1. Extracellular vesicles as modifiers of epigenomic profiles.
- Author
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Zhou, Haifeng, Hu, Sheng, and Yan, Wei
- Abstract
Extracellular vesicles (EVs) and epigenomic profiles are closely linked and reciprocally regulated. EVs reprogram the epigenomic profile by remodeling DNA, RNA, and histone modifications in recipient cells, by delivering cargoes mainly targeting methyltransferase and demethyltransferase. EVs display great potential as diagnostic markers and epidrug delivery vehicles for therapeutic applications. Advanced technologies and multi-omic profiling to define single EV characterization would improve the loading efficacy and delivery accuracy of EVs in disease treatments. Extracellular vesicles (EVs), emerging as novel mediators between intercellular communication, encapsulate distinct bioactive cargoes to modulate multiple biological events, such as epigenetic remodeling. In essence, EVs and epigenomic profiles are tightly linked and reciprocally regulated. Epigenetic factors, including histone and DNA modifications, noncoding RNAs, and protein post-translational modifications (PTMs) dynamically regulate EV biogenesis to contribute to EV heterogeneity. Alternatively, EVs actively modify DNA, RNA, and histone profiles in recipient cells by delivering RNA and protein cargoes for downstream epigenetic enzyme regulation. Moreover, EVs display great potential as diagnostic markers and drug-delivery vehicles for therapeutic applications. The combination of parental cell epigenomic modification with single EV characterization would be a promising strategy for EV engineering to enhance the epidrug loading efficacy and accuracy. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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