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The second edition of this book has been extensively revised and updated. There has been a lot of scientific advances in the radiology, pathology and risk assessment of benign breast lesions since the publication of the first edition. The first edition concentrated on screen-detected lesions, which has been rectified. New symptomatic and screen-detected lesions are discussed in the second edition and include: mastitis and breast abscess, idiopathic granulomatous mastitis, diabetic mastopathy, phyllodes tumour, gynaecomastia and pseudoangiomatous stromal hyperplasia. The chapters on columnar cell lesions and mucocele-like lesions have been extensively updated. Where applicable, genetic analysis of the benign lesions which in breast cancer is becoming part of personalised medicine has been included. The book includes detailed analysis of the main models such as the Gail Model used to assess the subsequent risk of breast cancer in individuals. The current trend in the management of all cancers is preventative. Screening mammography detects early curable cancers as well as indeterminate lesions. These indeterminate mammographic lesions are invariably pathologically benign. The author collated important benign lesions and based on peer-reviewed publications documented the relative risk of subsequent cancer to allow the patient and the clinician to institute preventative measures where possible. This book therefore will be an essential part of multidisciplinary management of patients with symptomatic and screen-detected benign breast lesions.

Este libro es una introducción al aprendizaje relacionado con las neoplasias que se presentan en la mujer en sus diferentes etapas de la vida que servirá, a todos los profesionales en cuidados primarios de salud de la mujer; como revisión actualizada, didáctico o como material de referencia ayudará a los conocimientos especializados necesarios para la detección y manejo de los diferentes procesos oncológicos en las mujeres. La lectura de esta obra instruye dentro de los conocimientos científicos del cáncer de la mujer, muchos de ellos ocultos en la vida cotidiana, pero aquí, en calidad de consulta, lleva de la mano a resolver mucho de lo que se hemos perdido y a consultar e instruir en lo que no sabemos. Este tratado, dividido en 16 secciones, incluye temas actualizados relacionados con la oncología de la mujer, una bibliografía actualizada nacional e internacional, en medio de una basta información que esta al día; el manejo oncológico se describe en varias áreas, para lograr una mejor calidad de vida, la cirugía conservadora de cáncer y profiláctica se indican para diferentes canceres, así como la descripción e indicaciones en cirugía vaginal, laparoscópica, oncoplástica; además exenterativa y de reconstrucción todas estas áreas se analizan en este libro, así como la técnica de ganglio centinela; los autores han contribuido en gran medida al desarrollo nacional e internacional para el establecimiento de las normas actuales del tratamiento de los cánceres.

This book provides a detailed update on all aspects of fine-needle aspiration cytology of breast lesions. It will serve as an up-to-date reference and atlas on new entities in breast pathology, including classic benign and malignant lesions, in accordance with current classification schemes and staging protocols. Emphasis is placed on description of characteristic diagnostic features as well as common cytological pitfalls. Correlation of cytology with histology is achieved through cyto-histological illustrations, enabling readers to gain a good understanding of the morphologic features of various lesions. Core-needle biopsy and fine-needle aspiration cytology are compared in depth, with attention to their relative strengths and weaknesses and indications. In addition, the impact of molecular classification of breast cancers on cytologic diagnosis is explored, and the use of molecular techniques and artificial intelligence in diagnostic cytology is discussed.

This book explores the latest developments in cancer research.

This comprehensive textbook incoporates all aspects of breast disease, including basic science, benign breast diseases, malignant neoplasms, diagnostics, multidisciplinary therapeutic options, and molecular biology research. It focuses on information useful for trainees, medical students, and practicing breast surgeons and oncologists. The highlight of the book is to present the controversies and arrive at a consensus in an evidence-based narrative. It aims to be useful not only for daily practice but also to establish a firm knowledge platform for clinicians and research scientists by outlining the guidelines for the treatment plan.Key Features• Has a global perspective and encourages implementation of the guidelines for management in daily practice• Enriched with high-quality illustrations and flowcharts for easy understanding of trainees, fellows, and breast surgeons• Covers the latest innovations and research in breast disease management

​The book covers the entire gamut of breast diseases including all necessary dimensions, such as radiology, pathology, surgery and oncology. It provides a complete spectrum from clinical scenario, imaging investigations and interventions, final histopathological diagnosis and complete treatment plan from medical, surgical and radiation to follow up protocols. It discusses about common and uncommon varied breast diseases encompassing all necessary specialties. It includes stepwise pictorial descriptions of ‘must know'in breast lesions. It presents high resolution images of the latest technologies in radiology and pathology based on typical case scenarios. The book features special chapters on recent updates and innovative technologies used in imaging, pathology and management of breast diseases. It contains line diagrams and flow charts for quick reading and easy understanding, to be practically implemented as and when required in any concerned specialties.The book is useful for consultants in radiology, pathology, general surgeons, onco-surgeons, super specialists and fellows in breast diseases, and postgraduates in these fields.

This book is a complete representation of all the gynecological cancers covering from the anatomical details of the individual gynecological organs along with the epidemiological pathophysiological aspects of the various gynecological cancers. It also covers the diagnostic workup of various gynecological cancers with recent evidence based treatment protocols. All the major gynecological oncological surgeries are described in a simple way along with photographs for easy understanding in all the chapters. In addition, numerous flowcharts and management algorithms are included in every chapters, as a ready reference for the benefits of the trainees and practitioners. This book includes chapters such as critical care in oncology, oncology nursing, benign and malignant breast disease, hormones and gynecological cancer, cancer infections and vaccines, palliative care which are not often found in many text books. Apart from these, this book has also included chapters like principlesand practice of Radiation oncology, surgical oncology and medical oncology, recent advances and imaging in gynecological malignancy to make it a complete package. Thus, it will serve as an excellent reference book for surgical oncologists, general gynecologists, medical and radiation oncologists fellows and trainees.

The available information on breast cancer has evolved so rapidly that a textbook understanding is no longer sufficient to make sound therapeutic decisions. Further, the latest findings and data are spread throughout the scientific literature of various medical fields, making it difficult for medical professionals to keep abreast of these advances, and to apply them in their day-to-day work. This book provides updated information on breast cancer, such as the modern molecular classification and staging, and demonstrates how imaging with pathologic correlation can be used in management decisions. In addition, it identifies the most suitable imaging modalities for screening, diagnosis and monitoring for each clinical case. Given its scope, the book offers a valuable resource for all medical professionals (practicing or still in training) whose work involves breast cancer, including radiologists, breast surgeons, pathologists, radiotherapists and nuclear medicine professionals.

The book provides detailed information on breast cancer and covers all the aspects of this rapidly spreading disease, such as applied anatomy and physiology, causative factors, various Investigations to reach a concise, definitive and complete diagnosis. The management of breast cancer involves multi-modality treatment and the book describes all the modalities in a very clear manner. It also discusses in a very lucid and practical way. the multi-prong treatment that the patient requires. Additionally, the book covers lesser-known areas of the subject like rehabilitation, management of lymphoedema, Extravasation of chemo-Infusion, organization of breast cancer management group, breast cancer awareness and patient education, follow up of the patient, and psychological support to these patients who have undergone mutilation of their organ. Edited by experts the chapters are contributed by renowned onco-sugeons from high volume and reputed centersin India such as, PGIMER, Chandigarh, AIIMS, New Delhi, and TMH, Mumbai among others. The book serves as a useful resource for surgeons, medical oncologists, radiotherapists, pathologists, radiologists and many other specialists interested in the field of breast cancer and actively working in this area. It is useful for practitioners and residents as well as for those who want to learn the different aspects of this disease.

This book provides an update on the latest development in the field of microRNAs in cancer research with an emphasis on translational research. Since the early 2000s, microRNAs have been recognized as important and ubiquitous regulators of gene expression. Soon it became evident that their deregulation can cause human diseases including cancer. This book focuses on the emerging opportunities for the application of microRNA research in clinical practice. In this context, computer models are presented that can help to identify novel biomarkers, e.g. in circulating microRNAs, and tools that can help to design microRNA-based therapeutic interventions. Other chapters evaluate the role of microRNAs in immunotherapy, immune responses and drug resistance. Covering key topics on microRNAs in cancer research this book is a valuable resource for both emerging and established microRNA researchers who want to explore the potential of microRNAs as therapeutic targets or co-adjuvants in cancer therapies.

This superbly illustrated atlas serves as a basic introduction to contrast-enhanced mammography (CEM), a breakthrough functional breast imaging modality, which is rapidly growing. This book is an essential guide for the latest developments with correlative findings, practical interpretation tips, physics, and information on how contrast mammography differs from conventional 2D and 3D Full Field of View digital mammography (FFDM). It includes: · over 1000 high-quality 2D, 3D and recombined contrast mammography images representing the spectrum of breast imaging · findings obtained in the full range of benign, pre-malignant and malignant conditions, including artefacts and postoperative changes, presented with high-quality illustrations from case examples · image interpretation tips using mammographic and DCE-MRI descriptors of the BI-RADS lexicon to effectively read and interpret this advanced imaging modality · practical tips to interpret this new modality and how it is used as an adjunct to 2D mammography · details on how integration of contrast-enhanced mammography drastically changes lesion work-up and overall workflow in the department ·'imaging pearls'boxes offering interpretation tips for expert clinical guidance · a case on the recently introduced CEM guided biopsy procedure The book's target audience consists of diagnostic radiologists, residents, fellows, technologists and clinicians involved in the care of breast cancer patients, including surgeons and oncologists. The goal is to provide a concise introduction to CEM and to lead to enhanced interpretation and better patient staging prior to surgery.

Symptoms of the breast in gravid women commonly represent physiological changes, however they may also be related to serious underlying breast disease; this challenging dilemma is aggravated by diagnostic and therapeutic limitations imposed by safety issues regarding the mother and fetus. A comprehensive coverage of all aspects of normal and pathologic breast changes during pregnancy and lactation, their diagnosis and management is provided in the present work. The organized structure of this book begins with gestational changes of the breast, while discussing safety, hazards, and arguments regarding diagnostic approaches. It then goes on by describing various clinical presentations and common and uncommon benign disorders during gravidity. The book then addresses pre-malignant lesions of the breast, opening the dialogue on how to manage these confusing lesions in pregnant and nursing women. It continues toward pregnancy-associated breast cancer, focusing on every facet of the problem, including epidemiology, diagnosis, treatment and complications, anesthetic considerations, prenatal care, and rare malignancies; and comes to an end by arguing main psychological concerns. In the midst of this orderly sequence fertility issues, pregnancy, and breastfeeding in women who have overcome their breast cancer are also discussed. This unique reference has been written by academic experts from different centers and diverse disciplines in a practical format. It is intended to be an ideal resource for every practitioner and specialist who manages complaints of gravid and nursing women or treats breast disorders in women of child bearing age.

This book provides a concise, step-by-step guide to accurate microscopic diagnosis for clinicians who deal with patients with breast lesions. The emphasis is on a practical approach to dealing with breast biopsies and reaching a diagnosis. It outlines the procedures used for the microscopic diagnosis of various breast lesions and the significance of the nomenclature and terms used in pathology reports, including those dealing with uncommon or rare lesions. Ample illustrations of the lesions discussed are included, particularly those dealing with uncommon and border-line lesions. There is a special emphasis on breast cancer and on the fact that not all breast cancers are the same. The different ways by which breast cancers are classified are discussed including recent classifications which lead to personalized therapy. The book is aimed at pathologists of all grades who deal with breast biopsies including those in training. It would be also useful for practicing and trainee surgeons and oncologists as well as other health professionals dealing with patients with breast diseases and scientists carrying out research on breast problems.

This contributed book covers all aspects concerning the clinical scenario of breast cancer in young women, providing physicians with the latest information on the topic. Young women are a special subset of patients whose care requires dedicated expertise. The book, written and edited by internationally recognized experts who have been directly involved in the international consensus guidelines for breast cancer in young women, pays particular attention to how the disease and its planned treatment can be effectively communicated to young patients. Highly informative and carefully structured, it provides both theoretical and practice-oriented insight for practitioners and professionals involved in the different phases of treatment, from diagnosis to intervention, to follow-up – without neglecting the important role played by prevention.

This book covers the full range of pathologic conditions encountered during childhood and youth, including tumors and tumor-like conditions of all organ systems, with direct links to developmental biology pathways and genetics. It provides a user-friendly road map to the main diagnostic criteria and combines an organ-related approach with an explanation of the diagnostic approaches to various specific diseases and syndromes, including sequential segmental analysis of congenital heart disease. More than 500 new full-color macro- and microphotographs using more than 500 multi-photographic panels are included to provide a realistic basis for comparison macroscopically and under the lens, and summarizing tables highlight key information in the concise form required for at-a-glance review. Pathologists will find the book very helpful when signing out complex and challenging cases, and it will also prove invaluable for exam preparation and continuing medical education.

Designed in a small-format for practical reading and point-of-care setting use, this work presents the most up-to-date concepts on breast diseases. The main objective of this book is to propagate current knowledge of the most frequent breast diseases, being a quick reference, evidence-based manual covering the major clinical scenarios in mastology. The essence of the work can be summarized in the following sentence:'access to maximum content in the least amount of time.” The book contains data that will allow readers to understand and treat patients with different complaints and diseases. Each chapter presents a flow chart and a summary of the five major publications on the subject. This is unique in comparison with other books in this medical specialty. Developed by a team of international expert specialists who deal with breast pathologies on a daily basis, the book also includes additional contributions from experienced, renowned professionals in interdisciplinary specialties related to the main area. This book will be of interest to physicians who deal with breast diseases and wish to improve their knowledge through exposure to state-of-the-art data and best practices advice. It is also directed to medical students and residents in training within mastology.(This title was originally published in Portuguese by the Brazilian publisher Atheneu in 2011 and has sold very well and gone into a third edition, published in 2017. The Editors have all English language rights, detailed in the attached contract, although it is in Portuguese).

This text is designed to present a practical and concise handbook on the diagnosis and management of breast diseases for quick reference by trainees and practitioners. It emphasizes the approach to diagnosis and management of breast tumors written from the perspectives of each member of the multidisciplinary management team (pathologist, radiologist, medical oncologist, surgical oncologist and radiation oncologist). The text is divided into two sections. The first section is written by each subspecialty with focus on the overview and management of breast tumors, current controversies, position statement when necessary, and quality assurance. The radiology overview addresses questions such as when to perform breast imaging, the difference between screening and diagnostic mammograms, when to perform Magnetic Resonance Imaging (MRI) and ultrasound, the meaning of radiological descriptors, and lastly the cost effectiveness and quality assurance of radiologic assessment of breasttumors. The pathology overview addresses approaches to evaluation of breast biopsies and excision for calcifications, densities, distortion, asymmetry and masses, pitfalls to histologic interpretations, the utility of immunohistochemical stains, quality assurance and cost effectiveness, and current controversies and position statements. Surgical, medical and radiation oncology overviews address when to treat and when to refrain, current treatment options or modalities and the factors informing choice, utility of genomics or molecular diagnostics in management, quality assurance, controversies and position statements. The second section discusses common breast tumors (focusing on radiologic-pathologic diagnosis and correlation) using the practical approach highlighted in the first section. The entities discussed include but are not limited to fibroepithelial tumors, papillary lesions, spindle cell lesions, in-situ and invasive carcinomas. The uniqueness of this book is the focus on the integrated subspecialty approaches with perspectives directly from subspecialty experts and emphasis on how each member of the multidisciplinary team can contribute to the optimal care of the breast cancer patient. The text aims to bridge the gap of the “what next” question and foster a comprehensive, team approach for trainees and practicing physicians by providing information about specific entities from diagnosis to treatment. Generous illustrations and tables in the text enhance appreciation of the entities being discussed.

This book presents the basic concepts for understanding and practicing breast pathology in routine practice. It explains how to tackle the diagnosis, emphasizing diagnostic clues for each entity as well as pitfalls and mimickers. Each chapter has concise, relevant text illustrated by numerous high-quality pictures highlighting the pearls and challenges in the diagnosis of breast lesions. Experts from around the world describe common and rarer conditions affecting the breast. Histology, immunohistochemistry, cytology, radiology and key morphologic criteria are covered. The book includes a chapter dedicated to breast normal histology, which is very important for understanding breast pathology, and a separate chapter for breast radiology, which is essential in understanding and diagnosing the breast lesions especially in a multidisciplinary team. Also, there is a chapter with the latest TNM staging system as well as the recently revised World Health Organization classification ofbreast tumors. Since in many breast units the cytology is still used to diagnose breast lesions there is a chapter dedicated to this technique. This book is aimed at trainees and practicing pathologists in surgical pathology, particularly those with an interest in breast pathology and those tackling the daily sign-out.

This is the second edition of a well-received book reflecting the state of the art in oncologic imaging research and promoting mutual understanding and collaboration between radiologists and clinical oncologists. It presents all currently available imaging modalities and covers a broad spectrum of oncologic diseases for most organ systems. Today, oncologic imaging faces the challenge of improving and refining concepts for precise tumor delineation and biologic/functional tumor characterization, as well as for purposes of creating individual treatment plans. The concept of radiomics has further advanced the conversion of images into mineable data and subsequent analysis of said data for decision-making support. Since the release of the book's first edition, radiomics has been introduced in oncology studies and can be performed with tomographic images from CT, MRI and PET/CT studies. The combination of radiomic data with genomic features is known as radiogenomics, and can potentially offer additional decision-making support. This book will be of interest to clinical oncologists with regard to the diagnosis, staging, treatment and follow-up on various tumors affecting the CNS, chest, abdomen, urogenital and musculoskeletal systems.

This richly illustrated book provides a comprehensive overview of the use of current ultrasound techniques, including contrast-enhanced ultrasound and ultrasonic elastography, in the diagnosis of breast disease. The advantages and pitfalls of the various imaging modalities are identified, and it is explained how combined use of the modalities – multiparametric ultrasound – aids diagnosis and in particular assists in the differentiation of benign and malignant disease. Readers will find detailed description and illustration of the imaging appearances of age-related features (including in children and adolescents), the most important benign diseases, different forms of breast cancer, mammary gland pathology in the contexts of pregnancy and female reproductive system disease, chest gland pathology in males, and recurrent and metastatic disease. In addition, ultrasound-guided breast interventions and imaging of breast implants are discussed. Specialists in ultrasound diagnostics, radiologists, oncologists, and surgeons will all find this topical book to be both interesting and helpful in daily clinical practice.

This book, written by leading international experts, deals exclusively with reconstruction techniques for the Nipple-Areolar Complex (NAC). The first chapters present the history of the Nipple-Areolar Complex reconstruction and the anatomy of this part of the body. After discussing the abnormalities of the Nipple-Areolar Complex and how to prevent Nipple-Areolar Complex disorders, the book provides extensive documentation on techniques for correcting nipple hypertrophy, nipple inversion, and for increasing nipple projection. Readers will also find helpful information of malposition and tumors of the Nipple-Areolar Complex, as well as complications that can arise during the various surgical techniques.The book offers an invaluable guide for residents and fellow, practicing and highly experienced plastic surgeons, general surgeons, and those in cosmetic surgical subspecialites.

Breast cytopathology is a field characterized by practicality and diagnostic efficacy. This book focuses mainly on morphology, with helpful hints for recognizing benign lesions and the main features of malignancy. It reviews specific features of various lesions and the consequences of the diagnosis for the management of the patient. Each chapter contains high-quality cytology images accompanying the descriptions, including comparison images to distinguish the most important morphological features and to help in the differential diagnosis. Fine needle aspiration cytology (FNAC) sampling and preparation technique, fixation, staining, and principles of its interpretation are covered. Immunocytochemistry and ancillary techniques are outlined, as well as the main clinical and radiological features of breast lesions, and the cytological diagnostics of axillary lymph nodes. This publication will be of great use to medical practitioners in their first approach to breast cytopathology, as well as to pathologists and cytotechnicians with little to moderate experience in the field.

Now completely updated with the latest classifications of breast pathology and molecular diagnosis, David J. Dabbs'Breast Pathology, 2nd Edition, remains your go-to source for integrated, comprehensive coverage of this fast-changing field. Written by internationally acclaimed pathologists, this definitive reference incorporates genomic and molecular information, clinical presentation, gross and microscopic pathologic findings, radiologic and laboratory diagnosis, immunohistochemistry, and theranostics – providing complete, authoritative information for pathology trainees, practitioners, and oncologists. - Approximately 2,000 full-color pathological images clearly depict clinical, radiological, molecular, immunohistochemical, and theranostic aspects of disease. - Quick reference points at the beginning of each chapter conveniently list all relevant diagnostic, theranostic, and genomic data for fast retrieval. - Immunohistochemistry for each entity is mapped according to diagnostic, theranostic, and genomic applications with specific regards to disease entities in each chapter. - Breast specimen handling is discussed in detail to ensure proper sampling and processing for optimal molecular and immunohistochemistry resulting. - Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. - All chapters have been updated with the latest breast pathology classifications and the most recent information on molecular diagnosis. - New chapter on next generation DNA sequencing and management of clinically advanced breast cancer.

Now in its 3rd Edition, this bestselling volume in the popular Requisites series, by Drs. Debra M. Ikeda and Kanae K. Miyake, thoroughly covers the fast-changing field of breast imaging. Ideal for residency, clinical practice and certification and MOC exam study, it presents everything you need to know about diagnostic imaging of the breast, including new BI-RADS standards, new digital breast tomosynthesis (DBT) content, ultrasound, and much more. Compact and authoritative, it provides up-to-date, expert guidance in reading and interpreting mammographic, ultrasound, DBT, and MRI images for efficient and accurate detection of breast disease. Features over 1,300 high-quality images throughout. Summarizes key information with numerous outlines, tables,''pearls,''and boxed material for easy reference. Focuses on essentials to pass the boards and the MOC exam and ensure accurate diagnoses in clinical practice. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. All-new Breast Imaging-Reporting and Data System (BI-RADS) recommendations for management and terminology for mammography, elastography in ultrasound, and MRI. Step-by-step guidance on how to read new 3D tomosynthesis imaging studies with example cases, including limitations, pitfalls, and 55 new DBT videos. More evidence on the management of high risk breast lesions. Correlations of ultrasound, mammography, and MRI with tomosynthesis imaging. Detailed basis of contrast-enhanced MRI studies. Recent nuclear medicine techniques such as FDG PET/CT, NaF PET.

This atlas illustrates the range of breast lesions with detailed correlation of gross and microscopic features. Where relevant, radiological images are incorporated. A description of normal, developmental and physiological breast morphology will serve as introduction to the main content of this atlas. Classification of tumors is based on the latest World Health Organization Classification of Tumors of the Breast, 4th edition, 2012. As immunohistochemistry is a key adjunctive tool in the workup of breast lesions as well as used in prognostic evaluation of breast cancers, appropriate examples are interspersed among the lesions where pertinent.

This superbly illustrated atlas of breast tomosynthesis covers all aspects and applications of the technology, which reduces tissue overlap and facilitates the recognition of small cancers. After clear explanation of basic principles of the technique, individual chapters address diagnostic criteria, indications, and use of breast tomosynthesis as a screening tool. The findings obtained in the full range of benign and malignant conditions, including postoperative changes, are then presented with the aid of a wealth of high-quality illustrations from case examples. Detailed attention is paid to the BI-RADS classification, bearing in mind the ability of tomosynthesis to reduce categorizations as BI-RADS 3 and 0, thereby decreasing the recall rate. The book concludes by examining tomosynthesis-guided interventions such as vacuum-assisted breast biopsy and galactography.

Breast cancer remains the leading cause of cancer in women, which makes accurate diagnoses on core needle biopsy (CNB) specimens of vital importance in staging and guiding therapy decisions for patients. The first edition of this multi-authored text written by leaders in the field from major academic medical centers provided a comprehensive guide on diagnostic breast pathology in the core biopsy setting. In addition to in-depth coverage of benign and malignant entities encountered in breast core biopsies, the book provided additional resources to improve diagnostic accuracy such as pattern-based approaches to evaluation, mimickers of breast lesions arising in extra-mammary sites, and pitfalls specific to small tissue samples. In recent years, there have been several notable developments in the field of breast pathology including revisions in AJCC breast cancer staging, updated guidelines in the testing and reporting of ER, PR, and HER2, as well as implementation of immunotherapy and companion biomarker testing. In addition, several key updates were included in the most recent edition of the WHO Classification of Breast Tumours (2020). In addition to updates specific to individual breast entities, the second edition will detail updates regarding biomarker testing in the primary and metastatic setting, and incorporate newly defined entities and updated definitions of rare tumors in alignment with the WHO Classification of Breast Tumours (2020). Furthermore, this edition will address the role of CNB in companion biomarker testing for eligibility for immunotherapy in the context of advanced triple-negative breast carcinoma. Written by leaders in the field and edited by expert breast pathologists, The Second Edition of Comprehensive Guide to Core Needle Biopsies of the Breast is the definitive reference on breast core needle biopsies for practicing pathologists, pathology trainees, oncologists and clinicians of patients with breast disease.

This text provides a comprehensive textbook summarizing the presentation, workup, and surgical solutions for common emergencies in the cancer patient. The use of medications (antibiotics, hormones, and biologic therapies) and interventional radiologic procedures as adjuncts or as replacements for the surgical solutions are discussed. The text covers emergencies that result as adverse effects for the systemic and local treatments for cancer, emergencies that result from mechanical issues with the cancer and those that result from surviving major extirpative surgery. Diagnosis and treatment of patients'immune-compromised or thrombocytopenic status from chemotherapy is discussed, as is surgical treatment in patients with prior complex surgical therapy or radiation treatment. Finally, the text covers alternatives to surgery, including new interventional radiologic and endoscopic procedures.Surgical Emergencies in the Cancer Patient will be of great value to healthcare professionals at all levels who are involved in the treatment of emergencies in the cancer patient. It is meant for a wide group of individuals, including medical students, residents in surgery and internal medicine, fellows in surgery and oncology, and practicing oncologists and surgeons. This work is meant to be a textbook for the student, a guide for the practitioner, and a reference for the general oncologist.

This text is intended as a practical guide for physicians and surgeons who treat diseases of the breast, both benign and malignant. Thus, general surgeons, internists, family practitioners, gynecologists, surgical oncologists, radiation oncologists, and medical oncologists will find this book useful. The management of breast diseases requires a multidisciplinary approach, and this textbook therefore includes the views of a wide range of specialists from throughout the world. Today the treatment of breast diseases is largely predicated on the results of randomized prospective trials. The results of many clinical trials are discussed in detail, and readers will find this book to be a useful guide to the evidence-based treatment of breast diseases.The revised edition provides a comprehensive update of the previous version of the book. Specifically, it contains 2 new chapters: “Molecular Classification of Breast Cancer” and “Breast Cancer Molecular Testing for Prognosis and Prediction”. In addition, since publication of the previous edition, the results of numerous adjuvant systemic therapy and neo-adjuvant systemic therapy trials have been published, and this edition provides a comprehensive overview of these trials and discusses how they have changed the management of breast cancer. Similarly, there have been, in the last few years, important new developments in the local therapy of breast cancer. This edition discusses these new developments and particularly recent developments and controversies concerning the management of the axilla in patients with primary breast cancer. New guidelines with respect to radiotherapy are also reviewed and discussed. Finally, all chapters in the book are thoroughly revised and updated to provide readers with current understanding of the biology and treatment of breast cancer.

This full-colour, richly-illustrated book is an excellent source of rapidly retrievable information on aspects of relevance in daily clinical practice in the outpatient breast clinic. Expert guidance is provided on a full range of topics, including pitfalls of clinical examination, imaging and related tissue diagnosis, approaches to management decision-making in different disorders, the role of surgery and adjuvant therapy, follow-up and rehabilitation. In outpatient breast clinics, effective communication with patients must be established in order to address symptoms that in most cases are not serious but can be very worrying and sometimes lead to misdiagnosis and also to litigation. Outpatient consultations also offer an opportunity to encourage a healthy lifestyle and to provide information on matters such as risk assessment, screening and the most reliable websites. A well-functioning outpatient clinic is essential to a breast unit's overall proficiency. Readers will find this book an invaluable aid to good practice. The authors place particular emphasis on quality indicators and key priorities for implementation of the main guidelines, at the same time specifying the level of evidence for them and degree of recommendation. Practical measures for achieving the best results are highlighted, and helpful advice is provided on optimizing patient communication and reducing the psychological burden.

This encompassing book is designed to contribute to a teamwork approach by promoting understanding between radiologists and clinical oncologists. All of the currently available imaging modalities of relevance in clinical oncology are covered, and the presentation of a broad spectrum of oncologic diseases (of most organ systems) on these modalities is discussed and illustrated. The role of multiparametric and multimodality imaging approaches providing both morphologic and functional information is considered in detail, and careful attention is paid to the latest developments in higher field (3T) MR imaging and advanced MR techniques such as diffusion-weighted imaging, diffusion tensor imaging, perfusion-weighted imaging and spectroscopy. The major challenge of incorporating progress in quantitative imaging technology into radiotherapy treatment planning, guidance, and monitoring is also addressed. This book will assist in refining the treatment approach in various oncologic diseases and organ systems based on specific imaging features. It will be of value to radiologists, oncologists, and other medical professionals involved in the diagnosis and treatment of oncology patients. ​

Stay on top of the latest knowledge in the field with this must-have resource for all clinicians who treat breast diseases. Expand your knowledge of every aspect of breast diseases as a diverse and distinguished group of internationally-recognized experts summarize the current knowledge, including biology and epidemiology, clinical features, and management. Ideal for any clinician seeing patients with breast disease, especially carcinoma of the breast, This full color 5th Edition of the authoritative text in the field is designed to foster the understanding necessary to provide optimal patient care.. Features Covering the latest major clinical trials, along with concise management summaries for each clinical chapter. Illustrations and tables that emphasize breast imaging, microscopic and gross histology, anatomy, and procedural technique enhance visual understanding. Algorithms on problem management in all aspects of breast disease from benign processes to breast carcinoma inform clinical practice. eBook with content updates is included with purchase New chapters have been added on pathology of in situ carcinomas, prophylactic contralateral mastectomy, implications of obesity in breast cancer, and an overview of survivorship issues To keep perspectives fresh and updated, over one third of the authors are new to this edition

This book presents the current trends and practices in breast imaging. Topics include mammographic interpretation; breast ultrasound; breast MRI; management of the symptomatic breast in young, pregnant and lactating women; breast intervention with imaging pathological correlation; the postoperative breast and current and emerging technologies in breast imaging. It emphasizes the importance of fostering a multidisciplinary approach in the diagnosis and treatment of breast diseases. Featuring more than 800 high-resolution images and showcasing contributions from leading authorities in the screening, diagnosis and management of the breast cancer patient, Breast Cancer Screening and Diagnosis is a valuable resource for radiologists, oncologists and surgeons.

Breast Disease: Comprehensive Management provides a clear, concise source of information in order to make real-life, evidence-based decisions for all aspects of breast disease, both benign and malignant. The volume provides the latest breakthroughs in breast cancer research, ranging from paradigm shifts in the surgical management of the axilla, the changing role of adjuvant and neoadjuvant chemotherapy, the impact of molecular medicine in decision-making and the controversial role of prophylactic mastectomy in our era. Within select chapters, “How I do it” clinical scenarios are supplied and described in very practical terms. Also included at the end of each chapter are synoptic questions with detailed answers, akin to the self-assessment (SESAP) format questions and answers. These questions provide a basis for continuous medical education (CME) for the practicing physician and surgeon, further in surgical oncology and breast surgery, medical oncologists, radiation oncologists, and breast radiologists enhancing a focused approach to the management of breast disease in preparation for the American Board of Surgery certification and re-certification for the general surgeon. Breast Disease: Comprehensive Management is of great value to general surgeons, breast surgeons, surgical oncologists, general surgery residents, and fellows.

A practical guide for the diagnostic surgical pathologist, this new edition of Biopsy Interpretation of the Breast presents the diverse spectrum of pathologic alterations that occur in the breast in a manner analogous to that in which they are encountered in daily practice. Lesions are grouped together according to their histologic patterns rather than by the traditional benign-malignant categorization in order to simulate the way pathologists face these lesions as they examine microscopic slides on a daily basis. The role of adjunctive studies in solving diagnostic problems in breast pathology is emphasized where appropriate. In addition, the clinical significance and impact on patient management of the various diagnoses are discussed and key clinical and management points highlighted.

I am honored to write the Foreword for this first volume of the M. D. Anderson Cancer Care series, because I believe the book represents a milestone not only for M. D. Anderson but also for cancer specialists everywhere. All of us, whether we work in academic medical institu­ tions, medical school hospitals, community hospitals, oncology clinics, or solo practice, have seen remarkable changes in our practice over the recent decades. We know that breast cancer patients live longer, feel better, and look better than ever before, and they face this dreaded disease with more optimism than ever before. Each of us deserves to be proud of this progress. Though I am now primarily a laboratory scientist and admin­ istrator, I am proud of my own work on factors that control the growth of tumor cells, most prominently through regulation of EGF receptors and HER-2/neu, and the promise that work holds for women who have breast cancer. The authors represented in this volume have made important contri­ butions to breast cancer care. Likewise, every reader of this book has and will continue to make critical contributions to the health of women with breast cancer. I would like to express the hope here that each of us takes the opportunity to step outside our subspecialties-surgeon, internist, radiation oncologist, pathologist, radiologist, laboratory scientist-and learn how we can better integrate our work with that of other specialists.

First Prize, BMA Medical Book Awards 2013Breast cancers are now detected earlier and are thus more likely to be confined to the breast itself and regional nodes. Many of these tumours will have minimal proclivity for hematogenous dissemination and formation of micrometastases. On the other hand, some patients have micrometastatic diseases which can

Die Mammographie ist eine makroskopisch-submakroskopische'Schatten-Pathologie', so sind - um zuverlässige Diagnosen stellen zu können - auch profunde Kenntnisse der gesamten Mammapathologie notwendig. Die alten Leitsätze, dass beispielsweise ein glattkonturierter Rundschatten benigne, eine strahlige Struktur maligne, mikrokalk P.E. bedeuten, sind nicht mehr allgemein gültig. Dieses Buch macht den mammographierenden Arzt mit der modernen Mammapathologie vertraut. Etwa 400 Abbildungen in über 600 Einzeldarstellungen und mehr als tausend Literaturhinweise helfen dem Leser, die pathologisch-mammographische Morphologie zu verstehen. Ausführliche Darstellung der klinischen Symptome, orientierende Zusammenfassung der ergänzenden diagnostischen Verfahren bzw. der therapeutischen Möglichkeiten vervollständigen das Buch.

Apply a systematic pattern recognition method to achieve more accurate diagnoses with Practical Breast Pathology: A Diagnostic Approach. Using a practical, pattern-based organization, this volume in the Pattern Recognition series guides you efficiently and confidently through the evaluation of even the most challenging neoplastic and non-neoplastic specimens in breast pathology, and also highlights patterns crucial to radiologic diagnosis. Consult this title on your favorite e-reader with intuitive search tools and adjustable font sizes. Elsevier eBooks provide instant portable access to your entire library, no matter what device you're using or where you're located. Compare specimens to commonly seen patterns, categorize them accordingly, and turn directly to in-depth diagnostic guidance using the unique, pattern-based Visual Index at the beginning of the book. Assess key pathologic and clinical aspects of both neoplastic and non-neoplastic conditions with over 530 high-quality, full-color images that help you evaluate and interpret biopsy samples.Apply the latest techniques and advances in the field, including optimal processing of breast specimens for early detection of breast cancer, the latest molecular diagnosis in breast pathology, and the use of radiology in optimizing detection of breast lesions.Progress logically from the histological pattern, through the appropriate work-up, around the pitfalls, and to the best diagnosis.Find the information you're looking for quickly and easily with patterns color-coded to specific entities in the table of context and text and key points summarized in tables, charts, and graphs.Review all the information essential for completing a sign-out report: clinical findings, pathologic findings, diagnosis, treatment, and prognosis.View key diagnostic features associated with less common conditions in a visual encyclopedia of unusual patterns at the end of the book.

This book aims to bring together clinical information on the biology, diagnosis, therapy and management of patients with inflammatory breast cancer. Authored by experts from the Instituto Nacional de Cancerologia in Mexico, this book will provide the reader with the state-of-the art treatment of this rare but pernicious disease.

This book provides a detailed update on all aspects of fine-needle aspiration cytology of breast lesions. It will serve readers as an up-to-date reference and atlas on both new entities in breast pathology, including borderline lesions such as flat epithelial atypia, and the classic benign and malignant lesions. Throughout, emphasis is placed on the characteristic diagnostic features as well as the common pitfalls faced by cytologists. As cytologic features can be highly variable, corresponding cytology and histology images are displayed together, enabling readers to gain a good understanding of the morphologic features of various lesions. Core-needle biopsy and fine-needle aspiration cytology are compared in depth, with attention to their relative strengths and weaknesses and indications. In addition, the impact of molecular classification of breast cancers on cytologic diagnosis is explored, and the use of molecular techniques in diagnostic cytology is discussed.

The aim of this atlas is to illustrate the wide range of histological appearances which can be seen in brea. st biopsies and mastectomy specimens. An attempt has been made to include photomicrographs showing the more usual appearances as well as some of the unusual patterns encountered in most common lesions of the breast. In addition some of the rarer forms of mammary pathology have been illustrated, sometimes extensively, where this was considered important in the differential diagnosis and where photomicrographs of good quality were available. Some of the low power photomicro­ graphs lack detail but have been retained as they illustrate Important microanatomical or architectural patterns. The majority of the photomicrographs are of histological preparations stained with haematoxylin and eosin, buta few special stains have been used to illustrate certain specific features. Only occasional photographs of gross specimens have been included. This is notto belittle the importance of gross appearances: indeed micro­ scopic examination of any tissue should always be complemented by careful naked-eye examination. A few mammographic pictures have also been included to illustrate characteristic patterns. There are no photo­ micrographs of cytological preparations as these were considered outside the scope of this book and excellent atlases of mammary cytology already exist. It is hoped thatthisatlaswill prove useful to surgical pathologists and others interested in the histological appearances of the breast. It is not intended as a comprehensive study of breast diseases, and details of clinical presentation and treatment have only been mentioned briefly.

For most areas of medical ultrasound, textbooks that provide physicians with detailed, practical information are readily available. Unfortunately, for the field of ultrasound mammography, such texts are few in number, in comparison to the num­ ber available for other fields of medical ultrasound. This textbook by Drs. Hack­ eHler, Duda, and Lauth fills this gap by presenting a clear overview of the usefulness and limitations of ultrasound mammography. Information based on clinical experiences with various types of automated and real-time instrumentation is presented in a manner that allows physicians to make their own judgments regarding the diagnostic capabilities of ultrasound mammogra­ phy. It also provides specific information on techniques required to obtain useful diagnostic data. Examples of the many possible image variations of specific breast pathologies are presented. The advantages of recent real-time systems, when used with a stand-off, are clearly outlined. The authors do not belabor the philosophical dilemma of which sys­ tem, an automated or a real-time, is best suited for ultrasound mammography. They simply present the information they have gained in their use of both of these systems and indicate that, in the future, a combination of automated and real-time would be the most valuable for the physician.

Breast cancer is the most frequent cancer of women in the western hemisphere. This book presents a new imaging modality of the breast which improves the possibilities of mammography at a very high level: Cancers can be detected at a very early stage y MRM. The huge number ofbreast biopsies can be reduced dramatically. Even tiny breast cancers (e.g.3mm) can be detected. The prognosis for women with breast cancer will improve due to earlier detection.

Breast Cancer, the second volume in the MD Anderson Solid Tumor Oncology series, this book provides the general surgeon, surgical oncologist, and medical oncologist with the state-of-the art multimodality care for breast cancer. Divided into five sections, the text brings the field's recognized esperts addressing the current status of breast imaging, breast pathology, the role of breast surgery including management of in situ and early stage carcinoma, prophylatic mastectomy, axillary node dissection, sentinel node and lymphatic mapping, and outpatient mastectomy, as well as coverage of special selected topics featuring breast cancer in pregnancy, inflammatory breast cancer and breast sarcoma. An important section on future research reviews on-going studies for the use of in situ laser ablation, cryosurgery, and translational research to bring the busy practitioner up-to-date on state-of-the art advances. This book is a must-have resource on the full specturm of current and prospective treatment options for this challenging disease.

Der vorliegende Band „Mamma, Weibliches Genitale, Schwangerschaft und Kindererkrankungen“ enthält eine systematische Darstellung der pathologischen Veränderungen der genannten Organe, Organsysteme und Erkrankungsgruppen. Dabei werden alle Erkrankungen, die sich in den verschiedenen, zum Teil miteinander funktionell verbundenen, zum Teil unabhängig voneinander existierenden Organen beobachten lassen, beschrieben. Die Verfasser der verschiedenen Unterkapitel sind renommierte europäische Pathologen aus den verschiedenen Arbeitskreisen, die sich mit den o. g. Themen diagnostisch und wissenschaftlich intensiv beschäftigen. Dabei wird insbesondere auf die modernen Entwicklungen der verschiedenen Teilbereiche eingegangen und die neuen Veränderungen in Terminologie, Klassifikation und molekularen Analysen detailliert dargestellt. Dieses stets unter dem Blickwinkel der diagnostischen Pathologie. Insgesamt ist das Ziel der vorliegenden Kapitel, Grundlage und Informationsquelle für die tägliche diagnostische Arbeit auf hohem Niveau zu sein.

Inflammatory breast cancer is the most deadly subtype of breast cancer because it can spread to other organs despite of multidisciplinary approach. However, the molecular characteristic of this aggressive disease is yet to be established. This book is the one of the few textbooks that summarizes the latest information dated to inflammatory breast cancer. The uniqueness of this book is that it has summarized the latest molecular and mechanistic findings, which may lead to novel diagnostic tool or therapeutic approach to fight this deadly disease.

Mammography can be thought of as a (sub)macroscopic'shadow pathology'- confident diagnosis necessitates comprehensive knowledge of breast pathology. The traditional rules of thumb, for example that a regular, rounded shadow means a benign lesion, a radiating structure represents a malignant tumor, and microcalcification indicates biopsy, no longer hold true. This volume aims to explain modern breast pathology to physicians practicing mammography. The over 600 individual illustrations and more than 1,000 references help the reader understand breast morphology. The book is rounded off by a detailed description of the clinical symptoms and a helpful summary of the supplementary diagnostic procedures and the possibilities for treatment.

Breast Pathology, edited by Dr. David J. Dabbs - leading expert in breast pathology and author of the best-selling reference Diagnostic Immunohistochemistry - presents an integrated and highly visual approach to breast pathology. This in-depth resource combines international perspectives and expertise on genomic and molecular information, clinical presentation, gross and microscopic pathologic findings, radiologic and laboratory diagnosis, immunohistochemistry, and theranostics so you can accurately diagnose the full spectrum of breast diseases. Stay current on hot topics in breast pathology, including theranostic aspects of diagnosis, genomic applications and molecular diagnosis, proper handling of breast specimens to ensure proper sampling and processing, and up-to-date immunohistochemical information. Get a clear picture of how diseases present from over 1750 high-quality images in full color. Tap into the expertise of leading authorities from around the world who offer an integrated approach, incorporating genomic and molecular information, clinical presentation, gross and microscopic pathologic findings, radiologic and laboratory diagnosis, and immunohistochemistry. Find information quickly and easily with the consistent format that features quick reference points at the beginning of each chapter.

Each volume in the Early Detection and Treatment of Cancer Series is packed with practical, authoritative information designed to cover the full range of diagnostic procedures, including pathologic, radiologic, bronchoscopic, and surgical aspects. You'll be able to determine the safest, shortest, least invasive way to reach an accurate diagnosis; stage the disease; and choose the best initial treatment for early stages. Based on current evidence in the literature, authors provide clinical, hands-on tools to help you make informed decisions on precisely what tests and imaging studies are needed to diagnose and stage each type of cancer. Practical, authoritative, and highly-illustrated, this volume in the brand new Early Detection and Treatment of Cancer series covers current protocols and the latest advances in diagnostic imaging and molecular and serologic markers for breast cancer. Apply expert advice on the best “next-step” plan for different presentations and tips for less invasive protocols. Get clinical, hands-on tools to help you make informed decisions on precisely what tests and imaging studies are needed for accurate diagnosis and staging. Clear figures, tables, and boxes illustrate step-by-step care of the full range of problems encountered. The small size and convenient format make this an ideal purchase for diagnostic reference.Outlines the steps after diagnosis to guide you through formulating a treatment or patient care plan. Emphasizes important points—such as the promising new breast cancer vaccine, sentinel node biopsy, and hormone receptor tests—with “key points” boxes at the beginning of each chapter and pedagogic features throughout. Summarizes the process of accurately diagnosing and staging cancer in a logical, almost algorithmic, approach for easy reference. Discusses the treatment of early-stage disease so you have clear options for care. Complements the procedures outlined in the text with full-color photographs and line drawings to reinforce your understanding of the material.