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A soil Streptomycesnov. sp. (MST-115088) isolatedfrom semiarid terrain near Wollogorang Station, Queensland, returnedtwo known and two new examples of a rare class of cyclic hexapeptide,desotamides A and B (1and 2) and E andF (3and 4), respectively, together withtwo new d-Orn homologues, wollamides A and B (5and 6). Structures were assigned by detailed spectroscopicand C3Marfey’s analysis. The desotamides/wollamidesexhibit growth inhibitory activity against Gram-positive bacteria(IC500.6–7 μM) and are noncytotoxic to mammaliancells (IC50>30 μM). The wollamides exhibit antimycobacterialactivity (IC502.8 and 3.1 μM), including reductionin the intracellular mycobacterial survival in murine bone marrow-derivedmacrophages. [ABSTRACT FROM AUTHOR]

Chemical analysis of a marine-derived Streptomycessp. (CMB-M0423) isolated from beach sand off Heron Island, Australia, yielded three new members of the rare pyrroloterpene biosynthetic structure class. Identified by detailed spectroscopic analysis as the first reported examples of naturally occurring 2-nitropyrroles, heronapyrroles A−C (1−3) displayed promising biological activitywith low to submicromolar IC50activity against Gram-positive bacteria but no cytotoxicity toward mammalian cell lines. [ABSTRACT FROM AUTHOR]