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Intermittent theta burst stimulation to the left dorsolateral prefrontal cortex improves working memory of subjects with methamphetamine use disorder.
- Source :
-
Psychological Medicine . Apr2023, Vol. 53 Issue 6, p2427-2436. 10p. - Publication Year :
- 2023
-
Abstract
- Background: Repetitive transcranial magnetic stimulation has been employed to treat drug dependence, reduce drug use and improve cognition. The aim of the study was to analyze the effectiveness of intermittent theta-burst stimulation (iTBS) on cognition in individuals with methamphetamine use disorder (MUD). Methods: This was a secondary analysis of 40 MUD subjects receiving left dorsolateral prefrontal cortex (L-DLPFC) iTBS or sham iTBS for 20 times over 10 days (twice-daily). Changes in working memory (WM) accuracy, reaction time, and sensitivity index were analyzed before and after active and sham rTMS treatment. Resting-state EEG was also acquired to identify potential biological changes that may relate to any cognitive improvement. Results: The results showed that iTBS increased WM accuracy and discrimination ability, and improved reaction time relative to sham iTBS. iTBS also reduced resting-state delta power over the left prefrontal region. This reduction in resting-state delta power correlated with the changes in WM. Conclusions: Prefrontal iTBS may enhance WM performance in MUD subjects. iTBS induced resting EEG changes raising the possibility that such findings may represent a biological target of iTBS treatment response. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PREVENTION of drug addiction
*PREFRONTAL cortex
*EVALUATION of medical care
*SUBSTANCE abuse
*ELECTROENCEPHALOGRAPHY
*TRANSCRANIAL magnetic stimulation
*DISCRIMINATION (Sociology)
*COGNITION
*METHAMPHETAMINE
*SHORT-term memory
*CLINICAL medicine
*DESCRIPTIVE statistics
*RESEARCH funding
*REACTION time
*DATA analysis software
*EVALUATION
Subjects
Details
- Language :
- English
- ISSN :
- 00332917
- Volume :
- 53
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Psychological Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 163612978
- Full Text :
- https://doi.org/10.1017/S003329172100430X