Asymmetric synthesis of 3,4-dihydro-2H-1,2,4-benzothiadiazine-1,1- dioxides catalyzed by scandium(III)-inda-Pybox.

Asymmetric synthesis of 3,4-dihydro-2 H -1,2,4-benzothiadiazine-1,1-dioxides (DHBDs) was realized using readily available scandium(III)- inda -Pybox as the catalyst. It represents the first example focusing on systematic study of asymmetric synthesis of DHBDs, and a series of enantioselective 3-alkyl, or 3-aryl DHBDs were obtained with up to 93% ee. [ABSTRACT FROM AUTHOR]