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Choice of Capping Group in Tripeptide Hydrogels Influences Viability in the Three-Dimensional Cell Culture of Tumor Spheroids.
- Source :
-
ChemPlusChem . Mar2017, Vol. 82 Issue 3, p383-389. 7p. - Publication Year :
- 2017
-
Abstract
- Two peptide-derived low-molecular-weight gelators bearing different capping groups, 9-fluorenylmethyloxycarbonyl (Fmoc) and phenothiazine, were synthesized and their gel networks were characterized. The variation of the N-terminal capping group affects the viability of these hydrogels as a three-dimensional cell culture for multicellular tumor spheroids. These results indicate that the phenothiazine capping group is a more biocompatible alternative to the widely used Fmoc moiety. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PHENOTHIAZINE
*HYDROGELS
*TUMORS
*CELL culture
*PEPTIDES
Subjects
Details
- Language :
- English
- ISSN :
- 21926506
- Volume :
- 82
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- ChemPlusChem
- Publication Type :
- Academic Journal
- Accession number :
- 121780364
- Full Text :
- https://doi.org/10.1002/cplu.201600464