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Start Over Author "Sagnella, Sharon M." Journal chempluschem Database Academic Search Index
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1. Choice of Capping Group in Tripeptide Hydrogels Influences Viability in the Three-Dimensional Cell Culture of Tumor Spheroids.

Author

Wojciechowski, Jonathan P., Martin, Adam D., Mason, Alexander F., Fife, Christopher M., Sagnella, Sharon M., Kavallaris, Maria, and Thordarson, Pall

Subjects
*PHENOTHIAZINE, *HYDROGELS, *TUMORS, *CELL culture, *PEPTIDES
Abstract

Two peptide-derived low-molecular-weight gelators bearing different capping groups, 9-fluorenylmethyloxycarbonyl (Fmoc) and phenothiazine, were synthesized and their gel networks were characterized. The variation of the N-terminal capping group affects the viability of these hydrogels as a three-dimensional cell culture for multicellular tumor spheroids. These results indicate that the phenothiazine capping group is a more biocompatible alternative to the widely used Fmoc moiety. [ABSTRACT FROM AUTHOR]

Published
2017
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