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To improve the antibacterial properties of medical polyvinyl chloride (PVC), atmospheric pressure plasma jet (APPJ) technology was used to graft and prepare quaternary ammonium compounds (QAC) coatings on the PVC surface. The flow state and active components of the plasma jet were diagnosed by ripple shadowing and emission spectroscopy, respectively. The hydrophilicity, microscopic morphology and chemical components of the PVC surface before and after plasma treatment were characterized by static water contact angle method, scanning electron microscopy and X-ray photoelectron spectroscopy, respectively. The antibacterial performance of QAC/PVC against Escherichia coli was also tested. The results showed that with the increase of discharge voltage, the plasma jet flow state in the area of contact with PVC changed from laminar to turbulent flow. After plasma modification, the hydrophilicity of the PVC surface was enhanced. The water contact angle of the modified PVC surface could be as low as 26°, and the content of oxygen-containing functional groups was as high as 31.02 at%. The increase of discharge voltage contributes to the enhancement of the amount of oxygen-containing functional groups on the PVC surface and promotes the grafting and polymerization of quaternary amines on the PVC surface to form a dense coating, which improves its antibacterial performance against E. coli. [ABSTRACT FROM AUTHOR]

Objective To explore the reliability and validity of the Chinese Nanjing persistent vegetative state scale(CNPVSS)in evaluating patients with acute disorders of consciousness(DOC). Methods 253 DOC patients who were admitted to Nanjing Zijin Hospital from January to December 2020 for early severe rehabilitation treatment, with a course of ≤28 days and meeting the admission criteria were selected, and scored by using the Glasgow Coma Scale(GCS)and CNPVSS respectively. The correlation between GCS and CNPVSS scores of patients of different genders was calculated. The reliability and validity of 2 scales were compared and analyzed. Results The extent of DOC in enrolled patients was relatively severe, with a tracheotomy rate of around 80％. The GCS score results were 8(6, 10) for male and 8(5, 10)for female, while the CNPVSS score results were 3 (2, 7) for male and 3(1, 6)for female. The scores of 2 scales were significantly correlated in both genders(P＜0. 001). The reliability index of CNPVSS, the Cronbach's alpha coefficient(0. 905 for males and 0. 882 for females)were higher than GCS (0. 580 for males and 0. 665 for females). The Kaiser Meyer Olkin (KMO) value of the validity indicator(0. 846 for male, 0. 834 for female)was also higher than GCS (0. 559 for male, 0. 593 for female). Conclusion CNPVSS can be used for the evaluation of acute DOC patients and has good reliability and validity. [ABSTRACT FROM AUTHOR]

Objective To investigate the efficacy and safety of hyperbaric oxygen therapy（HBOT） in the treatment of patients with moyamoya disease（MMD）. Methods The clinical data of 26 patients with MMD admitted to Nanjing Zijin Hospital from January 2020 to December 2021 were analyzed retrospectively. The analysis indicators mainly included age, after onset course, blood pressure, HBOT frequency and pressure, primary disease, surgical choice, consciousness in admission and discharge, limb function, and the adverse cerebrovascular disease events. Results The average age of the enrolled patients was（45.2±15.2）years old. The patients were admitted to the hospital for treatment within 1 month of the onset. The blood pressure of most patients fluctuated in the normal range when they were admitted to the hospital, and the blood pressure of a few patients fluctuated and stabilized after treatment. Of 26 patients, 13 had ischemic MMD, and 13 had hemorrhagic MMD. Of 26 patients, 21 received HBOT for 20 to 60 times, and 5 received more than 60 times. The pressure of HBOT was mainly 1.6 ATA or 1.6/2.0 ATA. No cerebrovascular events occurred during treatment. Among 26 patients, 21 improved significantly, 4 improved, and 1 remained unchanged. Conclusions HBOT can be used in children and adults with ischemic and hemorrhagic MMD, especially in the patients treated with intracranial revascularization and/or hematoma removal. No adverse cerebrovascular disease events such as rebleeding and reinfarction are observed during HBOT. Before and during HBOT, the patient’s blood pressure and intracranial pressure must be under good control, and different pressure therapies should be given according to different patients. [ABSTRACT FROM AUTHOR]

Objective: To study the relationship between serum interleukin-17（IL-17）, substance P（SP）, chemokine（Chemerin）levels and disease activity and immune function in patients with oral lichen planus（OLP）. Methods: 117 patients with OLP who were treated in our hospital from March 2019 to May 2021 were selected as the observation group, including 69 cases of non erosive type, and48 cases of erosive type. Another 60 volunteers who came to our hospital for physical examination in the same period were selected as the control group. The serum SP, IL-17 and Chemerin levels in the control group and patients with different types were compared, and the disease activity related scores and immune function indexes of patients with different types were compared. Pearson correlation analysis was used to analyze the relationship between serum SP, IL-17, Chemerin levels and disease activity related scores and immune function indexes. Results: The serum SP, IL-17 and Chemerin levels of the OLP patients with different types were higher than those of the control group（P<0.05）. The serum SP, IL-17 and Chemerin levels of erosive type OLP patients were higher than those of non erosive type OLP patients（P<0.05）. The CD3+and CD4+of erosive type OLP patients were lower than those iof non erosive type OLP patients（P<0.05）. The CD8+, immunoglobulin M（Ig M） level and the total scores of reticulo erosive ulcer disease activity score（REU） of erosive type OLP patients were higher than those of non type erosive OLP patients（P<0.05）. There was no significant difference in immunoglobulin A（IGA） and immunoglobulin G（Ig G） levels between erosive and non erosive OLP patients（P>0.05）. Pearson correlation analysis showed that serum SP, IL-17 and Chemerin levels were positively correlated with the total scores of Ig M level and REU total score（P<0.05）. Conclusion: The serum IL-17, SP and Chemerin levels in patients with OLP are abnormally increased. They are involved in the disease progression and immune function regulation of patients with OLP. [ABSTRACT FROM AUTHOR]

Objective: To investigate the relationship between gingival crevicular fluid intercellular adhesion molecule-1 ( ICAM-1), pentraxin 3 (PTX3), calcium binding protein S100A12 (S100A12) and sonic hedgehog (Shh) protein and periodontal indexes and inflammatory response in patients with chronic periodontitis. Methods: 120 patients with chronic periodontitis who were treated in our hospital from April 2017 to June 2021 were selected as the observation group, and 90 periodontal healthy volunteers were selected as the control group. The levels of gingival crevicular fluid ICAM-1, PTX3, S100A12 and Shh protein of the control group and the observation group were compared. The levels of gingival crevicular fluid ICAM-1, PTX3, S100A12, Shh protein, periodontal indexes and serum inflammatory factors of patients with different severity of the disease in the observation group were compared. Pearson correlation analysis the correlation between gingival crevicular fluid ICAM-1, PTX3, S100A12, Shh protein and periodontal indexes and serum inflammatory factors. Results: The levels of gingival crevicular fluid ICAM-1, PTX3, S100A12 and Shh protein in the observation group were higher than those in the control group, and the differences were statistically significant (P<0.05). The levels of gingival crevicular fluid ICAM-1, PTX3, S100A12, Shh protein, serum interleukin-6 (IL-6), tumor necrosis factor (TNF-α), attachment loss (AL), probing depth (PD) and gingival index (GI) in severe group were higher than those in mild group, and the above indexes in severe group were higher than those in moderate group, and the differences were statistically significant (P<0.05). Pearson correlation analysis showed that gingival crevicular fluid ICAM-1, PTX3, S100A12 and Shh protein were positively correlated with IL-6, TNF-α, AL, PD and GI (P<0.05). Conclusions: ICAM-1, PTX3, S100A12 and Shh protein can be used as auxiliary indexes to judge the severity of chronic periodontitis, and they have certain correlation with periodontal index and inflammatory response. [ABSTRACT FROM AUTHOR]