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Heronapyrroles A−C: Farnesylated 2-Nitropyrroles from an Australian Marine-Derived Streptomycessp.
- Source :
-
Organic Letters . Nov2010, Vol. 12 Issue 22, p5158-5161. 4p. - Publication Year :
- 2010
-
Abstract
- Chemical analysis of a marine-derived Streptomycessp. (CMB-M0423) isolated from beach sand off Heron Island, Australia, yielded three new members of the rare pyrroloterpene biosynthetic structure class. Identified by detailed spectroscopic analysis as the first reported examples of naturally occurring 2-nitropyrroles, heronapyrroles A−C (1−3) displayed promising biological activitywith low to submicromolar IC50activity against Gram-positive bacteria but no cytotoxicity toward mammalian cell lines. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15237060
- Volume :
- 12
- Issue :
- 22
- Database :
- Academic Search Index
- Journal :
- Organic Letters
- Publication Type :
- Academic Journal
- Accession number :
- 55372239
- Full Text :
- https://doi.org/10.1021/ol102162d