1. Dihydrostilbenes and flavonoids from whole plants of Jacobaea vulgaris.
- Author
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Lee, Shinae, Son, Min-Gyung, Kim, Young-Mi, An, Chae-Yeong, Kim, Hyun Ji, Nhoek, Piseth, Pel, Pisey, Won, Hongic, Lee, Yoonkyung, Yun, Narae, Paik, Jin-Hyub, Bazarragchaa, Badamtsetseg, Kim, Hyun Woo, Choi, Young Hee, Oh, Won Keun, Lee, Chang Hoon, and Chin, Young-Won
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SENECIO , *GENE expression , *NUCLEAR magnetic resonance spectroscopy , *CYTOTOXINS - Abstract
The isolation of previously undescribed 12 compounds from the MeOH extract of Jacobaea vulgaris whole plants is disclosed, comprising 11 dihydrostilbenes (1 – 11) and one flavanone (12), and eight known compounds (six flavonoids, one dihydrostilbene, and one caffeoylquinic acid). Structural elucidation employed spectroscopic methods, including 1D and 2D NMR spectroscopy, HRESIMS, and ECD calculations. Evaluation of the compounds' effects on PCSK9 and LDLR mRNA expression revealed that compounds 1 and 3 downregulated PCSK9 mRNA while increasing LDLR mRNA expression, suggesting potential cholesterol-lowering properties. [Display omitted] • Undescribed dihydrostilbenes and flavanone were isolated from Jacobaea vulgaris. • Compounds without cytotoxicity were evaluated for their effects against PCSK9 expression. • Compounds 1 and 3 downregulated PCSK9 expression in mRNA level, implying the potentials of lowering cholesterol. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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