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Objective To understand the epidemiologic situation and high-risk pathogenic factors of cervical cancer and to investigate the current preventive measures of cervical cancer in Changzhou in order to provide a scientific basis for its prevention and treatment. Methods Two hundreds and thirty-eight patients "case group) with pathologically confirmed cervical cancer in our hospital from January 2014 to December 2015 and 714 age-matched and area-matched healthy females "control group) were selected and conducted the related factors questionnaire survey. The related factors included general condition， diet and life style，menstrual，marital and bearing history，hormone use，past disease history，family history，women disease general survey knowledge and HPV infection situation and so on. Results Adopting the contraceptive measures and conducting cervical screening at regular interval had the protective effect on cervical cancer occurrence % while cervical HPV infection， cervical cancer family history，many sexual partners and smoking were the high-risk factors of cervical cancer (P<0.05). The clinical symptoms"including irregular bleeding，vaginal discharge，contact bleeding) in the case group were more significant than those in the control group，the difference was statistically significant (P<0.05). Conclusion Advocating to use condom，quit smoking， regular cervical screening， strengthening monitoring on the high-risk populations such as cervical cancer family history and many sexual partners will conduce to reduce the incidence rate of cervical cancer. [ABSTRACT FROM AUTHOR]

目的探讨常州地区人类乳头状瘤病毒（HPV）感染情况及感染类型的变化。方法回顾性分析2012年1月至2016年12月该地区HPV检测结果，以自愿接受HPV分子检测的63864例妇女作为研究对象，采用PCR-反向点杂交法对HPV进行基因分型检测。结果63864名妇女经HPVDNA检测高危型HPV感染率为19.75%（12616/63864），低危型HPV感染率为4.18%（2669/63864）。但2012—2016年HPV感染率比较，差异无统计学意义（P>0.05）。高危型HPV感染妇女主要的感染类型为HPV52、HPV16、HPV58，所占比例分别为16.69%（2106/12616）、13.80%（1741/12616）、11.19%（1412/12616）；低危型HPV感染主要的感染类型为HPV11、HPV6、HPV42，所占比例分别为4.76%（127/2669）、4.53%（121/2669）、4.31%（115/2669）。5年间，HPV52亚型感染率从11.3%上升至18.8%，跃居感染类型第1位；HPV16亚型感染率逐年下降（从22.4%下降至11.0%），目前位居第二。结论2012—2016年常州地区HPV感染率虽然未发生明显变化，但其感染类型发生了变化，值得关注。 [ABSTRACT FROM AUTHOR]