1. Successful Treatment of Ulcerative-Type Pyoderma Gangrenosum with a Combination Therapy of Oral Prednisolone, Vacuum-Assisted Closure, and Skin Grafting.
- Author
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Goto, Hiroyuki, Okada, Yoshimoto, Watanabe, Seimi, Danno, Kanako, Yamamoto, Shinya, Ishiura, Ryohei, Nakayama, Yuichi, Mitsui, Kohei, Ueki, Ayaka, Nakai, Yasuo, Narushima, Mitsunaga, and Yamanaka, Keiichi
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SKIN grafting , *PYODERMA gangrenosum , *TREATMENT effectiveness , *SKIN ulcers , *PREDNISOLONE , *SKIN diseases - Abstract
Pyoderma gangrenosum (PG) is a relatively rare inflammatory skin disease that progressively causes necrotic ulceration mainly on the lower extremities and trunk. Systemic corticosteroid is considered a first-line treatment for PG as it facilitates wound healing; however, several cases where tumor necrosis factor-α inhibitors, adalimumab and infliximab, were administered showed good response. For intractable PG with a large ulcer or problematic epithelization, chemical or mechanical debridement of necrotic tissue in combination with skin grafting may be necessary to promote wound healing. Our report presents a case of intractable ulcerative PG requiring oral prednisolone and skin grafting. Although mechanical debridement was performed, granulation was poor; therefore, after the PG activity became quiescent, we utilized a vacuum-assisted closure (VAC) system to promote granulation and adaptation of the grafted skin. Although more cases are required for a definitive conclusion, the VAC system may be a choice for PG with large ulcers. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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