1. Virus detection and monitoring of viral load in Crimean-Congo hemorrhagic fever virus patients.
- Author
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Wölfel, Roman, Paweska, Janusz T., Petersen, Nadine, Grobbelaar, Antoinette A., Leman, Patricia A., Hewson, Roger, Georges-Courbot, Marie-Claude, Papa, Anna, Günther, Stephan, Drosten, Christian, Wölfel, Roman, and Günther, Stephan
- Subjects
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HEMORRHAGIC fever , *POLYMERASE chain reaction , *VIRUS diseases , *SERUM , *VIRUSES , *INFECTION , *DIAGNOSIS , *PATIENTS , *REVERSE transcriptase polymerase chain reaction , *RESEARCH , *GENETICS , *BIOLOGICAL evolution , *VIRAL load , *RESEARCH methodology , *MEDICAL cooperation , *EVALUATION research , *COMPARATIVE studies , *IMMUNITY , *RNA viruses , *STANDARDS ,RESEARCH evaluation - Abstract
We developed a real-time reverse transcription--PCR that detected 1,164 copies/mL of Crimean-Congo hemorrhagic fever virus per milliliter of serum at 95% probability (probit analysis) and was 100% concordant with nested PCR on 63 samples from 31 patients with confirmed infection. Infected patients who died appeared to have higher viral loads; low viral loads correlated with IgG detection. [ABSTRACT FROM AUTHOR]
- Published
- 2007
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