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Novel involvement of miR-522-3p in high-mobility group box 1-induced prostaglandin reductase 1 expression and reduction of phagocytosis.
- Source :
-
BBA - Molecular Cell Research . Apr2017, Vol. 1864 Issue 4, p625-633. 9p. - Publication Year :
- 2017
-
Abstract
- Resolution of inflammation is important for physiological homeostasis. Chronic inflammatory diseases may be caused by abnormal resolution of inflammation. However, what causes a failure of inflammatory resolution is unclear. Here we investigated the involvement of high mobility group box 1 (HMGB1) protein in the control of inflammatory resolution as an ‘anti-resolution factor’. We first confirmed the increased expression of HMGB1 and prostaglandin reductase 1 (PTGR1) in inflammatory conditions and HMGB1-mediated regulation of the expression of PTGR1. The inhibition of phagocytosis by HMGB1 was abrogated by PTGR1 silencing. PTGR1 was a direct target of miR522-3p and its expression was regulated by miRNA-522-3p inhibitor or mimic. Finally, miR-522-3p had an important role in the regulation of PTGR1 expression by HMGB1. The data indicates that HMGB1-miR-522-3p-PTGR1 axis may be involved in the abnormal resolution of inflammation and suggests that this mechanism might be a target for modulation of chronic inflammatory disorder. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01674889
- Volume :
- 1864
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- BBA - Molecular Cell Research
- Publication Type :
- Academic Journal
- Accession number :
- 121376106
- Full Text :
- https://doi.org/10.1016/j.bbamcr.2017.01.006