口腔扁平苔藓患者血清白介素-17、P物质、趋化素水平与疾病活动和免疫功能的关系研究.

Objective: To study the relationship between serum interleukin-17（IL-17）, substance P（SP）, chemokine（Chemerin）levels and disease activity and immune function in patients with oral lichen planus（OLP）. Methods: 117 patients with OLP who were treated in our hospital from March 2019 to May 2021 were selected as the observation group, including 69 cases of non erosive type, and48 cases of erosive type. Another 60 volunteers who came to our hospital for physical examination in the same period were selected as the control group. The serum SP, IL-17 and Chemerin levels in the control group and patients with different types were compared, and the disease activity related scores and immune function indexes of patients with different types were compared. Pearson correlation analysis was used to analyze the relationship between serum SP, IL-17, Chemerin levels and disease activity related scores and immune function indexes. Results: The serum SP, IL-17 and Chemerin levels of the OLP patients with different types were higher than those of the control group（P<0.05）. The serum SP, IL-17 and Chemerin levels of erosive type OLP patients were higher than those of non erosive type OLP patients（P<0.05）. The CD3+and CD4+of erosive type OLP patients were lower than those iof non erosive type OLP patients（P<0.05）. The CD8+, immunoglobulin M（Ig M） level and the total scores of reticulo erosive ulcer disease activity score（REU） of erosive type OLP patients were higher than those of non type erosive OLP patients（P<0.05）. There was no significant difference in immunoglobulin A（IGA） and immunoglobulin G（Ig G） levels between erosive and non erosive OLP patients（P>0.05）. Pearson correlation analysis showed that serum SP, IL-17 and Chemerin levels were positively correlated with the total scores of Ig M level and REU total score（P<0.05）. Conclusion: The serum IL-17, SP and Chemerin levels in patients with OLP are abnormally increased. They are involved in the disease progression and immune function regulation of patients with OLP. [ABSTRACT FROM AUTHOR]