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Successful Treatment of Ulcerative-Type Pyoderma Gangrenosum with a Combination Therapy of Oral Prednisolone, Vacuum-Assisted Closure, and Skin Grafting.
- Source :
-
Case Reports in Dermatology . 2021, Vol. 13 Issue 3, p497-501. 5p. - Publication Year :
- 2021
-
Abstract
- Pyoderma gangrenosum (PG) is a relatively rare inflammatory skin disease that progressively causes necrotic ulceration mainly on the lower extremities and trunk. Systemic corticosteroid is considered a first-line treatment for PG as it facilitates wound healing; however, several cases where tumor necrosis factor-α inhibitors, adalimumab and infliximab, were administered showed good response. For intractable PG with a large ulcer or problematic epithelization, chemical or mechanical debridement of necrotic tissue in combination with skin grafting may be necessary to promote wound healing. Our report presents a case of intractable ulcerative PG requiring oral prednisolone and skin grafting. Although mechanical debridement was performed, granulation was poor; therefore, after the PG activity became quiescent, we utilized a vacuum-assisted closure (VAC) system to promote granulation and adaptation of the grafted skin. Although more cases are required for a definitive conclusion, the VAC system may be a choice for PG with large ulcers. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 16626567
- Volume :
- 13
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Case Reports in Dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 154541691
- Full Text :
- https://doi.org/10.1159/000519659