Absence of CC chemokine receptor 8 enhances innate immunity during septic peritonitis.

Explores the role of CCR8 in innate immune response during septic peritonitis induced by cecal ligation and puncture (CLP). Expression of CCR8 in peritoneal macrophages during CLP; Resistane of CCR8 mice to CLP-induced lethality; Increased bacterial clearance in CCR8; Augmented innate immune response in CCR8 macrophages; Altered cytokine response and prevention of renal injury in CCR8 mice.