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Digital Pathology: Implementation in Clinical Practice with AI Applications covers digital pathology applications in a clinical pathology laboratory setting, providing guidance and various tools for practical implementation. This comprehensive and detailed description of nuts and bolts of digital pathology implementation is unique and comes from the experience of high throughput scanning from a large surgical pathology laboratory. This is a valuable reference to prepare the end users not only about thoughtful launch of digital pathology but also to prepare for the future use of AI mediated decision support tools as the field advances. This book covers the entire range of this topic and can be used as a practical reference for individuals that wish to be part of the evolution of diagnostic pathology. Sections include pre-analytic, analytic, and post-analytic processes, encompassing hardware, software, space, staffing, quality control, laboratory information system applications, clinical validation, use cases and future applications, including computer assisted diagnosis and decision support tools. - Provides detailed aspects of the implementation of digital pathology in the clinical laboratory, including machine learning/artificial intelligence tools - Presents examples of how digital imaging and AI are drivers in research and development in radiology, with parallels to situations in pathology - Includes best practices and guidelines that can be practically applied by pathologists and data scientists

Das seit 1949 bewährte Weinbaujahrbuch erscheint dieses Jahr zu 75. Mal. Es enthält die neuesten Entwicklungen, interessante historische Beiträge und aktuelle Fachbeiträge aus dem Weinbau und der Kellerwirtschaft. Ein Muss für Winzer und alle am Weinbau Interessierten.

This volume provides a synthesis of recent work on evolutionary aspects of metal tolerance in plants. It presents contributions from scientists with a wide diversity of expertise. It covers the evolution of heavy metal tolerance in groups of plants, fungi, and protists. The book discusses the physiological, genetic and molecular aspects of metal tolerances. It deals with the evolution of populations in metal-contaminated environments. Several chapters include tolerance in animals in order to place the rest of the book on plants in proper perspective. This publication is an exciting addition for scientists with both applied and basic interest in metal toxicity and tolerance. It is of importance to those in vegetation ecology, land reclamation, agronomy, physiology, population ecology, ecological genetics, evolutionary biology and molecular biology.

Viruses, bacteria, fungi and parasites are known to cause the most common human disease. It frequently spreads through direct contact (from human to human, animal to human), and through contaminated food or water. With the advancement of diagnostic techniques, it is now possible to rapidly identify microorganisms causing human disease and correlate with the corresponding clinical infection. Therefore, there is a need to develop robust and high-throughput diagnostic methods to prevent and control human disease of public health importance. This book entitled “Recent Advancements in the Diagnosis of Human Disease” will help the scientific community to better understand the transmission dynamics of some human diseases.

Poisonous plants are used in traditional medicine systems in various healing therapies. They are a rich resource of ingredients used in herbal drug formulations that are also used in the development of synthetic drugs. They are recognized for their antioxidant, anti-inflammation, anti-cancer, and anti-diabetic activities and for many other health benefits. Exploring Poisonous Plants: Medicinal Values, Toxicity Responses, and Therapeutic Uses provides an analysis of the most important poisonous herbs, shrubs, and trees, detailing poisonous plants while demonstrating endorsements for their potential therapeutic values.Features:Presents therapeutic potentials on various poisonous herbs, shrubs, and trees.Provides descriptions of notable toxic compounds and discusses their adverse effects when consumed by animals or people.Gives practical guidance for botanical description, distribution, phytochemical constituents, pharmacological studies, and traditional and other potential uses of selected poisonous plants.This volume in the Exploring Medicinal Plants series is appropriate for scientists, researchers, and students working with poisonous plants, as well as in areas of economic botany, plant biochemistry, biotechnology, pharmacognosy, pharmaceuticals, industrial chemistry, and nanomedicine.

Informed by the Biopsychosocial Model, this Encyclopedia of Child and Adolescent Health examines multiple aspects of child and adolescent development and physical and mental health. According to the Biopsychosocial Model, health is determined by the reciprocal interactions between biological (e.g., genetics, physical development, family health history), psychological (e.g., mental health, identity developmental, attitudes), and social (e.g., family, peers, school, social supports) factors. This theory posits that each one of these factors alone is not sufficient to understand health; instead, it is important to understand how these interactive components ultimately influence health outcomes. In addition to the Biopsychosocial Model, this Encyclopedia of Child and Adolescent Health has a translational approach. Each section and all applicable entries include a discussion of prevention or intervention efforts that can inform health and health promotion, and prevent health risks. - Presents a comprehensive review of current child and adolescent research, along with critical insights into the future direction of the field, including translation and prevention - Includes concise, authoritative chapters that are expertly authored make this an easy-to-read, reliable reference resource - Provides a clear thematic structure that allows for easy exploration across the discipline's different sub-fields. - Helps readers find their topics of interest, all of which are contextualized and linked to relevant literature

Invertebrate Zoology: A Tree of Life Approach is a comprehensive and authoritative textbook adopting an explicitly phylogenetic organization. Most of the classical anatomical and morphological work has not been changed – it established the foundation of Invertebrate Zoology. With the explosion of Next-Generation Sequencing approaches, there has been a sea-change in the recognized phylogenetic relationships among and between invertebrate lineages. In addition, the merger of evolutionary and developmental biology (evo-devo) has dramatically contributed to changes in the understanding of invertebrate biology. Synthesizing these three approaches (classical morphology, sequencing data, and evo-devo studies) offers students an entirely unique perspective of invertebrate diversity.Key Features One of the first textbooks to combine classical morphological approaches and newer evo-devo and Next-Generation Sequencing approaches to address Invertebrate Zoology Organized along taxonomic lines in accord with the latest understanding of invertebrate phylogeny Will provide background in basic systematic analysis useful within any study of biodiversity A wealth of ancillary materials for students and teachers, including downloadable figures, lecture slides, web links, and phylogenetic data matrices

Xenobiotics in Chemical Carcinogenesis: Translational Aspects in Toxicology covers the translational toxicology of xenobiotics substances in carcinogenesis by explaining the toxicokinetic and toxicodynamic, toxicogenomic, biotransformation, and resistance mechanisms in the human body. The book begins with a historical review and link to future prospects for chemical carcinogenesis. It discusses major environmental xenobiotics and their risks in inducing cancer, along with content on toxic xenobiotics and their routes of exposure in humans, the role of xenobiotic metabolism in carcinogenesis, and the toxicokinetic and toxicodynamic of xenobiotics in cancer development. Lastly, the book explores current achievements such as using toxicogenomics for predicting the carcinogenicity of xenobiotic substances and the challenges posed by carcinogenic xenobiotic substances when examining preventive methods, diagnosis, and the development of anticancer drugs for specific toxicants. - Covers the exposure and transmission of various toxic xenobiotics substances, including nanomaterials, to humans and their interaction with specific tissues in precipitating the development of cancers - Unravels the toxicokinetic and toxicodynamic processes of toxic xenobiotics in bioaccumulation - Examines the genetic aberrations in cancer genomes by genetic-environmental interactions in carcinogenesis - Explains the biotransformation mechanisms of toxic xenobiotics by gut microbes in humans

Carotenoids are a large class of isoprenoid pigments produced by plants and certain microbes. More than 700 naturally occurring carotenoids have been identified. Apocarotenoids are tailored from carotenoids by oxidative enzymes. Apocarotenoids act as visual or volatile signals to attract pollinating and seed dispersal agents. They are also the key players in allelopathic interactions and plant defense. Biology, Chemistry and Applications of Apocarotenoids provides detailed account of the fundamental chemistry of apocarotenoids and the basic methods used in carotenoid research, and critical discussions of the biochemistry, functions, and applications of these important compounds. Topics covered in the proposed book include various aspects of the roles of apocarotenoids in colour and colouration, photosynthesis and other photofunctions and protection. The formation and roles of carotenoid metabolites and breakdown products as perfume/aroma compounds are also be outlined. Features: Provides an organized overview of apocarotenoids and their chemistry and biological functions Focuses on recent discoveries on apocarotenoids, their nature and functions. Details potential uses of apocarotenoids in agriculture, pharmacy, food industry, and apocarotenoid production at industrial level This book has been written by leading experts in apocarotenoid research and gives a comprehensive overview on the diversity of apocarotenoid compounds and would serve as a reference book for researches in Plant Physiology, Molecular Biology, Biochemistry, Biophysics and Medicine.

Biodiversity and Biomedicine: Our Future provides a new outlook on Earth's animal, plant, and fungi species as vital sources for human health treatments. While there are over 10 million various species on the planet, only 2 million have been discovered and named. This book identifies modern ways to incorporate Earth's species into biomedical practices and emphasizes the need for biodiversity conservation. Written by leading biodiversity and biomedical experts, the book begins with new insights on the benefits of biologically active compounds found in fungi and plants, including a chapter on the use of wild fruits as a treatment option. The book goes on to discuss the roles of animals, such as amphibians and reptiles, and how the threatened presence of these species must be reversed to conserve biodiversity. It also discusses marine organisms, including plants, animals, and microbes, as essential in contributing to human health. Biodiversity and Biomedicine: Our Future is a vital source for researchers and practitioners specializing in biodiversity and conservation studies. Students in natural medicine and biological conservation will also find this useful to learn of the world's most bio-rich communities and the molecular diversity of various species. - Presents new developments in documenting and identifying species for biodiversity conservation and ethical considerations for biodiversity research - Examines biodiversity as an irreplaceable resource for biomedical breakthroughs using available species for medical research - Discusses challenges and opportunities for biodiversity protection and research in biosphere reserves

This book is a comprehensive compilation of modern and cutting-edge chromatographic techniques written by pharmaceutical industry experts, academics, and vendors in the field. This book is an inclusive guide to developing all chromatographic methods (such as liquid chromatography and gas chromatography). It covers modern techniques for developing methods using chromatographic development software, requirements for validations, discussion on orthogonality, and how to transfer methods from HPLC to UHPLC. The text introduces some newer techniques that are heavily employed by chemists analyzing proteins and RNAi, as well as novel techniques such as counter current chromatography. This book is valuable for both the novice starting out in undergraduate labs and those who are new to the pharmaceutical industry and is a useful reference for seasoned analysts.

The enormous advances in nanomedicine and precision medicine in the past two decades necessitated this comprehensive reference, which can be relied upon by researchers, clinicians, pharmaceutical scientists, regulators, policymakers, and lawyers alike. This standalone, full-color resource broadly surveys innovative technologies and advances pertaining to nanomedicine and precision medicine. In addition, it addresses often-neglected yet crucial areas such as translational medicine, intellectual property law, ethics, policy, FDA regulatory issues, nano-nomenclature, and artificial nano-machines—all accomplished in a user-friendly, broad yet interconnected format. The book is essential reading for the novice and the expert alike in diverse fields such as medicine, law, pharmacy, genomics, biomedical sciences, ethics, and regulatory science. The book's multidisciplinary approach will attract a global audience and serve as a valuable reference resource for industry, academia, and government.

The enormous advances in nanomedicine and precision medicine in the past two decades necessitated this comprehensive reference, which can be relied upon by researchers, clinicians, pharmaceutical scientists, regulators, policymakers, and lawyers alike. This standalone, full-color resource broadly surveys innovative technologies and advances pertaining to nanomedicine and precision medicine. In addition, it addresses often-neglected yet crucial areas such as translational medicine, intellectual property law, ethics, policy, FDA regulatory issues, nano-nomenclature, and artificial nano-machines—all accomplished in a user-friendly, broad yet interconnected format. The book is essential reading for the novice and the expert alike in diverse fields such as medicine, law, pharmacy, genomics, biomedical sciences, ethics, and regulatory science. The book's multidisciplinary approach will attract a global audience and serve as a valuable reference resource for industry, academia, and government.

Accumulation into one source of what is known regarding the feeding value of these materials and systems which have been developed for improving their digestibility, palatability or methods of handling was the motivation for organising this book. These has been an effort to include the major categories of unconventional materials which can potentially be upgraded to provide the ruminant with needed nutrients, but certainly some have been missed. It is hoped that this treatise will prove to be a valuable tool for workers involved in improving the utilization of residues and waste products for animals.

A comprehensive reference text explores the nature of chelating agents and the underlying reasons for their metal-binding properties and discusses the mechanisms of absorption for various metals and the possible role of chelating agents in influencing the utilization of certain minerals. Topics include: the physico-chemical characteristics of chelates and chelation and their measurements; the bioavailability of metals and proteins as ligands; the role of phytic acid and other phosphates as chelating agents; miscellaneous chelates (oxalic acid, ionophores, clays); the chelation, uptake, and transport of zinc, and the influence of various foods and synthetic chelates on zinc availability; the chelation, and bioavailability of iron, and the effect of various chelating agents on nonheme iron absorption; chelation of copper by food substances; the chelation of miscellaneous minerals; the role of iron and copper chelation in reproduction; chelate toxicity; the use chelates in metal detoxification and therapy; and the use of chelates for removing metals from dietary ingredients. Technical data and illustrations are presented throughout the text, and reference citations are appended to each of the 12 principal text chapters

This text covers in detail bacteria and yeasts, including an overall perspective of microbial aggregation as fundamental form and function, which is presented here to include systems still to be treated in detail.

The sections in this handbook series reflect the input of different editors and advisory boards, and as a consequence, there is considerable variation in both the depth and coverage offered within a given area. However, an attempt has been made throughout to bring together pertinent information that will serve the needs of nonspecialists, provide a quick reference to material that might otherwise be difficult to locate, and furnish a starting point for further study.The project was undertaken with the realization that the initial volumes in the series could have some obvious deficiencies that will necessitate subsequent revisions. In the meantime, it is felt that the primary objectives of the Sections Editors and their Advisory Boards has been met in this first Edition.

This book attempts to provide a broad coverage of current information needed by public health workers, physicians, veterinarians, parasitologists, technicians, and various biologists who encounter or work with the parasitic disease Cryptosporidium.

The aim of this volume is to provide a compendium of state of the art overview chapters by leading research, from diverse scientific fields, who share a common involvement in understanding and utilizing the interactions between chemicals and plant leaves.

This comprehensive volume focuses on the ways in which synthetic peptides have been exploited in order to expand our understanding of the molecular mechanisms involved in protein phosphorylation. It recognizes that virtually all physiological processes are regulated by protein phosphorylation. It discusses the use of synthetic peptides in studying the catalytic mechanism and regulation of protein kinases. It also includes the chemical synthesis of phosphorylated peptides and preparation of specific antisera. This incredible work has lead to the development of a new generation of peptide inhibitors with potencies of greater magnitude than those previously known. Everyone involved with biochemistry and molecular biology will find this one-of-a-kind resource fascinating and filled with useful information.

Handbook of Mammalian Metabolism of Plant Compounds provides an extensive survey of how mammals metabolize compounds found in higher plants. Information about these compounds is important to researchers in pharmacology, toxicology, medical and natural products chemistry, and food sciences. Although there is plenty of literature about mammalian metabolism of plant compounds, it is scattered, and summaries of specific plant compounds are often difficult to obtain. This book contains 11 chapters discussing the metabolic fate of individual plant compounds grouped according to chemical class. It also features structural formulas of the compounds and their metabolites, including probable pathways of metabolism. This book provides a convenient single-volume reference source that will benefit all researchers requiring this type of information.

Food Biopreservatives of Microbial Origin provides basic and applied information regarding how antimicrobial metabolites of safe, food-grade bacteria (used in food fermentation) can be utilized as food preservatives. The authors discuss why biopreservation of food is important, identify the foods and microoganisms for which biopreservation is suitable, and explore the potential of bacteriocins of food-grade starter culture bacteria and the antimicrobial proteins of yeasts as possible food biopreservatives. The book is a valuable reference resource that will benefit students of food science and researchers in food industries, regulatory agencies, and advisory groups.

Nanoscience and nanotechnology are interdisciplinary fields that bring together physicists, chemists, materials scientists, and engineers to meet the potential future challenges that humankind will face, including the search for renewable energies for sustainable development and new technologies for carbon capture and environmental protection. Among the current subjects in nanoscience and nanotechnology, nanomaterials are developing fast and explosively and attracting a huge amount of attention. They continue to show promising potential and have found application in solar cells, fuel cells, secondary batteries, supercapacitors, air and water purification, and removal of domestic and outdoor air pollutants. To summarize the past developments and encourage future efforts, this book presents contributions from world-renowned specialists in the fields of nanomaterials, energy, and environmental science. It discusses the design and fabrication of nanostructured materials and their energy and environmental applications.

Traditional preclinical mouse models of cancer have been very useful for studying the biology of cancer, however they often lack key characteristics of human cancers. As a result, many novel drug candidates fail in human clinical trials despite evidence of drug efficacy in those preclinical models. Thus, researchers are seeking new approaches to augment preclinical knowledge before undertaking clinical trials for human patients. Recently, there has been renewed interest in comparative oncology - the study of naturally developing cancers in animals as models for human disease - as one way to improve cancer drug development and reduce attrition of investigational agents. Tumors that spontaneously develop in pet dogs and other companion animals as a result of normal aging share many characteristics with human cancers, such as histological appearance, tumor genetics, biological behavior, molecular targets, and therapeutic response. In June 2015 the Institute of Medicine hosted a workshop to examine the rationale and potential for integrating clinical trials for pet patients with naturally occurring cancers into translational cancer research and development. Participants discussed the research needs, strategies, and resources to support greater integration of clinical trials for pets with cancer into translational research pathways, and challenges and potential solutions for facilitating that integration. This report summarizes the presentations and discussions from the workshop.

The use of forensic entomology has become established as a global science. Recent efforts in the field bridge multiple disciplines including, but not limited to, microbiology, chemistry, genetics, and systematics as well as ecology and evolution. The first book of its kind, Forensic Entomology: International Dimensions and Frontiers provides an inc

Individually and collectively, resident microbes play important roles in host health and survival. Shaping and shaped by their host environments, these microorganisms form intricate communities that are in a state of dynamic equilibrium. This ecologic and dynamic view of host-microbe interactions is rapidly redefining our view of health and disease. It is now accepted that the vast majority of microbes are, for the most part, not intrinsically harmful, but rather become established as persistent, co-adapted colonists in equilibrium with their environment, providing useful goods and services to their hosts while deriving benefits from these host associations. Disruption of such alliances may have consequences for host health, and investigations in a wide variety of organisms have begun to illuminate the complex and dynamic network of interaction - across the spectrum of hosts, microbes, and environmental niches - that influence the formation, function, and stability of host-associated microbial communities. Microbial Ecology in States of Health and Disease is the summary of a workshop convened by the Institute of Medicine's Forum on Microbial Threats in March 2013 to explore the scientific and therapeutic implications of microbial ecology in states of health and disease. Participants explored host-microbe interactions in humans, animals, and plants; emerging insights into how microbes may influence the development and maintenance of states of health and disease; the effects of environmental change(s) on the formation, function, and stability of microbial communities; and research challenges and opportunities for this emerging field of inquiry.

Today, we are exposed to an increasing number of chemicals in the environment and there is a growing awareness of the effects of these chemicals on the ovaries. Infertility resulting from environmental exposures may not be obvious until the reproductive life span is waning. As such, the potential for xenobiotic-induced infertility needs to be bette

The book by M. Imran Kozgar aims to cover the problems of mutation breeding in pulse crops in the light of issues related to food insecurity and malnutrition, which according to FAO are the major threats at the present time. So far the research on induction of mutation in pulse crops is negligible compared to cereal crops, though the pulse crops and especially the chickpea are the largest grown crops in India. The main objective of the book is to reveal and explore the possibility of inducing genetic variability in early generations of mutated chickpea, describe the positive aspects of mutagenic treatments, evaluate the content of mineral elements (iron, manganese, zinc and copper) and physiological parameters of isolated high yielding mutant lines. The author hopes that his book will help to advance studies on pulse crops, and that in the long term it will help to reduce the food insecurity and malnutrition problems presently persisting in various developing countries, including India.

The Mouse in Biomedical Research, Volume III: Normative Biology, Immunology, and Husbandry focuses on the normative biology, immunology, and husbandry of laboratory mice. Topics covered range from gnotobiotics and gastrointestinal microflora to animal health surveillance and health delivery systems, along with environmental monitoring. The management and design of breeding and research facilities are also discussed. Comprised of 18 chapters, this volume begins with an overview of studies involving gnotobiotic mice, the induction of gnotobiosis, and microbiological testing of gnotobiotic animals. Maintenance of breeding colonies of gnotobiotic animals is also considered, together with the shipment of gnotobiotes and laboratory facilities for using gnotobiotes. The reader is then introduced to management and design of breeding and research facilities for gnotobiotic mice; practical factors associated with providing adequate nutrition for laboratory mice; and environmental and equipment monitoring. Subsequent chapters deal with the basic biology of the mouse, including anatomy, embryology, reproductive physiology, physiology, endocrinology, hematology, clinical biochemistry, and gastrointestinal microflora. The book also examines immunoglobulins and immunoglobulin genes; lymphocyte immunogenetics; immune response disorders; and biomethodology and surgical techniques. This monograph will be useful to biologists, immunologists, researchers, and others those who use mice in the laboratory or are concerned with the production and maintenance of colonies of mice.

This book presents a concise synthesis of the current knowledge and recent advances in the structure, organization, and functional role of the cytoskeleton in endothelial cells. Particular attention has been given to the different features of the regulation of vascular function mediated by the endothelium. Since cytoskeleton regulates the architecture of the cell and controls several fundamental aspects of intracellular signaling, this book serves as a comprehensive resource on these fascinating biological processes associated with vascular biology.

Dieser Buchtitel ist Teil des Digitalisierungsprojekts Springer Book Archives mit Publikationen, die seit den Anfängen des Verlags von 1842 erschienen sind. Der Verlag stellt mit diesem Archiv Quellen für die historische wie auch die disziplingeschichtliche Forschung zur Verfügung, die jeweils im historischen Kontext betrachtet werden müssen. Dieser Titel erschien in der Zeit vor 1945 und wird daher in seiner zeittypischen politisch-ideologischen Ausrichtung vom Verlag nicht beworben.

Over the past several decades, new scientific tools and approaches for detecting microbial species have dramatically enhanced our appreciation of the diversity and abundance of the microbiota and its dynamic interactions with the environments within which these microorganisms reside. The first bacterial genome was sequenced in 1995 and took more than 13 months of work to complete. Today, a microorganism's entire genome can be sequenced in a few days. Much as our view of the cosmos was forever altered in the 17th century with the invention of the telescope, these genomic technologies, and the observations derived from them, have fundamentally transformed our appreciation of the microbial world around us. On June 12 and 13, 2012, the Institute of Medicine's (IOM's) Forum on Microbial Threats convened a public workshop in Washington, DC, to discuss the scientific tools and approaches being used for detecting and characterizing microbial species, and the roles of microbial genomics and metagenomics to better understand the culturable and unculturable microbial world around us. Through invited presentations and discussions, participants examined the use of microbial genomics to explore the diversity, evolution, and adaptation of microorganisms in a wide variety of environments; the molecular mechanisms of disease emergence and epidemiology; and the ways that genomic technologies are being applied to disease outbreak trace back and microbial surveillance. Points that were emphasized by many participants included the need to develop robust standardized sampling protocols, the importance of having the appropriate metadata, data analysis and data management challenges, and information sharing in real time. The Science and Applications of Microbial Genomics summarizes this workshop.

Since the first volume of The Biology of Sea Turtles was published in 1997, the field has grown and matured in ways few of the authors would have predicted—particularly in the areas of physiology, behavior, genetics, and health. Volume III presents timely coverage of emerging areas as well as the integration of approaches and information that did not exist even a decade ago. The book assembles the foremost experts in each topic to provide the most up-to-date and comprehensive book on sea turtles available today. New areas covered include in vivo imaging of structure, spatial distributions of marine turtles at sea, epibiosis, imprinting, parasitology, and climatic effects. Life history is explored in three chapters covering age determination, predator-prey interactions, and mortality from bycatch.The Biology of Sea Turtles, Volume III will inspire scientists and students to explore and expand their understanding of these intriguing animals. The book provides clear baseline summaries, thoughtful syntheses, and effective presentation of the most fundamental topics spanning form and function, health, distributions, behavior, genetics, evolution, and ecology. Its scope and depth make it the definitive go-to reference in the field.

While ecology is one of the scientific disiplines that most clearly belongs to''basic research', it also strives to serve as a predictive tool for management. Outstanding examples of predictive ecology are Vollenweider's models on the relationship between phosphorus load and water renewal time of lakes, and the resulting algal biomass. The needed few and easily accessible input parameters to very simple models provided a direct link from basic ecology to management, and today these models are key tools for managers worldwide to control lake eutrophication and algal blooms. The baseline of this success is the general relation between phosphorus concentration and phytoplankton biomass that is observed for most lakes. While these relationships are most frequently presented in log-log diagrams, the aquatic ecologist who replots these a linear scale may ask himself why, in spite of the overall correlation, there is still such a variability. It is possible to predict levels of algal biomass that may be synthesized at a given phosphorus load. Some lakes apparently offer optimal conditions for their phytoplankton communities, while others may support less than half the biomass at the same phosphorus load. There are limits to growth, however, and the predic­ tive outcome of phosphorus load decreases as the load increases. This holds in particular for the higher trophic levels like zooplankton and fish. With increased enrichment there are signs of decreased efficiency of energy trans­ fer between foodweb compartments.

Dieser Buchtitel ist Teil des Digitalisierungsprojekts Springer Book Archives mit Publikationen, die seit den Anfängen des Verlags von 1842 erschienen sind. Der Verlag stellt mit diesem Archiv Quellen für die historische wie auch die disziplingeschichtliche Forschung zur Verfügung, die jeweils im historischen Kontext betrachtet werden müssen. Dieser Titel erschien in der Zeit vor 1945 und wird daher in seiner zeittypischen politisch-ideologischen Ausrichtung vom Verlag nicht beworben.

Essential Astrophysics is a book to learn or teach from, as well as a fundamental reference volume for anyone interested in astronomy and astrophysics. It presents astrophysics from basic principles without requiring any previous study of astronomy or astrophysics. It serves as a comprehensive introductory text, which takes the student through the field of astrophysics in lecture-sized chapters of basic physical principles applied to the cosmos.This one-semester overview will be enjoyed by undergraduate students with an interest in the physical sciences, such as astronomy, chemistry, engineering or physics, as well as by any curious student interested in learning about our celestial science. The mathematics required for understanding the text is on the level of simple algebra, for that is all that is needed to describe the fundamental principles. The text is of sufficient breadth and depth to prepare the interested student for more advanced specialised courses in the future. Astronomical examples are provided throughout the text, to reinforce the basic concepts and physics, and to demonstrate the use of the relevant formulae. In this way, the student learns to apply the fundamental equations and principles to cosmic objects and situations. Astronomical and physical constants and units as well as the most fundamental equations can be found in the appendix. Essential Astrophysics goes beyond the typical textbook by including references to the seminal papers in the field, with further reference to recent applications, results, or specialised literature.

This handbook acquaints readers with the exciting developments in various areas of cyanobacterial research in the backdrop of the publication of complete genome sequence of the cyanobacterium Synechocystis sp. strain PCC 6803 in 1996. It begins with a summary of the current knowledge on the taxonomy, phylogeny and evolution of cyanobacteria followe

Vitamin D insufficiency/deficiency is a worldwide, public health problem in both developed and developing countries. Rickets among infants has reemerged. Low levels of vitamin D are associated with increased risk and mortality from cancer. At the same time, the beneficial effects of vitamin D on a host of conditions have recently been discovered. F

Many North American plants have characteristics that are especially promising as candidates for expanding our food supply and generating new economically competitive crops. This book is an informative analysis of the top 100 indigenous food plants of North America, focusing on those species that have achieved commercial success or have substantial market potential. The book's user-friendly format provides concise information on each plant. It examines the geography and ecology, history, economic and social importance, food and industrial uses, and the economic future of each crop.

It has been shown both experimentally {2} and theoretically {2,3} that surface skimming SH waves propagating along symmetry axes of the texture have velocities that differ in proportion to the magnitude of any stress that lies along one of the symmetry axes. Specifically, the stress is directly proportional to the relative velocity difference through the equation -,--V ik=---V. -=ki) ( I) cr. = 2G (-V ~ ik where cr. is the stress in the direction i, G is the shear modulus and Vik is the ~elocity of an SH wave propagating in the i direction and polarized in the k direction. This rather simple relationship is particularly useful because the constant of proportionality involves only the well known shear modulus and the velocity term can be measured directly by observing the transit time shift when a transmitter-receiver pair of SH wave transducers are rotated through 90 degrees on the surface of the part. Experimentally, Equation (I) was tested on the web of railroad rails which had been loaded by a 200,000 pound mechanical testing machine {I}. The method of exciting and detecting the necessary surface skimming SH waves used electromagnetic acoustic transducers (EMATs) that operated through a magnetostrictive mechanism at high magnetic fields {4}. Wave velocities parallel and perpendicular to the axis of the rail on the web differed by the amount predicted by Equation (I) to an absolute accuracy of 30 percent in the worst case.

The nanosciences are a rapidly expanding field of research with a wide applicability to all areas of health. They encompass a variety of technologies ranging from particles to networks and nanostructures. This book focuses on the application of nanomedicine and nanotechnology to cancer. It introduces nanocarriers, nanorods, nanoprobes nanoplat

Winner of the Wildlife Society Outstanding Edited Book Award for 2013!Winner of the Texas Chapter of The Wildlife Society Outstanding Book Award for 2011!Winner of a CHOICE Outstanding Academic Title Award for 2011!Biology and Management of White-tailed Deer organizes and presents information on the most studied large mammal species in the world. The book covers the evolutionary history of the species, its anatomy, physiology, and nutrition, population dynamics, and ecology across its vast range (from central Canada through northern South America). The book then discusses the history of management of white-tailed deer, beginning with early Native Americans and progressing through management by Europeans and examining population lows in the early 1900s, restocking efforts through the mid 1900s, and recent, overabundant populations that are becoming difficult to manage in many areas. Features: Co-published with the Quality Deer Management Association Compiles valuable information for white-tailed deer enthusiasts, managers, and biologists Written by an authoritative author team from diverse backgrounds Integrates white-tailed deer biology and management into a single volume Provides a thorough treatment of white-tailed deer antler biology Includes downloadable resources with color images The backbone of many state wildlife management agencies'policies and a featured hunting species through much of their range, white-tailed deer are an important species ecologically, socially, and scientifically in most areas of North America. Highly adaptable and now living in close proximity to humans in many areas, white-tailed deer are both the face of nature and the source of conflict with motorists, home-owners, and agricultural producers. Capturing the diverse aspects of white-tailed deer research, Biology and Management of White-tailed Deer is a reflection of the resources invested in the study of the species'effects on ecosystems, predator-prey dynamics, population regulation, foraging behavior, and browser physiology.

The Pacific Symposium on Biocomputing (PSB) 2011 is an international, multidisciplinary conference for the presentation and discussion of current research in the theory and application of computational methods in problems of biological significance. Presentations are rigorously peer reviewed and are published in an archival proceedings volume. PSB 2011 will be held on January 3 - 7, 2011 in Kohala Coast, Hawaii. Tutorials and workshops will be offered prior to the start of the conference.PSB 2011 will bring together top researchers from the US, Asia Pacific, and around the world to exchange research results and address pertinent issues in all aspects of computational biology. It is a forum for the presentation of work in databases, algorithms, interfaces, visualization, modeling, and other computational methods, as applied to biological problems, with emphasis on applications in data-rich areas of molecular biology.The PSB has been designed to be responsive to the need for critical mass in sub-disciplines within biocomputing. For that reason, it is the only meeting whose sessions are defined dynamically each year in response to specific proposals. PSB sessions are organized by leaders of research in biocomputing's “hot topics”. In this way, the meeting provides an early forum for serious examination of emerging methods and approaches in this rapidly evolving field.

Freshwater Ecology, Second Edition, is a broad, up-to-date treatment of everything from the basic chemical and physical properties of water to advanced unifying concepts of the community ecology and ecosystem relationships as found in continental waters.With 40% new and expanded coverage, this text covers applied and basic aspects of limnology, now with more emphasis on wetlands and reservoirs than in the previous edition. It features 80 new and updated figures, including a section of color plates, and 500 new and updated references. The authors take a synthetic approach to ecological problems, teaching students how to handle the challenges faced by contemporary aquatic scientists.This text is designed for undergraduate students taking courses in Freshwater Ecology and Limnology; and introductory graduate students taking courses in Freshwater Ecology and Limnology. Expanded revision of Dodds'successful text. New boxed sections provide more advanced material within the introductory, modular format of the first edition. Basic scientific concepts and environmental applications featured throughout. Added coverage of climate change, ecosystem function, hypertrophic habitats and secondary production. Expanded coverage of physical limnology, groundwater and wetland habitats. Expanded coverage of the toxic effects of pharmaceuticals and endocrine disrupters as freshwater pollutants More on aquatic invertebrates, with more images and pictures of a broader range of organisms Expanded coverage of the functional roles of filterer feeding, scraping, and shredding organisms, and a new section on omnivores. Expanded appendix on standard statistical techniques. Supporting website with figures and tables - http://www.elsevierdirect.com/companion.jsp?ISBN=9780123747242

Dr. Joshua Lederberg - scientist, Nobel laureate, visionary thinker, and friend of the Forum on Microbial Threats - died on February 2, 2008. It was in his honor that the Institute of Medicine's Forum on Microbial Threats convened a public workshop on May 20-21, 2008, to examine Dr. Lederberg's scientific and policy contributions to the marketplace of ideas in the life sciences, medicine, and public policy. The resulting workshop summary, Microbial Evolution and Co-Adaptation, demonstrates the extent to which conceptual and technological developments have, within a few short years, advanced our collective understanding of the microbiome, microbial genetics, microbial communities, and microbe-host-environment interactions.

Edited by a leading expert, this book delineates the successful means to prevent, identify, and manage the effects of CO poisoning. It provides new information on CO toxicity, including rehabilitation, the dissemination of information to the public, litigation involving CO poisoning, economic loss assessment, and firefighting. The book addresses the pros and cons of hyperbaric oxygen therapy and thoroughly reviews the physiological effects of acute and long term exposure to CO, as well as the neurocognitive and neurobehavioral sequelae. The only comprehensive reference on the subject, this multi-faceted guide takes an innovative look at how to identify, treat, and prevent harmful exposure to carbon monoxide.

For millennia, the presence of fungi in food has been both boon and bane to food stores. Fungi can spoil large quantities of food and produce dangerous toxins that threaten human health; however, fungal spoilage in certain foods can produce a unique, highly prized food source and there are some very effective fungal derived medicines. A thorough un