1. Intermittent theta burst stimulation to the left dorsolateral prefrontal cortex improves working memory of subjects with methamphetamine use disorder.
- Author
-
Zhang, Yi, Ku, Yixuan, Sun, Junfeng, Daskalakis, Zafiris J., and Yuan, Ti-Fei
- Subjects
- *
PREVENTION of drug addiction , *PREFRONTAL cortex , *EVALUATION of medical care , *SUBSTANCE abuse , *ELECTROENCEPHALOGRAPHY , *TRANSCRANIAL magnetic stimulation , *DISCRIMINATION (Sociology) , *COGNITION , *METHAMPHETAMINE , *SHORT-term memory , *CLINICAL medicine , *DESCRIPTIVE statistics , *RESEARCH funding , *REACTION time , *DATA analysis software , *EVALUATION - Abstract
Background: Repetitive transcranial magnetic stimulation has been employed to treat drug dependence, reduce drug use and improve cognition. The aim of the study was to analyze the effectiveness of intermittent theta-burst stimulation (iTBS) on cognition in individuals with methamphetamine use disorder (MUD). Methods: This was a secondary analysis of 40 MUD subjects receiving left dorsolateral prefrontal cortex (L-DLPFC) iTBS or sham iTBS for 20 times over 10 days (twice-daily). Changes in working memory (WM) accuracy, reaction time, and sensitivity index were analyzed before and after active and sham rTMS treatment. Resting-state EEG was also acquired to identify potential biological changes that may relate to any cognitive improvement. Results: The results showed that iTBS increased WM accuracy and discrimination ability, and improved reaction time relative to sham iTBS. iTBS also reduced resting-state delta power over the left prefrontal region. This reduction in resting-state delta power correlated with the changes in WM. Conclusions: Prefrontal iTBS may enhance WM performance in MUD subjects. iTBS induced resting EEG changes raising the possibility that such findings may represent a biological target of iTBS treatment response. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF