adenocarcinoma and to provide a theoretical basis for the screening of clinical biomarkers and targeted intervention for lung adenocarcinoma. Methods The UAlcan database was used to access the Cancer Genome Atlas (TCGA) database and the CPTAC database to compare the expression of ETSI in lung adenocarcinoma tissues and normal adjacent tissues. According to the expression of ETSI in lung adenocarcinoma tissues of the TCGA database, the overall survival (OS) of lung adenocarcinoma patients with high and low ETS1 expression was compared. Human lung adenocarcinoma A549 cells in the logarithmic growth phase were randomly divided into the si-NC group, si-ETS1 group, vector group and ETS1-OE group, which were transfected with si-NC, si-ETS1, peDNA3. 1 unloaded plasmid and peDNA3. 1-ETS1 overexpression plasmid by Lipofectamine™ 3000 transfection reagent, respectively. The relative expression of ETSI protein and mRNA was detected by Western blotting and real-time quantitative PCR, the cell proliferation ability (expressed by optical density value) was observed by CCK-8, the cell migration ability (expressed by scratch healing rate) was observed by cell scratch assay, and the cell invasion ability (expressed by the number of invasive cells) was observed by Transwell chamber assay. Results The results of TCGA and CPTAC database analysis showed that the expression of ETS1 in lung adenocarcinoma tissues was lower than that in the normal adjacent tissues (P<0.05). Compared with patients with low ETSI expression in lung adenocarcinoma, patients with high ETSI expression had longer OS (P<0.05). Compared with the si-NC group and the vector group, the relative expression levels of ETSI protein and mRNA in the si-ETS1 group decreased, and the relative expression levels of ETSI protein and mRNA in the ETS1-OE group increased (all P<0.05). Over the time of culture, the OD value of cells in each group showed an increasing trend. Compared with the si-NC group and the vector group at the same time point, the OD value of cells in the si-ETSI group increased, and the OD value of cells in the ETSI-OE group decreased (all P< 0.05). Compared with the si-NC group and the vector group at the same time point, the scratch healing rate and the number of invasive cells in the si-ETS1 group increased, and the scratch healing rate and the number of invasive cells in the ETS1-OE group decreased (all P<0.05). Conclusions ETSI expression in lung adenocarcinoma tissue decreases, which is associated with the prognosis of patients. The down-regulation of ETSI expression can accelerate the proliferation, migration and invasion of lung adenocarcinoma cells, suggesting its potential as a prognostic biomarker and therapeutic target gene for lung adenocarcinoma patients. [ABSTRACT FROM AUTHOR]

Objective To explore the application value of secondary decalcification in the hematoxylin-eosin（HE） pathological section of the osseous tissue in clinical pathology. Methods A total of 100 pieces of wax blocks with insufficient decalcification, bone tissue or calcified tissue were collected in this hospital from June 2022 to December 2022. The wax blocks were made into pathological section and divided into the control group and the experimental group according to the different decalcification methods. The control group used the conventional decalcification method, and the experimental group used secondary delcalcifiaction method. Finally, the quality of the two groups of pathological section was compared. Results The structural integrity of the HE pathological section, HE staining satisfaction, and excellent rate of pathological section in the experimental group were all higher than those of the control group. The differences were statistically significant（P＜0. 05）. Conclusion The second ary decalcification method has a high application value in HE pathological section of clinical pathological bone tissue. [ABSTRACT FROM AUTHOR]

For promoting a green, low-carbon way of disposition of architecture sediment and resource utilization, alkali-activated blast furnace slag (GGBS) as a green solidification agent was adopted to solidify mucky engineering waste soil for subgrade filling. The influence of different dosages of solidification agent on the comprehensive performance of solidified soil was explored. Furthermore, X-ray diffraction, scanning electron microscopy and nuclear magnetic resonance were carried out to characterize the properties of the solidification. Fractal theory was used to describe the micropore characteristics and a generalized model was established to reveal the mechanism of alkali-activated GGBS solidification of muddy muck. The results show that the liquid limit and plastic limit of the solidified soil is increased and the plasticity index is reduced owing to the curing agent. The optimum moisture content decreased first and then increased with the increase of the content of the curing agent. The maximum dry density is the opposite compared with that of the optimum moisture content. The addition of curing agent can improve the mechanical properties and water stability of slag soil. The strength, CBR, water stability, and permeability of 10% solidified slag is 2. 36 MPa, 210. 7%, 81. 3%, and 1. 36 × 10 - 7 cm/ s, respectively. All indicators can satisfy the engineering application requirement. The micro-mechanism showes that the main hydration products of the improved soil are (N, C)-A-S-H and ettringite Aft. The number of main pores in the solidified soil is reduced. For the slag with 10% of calcium solidification agent, the middle pores are reduced by 14. 7%, and the fractal dimension of pore distribution is reduced from 1. 23 to 1. 06. The solidification of muddy engineering waste soil by alkali activated GGBS has improved the stability of the waste soil and has good application prospects. [ABSTRACT FROM AUTHOR]

To analyze the influencing factors of readmission within 1 year after discharge of patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD), and to explore the predictive value of serum albumin to globulin ratio (AGR) combined with platelet to lymphocyte ratio (PLR) for readmission within 1 year after discharge of patients with AECOPD at the same time. 261 patients with AECOPD who were admitted to Guangdong Provincial People's Hospital from May 2018 to October 2021 were selected, and they were divided into readmission group(n=96) and non readmission group(n=165) based on whether they were readmission within 1 year after discharge. The AGR and PLR were compared between the two groups, and the influencing factors of readmission within 1 year after discharge of patients with AECOPD were analyzed by univariate and multivariate Logistic regression analysis. The predictive value of AGR and PLR for readmission within 1 year after discharge of patients with AECOPD was analyzed by the receiver operating characteristic (ROC) curve. The AGR of the readmission group was lower than that of the non readmission group, while the PLR was higher than that of the non readmission group (P<0.05). The readmission within 1 year after discharge of patients with AECOPD was related to ADL scores, daily average time of moderate to low intensity physical activity, home oxygen therapy, number of acute exacerbations in the first year before admission, FEV1% Pred, time of use antibiotic (P<0.05). Multivariate Logistic regression analysis showed that daily average time of moderate to low intensity physical activity less than 2 h, number of acute exacerbations in the first year before admission greater than or equal 2 times, FEV1%Pred less than 50, low AGR, and high PLR were risk factors for readmission within 1 year after discharge of patients with AECOPD (P<0.05). ROC curve analysis showed that the area under the curve (AUC) predicted by the combination of AGR and PLR for readmission within 1 year after discharge of patients with AECOPD was greater than that predicted by AGR and PLR alone. The predictive value of AGR combine with PLR for readmission within 1 year after discharge of patients with AECOPD are higer. daily average time of moderate to low intensity physical activity less than 2 h, number of acute exacerbations in the first year before admission greater than or equal 2 times, FEV1%Pred less than 50, low AGR, and high PLR were risk factors for readmission within 1 year after discharge of patients with AECOPD. [ABSTRACT FROM AUTHOR]

[Objective] To determine the soil acidity and alkalinity suitable for the growth of Phoebe bournei. [Method] Using container seedlings of current year old Phoebe bournei as experimental materials,the effects of different pH on root activity,relative water content of leaves, chlorophyll a and b content,cell membrane permeability,and malondialdehyde (MDA) content were investigated. [Result]After 11 days,the root activity ranked from strong to weak in the order of pH 7 treatment>pH 9 treatment>pH 5 treatment>pH 3 treatment. The relative water content of plant tissues was higher under the treatment of pH 5 and pH 7,and the water status of plants was better. As the acidity increased,the tolerance of chlorophyll a and b gradually decreased,and the total chlorophyll content remained at a high level under pH 5 and 7 treatments. The membrane permeability of leaf cells gradually increases under high or low pH conditions,and the degree of membrane damage is proportional to the intensity of acidity and alkalinity. With the increase of pH,the MDA content of Phoebe bournei container seedlings gradually decreased. With the passage of time,the MDA content of pH 5,7,and 9 treatments showed a trend of first increasing and then decreasing. [Conclusion] The suitable substrate pH for the growth of container seedlings of Phoebe bournei was 5-7. [ABSTRACT FROM AUTHOR]

Objective To investigate the influence of ginsenoside Rg3 on the radiosensitivity of lung cancer cells by inhibiting the pentose phosphate pathway (PPP) mediated by mammalian target of rapamycin (mTOR) pathway. Methods A549 lung cancer cells were treated with 0, 10, 20, 40, 60, 80 mg/L ginsenoside Rg3. The proliferation of A549 cells was detected by MTT method. Cells were divided into the control group (normal culture, no irradiation), the radiation group (Xray irradiation), the ginsenoside Rg3 group (60 mg/L ginsenoside Rg3, no irradiation), the combination group (X-ray irradiation +60 mg/L ginsenoside Rg3) and the activator group (X-ray irradiation +60 mg/L ginsenoside Rg3+100 nmol/L mTOR pathway activator MHY1485). All of groups were irradiated by 8 GyX ray after 48 h of culture with corresponding drugs. Plate cloning experiment was applied to detect the formation rate of cell clones in each group. Enzyme-linked immunosorbent assay (ELISA) was applied to determine levels of glucose-6-phosphate dehydrogenase (G6PD) and reduced nicotinamide adenine dinucleotide phosphate (NADPH) in cell supernatant of each group. DCFH-DA fluorescent probe method was applied to detect the level of intracellular reactive oxygen species (ROS). Cell apoptosis was detected by flow cytometry. γ -H2AX immunofluorescence staining was applied to analyze DNA damage repair. Western blot assay was applied to detect expression levels of mTOR, p-mTOR, proliferating cell nuclear antigen (PCNA), Bcl-2-associated X protein (Bax), caspase-3 and γ-H2AX protein in cells. Results Ginsenoside Rg3 inhibited the proliferation of A549 cells in a dose-dependent manner (P＜0.05). Compared with the control group, the cell clone formation rate, G6PD, ROS, NADPH levels, p-mTOR/mTOR and PCNA protein expressions were significantly decreased in the radiation group and the ginsenoside Rg3 group, and the cell apoptosis rate, γ-H2AX foci number, Bax, caspase-3, γ-H2AX protein expressions were significantly increased (P＜0.05). Compared with the radiation group and the ginsenoside Rg3 group, the cell clone formation rate, G6PD, ROS, NADPH levels, p-mTOR/mTOR, and PCNA protein expressions were significantly decreased in the combination group, the cell apoptosis rate, γ-H2AX foci number, Bax, caspase-3, γ-H2AX protein expressions were significantly increased (P＜0.05). Compared with the combination group, the cell clone formation rate, G6PD, ROS, NADPH levels, p-mTOR/mTOR and PCNA protein expressions were significantly increased in the activator group, and the cell apoptosis rate, γ-H2AX foci number, Bax, caspase-3, γ-H2AX protein expressions were significantly decreased (P＜0.05). Conclusion The inhibitory effect of ginsenoside Rg3 on lung cancer cells may be realized through inhibition of PPP mediated by mTOR. [ABSTRACT FROM AUTHOR]

Many studies on dust detection by remote sensing have been carried out in the past. However, for the thin dust and complex conditions on various surface, the effect of traditional methods was poor. Himawari-8 data were used to propose a targeted method, thus the fractional dust cover index ( FDCI) was introduced based on the dynamic brightness temperature background map. The index could effectively identify dust with different intensities, and improve the identification accuracy of thin dust. At the same time, an enhanced dust intensity index( EDII) method for estimating the dust intensity index was proposed based on the results. The identified results of four dust weather were given and verified by the ground observation. The ground verification of the dust intensity on May 3, 2017 showed that the dust intensity observed on the ground was consistent with the estimated results at 22 stations. For various surface and dust intensity, this method was an effective improvement of the brightness temperature difference. [ABSTRACT FROM AUTHOR]

This paper takes the archaeological remains of Egou site in Peiligang culture period as the analysis object. By introducing the perspective of abandonment process, it is found that the houses and potteries have obvious expediency characteristics, which is not suitable for long-term stable settlement life. Grinding stone tools are mostly tools for processing, hunting, and gathering plants, so it is speculated that agricultural economy accounted for a relatively low proportion of subsistence pattern, and the overall development level was still in its initial stage. It can be seen that the establishment of early agricultural economy might be a gradual and slow development process. [ABSTRACT FROM AUTHOR]

Objective To evaluate the efficacy of two different types of exercise in adolescent patients with scoliosis. Methods　43 children who received rehabilitation treatment for scoliosis from January to December 2022 were included in this study and randomly divided into 2 groups, including Schroth and core group (n = 27) and home exercise intervention group (n = 16). Both groups exercised for 1 hour, 2 days a week. Height, weight, BIM, cobb angle, trunk rotation (scoliosis meter), and thoracic expansion (cm) were continuously evaluated for efficacy during treatment. Results　After 12 months of rehabilitative treatment for patients with scoliosis, there were statistical significance between the trunk rotation angles in right thoracic segment and left lumbar segment, and thoracic expansion in Schroth and core group (P < 0.05), and there were statistical significance between the trunk rotation angle of left lumbar segment and thoracic expansion in the home exercise intervention group （P < 0.05）. Conclusion　Exercise therapy combined with bracing improved trunk rotation and thoracic expansion in mild and moderate scoliosis, and the earlier the detection and intervention, the better the curative effect. The Schroth and core group exercise therapy was superior to the home exercise intervention. Exercise therapy has an effect on trunk rotation angle in scoliosis. [ABSTRACT FROM AUTHOR]

In recent years, convolutional neural network has shown good results in single image super-resolution reconstruction task, and has become the most widely used algorithm in this field. However, this algorithm fails to effectively weaken the one-to-many ill-conditioned problem and reduce the solution space range of the reconstructed image, so the effect of this algorithm in improving the image reconstruction quality is becoming more and more limited. At present, it faces the bottleneck problem, and it is difficult to improve the performance greatly. In order to effectively reduce the solution space of reconstructed images and improve the performance of reconstructed images, this paper propose an image super-resolution reconstruction algorithm based on invertible neural network. Through model design, the image degradation and reconstruction process is designed as a reversible transformation process, which effectively constrains the image solution space. The application of invertible convolution structure makes the algorithm obtain the most suitable channel arrangement rules, thus effectively improving the model performance. Experimental results on mainstream data sets show that the proposed algorithm greatly improves the accuracy of image reconstruction compared with the existing SISR algorithm, and achieves the best PSNR and SSIM performance. [ABSTRACT FROM AUTHOR]

The experiment was conducted to study the effect of different levels of rumen bypass fat on serum hormone, apparent digestibility of nutrients and reproductive performance of Angus cows. A total of 40 Angus cows were randomly divided into four groups, with ten replicates in each group and one cow in each replicate. The cows in control group were fed with basic diet, the cows in group 1 were fed with basic diet + 100 g/(head·d) of rumen bypass fat, the cows in group 2 were fed with basic diet + 200 g/(head·d) of rumen bypass fat, and the cows in group 3 were fed with basic diet + 300 g/(head·d) of rumen bypass fat. The test period was 60 d. The results showed that compared with control group, the content of serum insulin, bovine insulin-like growth factor binding protein-4, follicle stimulating hormone, progesterone and estradiol of cows in group 2 and group 3 were significantly increased (P<0.05). Compared with control group, the crude protein and neutral detergent fiber apparent digestibility of cows in group 2 and group 3 were significantly increased (P<0.05), and the crude fat apparent digestibility of cows in each test group was significantly increased (P<0.05). Compared with control group, the first oestrus time of cows in group 2 and group 3 was significantly decreased (P<0.05), the first mating days of cows in each test group were significantly reduced (P<0.05), and the pregnancy rate was significantly increased (P<0.05). The study indicates that the use of 200 g/(head·d) and 400 g/(head·d) rumen bypass fat in cow production can promote the digestion and absorption of nutrients, improve reproductive performance. [ABSTRACT FROM AUTHOR]

Objective To develop a questionnaire on knowledge attitude practice (KAP) of emerging infectious diseases (EID) for the emergency department (ED) nurses, and conduct a reliability and validity test. Methods Based on the theoretical model of KAP, the first draft of the questionnaire was formed through literature review and Delphi expert consultation. A total of 293 emergency nurses from three tertiary general hospitals in Shanghai were conveniently selected for investigation in May 2021 to complete items selection and to examine the reliability and validity of the questionnaire. Results A questionnaire of ED nurses on EID was formed, including 12 items in knowledge dimension, 10 items in attitude dimension, and 12 items in practice dimension. After testing, the overall Cronbach's α coefficient of the questionnaire was 0.926, and it of each dimension ranged from 0.617 to 0.968. The overall split-half reliability was 0.846, and it of each dimension ranged from 0.614 to 0.958. The scale-level content validity index (S-CVI) of the questionnaire was 0.99, and the item-level content validity index (I-CVI) were 0.99 to 1.00. The exploration factor analysis (EFA), showed that 4, 1 and 2 common factors were extracted from the three dimensions of knowledge, attitude and practice, respectively, and the cumulative variance contribution rate was respectively 50.192%, 78.319% and 73.341%, which of the overall factors of the questionnaire was 67.242%. The confirmatory factor analysis (CFA) showed that the overall and dimensional fit of the questionnaire were good. Conclusion The questionnaire is of good reliability and validity, and it can be used as a tool to evaluate the KAP level of ED nurses on EID. [ABSTRACT FROM AUTHOR]

Objective To investigate the protective effects of empagliflozin, a highly selective SGLT-2 inhibitor, on cardiac function in mice with acute myocardial infarction (AMI) and to explore its mechanism. Methods Thirty-four 6- week-old male C57BL/6J mice were randomly divided into the sham group (n=11), model group (n=11) and treatment group (n=12) . AMI was induced in the model group and treatment group by left anterior descending (LAD) artery ligation. The mice in the sham group underwent the same procedure except that the LAD was not ligated. The mice in the treatment group were given empagliflozin (10 mg/kg/day, oral gavage) at 4 h after MI surgery for 7 days. The mice in the sham group and model group were given 0. 5% hydroxyethyl cellulose. The left ventricular internal dimension in diastole (LVIDd), left ventricular internal dimension in systole (LVIDs), fractional shortening (FS) and ejection fraction (EF) were measured by echocardiography in all three groups. TUNEL staining was used to measure cardiac apoptosis. Blood samples were collected on day 7 after AMI to measure serum levels of NLRP3, ASC, Caspase-1, IL-1β, IL-18 and CRP by ELISA. The expression levels of NLRP3, ASC, Caspase-1, cleaved Caspase-1, IL-1β, and IL-18 were analyzed by Western blotting. Results There was no difference in LVIDd among these groups (P>0. 05). Compared with the sham group, the treatment group and model group had increased LVIDs (both P<0. 05). Compared with the sham group, the treatment group and the model group had decreased EF and FS, increased serum levels of NLRP3, IL-1β, IL-18, CRP, and up-regulated protein levels of NLRP3, ASC, cleaved Caspase-1, IL-1β, and IL-18 in the cardiac tissues of mice, with much more significant changes in the model group (all P<0. 05). The mice in the model group had significantly higher cardiac apoptosis rate than the sham group and the treatment group (both P<0. 05), while there was no statistical difference between the sham group and the treatment group (P>0. 05). There was no significant difference in the serum levels of Caspase-1 between the sham group and the model group (P>0. 05). Similarly, no statistical difference was found in the protein level of Caspase-1 in the cardiac tissues of mice among all three groups (P>0. 05). Conclusion Empagliflozin improves cardiac function and reduces cardiomyocyte apoptosis in AMI mice, and its mechanism may be related to the inhibition of the NLRP3/ASC/Caspase-1 signaling pathway and reduction of the inflammatory response. [ABSTRACT FROM AUTHOR]

Maintaining the authority and centralized and unified leadership of the CPC Central Committee is a major subject of Marxist party construction. The central authority of Marxist political parties emphasizes the dialectical unity of compulsory power and conscious obedience, leading core and leading collective, centralization and democracy. The central authority is of great significance to maintaining the cohesion of Marxist party organization, the efficiency of policy implementation and the strategic choice of the party at the important moment. Scientific theoretical guidance, the authority of the leadership core, democratic centralism, party discipline and system construction are important mechanisms to safeguard the central authority of Marxist political parties. Socialism with Chinese characteristics has entered a new era, the "two establishments" should be put into practice, and the "core consciousness" should be strengthened. Under the leadership of political construction and on the basis of ideological construction, we should constantly improve the construction of democratic centralism and institutional system, and transform the "two establishments" into the political consciousness, ideological consciousness and action ability of "two maintenance". [ABSTRACT FROM AUTHOR]

The calibration processes of current distributed hydrological model has been a critical issue in data-scared or ungauged regions. In this study, we setup a hydrological model, in which, the variable saturated zone concept originated from the real-time interactive basin simulator is applied for runoff generation and the grid water droplet method for flow concentration. We also proposed a method for parameter estimation based on the characteristics of underlying surface. Based on field infiltration experiments and parameter sensitivity analysis, the quantitative statistical relationships were built between two sensitive parameters (surface saturated hydraulic conductivity K0z, coefficient of attenuation of saturation hydraulic conductivity with depth f) and the topographic parameters and soil types. The overland confluence parameters were determined by field overland flow observation experiments. The proposed parameter estimation method was verified in selected basins. Our results showed that: ① The proposed method for K0z estimation contributes to a better modeling performance for flood simulation in Jiangwan experimental watershed, the average Nash- Sutcliffe efficiency coefficient increased from 0. 82 to 0. 86, and the average absolute values of peak and flood volume errors decreased by 2. 2% and 0. 95%, respectively, but the average absolute value of the peak present time error increased by 4% (still controlled within 2 h). ② Using the measured flood data of 14 basins such as Jiangwan to calibrate the parameter f, we established the quantitative relationship between the calibrated parameter f and the soil type data of different depths was built in 14 basins including Jiangwan, and further tested in other six basins. The parameter f estimated by the soil type data of different depths was very close to that determined by traditional model calibration processes, the average absolute relative error is 2. 8%, the average Nash-Sutcliffe efficiency coefficient of the flood simulation is 0. 83, and the average absolute values of flood peak error and flood volume error were 10. 07% and 6. 86%, respectively, and the average absolute peak present time error was 2. 61 h. Our results indicated that the proposed methods for determining sensitive runoff generation parameters are applicable in data-sparse areas and could provide a better or comparable parameter estimation and flood simulation than that determine by field measurements, model calibration, remote sensing data estimation, and other methods. [ABSTRACT FROM AUTHOR]

射血分数保留心力衰竭（HFpＥF）是由于左心室舒张期主动松弛能力受损和心肌顺应性降低，导致左心 室在舒张期充盈受损、心搏量减少、左心室舒张末期压升高而引起的心力衰竭。HFpＥF 的病理生理机制尚不十分 明确，临床上对其规范的治疗方法也尚无定论。目前，临床上对HFpＥF 的常用治疗方法有药物治疗、物理治疗、有 创治疗等。深入研究HFpＥF 的治疗方法，或可为发掘HFpＥF 的潜在治疗方式提供新的方向 [ABSTRACT FROM AUTHOR]

This paper proposed an improved method for automatic extraction of multi-band spectral relationship of narrow and deep rivers in mountains and valleys with high sediment concentration from Landsat 8 OLI images, which overcame the mixed pixel effect of mountain shad ow and exposed bedrock in the downstream section of the reservoir. Taking Jingeun to Dongzhuang Reservoir section in the middle reaches of Jinghe River on the Loess Plateau as an example, it separated the water body and mountain shadow, bare mountain and bedrock beach by considering the characteristics of the multi-band spectral, and then constructed a water body extraction model suitable for narrow and deep rivers with high sediment concentration in valleys. Compared with other water extraction models, the method proposed in this paper can over come the influence of shadow close to river channel and bedrock downstream of reservoir on water extraction, and improve the extraction accuracy of narrow and deep rivers with high sediment concentration in mountain canyon. [ABSTRACT FROM AUTHOR]

Low-slope bedrock meandering rivers widely exist in areas controlled by geological structures (the bed slope is less than 5‰). Flood has a great influence on riverbed sedimentation and erosion in bedrock meandering rivers, however, we have a poor understanding of dynamic structure of flood for bedrock meandering rivers. By geometrically generalizing bedrock meandering reaches, considering the Froude similarity and side wall roughness, a generalized model of a bedrock meandering channel is established in order to analyze the water surface profile distribution, time average flow fields and turbulence structure characteristics for bends under flood. The results show that under the flood flow, the minimum water surface transverse gradient, separation of flow on the convex bank, development of double circulation on the concave bank, velocity-dip-phenomenon and maximum secondary circulation intensity are caused at the upstream of the bend apex, and the maximum water surface transverse gradient and circulation splitting are caused at the downstream of the bend apex; the bed shear stress is distributed in the flow separation area at the convex bank as well as the center of the upstream of the bend apex, and the transverse momentum transport is concentrated at the upstream of the bend apex. The experiment results show an explanation in view of hydrodynamics in respect to bed erosion and sedimentation in bedrock meandering rivers. [ABSTRACT FROM AUTHOR]

新冠病毒肺炎疫情暴发后,团体献血“熔断”,街头献血人数骤降,特殊时期无偿献血现招募模 式“短板”被无限放大。为保障临床用血需求,血站紧急启动了电话邀约献血的应急招募措施,取得了献血人数 及献血量显著提升,有效缓解了疫情期间临床用血供给紧张情况。以此工作作为启示,构想血站大数据分析平 台通过内部数据的挖掘、数据分析及建立数学模型,能够快速通过系统计算和推荐再次献血者的概率,通过电 话、短信推送、公众号等方式再次招募符合献血条件的人。作者通过阐述血站大数据分析平台建设意义、建设 目标、建设思路、建设任务及关键技术、建设核心内容等方面,旨在构建无偿献血人群数据仓库的基础上,生成 无偿献血人群分析数据集。通过数据挖掘,采用聚类算法进行空间格局分析,探讨无偿献血者空间聚类分布规 律及特征;结合分类算法、回归算法等对献血人群重复献血概率进行预测,为无偿献血者招募及筛选、血液安全 保障、应急处理等提供数据信息基础和实用方法。 [ABSTRACT FROM AUTHOR]

目的 通过回顾性对照研究,探讨人文关怀护理和常规护理模式在特勤疗养官兵中的应用效果,为提高护理服务 质量、维护巩固部队战斗力提供理论依据。方法 选取2018年3月至2019年3月来该科疗养的288例特勤疗养官兵作为研究 对象,按照随机数字表法分为对照组(155例)和研究组(133例)。对照组给予常规基础护理,研究组在常规基础护理的基础上给 予人文关怀。对2组特勤疗养员护理满意度及睡眠质量指数进行评价评分。结果 研究组满意度高于对照组,差异有统计学意 义(P<0.05)。干预后2组除睡眠时间和催眠药物因子外,研究组 PSQI总分和其他因子分均差异显著,且研究组低于对照组, 差异均有统计学意义(P<0.05)。干预后研究组睡眠获益除睡眠时间和催眠药物因子外,其余均显著高于对照组,差异均有统 计学意义(P<0.05)。结论 人文关怀护理在特勤疗养官兵中的应用效果良好,可提高服务满意度,有效地调节特勤疗养员的机 体生理心理功能,提高部队战斗力。 [ABSTRACT FROM AUTHOR]

Single image super-resolution (SISR) refers to the recovery of a high-resolution image from a single low-resolution image. With deep learning used in the field of image super-resolution, deep networks can independently learn the mapping relationship between low-resolution and high-resolution training images, showing better reconstruction performance than the traditional methods. Therefore, deep learning has become dominant in super-resolution. This paper focuses on the exploration of the existing deep network model of super-resolution in terms of reconstruction mode, network structure, and loss function. By comparing the similarities and differences between different models, the advantages and disadvantages of different model building methods and the applicable application scenarios are analyzed. Meanwhile, the reconstruction results of different network models on the benchmark test datasets are compared and the potential directions are concluded. [ABSTRACT FROM AUTHOR]

BACKGROUND: Specific gene expression at specific injury sites enhances cell regeneration. OBJECTIVE: To summarize the concept of gene therapy, to review the strategies of gene therapy and the mechanism of gene therapy for osteoarthritis, and to introduce the research direction of gene therapy. METHODS: Extensive consulted the literature on osteoarthritis gene therapy and related content in foreign databases such as PubMed and Science Direct. The key words were “Gene therapy, Cartilage, Cartilage repair, Osteoarthritis, Expression vectors, miRNA”. Above data were analyzed and summarized. RESULTS AND CONCLUSION: Gene therapy for osteoarthritis can be applied to all aspects of the pathogenesis of osteoarthritis and affect the metabolism of related substances. The target gene is delivered to the target cells through viral or non-viral vectors. At present, the focus of gene therapy is to accelerate cell repair and reduce inflammatory response. At the same time, multiple choices of gene vectors and target genes provide better individualized treatment options. The specific mechanism of gene therapy for osteoarthritis in clinic is not clear, and there is the possibility of gene mutation, which needs to be further studied to verify the safety. [ABSTRACT FROM AUTHOR]

Objective : To investigate the clinical efficacy and safety of low-dose (0.6 mg / kg) alteplase in patients with acute cerebral infarction. Method : 40 acute cerebral infarctionpatients within thrombolysis time window admitted in neurology department of our hospital from January 2016 to December 2019were randomly divided into standard dose group (0.9 mg / kg) and small dose group (0.6 mg / kg), there were 20 cases in each group. National Institutes of Health Stroke Scale (NIHSS) scores were assessed before and 1 hour after thrombolysis. CT scan was performed before and 24 hours after thrombolysis to exclude cerebral hemorrhage and close monitor of adverse reactions. Results : The effective rate was 80.00% in standard dose group and 75.00% in small dose group, there was no significant difference between the two groups (P＞0.05). There was no significant difference in NIHSS scores between the two groups before treatment (P＞0.05). NIHSS scores in both groups were decreased after treatment, the difference was statistically significant compared with before treatment (P＜0.05). There was no significant difference in NIHSS score between the two groups after treatment (P＞0.05). The total incidence of adverse reactions was 40.00% in the standard dose group, which was higher than 20.00% in the small dose group,the difference was no statistically significant (P＞0.05). Conclusion : Alteplase can effectively improve the neurological function of patients with acute cerebral infarction. The thrombolytic effect of low dose (0.6 mg / kg) is similar to that of standard dose (0.9 mg / kg), the safety is good and the incidence of bleeding is low.Small dose can be selected according to the patient's condition. [ABSTRACT FROM AUTHOR]

Atmospheric nitrogen deposition is one of the most concerned issues in global changes. Grassland communities respond significantly to nitrogen deposition and then have influences on soil erosion. In this study, the typical zonal grass species (Bothriochloa ischaemum (Linn.) Keng) on the Loess Plateau was selected as the research object. The nitrogen deposition process was simulated through nitrogen additions, and the influences of seasonal changes of vegetation communities on overland flow hydrodynamics were explored by the artificial simulated rainfall method. This experiment was conducted at the Institute of Soil and Water Conservation, CAS & MWR (108°04′27.95″ E and 34°16′56.24″ N), Yangling City, Shaanxi Province, China in 2016. Five treatments with different nitrogen addition levels of 0, 2.5, 5, 10 g/(m2·a) (based on N) were designed and they were regarded as N0, N2.5, N5 and N10, respectively. All the treatments were subjected to simulated rainfall under three rainfall intensities of 60, 90 and 120 mm/h monthly from June to September. In addition, from May to September, the coverage of Bothriochloa ischaemum (Linn.) Keng and biological soil crusts before the first rainfall test of each month were monitored. During the rainfall, the mixed samples of runoff and sediment were collected when the flow velocity became stable, and the surface flow velocity and water temperature were measured at the same time. According to the formula of open channel flow, the hydrodynamic parameters such as flow discharge, mean flow velocity, water depth, Reynolds number, Froude number, Darcy-Weisbach resistance coefficient, Manning’s roughness coefficient, flow shear stress, stream power and unit energy of water-carrying section were calculated. The results showed that nitrogen additions promoted the coverage of Bothriochloa ischaemum (Linn.) Keng and algal crusts, but inhibited the moss crusts. Compared with no nitrogen treatment (N0), the overland flow resistances values of treatments of N2.5, N5 and N10 were significantly decreased by 68.6% to 71.5% (Darcy-Weisbach resistance coefficient) and by 44.7% to 47.4% (Manning’s Roughness coefficient). The mean flow velocity values were accelerated by 32.0% to 44.0% and water depth values were reduced by 25.1% to 28.7%. The flow shear stress and stream power values were increased significantly by 228.7% to 327.4% and 313.5% to 543.2%, respectively. The unit energy of water-carrying section values was reduced by 24.4% to 27.9%. With seasons changing, the resistance values to overland flow in September were increased significantly by 220.2% to 496.9% (Darcy-Weisbach resistance coefficient) and 79.5% to 139.4% (Manning’s roughness coefficient), compared with the early-mid period (from June to August). Furthermore, the mean flow velocity values were decreased by 23.5% to 29.7%, the water depth values increased by 36.4% to 66.9%. The flow shear stress and stream power values were decreased by 97.7% to 99.4% and 98.1% to 99.7%, respectively, and the unit energy of water-carrying section values was increased by 20.8% to 64.2%. Moreover, overland flow resistance was decreased with the increase of rainfall intensity, which promoted mean flow velocity, water depth, and stream power. All in all, with the nitrogen addition increasing, the overland flow resistance was significantly reduced, the flow velocity was accelerated, the water depth was decreased, the flow shear stress and stream power were significantly increased, and the unit energy of water-carrying section was reduced. Grassland plays vital roles in regulating overland flow. However, the increase of atmospheric nitrogen deposition may exacerbate soil erosion on the slope. Overall, the results can provide a scientific instruction for grassland vegetation construction and soil erosion control in the Loess Plateau. [ABSTRACT FROM AUTHOR]

【Objective】Effects of NPK application on yield and quality of cabbage and NPK absorption of cabbage were studied.【Methods】The effects of NPK ratio on yield,quality,plant nutrient and soil nutrient of cabbage were studied with “sugan 25” as the experimental material and “3414” as the implementation plan.【Results】The fresh weight and dry weight of each part of cabbage were increased after NPK treatment.The content of VC was increased and the content of nitrate was decreased.Nitrogen,phosphorus and potassium fertilization increased the nutrient content of each part of the plant and improved the soil nutrient.Among them,treatment E（N2P2K2） has the highest yield,the best quality and relatively good plant and soil nutrients.【Conclusion】Considering the indexes of yield,quality,plant nutrient content and soil nutrient,N （300 kg/hm2）,P2O5 （75 kg/hm2） and K2O （360 kg/hm2） are recommended to be a good ratio of NPK,which has certain guiding significance for cabbage cultivation. [ABSTRACT FROM AUTHOR]

Hunan province is rich in endogenic minerals, which are formed mainly in three mineralization events such as Caledonian(mainly Silurian), Late Indosinian(Late Triassic)and Middle-Late Yanshanian(Late Jurassic-Early Cretaceous). Based on regional mineral data and achievements of geotectonic, diagenetic and metallogenic ages, the tectonic framework controlling characteristics and dynamic mechanisms of the three endogenous mineralization events were discussed. (1)In Caledonian, controlled by the expanding of Caledonian movement and deep lithosphere structural differences, Hunan province could be divided into three tectonic belts with different mineralization characteristics from southeast to northwest. In the central-southeastern Hunan tectono-magmatic belt(I), there occurred post-collisional granitic magmatism, which caused W and fluorite deposits locally; in Xuefeng thrust-fault zone(II1)of the eastern Xuefeng tectonic belt(II), there occurred Au and Au-Sb deposits related mainly with structural activation; in Wuling gentle fold zone(II2)of the western Xuefeng tectonic belt(III)and in the northwestern Hunan tectonic lifting belt(I), there occurred Hg-Pb-Zn deposits related with Cambrian synsedimentary faults, extension after Caledonian movement and hydrothermal activity. (1)In Late Indosinian, controlled by deep lithosphere structural differences, Hunan province could be divided into three tectonic belts from southeast to northwest. In the central-southeastern Hunan tectono-magmatic belt(I), there occurred larger-scale post-collisional granitic magmatism for the weakening of stress, which caused W-Sn-Pb-Zb-polymetallic deposits in the southeast and Sb-Au-W-polymetallic deposits in the northwest; Xuefeng tectonic belt(II)maybe has no endogenous hydrothermal mineralization; in the northwestern Hunan fold belt(III), there occurred small vein type of Pb-Zn deposits. (3)In Middle-Late Yanshanian, Hunan province could be divided into three tectonic belts from southeast to northwest. In the central-southeastern Hunan tectono-magmatic belt(I), there occurred larger-scale granitic magmatism due to deep tectonisms such as lithospheric delamination, upwelling of asthenosphere mantle, temperature rising and stress weakening after intracontinental collision, and subduction plate collapse, and accordingly enormous norferrous and Au deposits were formed; in the western Xuefeng tectonic belt(II), there occurred weak mineralization with Au, Hg deposits locally; in the northwestern Hunan fold belt(III), there occurred a few low temperature hydrothermal filling fluorite and As deposits. [ABSTRACT FROM AUTHOR]

BACKGROUND: The traditional fixation method for femoral neck fractures is three hollow screws inverted triangle fixation, and the optimal fixation method for femoral neck fractures that have not achieved anatomical reduction is inconclusive. OBJECTIVE: To compare the biomechanical properties of cannulated screws internal fixation for sub-capitated femoral neck fracture with different reduction qualities based on finite element analysis. METHODS: The three-dimensional digital model was reconstructed using CT data of the proximal femur from a healthy male volunteer. The femur was modeled to sub-capitated femoral neck fractures. Fracture models were divided into anatomical reduction group, coxa vara group, and coxa valgus group. All fracture model groups were transferred using the standard group, screw depression group, and screw elevation group. A vertical downward stress of 1 400 N was applied to the femoral head at the top of the acetabulum. The displacement and stress distribution of the femur and internal fixator under different fixation methods were observed, and the maximum stress and displacement of the femur and fixator were compared. RESULTS AND CONCLUSION: (1) For anatomical reduction femoral neck fracture, the peak stress of fixation in the standard group, screw depression group and screw elevation group was 41.35, 31.27 and 43.32 MPa, respectively. The maximum peak stress of the femur was found on the screw elevation group (28.58 MPa), and the standard group had the maximum peak displacement. (2) During hip varus, the stresses in the three subgroups were relatively dispersed and even. The peak stress of the femur in the standard group was the smallest, but the peak displacement was the largest. The stability of fixation might be poor. The peak displacement of the femur in the screw depression group was the smallest. (3) In the hip valgus, obvious screw stress concentration appeared in the screw depression group, and the peak displacement was the largest among the three subgroups, and an in-out-in phenomenon appeared. The peak stress of the screws in the screw elevation group was the largest among the three subgroups, but the peak displacement was the smallest. (4) It is concluded that for sub-capitated femoral neck fractures that are completely anatomically reduced, it is recommended to use standard inverted triangular nails for fixation. When the hip varus and hip valgus occur within the allowable range of the reduction standard, it is recommended to use the inverted triangle screw to fix it by rotating the corresponding angle in the same direction as the hip varus or valgus. [ABSTRACT FROM AUTHOR]

This study was aimed at understanding the effects of nitrogen gradient loading on the growth and chlorophyll fluorescence characteristics of Phoebe bournei seedlings through a simulated experiment on two-year-old P. bournei seedlings under seven nitrogen levels, N0 (0 g·m-2·a-1), N1 (5 g·m-2·a-1), N2 (10 g·m-2·a-1), N3 (15 g·m-2·a-1), N4 (20 g·m-2·a-1), N5 (25 g·m-2·a-1), and N6 (30 g·m-2·a-1) after 6 months of planting. The results showed that with an increase in nitrogen concentration, seedling height, ground diameter, and whole plant biomass showed an increase-decrease-increase pattern. Seedling height reached the maximum at N1 (142.41 cm), ground diameter and whole plant biomass reached the maximum at N2 (15.31 mm and 192.22 g, respectively), and these growth indices increased by 48.33%, 28.55%, and 114.58%, respectively, compared with the control group. Different nitrogen gradient loading treatments promoted an increase in total chlorophyll content in the leaves of P. bournei seedlings; the total chlorophyll content in leaves of the N2 and N3 groups was significantly higher and that of the N6 group was significantly lower than in the leaves of the N0 group (P < 0.05). With an increase in nitrogen intensity, the maximum photochemical efficiency (Fv/Fm), potential photochemical activity (Fv/Fo), and actual photochemical efficiency (Yield) of P. bournei seedlings showed an increase-decrease-increase trend, and the photochemical quenching coefficient (qP) and nonphotochemical quenching coefficient (qN) showed a decrease-increase-decrease trend. From the perspective of chlorophyll fluorescence parameters, N3 and N4 were the optimum concentration ranges of N For P. bournei seedlings; the photosynthetic efficiency of P. bournei seedlings could be significantly improved by an appropriate increase in nitrogen supply. [ABSTRACT FROM AUTHOR]

In order lo explore llie effect of different film mulching methods on soil moisture accumulation in dry fanning areas under simulated rainfall conditions, this paper analyzed the effects of different mulching methods mi soil water conditions under different rainfall conditions. The results show that, with the increase of simulated rainfall, the soil water storage in sandy loam and clay loam are increased, ridge covered (QLM)>half covered ridge (BLM) traditional flat (CKM). For the sandy loam, the increase of the total amount of corrugated mulch is 0.9-3.4 mm, and the flow efficiency is 10.5%-27.5%. The increase rate is 36.21%-95.65%. The yield of the raised bed is 0.6-2.1 mm, and the yield is 5%-15%, and the increase rate is 17.24%-55.26%. Compared with the traditional level, the total mulch is 1.7-6.8 mm. and the yield efficiency is 31%-45.83%, and the increase rate is 75.68%-95.77%. The yield of the raised bed is 1.4-4.2 mm higher than that of the conventional level, and the yield efficiency is I5%-35%, and the increase rate of accumulation is 75.68%-95.77%. The effect of rain collection and soil water storage and soil moisture conservation under different film mulching modes, and the film covering the whole film and semi ridge furrow sowing mode play a great role in collecting rainwater, increasing the ground temperature and keeping soil moisture. The popularization and application of the research results can effectively improve the efficient utilization of precipitation resources in this area. [ABSTRACT FROM AUTHOR]

Orbital covariance propagation plays a vital role in the space situation awareness tasks such as the space conjunction analysis and space mission planning. Orbital errors, usually expressed by the orbital covariance matrix, can be propagated with linear models or non-linear models. Linear models are analytical and computationally fast since only the state transition matrix is needed. However, the propagation accuracy declines quickly with the time due to the linearization of highly nonlinear orbital dynamic systems. The non-linear models are accurate but computationally intensive, and thus are less attractive in the orbital covariance propagation for massive space debris. On the basis of the analysis of the propagated orbital errors, this paper proposes a dynamic calibration method to improve the accuracy of orbit error propagation. The method has three steps:the generation of realistic initial orbit covariance matrix, the linear propagation of the covariance matrix, and dynamic calibration of the propagated covariance using past observations. Experiments of real data processing show that the accuracy of calibrated orbit covariance can be improved by more than 60% compared to the linearly propagated covariance, and can provide more accurate propagated covariance for many space applications require high-accuracy such as the space collision probability computation. [ABSTRACT FROM AUTHOR]

The heating free direct rolling technology for bar and wire rod can transport the billet directly from the continuous casting machine to the rolling mill for rolling, completely eliminating the traditional heating furnace and achieving the goal of energy conservation and emission reduction. Compared with traditional bar and wire rolling processes, the lower direct rolling rate is one of the factors that affects the promotion of non heating direct rolling technology. A new steel feeding control model was proposed, and based on the actual production process parameters on site, the operational effects of the first in first out ( FIFO) model and the proposed control model were studied and compared. The results show that under the connection of four machines and four streams on a rolling line, the direct rolling rate using FIFO control model is 88. 7%, which is in good agreement with the measured direct rolling rate. However, using the proposed control model can increase the direct rolling rate to 94. 3% . At the same time, simulation studies were conducted on the direct rolling rates of two models under the connection of five machines and five streams on a rolling line. The results show that the direct rolling rates using the FIFO control model and the proposed control model are 74. 3% and 81. 7%, respectively. Through comparison of results, it was found that the control factors of steel feeding directly affect the direct rolling rate. In addition, the matching degree between the flow rate of the continuous casting machine and the capacity of the rolling mill is also an important factor affecting the direct rolling rate. [ABSTRACT FROM AUTHOR]

With the advancement of new energy grid integration, the scale of wind power installations has been expanding annually. Affected by regional weather changes, the intermittency and fluctuation characteristics of wind turbine output pose an increasingly significant threat to the power grid. Extreme weather-induced wind power output anomalies, known as ramp-up events, can lead to power grid imbalances and place tremendous pressure on power system unit dispatch and load balancing. Reasonable detection of wind power ramp-up events and accurate wind power forecasting can provide prior guidance for wind farm operation and maintenance and power system dispatch, effectively alleviating the harm caused by wind power uncertainty. Firstly, the blind spots in the current mainstream definitions of wind power ramp-up events are discussed. Following this, the power change characteristics of three wind power ramp-up scenarios were classified and analyzed. Then, a method for detecting wind power ramp-up events based on sliding window bilateral Cumulative Sum(CUSUM) was proposed. This method extracts time series coupling information, captures abnormal fluctuations in wind power data within a short time window, and improves the accuracy of wind power ramp-up event detection. Furthermore, a long short-term memory (LSTM) neural network optimized by Bayesian optimization was employed to optimize model hyperparameters and improve the model􀆳s predictive performance for wind turbine output during ramp-up events. The proposed wind power ramp-up event detection method was further applied to detect wind power ramp-up events within the model prediction interval, verifying the effectiveness of the proposed method. [ABSTRACT FROM AUTHOR]

In order to get a more reliable composite pressure hull structure of underwater vehicle, the effects of anisotropy and uncontrollable processing of composite materials on the structural performances should be taken into consideration. 6σ design is introduced into the optimization of ring-stiffened composite pressure hull. Monte Carlo sampling simulation is used for the reliability analysis of hull structure, and the reliability optimization design of pressure hull is conducted by taking sigma level as an evaluation index based on the radial basis function (RBF) neural network approximation model. The results show that, although the structural mass designed by 6σ optimization is 3.11 kg higher than that designed by deterministic optimization, the sigma levels of structural performance constraints are up to 8 and more, and the reliability reaches to 100%. Both structural mass and reliability are considered in the optimal design. The proposed optimization method of RBF approximation model-based 6σ design and reliability evaluation can be used for the accurate, efficient and reliable optimization of ring-stiffened composite pressure hull of underwater vehicle and solve the problem of low structural reliability due to variation of random factors. [ABSTRACT FROM AUTHOR]

In the last few years, considerable literature relating to soil quality has grown up. There has been a great change in the research field of soil quality as the global climate change and environment pollution problems are getting worse. Confronting a massive amount of research literature, the use of traditional methods for reviewing publications has a certain limitation. Therefore, it is necessary to take the advantage of scientific metrology and information technology to quantify and qualify the research literature in this field. Using Citespace V software for visualizing patterns and trends in scientific literature, we analyzed classical literature which focused on this field, documented the association of co- citation literature with keyword co-appearance network. According to clustering analysis and the burst detection, we found that the focuses of global soil quality research changed from the response of soil organic carbon and its fractions to management practices, the sensitivity of microbial indicators, and definition of soil quality to methods, indicators and framework of soil quality assessment. Compared to theoretical research, the application soil quality research in practice such as agricultural production and environmental monitoring was gradually strengthened. Currently, the soil quality monitoring and its response to global climate change and soil amendment have attracted a large number of attentions. The proportion of environment rather than agriculture application has been progressively increased. In the near future, soil quality research will show following trends: 1) Developing countries will play an important role in this field due to their increasing needs for food safety and environmental protection. 2) The response of soil quality to global climate change and soil restoration will be the research priority. 3) Sustainable development is still the topic in this research field. We suggested that soil quality assessment, monitoring and restoration should be implemented based on the features of the countries and regions. Laws and regulations should be made to guarantee the normalization and sustainability of soil management. Visualization of research literature enables us to observe and understand the state of the research field more intuitively and explore the hidden rules and patterns, which can be a useful supplementary to traditional literature reviews. [ABSTRACT FROM AUTHOR]

Objective：This study aims to investigate the effects of intraoperative neuromonitoring (IONM) on postoperative voice outcomes of by differentiated thyroid cancer (DTC) . Methods：We assessed patients with DTC underwent thyroid surgery in the First Affiliated Hospital of Sun Yat⁃sen University from September 2018 to March 2019. According to whether IONM was used or not，the patients were divided into IONM group and non ⁃ IONM group. Clinicopathological characteristics and voice outcomes between IONM and non ⁃ IONM patients with DTC were compared using propensity score matching (PSM) . Results：In the whole population and the subgroup of lymph node dissection in the prevention center，there was no statistical difference between the two groups in the total score of the voice handicap index ⁃ 10 (VHI⁃10) and the voice field of the thyroid cancer specific quality of life (THYCA⁃QoL) questionnaire 1 and 6 months after surgery (P>0.05) . In the subgroup of approaching or invading the posterior capsule，the median (quartile) THYCA⁃ QoL voice score in the IONM group at 1 month and 6 months after surgery was 0.00 (0.00，0.00) lower than in the non⁃IONM group 0.00 (0.00，33.33) ， (P=0.034) . The score of THYCA⁃QoL in the IONM group was 5.73 lower than that in the non⁃IONM group 15.66 (P= 0.029) . There was no statistical difference in the VHI ⁃ 10 questionnaire. Conclusion：IONM has no significant effect on subjective phonation disorder in patients with DTC and subgroup patients with preventive central lymphadenectomy. However，it can significantly improve the subjective voice abnormalities of patients in the approaching or invading the posterior capsule subgroup after surgery. [ABSTRACT FROM AUTHOR]

Ｔｈｅ ａｄａｐｔｉｖｅ ｃｈａｏｓ ｃｏｎｔｒｏｌ （ＡＣＣ） ｍｅｔｈｏｄ ｗａｓ ａｎ ｅｆｆｉｃｉｅｎｔ ａｎｄ ｒｏｂｕｓｔ ｍｅｔｈｏｄ ｆｏｒ ｉｎｖｅｒｓｅ ｒｅｌｉａｂｉｌｉｔｙ ａｎａｌｙｓｉｓ． Ｈｏｗｅｖｅｒ， ｆｏｒ ｓｔｒｏｎｇｌｙ ｎｏｎｌｉｎｅａｒ ｃｏｎｃａｖｅ ｐｅｒｆｏｒｍａｎｃｅ ｆｕｎｃｔｉｏｎｓ， ｔｈｅ ｃｏｍｐｕｔａｔｉｏｎａｌ ｅｆｆｉｃｉｅｎｃｙ ｏｆ ＡＣＣ ｓｔｉｌｌ ｎｅｅｄｓ ｔｏ ｂｅ ｅｎｈａｎｃｅｄ． Ｍｏｒｅｏｖｅｒ， ｉｔ ｍｉｇｈｔ ｂｅ ｔｒａｐｐｅｄ ｉｎ ｔｈｅ ｌｏｃａｌ ｏｐｔｉｍｕｍ． Ｔｈｒｏｕｇｈ ｒｅｖｉｓｉｏｎ ｏｆ ｔｈｅ ｕｐｄａｔｅ ｓｔｒａｔｅｇｙ ｆｏｒ ｔｈｅ ｃｈａｏｓ ｃｏｎｔｒｏｌ ｆａｃｔｏｒｓ， ａｎ ｉｍｐｒｏｖｅｄ ａｄａｐｔｉｖｅ ｃｈａｏｓ ｃｏｎｔｒｏｌ ｍｅｔｈｏｄ ｗａｓ ｐｒｅｓｅｎｔｅｄ ｆｏｒ ｔｈｅ ｉｎｖｅｒｓｅ ｒｅｌｉａｂｉｌｉｔｙ ａｎａｌｙｓｉｓ． Ｎｕｍｅｒｉｃａｌ ｒｅｓｕｌｔｓ ｓｈｏｗ ｔｈａｔ ｔｈｅ ｐｒｏｐｏｓｅｄ ｍｅｔｈｏｄ ｅｆｆｅｃｔｉｖｅｌｙ ｉｍｐｒｏｖｅｓ ｔｈｅ ｒａｔｉｏｎａｌｉｔｙ ｏｆ ａｄａｐｔｉｖｅ ｓｅｌｅｃｔｉｏｎ ｏｆ ｃｈａｏｓ ｃｏｎｔｒｏｌ ｆａｃｔｏｒｓ， ｓｏ ａｓ ｔｏ ｇｅｔ ｂｅｔｔｅｒ ｃｏｎｖｅｒｇｅｎｃｅ ａｎｄ ｈｉｇｈｅｒ ｅｆｆｉｃｉｅｎｃｙ ｉｎ ｃｏｍｐｕｔａｔｉｏｎ． Ｆｕｒｔｈｅｒｍｏｒｅ， ｉｔ ｍａｋｅｓ ａ ｍｏｒｅ ｅｆｆｉｃｉｅｎｔ ａｎｄ ｒｏｂｕｓｔ ａｐｐｒｏａｃｈ ｆｏｒ ｔｈｅ ｒｅｌｉａｂｉｌｉｔｙ ａｎａｌｙｓｉｓ ａｎｄ ｒｅｌｉａｂｉｌｉｔｙ⁃ｂａｓｅｄ ｄｅｓｉｇｎ ｏｐｔｉｍｉｚａｔｉｏｎ． [ABSTRACT FROM AUTHOR]

Objective: To investigate the effect of chronic intermittent hypobaric hypoxia exposure on mice spatial memory function, and on the release of synaptic vesicle and the phosphorylation of protein GluR1 ser831/ser845 in hippocampus. Methods: Adult male C57 mice, were randomly divided into control group (n = 16) and hypoxia group (n = 16). The hypoxia group were given six hours of 5000m exposure per day, lasting for 4 weeks while the control group were feeding in normal environment. There was no difference in other feeding condition. Morris water maze was employed to test the mice spatial memory ability. Western blot was used to test the phosphorylation of protein GluR1 ser831 and ser845. The transmission electron microscope was used to measure the release of synaptic vesicle in hippocampus. Results: (1) In the Morris Water Maze test, the average escape latency in the hypoxia group (17.6± 1.69 s) was decreased compared with that in the control group (27.3± 1.45 s), and the ability to searching platform increased significantly in the hypoxia group. (2) The Western blot result showed that level of phosphorylation of protein GluR1 ser831/ser845 in hippocampus in hypoxia group are both significantly higher than that in control group; (3) The results of transmission electron microscopy showed that the level of synaptic vesicle in hypoxia group is significantly higher than that in control group. Conclusions: The exposure of chronic intermittent hypobaric hypoxic can significantly enhance mice spatial memory ability, increase the phosphorylation of protein GluR1 ser831/ser845 and the release of synaptic vesicle in hippocampus of adult C57 mice. [ABSTRACT FROM AUTHOR]

先天性马蹄内翻足是小儿最常见的下肢先天性畸形，是由复杂的肌肉、骨骼、神经系统病变等而引起的，临床表现主要有马蹄畸形、后足内翻、前足内收和高弓畸形等。先天性马蹄内翻足的发病机制尚不明确，其发病主要与吸烟环境、遗传、基因突变（同源盒结构基因A和D、PITX1、TBX4、肌肉收缩基因）、血管和肌肉异常等有关。产前检查是筛查先天性马蹄内翻足的重要手段，二维超声、三维超声、MRI均为有效的诊断方法。 [ABSTRACT FROM AUTHOR]

Aiming at the technical problem of accurate detection of underground hidden goaf in open-pit iron mines， based on the geological characteristics of actual ore deposits in an open-pit iron mine and the resistivity values of different rock ore bodies， three anomaly identification models were established to analyze the abnormal response characteristics of goaf under the condition of uneven transverse electrical properties， and the distribution rule of geoelectric field was obtained， the application research was carried out through the field test. The results show that the anomaly identification model can simulate the geoelectric field distribution accurately. In large area detection work， 3D high-density resistivity method can effectively overcome the interference of the volume effect of 2D high-density resistivity method on the accurate location discrimination of goaf and weaken the abnormal expansion effect. [ABSTRACT FROM AUTHOR]

Objective To evaluate the effect of type WIYIS-6/90 plateau oxygen generating vehicle on the high altitude spot. Methods Totally 20 male soldiers during field training at 4 280 m altitude were involved in this trial. They were given administration of oxygen inhalation at 2 L/min by nasal cannula. Blood pressure, heart rate, blood oxygen saturation, vital capacity, left and right hand strength, digit span and discriminative reaction time were detected before and after oxygen inhalation for 20 minutes and finished for 10 minutes. Results After oxygen inhalation for 20 minutes, blood oxygen saturation, vital capacity, left and right hand strength, digit span and correct times increased and heart rate decreased compared with before oxygen inhalation (P<0.05, or P<0.01). Stopping oxygen inhalation for 10 minutes, vital capacity and right hand strength increased and response time decreased (P<0.05, or P<0.01). Conclusion Using type WIYIS-6/90 plateau oxygen generating vehicle for oxygen supply at high altitude can improve brain-body function and promote work ability. [ABSTRACT FROM AUTHOR]

Objective To identify the characteristics of organizational culture as perceived by dental nurses and quality of nursing work life of dental nurses in hospital， and to investigate the relationship between each dimension of organizational culture and quality of nursing work life. Methods 126 dental nurses were investigated using Sarros' Organizational Culture Profile （QCP） and Brooks' quality of nursing work life （QNWL） . Results Among the seven dimensions of organizational culture， the dimensions of performance orientation， stability and social responsibility played major roles. However， the dimensions of supportiveness，innovation，competitiveness and emphasis on rewards played second fiddle. The overall score of QWNL as perceived by the subjects was at a moderate level. There were positive relationships between quality of work life and the three dimensions of organizational culture （ < 0.05） . Conclusion Organizational Culture can effectively improve quality of nursing work life of dental nurses，and then guarantee the nursing quality. [ABSTRACT FROM AUTHOR]

This paper studies a reliable supply chain network design problem (RSCNDP) including supply, transshipment and demand. The provider-side uncertainty (facility disruption) and the receiver-side uncertainty (demand uncertainty) are both considered, and scenario method is used to describe these uncertainties. Based on the p-robust model, a mixed-integer programming (MIP) model is proposed, where two parameters are used to describe the risk preferences of decision makers towards facility disruption and demand uncertainty. The objective function is to minimize the sum of facility fixed cost and transportation cost under a given pair of risk preference values. We develop a hybrid meta-heuristic algorithm based on the shortest augmenting path method and genetic algorithm (GA) to solve the MIP. The numerical study is conducted in the end. Numerical result verifies that decision-maker's risk preferences have a huge impact on the structure of supply chain network and the average performance of reliable supply chain network is much better than that of deterministic supply chain network in the presence of risks. [ABSTRACT FROM AUTHOR]

The electron multiplication gain needs to be corrected during operation of the EMCCD camera. According to the structural characteristics of the electron multiplying CCD and the charge multiplication of the single stage multiplier, the limitation of the existing multiplication model has to be analyzed in practical application. For TI EMCCD devices, the key parameters, including the operation voltage and temperature of EMCCD, of original multiplication model can be derived by simulation, a mathematical equation of the parameters is also presented by multiple regression analysis. And then the equation is introduced into the model, and a new method for determining the EMCCD gain is obtained, which is universal and simpler. It expands the application range of the original multiplication model. The simulation results of the model agree well with the actual data of EMCCD device. It shows that, the gain model is convenient for calculating the electron multiplier average gain as the charge multiplication gate voltage is changed. [ABSTRACT FROM AUTHOR]

Wangu-Huangjindong area is one of the most important gold producing areas in Hunan province. Previous studies on the formation age of ore-controlling faults in the area are meager, and the summary of structural types in different times is not comprehensive. Through observation and analysis of surface outcrop structures, combined with the existing research results of regional tectonic events, this paper determined the tectonic deformation sequence and their age background of Wangu gold deposit, discussed the metallogenic age, and determined the types and formation ages of ore-controlling structures. The main achievements are as follows: (1)The study area has experienced seven main deformation events from early to late: ①Regional NNE compression in the Middle Neoproterozoic formed NWW-trending slaty cleavages, bedding thrust shear faults and fold; ②Regional SN compression in the Late Silurian formed EW-trending slaty cleavages and thrust faults; ③Regional NW compression in the Late Middle Triassic formed NWW-trending dextral strike-slip faults, NE-trending thrust shear fractures and faults; ④Regional SN compression in the Late Triassic formed NW-NNW-trending dextral shear fractures, NEtrending sinistral strike-slip faults, NEE-trending sinistral strike-slip-thrust shear fractures; ⑤Regional NWW compression in the Late Middle Jurassic formed NNE-trending thrust faults and EW-trending dextral strike-slip faults; ⑥Regional NW-SE extension in the Cretaceous formed NE-trending normal faults and faulted basin; ⑦Regional NE compression in the Middle Late Paleogene formed EW-trending sinistral strike-slip faults. (2)The preliminary enrichment of minerals is caused by the tectonic activation in Late Silurian, and the formation of gold deposit is caused by the granitic magmatism of Yanshanian. (3)The host structure is mainly the NWW-trending and northward-dipping thrust interlayer shear faults formed in the middle of Neoproterozoic; NE-trending thrust faults of Late Middle Triassic are the passages of ore fluid; the Paleogene EW-trending sinistral strike-slip faults can become ore-breaking structures; the thrust faults and strike-slip faults formed in Silurian, the Late Middle Triassic and Late Triassic may also cut or limit the development of NWW-trending veins. [ABSTRACT FROM AUTHOR]

Some subway tunnels are V-shaped slope tunnels due to the need of crossing tunnel, pipeline, geological conditions and tunnel drainage. Smoke competition in V-shaped slope tunnel will increase the complexity and difficulty of smoke control in subway tunnel fires. The influences of tunnel slope, tunnel slope and height difference of V-shaped slope tunnel on critical velocity and smoke back-layering length in subway tunnel fires are investigated by using the theoretical analysis method and numerical simulation method. Results show that tunnel slope and V-shaped slope has significant effects on critical velocity and smoke back-layering length in subway tunnel fires. The critical velocity decrease with the increasing of the tunnel slope for the uphill tunnels. The critical velocity increase with the increasing of the tunnel slope for the downhill tunnels. The critical velocity decrease with the increasing of the tunnel slope for the uphill tunnels of V-shaped slope tunnels. The critical velocity decrease with the increasing of the height difference for the downhill tunnels of V-shaped slope tunnels. Research results can provide the theoretical basis and technical support for determining the critical velocity in the ventilation design and smoke control system design for V-shaped slope subway tunnels. [ABSTRACT FROM AUTHOR]

目的比较微创经椎间孔椎体间融合术与传统开放手术在腰椎滑脱症治疗中的临床效果。方法选取该院2012年9月至2014年12月收治的腰椎滑脱患者90例,按随机数字表法分为对照组和观察组,各45例。对照组患者通过传统开放手术进行治疗,观察组患者行微创经椎间孔椎体间融合术治疗,术后随访12个月。临床疗效根据治疗过程中两组患者的术中出血量、手术时间、术后住院时间、术后并发症,治疗前后疼痛视觉模拟评分法(VAS)、Oswestry功能障碍指数(ODI)评分来评判。结果两组患者的手术时间比较,差异无统计学意义(P>0.05),观察组术后引流量、术中出血量、术后住院时间显著低于对照组,差异均有统计学意义(P<0.05)。治疗后,两组患者VAS、ODI评分较治疗前均有明显改善,观察组VAS评分较对照组改善情况更明显(P<0.05)。另外,对照组3例患者出现创口浅表感染,恢复缓慢,观察组患者未出现感染现象,病情恢复较为迅速,两组患者均未出现神经损伤、固定不牢固、脱钉断棒、内置物移位的现象。结论行微创经椎间孔椎体间融合术治疗腰椎滑脱症能有效减少对患者的手术创伤,缩短术后住院时间,减少术中出血量、术后引流量、改善患者预后,值得临床推广使用。 [ABSTRACT FROM AUTHOR]

目的　探讨颈动脉交感神经网切除术对脑性瘫痪患儿吞咽障碍及流涎的改善作用。方法　脑性瘫痪 患儿42例，随机分为手术组及对照组各21例。对照组仅行康复治疗，手术组行颈动脉交感神经网切除术＋康复 治疗，分别采用洼田饮水试验(洼田评分)及Ｔｅａｃｈｅｒ流涎分级法(ＴＤＳ)对手术组术前、术后2周、术后6个月及同 期对照组的吞咽功能、流涎情况进行评价。结果　手术组术后2周及6个月时洼田评分、ＴＤＳ低于治疗前及对照 组(Ｐ均<0.05)。两组治疗后6个月与治疗后2周各指标比较，Ｐ均!0.05。结论　颈动脉交感神经网切除术 可改善脑性瘫痪患儿吞咽功能，减少其流涎。 [ABSTRACT FROM AUTHOR]

The new technology for lifting precast block, which used new lifting device, was mainly introduced in this paper. The hook could automatically open, which be easier to operate, more universality, lower safety risk, high efficiency and greatly reduce the work cost to compared with traditional precast block lifting method. The application of new lifting device in project under construction can ensure the safety and efficiency of lifting works. [ABSTRACT FROM AUTHOR]

Objective To investigate the clinical efficacy of glycyrrhizin in the treatment of children with hand-foot-mouth disease (HFMD) at the stage of nervous system involvement. Methods A total of 138children with HFMD at the stage of nervous system involvement in this hospital from January 2017to October 2019were selected and divided into the conventional treatment group (66cases) and the study group (72cases) according to the random number table method. At the same time, healthy physically examined children were selected as the control group (63cases). The levels of immune cells, immunoglobulins and inflammatory cytokines in the three groups were compared, and the clinical efficacy of the conventional treatment group and the study group were analyzed. Results There were significant differences between the conventional treatment group and the study group in the onset time of antipyretic effect, the time of recovery of normal body temperature, the time of disappearance of rash, the time of recovery of mental state or the time of disappearance of tremor and clinical efficacy (P<0.05). There were significant differences in the related indexes of immune function between the control group and the conventional treatment group (P<0.05). There were significant differences in the related indexes of immune function (except Tc cells, NK cells and B lymphocytes) between the control group and the study group (P<0.05). There were significant differences in immune function related indexes (except Tc cells and NK cells) between the conventional treatment group and the study group (P<0.05). IgM level was positively correlated with B lymphocyte level (r=0.852,P=0.016). Conclusion Glycyrrhizin can effectively improve the clinical symptoms and immune dysfunction of children with HFMD at the stage of nervous system involvement, and has a good clinical therapeutic effect. [ABSTRACT FROM AUTHOR]