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Chemical thermodynamics is often perceived as abstract, making it challenging to integrate ideological cultivation into the curriculum. In this paper, we present our practice of seamlessly integrating ideological elements into the teaching of “chemical reaction heat” and share our experiences in achieving the holistic development of students’ knowledge, skills, and qualities. [ABSTRACT FROM AUTHOR]

In order to solve the problem of inefficient transit connection at domestic airports, by analyzing the factors affecting the airport flight transfer connection, the concept and calculation method of hit were defined based on the theory of flight wave. On this basis, a time adjustment model was constructed with the goal of maximizing the number of hits of one-day transit connection at the hubs, and taking the time constraints, the detour constraints and the runway capacity constraints into account at the same time. An adaptive simulated annealing genetic algorithm was designed to solve this model, and the idea of simulated annealing was introduced into the adaptive genetic algorithm to improve the global search capability and convergence speed of the algorithm, and compared with traditional genetic algorithm and simulated annealing. Through the empirical analysis of the one-day flight data of the capital airport, the optimal number of hits under the three kinds of time window adjustment durations was solved respectively, and the corresponding flight schedules were iterated. The results show that the improved algorithm can obtain high-quality near-optimal solutions in a shorter time. The optimized time structure presents an obvious waveform structure, and the transit connection performance of the airport has been effectively improved. [ABSTRACT FROM AUTHOR]

For a reaction occurring between volatile solutes in a solution system, the calculation of the Gibbs function is fundamentally different from that of other reaction systems. This paper discusses the calculation of the Gibbs function and suggests that the significant difference in the calculation should be indicated in physical chemistry textbooks to avoid possible errors in teaching and application. [ABSTRACT FROM AUTHOR]

Using the liquid-gas phase transition as an example, this study discussed how to achieve the triune teaching goal better for physical chemistry course, that is, to simultaneously cultivate the "knowledge-ability-quality" of the students. [ABSTRACT FROM AUTHOR]

Myocardial ischemia-reperfusion injury (MI/RI) is potentially associated with activation of mitophagy through a variety of molecular mechanisms. Moderate mitophagy is effective in maintaining mitochondrial membrane potential and cell membrane structure and function, thereby reducing MI/RI, whereas mitochondrial dysfunction, inadequate clearance or over-activated mitophagy can make MI/RI more severe. [ABSTRACT FROM AUTHOR]

吕洋，教授，主任医师，医学博士，硕士研究生导师，重庆医科大学附属 第一医院老年病科副主任，重庆市老年病科临床医疗质量控制中心副主任，曾先后留学德 国、美国和法国。现任中华医学会老年医学分会青年委员，中华预防医学会老年病预防专 业委员会委员，中国医师协会神经内科医师分会神经遗传专业委员会委员，中国老年保健 医学研究会抗衰老研究分会常委，中国老年医学学会认知障碍分会委员，西部老年医学中 心联盟副主席，重庆市老年痴呆防治协会副会长，重庆市老年学学会副会长，重庆市医师 协会老年医学专委会副会长，重庆市老年学学会老年保健康复委员会主任委员，重庆市中 西医结合学会慢病与健康管理委员会副主任委员。主要从事老年神经与心理疾病（癫痫和 认知障碍）的研究，主持包括国家自然科学基金在内的各级科研课题14项，主持获得重庆 市科技进步二等奖1项、重庆市卫计委科技成果二等奖1项，主（参）编著作10部；在国内；在国内 外发表论文72篇，其中第一或通讯作者SCI论文26篇，丨参与指南共识撰写1篇。 [ABSTRACT FROM AUTHOR]

Objective To study the expression and significance of tumor metastasis suppressor gene-1(TMSG-1) in esophageal squamous cell carcinoma (ESCC) and EC109 cells. Methods Immunohistochemistry S-P method was used to examine the expression of TMSG-1 protein in 136 cases of ESCC and 37 cases of normal esophageal mucosa. We analyzed the relationship between TMSG-1 and clinicopathological data of ESCC patients. EC109 cells were treated with 3μg/mL of cisplatin (CDDP) in vitro for 24h (the intervention group) and the control group was set up at the same time. The proliferation-inhibitory capability was analyzed with MTT assay. RT-PCR was used to examine the expression of TMSG-1 in the intervention group and the control group. Results The positive rate of TMSG-1 in ESCC and normal esophageal mucosa was 52.2%(71/136) and 94.6%(35/37), respectively. The expression of TMSG-1 in ESCC was significantly lower than that in normal esophageal mucosa (P<0.05). The expression of TMSG-1 was related to TNM stage, differentiation degree and lymph node metastasis (P<0.05). After EC 109 cells were treated with CDDP for 24h, the proliferation inhibition rate was increased significantly compared with the control group (P<0.01). RT-PCR results showed that the expression of TMSG-1 in the cells of the intervention group was significantly higher than that in the control group (P<0.01). Conclusion The abnormal expression of TMSG-1 may play a role in the development and metastasis of ESCC. Examination of TMSG-1 may be useful for making diagnosis and guiding clinical therapy of ESCC. [ABSTRACT FROM AUTHOR]

目的观察食管鳞状细胞癌（ESCC)组织中三磷酸腺苷结合盒转运蛋白G2(ABCG2)及P16表达变化， 并探讨其临床意义。方法选取136例份ESCC组织及37例份正常食管黏膜组织（距癌组织>5 cm)，用免疫组 化SP染色法检测两种组织中ABCG2及P16蛋白表达，用qRT-PCR法检测两种组织中ABCG2与P16 mRNA表达。 分析ABCG2及P16蛋白阳性表达与患者临床病理参数的关系，用Spearman等级相关分析ABCG2、P16表达的相关 性结果与正常食管黏膜组织比较，ESCC组织中ABCG2蛋白阳性表达率高(P <0.05)、P16蛋白阳性表达率低 (P<0.05)。与正常食管黏膜组织比较，ESCC组织中ABCG2 mRNA相对表达量高（P<0• 05)、pl6 mRNA相对表 达量低(P<0.05)。ABCG2及P16蛋白阳性表达与食管鳞癌肿瘤浸润深度、TNM分期及淋巴结转移有关(P均< 0. 05)，与患者性别、年龄及肿瘤组织学分级无关(P均>0. 05)。ESCC组织中ABCG2与P16蛋白表达呈负相关(r =-0.438，P<0.05)。结论 ABCG2在ESCC组织中呈高表达，P16呈低表达;二者可能协同作用参与ESCC的发 生发展。 [ABSTRACT FROM AUTHOR]

目的　探讨ASPP2、p53、E-cad在食管鳞癌组织中的表达，分析其与预后的相关性。方法　采用免疫组 化SP法检测136例食管鳞癌及37例正常食管黏膜组织中ASPP2、p53、E-cad的阳性表达情况，分析其与食管鳞癌 患者临床病理特征的关系，采用单因素Kaplan-Ｍeｉer法及Coｘ多因素比例风险模型分析ASPP2、p53、E-cad的表达 与患者术后生存的关系。结果　ASPP2、p53、E-cad在食管鳞癌组织中的阳性率分别为49.3%、89.7%、46.3%，在 正常食管黏膜组织中的阳性率分别为94.6%、21.6%、78.4%(P均<0.05)。ASPP2、p53、E-cad的异常表达均与食 管鳞癌的淋巴结转移情况有关，ASPP2、E-cad的异常表达与肿瘤的组织学分级和TNＭ分期有关，E-cad的异常表达 与肿瘤浸润深度有关(P<0.05或<0.01)。食管鳞癌组织中，ASPP2与p53呈负相关，ASPP2与E-cad呈正相关， p53与E-cad呈负相关(r分别为-0.295、0.620、-0.169，P均<0.05)。ASPP2、E-cad是影响食管鳞癌术后生存的 独立因素。结论　ASPP2、p53、E-cad异常表达在食管鳞癌的淋巴结转移中可能起协同作用，且ASPP2、E-cad与食 管鳞癌的预后密切相关，联合检测ASPP2、p53、E-cad有助于判断食管鳞癌患者的预后。 [ABSTRACT FROM AUTHOR]

Objective: To investigate the change and mechanism of calcium sensing receptor expression in atherosclerosis rat combined with myocardial infarction. Methods: A rat atherosclerosis model combined with myocardial infarction was established, in which rats received a single dose of vitamin D3 and were fed a high-fat and received isoproterenol (ISO) treatment. ISO was used to induce myocardial infarction. The rat myocardial infarction models were prepared using subcutaneous injection of isoprel (200 mg kg-1 d-1.Wistar rats were divided into four groups randomly: l) Control group: 1 ISO group: 2 AS group: 3 AS ISO group. The expressions of CaSR. Bcl-2. Bax and caspase-3 mRNA were analyzed using RT-PCR respectively. Apoptotic cells were measured by TUXEL staining assay. The morphological changes of cardiac tissues were observed under optical microscope. The activity of creatine kinase (CK). were assayed with ultraviolet spectrophotometer. The level of cTnT was detected by electrochemical immunofluorescence. Results: Compared with the control group, the activity of CK and cTnT. apoptosis index, expression of CaSR. Bax and caspase-3 were increased, but the Bcl-2 expression was decreased, the myocardial ultrastructure injury was aggravated in the ISO group. The further increased of above parameters in AS ISO group. Conclusions: The increased expression of CaSR was involved in the pathogeneisi of atherosclerosis combined with myocardial infarction, which might be related with and the increase of apoptosis. [ABSTRACT FROM AUTHOR]

分级诊疗可实现医疗资源的合理分配及充分应用，近年来成为医改条件下的一种医疗制度。在这种形势 下，培养全科医生既可使得医疗卫生资源优化配置，又可为群众提供便利的医疗卫生服务。因此，在分级诊疗发展过程 中，全科医生的培养显得尤为关键。全科医生可提供优质的初级卫生保健，其是社区健康保健系统的重要守卫者。只有着 重培养全科医生的临床技能并提高其整体素质，才能提供良好的全科医疗服务，更好地落实并实现分级诊疗。 [ABSTRACT FROM AUTHOR]