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Technologies and Innovations for Sustainable Development offers a comprehensive exploration of cutting-edge solutions that can help us build a greener, more equitable future. Too often, technologies are either not developed for a sufficiently profitable market, or if developed, are not accessible or well-adapted to end-user needs. This edited book seeks to advance knowledge and understanding of how to equitably improve the functioning of the “global innovation system” for sustainable development of technologies. This volume aims to examine specific cases of “system interventions” (e.g., policy interventions, institutional innovations, new approaches to shaping the innovation process, etc.) intended to strengthen the global innovation system, with the broader aim of developing policy recommendations and are generalizable across multiple sectors.This book brings together contributions from leading experts across diverse fields, showcasing the latest advancements in technology and innovative practices that address pressing sustainability issues. From hydrogen production and fuel blending to waste management and additive manufacturing process and application of emerging technologies such as machine learning, deep learning, and CFD simulation, this book provides a roadmap for harnessing innovation to achieve global sustainability goals.Key features include: An integrative overview of emerging and cutting-edge solutions to sustainable development Discussion on policy framework to address global environmental and public health challenges Forward-looking insights into emerging trends and future directions in sustainable development. Whether you are a policymaker, researcher, industry professional, or student, Technologies and Innovations for Sustainable Development is an essential resource for understanding the pivotal role of technology in creating a sustainable future. Join us in exploring the innovations that hold the key to a better world for generations to come.

In Molecular and Computational Modeling of Cardiac Function, a group of prominent professors and researchers explain the fundamental concepts of molecular modeling and illustrate the biomedical applications. The book covers the following topics: Principles of atomistic modeling and simulation of biomolecular systems. Using atomistic modeling to predict the cardiotoxicity of an arrhythmia drug molecule. Bifurcation phenomena in cardiac system as control design of automaticity and arrhythmia. Modeling the role of myoglobin as a fatty acid transporter. Population-based computational approaches to investigate cardiac arrhythmia.

Artificial Intelligence in Biomedical and Modern Healthcare Informatics provides a deeper understanding of the current trends in AI and machine learning within healthcare diagnosis, its practical approach in healthcare, and gives insight into different wearable sensors and its device module to help doctors and their patients in enhanced healthcare system. The primary goal of this book is to detect difficulties and their solutions to medical practitioners for the early detection and prediction of any disease. The 56 chapters in the volume provide beginners and experts in the medical science field with general pictures and detailed descriptions of imaging and signal processing principles and clinical applications. With forefront applications and up-to-date analytical methods, this book captures the interests of colleagues in the medical imaging research field and is a valuable resource for healthcare professionals who wish to understand the principles and applications of signal and image processing and its related technologies in healthcare. - Discusses fundamental and advanced approaches as well as optimization techniques used in AI for healthcare systems - Includes chapters on various established imaging methods as well as emerging methods for skin cancer, brain tumor, epileptic seizures, and kidney diseases - Adopts a bottom-up approach and proposes recent trends in simple manner with the help of real-world examples - Synthesizes the existing international evidence and expert opinions on implementing decommissioning in healthcare - Promotes research in the field of health and hospital management in order to improve the efficiency of healthcare delivery systems

The book Neuroepigenetic Mechanisms in Health and Disease provides insight into mechanisms of epigenetic control, focusing on molecular, cellular and integrative aspects of neurobiology. Here, leading investigators in the field discuss in each chapter landmark scientific discoveries and recent advances in (neuro) epigenetics. Whereas some chapters concentrate in overviewing basic epigenetic mechanisms and the power of epigenome editing, other sections of the book discuss epigenetic control during learning and memory as well as in diverse brain related alterations, including neurodegenerative and rare neurologic diseases, and psychiatric disorders. In addition, the book covers relevant topics for modern human societies, including how drug abuse, environmental enrichment and meditation can influence brain function through epigenetic mechanisms. This book aims to serve as a useful source for junior scientists to first learn about the topic, as well as to more experienced researchers that seek for a broader view of this rapidly growing field that is beyond their area of specialization.

Hydrogen peroxide (H2O2) is recognized as a crucial signaling molecule that mediates physiological and biochemical processes in plants, regulating various development and stress responses. Hydrogen Peroxide: Signalling Mechanisms and Crosstalk in Plant Development and Stress Responses presents a comprehensive overview of hydrogen peroxide's modes of action in plants demonstrating the important role played in plant stress signaling and communication. It introduces key topics in H2O2 research such as plant signaling, molecular responses, and interaction with other hormones.Features Discusses experiments interrelated to H2O2 signaling pathway in plants under various environmental conditions Addresses important concerns in H2O2 research from a wide range of organisms, including plants and prokaryotes such as bacteria and archaea Collects, summarizes, and presents developments in plant signaling and communication Aids scientists and breeders in developing strategies to enhance plant growth and stress tolerance Environmental stress is destructively disturbing plant growth and efficiency resulting in concerns to improve food crop yield, and H2O2 has immense field implications as it is vital in regulating plant growth and stress responses. Hydrogen Peroxide: Signalling Mechanisms and Crosstalk in Plant Development and Stress Responses is an invaluable resource for researchers and scientists to use as a guide to conduct studies on environmental conditions of the plant hydrogen peroxide signaling systems.

Profiles of Drug Substances, Excipients, and Related Methodology, Volume 50 includes comprehensive profiles of four drug compounds: Sofosbuvir, Nateglinide, Linagliptin, and Dronedarone, providing comprehensive knowledge on their physical and chemical properties, synthesis and degradation pathways, analytical techniques for identification and quantification, separation methods, and pharmacology of drug substances. Finally, this volume includes a review article related to the Applications of Cyclodextrins in Pharmaceutical and Related Fields, along with a chapter on Fenamates Degradation. This information is highly valuable to professionals in the field, but having it all in one place is a great benefit to readers.The Profiles series encompasses five review articles and database compilations on various topics, including the physical profiles, analytical profiles, ADME profiles, methodologies related to the characterization, and methods of chemical synthesis of drug substances and excipients. - Provides synthesis and pathways of physical or biological degradation of selected drug substances - Offers a comprehensive review of the biological, chemical, physical characteristics, and pharmacology of certain drug substances - Describes nearly all analytical methods available in the literature used to identify and quantify drug substances - Offers applications of certain materials in pharmaceuticals and related fields - Provides a cumulative index for each volume in the series

Biosecurity in the Age of Synthetic Biology is a comprehensive review of the biosecurity issues faced by the innovative and rapidly evolving field of synthetic biology. This is a meticulous review of the groundbreaking biotechnological advancements and the critical need for robust biosecurity measures. The book provides an in-depth examination of the ethical, legal, and societal dimensions shaping the future of synthetic biology research, in addition to a practical protocol for biosecurity risk assessment. This is the first book to offer a structured guideline for biosecurity risk assessment in synthetic biology. The author's balanced view of the opportunities of synthetic biology and the inherent security risks reveals foundational concepts, cutting-edge applications, and international perspectives on biosecurity. This essential guide illuminates scientific and technological frontiers and advocates for a proactive approach ensuring the responsible development and use of synthetic biology. It is an indispensable resource for scientists, policymakers, and anyone interested in the intersection of biotechnology and biosecurity.Key Features: Provides instructions and examples for a biosecurity risk assessment. Includes detailed proposed outline for creating a Biosecurity Manual for broad adoption. Emphasizes the future challenges and opportunities. Offers insights on the role of artificial intelligence in synthetic biology and biosecurity.

Endophytes from medicinal plants have garnered global attention due to their remarkable capacity to produce unique phytochemicals, pharmaceuticals and promising lead compounds. This book explores cutting-edge advancements in endophytic fungi research, encompassing a comprehensive exploration of their biodiversity, ecological dynamics, mechanisms of interaction and adaptive strategies. The book offers valuable insights into the therapeutic potential, agricultural applications, environmental impacts and commercial prospects of these fascinating organisms.While the contemporary books are limited to either taxonomic, ecological or practical discussions, this book presents a systematic compilation of biology and biotechnological applications of endophytic fungi from medicinal plants.Key Features Comprehensive exploration of the diversity, ecology and interactions of endophytes derived from medicinal plants found in their natural habitats Highlights the potential of endophytes derived as prolific producers of novel pharmaceutical and lead compounds Showcases the practical applications of endophytes in plant development and sustainable agriculture practices Includes contribution from researchers and academicians having vast experience in the field This book is a collection of informative illustrations, strategically integrated throughout the content, to facilitate the understanding of concepts and aid in smooth transitions between topics. Given the vast and diverse nature of the discipline, this book serves as an invaluable reference resource for students and researchers in various fields, including mycology, microbiology, biotechnology, pharmacology, botany, ecology, agronomy and molecular biology. Additionally, professionals in environmental conservation and policymakers dedicated to preserving biodiversity of medicinal plants will find this book to be a valuable asset in their work.

The book explores the role of flow cytometry in varied fields, from clinical diagnosis to toxicology. This comprehensive book offers insights into biomarkers, cellular analysis, and safety evaluations. Organized into fifteen chapters, this book explores flowcytometry's historical journey, scientific validation, and implementation in toxicity studies with case studies, technical and applied approaches, pictorial representations, informative tables, and simple language, It will be an invaluable resource for researchers, academia, biopharma industries, graduate and postgraduate students, Ph.D., and post-doctoral fellows working in the fields of toxicology/biosafety, and biomedical research.

Advances in Protein Chemistry and Structural Biology, Volume 143 in the series, covers reviews of methodology and research in all aspects of protein chemistry, including purification/expression, proteomics, modeling and structural determination and design. Chapters in this new release include Therapeutic insight into the role of nuclear protein HNF4α in liver carcinogenesis, Structural mechanism of nucleoporins in cancer disease, Identification of nuclear matrix proteins (novel genes) in bladder cancer using Bioinformatic approaches, A comparative study of nuclear proteins of different cancers - A systematic review, Role of lamins in cellular physiology and cancer, and much more.Other chapters cover Nuclear Hormone Receptors as Drug Targets: Advancements and Future Prospects, Proteins binding to tandemly repeated DNA: familiar strangers, HMGB1, R-loops and genome stability, Nuclear tau accumulation in Alzheimer's Disease, and Histone deacetylase's (HDACs) regulates Tau function in Alzheimer's Disease. - Covers various aspects, such as their structure, function, regulation, and roles in cellular processes - Includes subclasses of nuclear proteins, discussing their specific functions and involvement in different cellular processes such as DNA replication, transcription, DNA repair, and chromatin remodeling - Presents the signaling pathways and biochemical processes involved in their activation, transport, and localization within the nucleus

Cell Signaling provides undergraduate and graduate students with the conceptual tools needed to make sense of the dizzying array of pathways that cells use to detect, process, and respond to signals from the environment. By emphasizing the common design principles and molecular processes that underlie all signaling mechanisms, the book develops a broad conceptual framework through which students can understand diverse signaling pathways and networks. The book first examines the common currencies of cellular information processing and the core components of the signaling machinery. It then shows how these individual components link together into networks and pathways to perform more sophisticated tasks. Many specific examples are provided throughout to illustrate common principles, and to provide a comprehensive overview of major signaling pathways.Thoroughly revised, this second edition includes two new chapters and substantial updates to the text and figures throughout the book.Key features: The book provides a conceptual framework through which all signaling pathways can be understood without memorization of details It is extensively illustrated, including high-quality diagrams and schematics to elucidate important concepts and processes Each chapter concludes with a useful summary section that brings together the key concepts End-of-chapter review questions test the reader's understanding of the material covered Two new chapters have been written especially for this edition:'Signaling and Disease'and'Diversity in Signaling across Phylogeny'

Deep Learning in Diabetes Mellitus Detection and Diagnosis focuses on deep learning-based approaches in the field of diabetes mellitus detection and diagnosis, including preprocessing techniques that are an essential part of this subject. This is the first book of its kind to cover deep learning-based approaches in the specific field of diabetes mellitus. This book includes a detailed introductory overview as well as chapters on current applications, preprocessing of data using deep learning, deep learning techniques, complexity, challenges, and future directions. It will be of great interest to researchers and professionals working on diabetes mellitus as well as general medical applications of machine learning.Features: Highlights how the use of deep neural networks-based applications can address new questions and protocols, as well as improve upon existing challenges in diabetes mellitus detection and diagnosis Assists scholars and students who might like to learn about this area as well as others who may have begun without a formal presentation, with no complex mathematical equations Involves exceptional subject coverage and includes the principles needed to understand deep learning

The new edition of Gene Control, for the first time, provides extensive coverage on prokaryotic gene regulation, which makes it the only textbook offering a complete and detailed account of gene control for both prokaryotic and eukaryotic organisms. The core objective of this edition is to educate students about the fundamental principles and mechanisms governing gene expression, regulation, and function. To reinforce these ideas, each chapter now includes discussion questions to promote critical thinking. There are also multiple choice questions and animations for students, and a large question bank and figure slides for instructors. The textbook also emphasizes the vital role of scientific experiments and evidence in shaping our current understanding of gene control and provides comprehensive coverage of essential gene expression techniques and methodologies throughout the book.This extensively updated edition of the renowned textbook Gene Control will remain a valuable resource for students, instructors, researchers, and medical professionals exploring various aspects of gene control, ranging from the regulation of genes in infectious diseases to embryonic development across different organisms, from bacteria to humans.

Nowadays, genetics focuses on DNA. Just like the first edition, the theme of this new edition, Introduction to Genetics: A Molecular Approach, is therefore the progression from molecules (DNA and genes) to processes (gene expression and DNA replication) to systems (cells, organisms and populations). This progression reflects both the basic logic of life and the way in which modern biological research is structured. The molecular approach is particularly suitable for students for whom genetics is part of a broader program in biology, biochemistry, the biomedical sciences or biotechnology. This book presents the basic facts and concepts with enough depth of knowledge to stimulate students to move on to more advanced aspects of the subject.This second edition has been thoroughly updated to cover new discoveries and developments in genetics from the last ten years. There are new chapters that introduce important techniques such as DNA sequencing and gene editing, and the applications of genetics in our modern world are covered in chapters describing topics as diverse as gene therapy and the use of ancient DNA to study prehistoric ecosystems. Key Features: This book provides a molecular approach to the study of genetics. It is a highly accessible and well-structured book with chapters organized into four parts to aid navigation. It presents high-quality illustrations to elucidate the various concepts and mechanisms. Each chapter ends with a Key Concepts section, which serves to summarize the most essential points. Self-study questions enable the reader to assess their comprehension of chapter content, and discussion topics facilitate a deeper understanding of the material by encouraging conversation and critical evaluation. Key terms are emboldened throughout the text and are listed at the end of each chapter, and definitions can be found in the Glossary. For instructors who adopt the book, an affiliated question bank is free to download.

This book provides an up-to-date outlook on the origin, evolution, structure, genomic organization, expression, regulation and transposition mechanism of retrotransposons in the plant genome and computational tools and algorithms to analyze retrotransposons across different species, and their use as genetic tools in crop breeding and improvement. The book also highlights the biotechnological applications of the retrotransposon transposable elements. Previously dismissed as parasites/selfish or JUNK DNA, these elements are now recognized as “Just Unexplored Novel Know-how”. Retrotransposons play crucial roles in gene function, genomic organization, mutations, stress responses, genome regulation, epigenomics, diversity, evolution, and plant speciation. Leveraging these as biotechnological tools can help develop climate-smart crops for sustainable agriculture.