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1. Absence of CC chemokine receptor 8 enhances innate immunity during septic peritonitis.

Author

Matsukawa, Akihiro, Kudoh, Shinji, Sano, Gen-ichiro, Maeda, Takako, Ito, Takaaki, Lukacs, Nicholas W., Hogaboam, Cory M., Kunkel, Steven L., and Lira, Sergio A.

Subjects
*IMMUNE response, *IMMUNOLOGY, *PERITONITIS, *MACROPHAGES, *MICE, *CELLULAR immunity
Abstract

Explores the role of CCR8 in innate immune response during septic peritonitis induced by cecal ligation and puncture (CLP). Expression of CCR8 in peritoneal macrophages during CLP; Resistane of CCR8 mice to CLP-induced lethality; Increased bacterial clearance in CCR8; Augmented innate immune response in CCR8 macrophages; Altered cytokine response and prevention of renal injury in CCR8 mice.

Published
2006
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