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It is expected that an estimated one in six white men and one in five Black men would be diagnosed with prostate cancer in their lifetime, with the likelihood increasing with age. The American Cancer Society had estimated that 288,300 new cases of prostate cancer would be diagnosed in 2023. Rare prostate cancers do portend a more aggressive biological behaviour with inferior prognosis. Many of these rare prostate cancers had tended to be mis-diagnosed initially or there has tended to be a delay in the correct diagnosis. The ensuing book would hopefully help in updating the literature on rare neoplasms of the prostate gland to help speed up the correct diagnosis and treatment of these more aggressive tumours and to encourage clinicians to undertake more research to find new treatment options for rare malignant tumours of the prostate gland.

This book encompasses an up-to-date, comprehensive review of the state-of-the-art for prostate gland preserving therapies. It provides insight into the latest research and clinical applications of image-guided diagnosis and minimally invasive focal, gland-preserving treatment for prostate cancer. Fully updated and revised, this text evaluates the scientific evidence for the evolving trend to treat intermediate risk, clinically localized prostate cancer in a focally ablative manner with novel gland-preserving, image-targeted therapy methods. Imaging and Focal Therapy of Early Prostate Cancer, Third Edition opens with a discussion of why patients and clinicians should consider focal therapy, then moves on to consider the question of active surveillance versus focal therapy from a global perspective, with chapters on North American, European, Southeast Asian, and South American perspectives. From there, chapters cover the scientific foundation of focal therapy, current and new approaches to image cancer foci within the prostate (multiparametric ultrasonography, multiparametric magnetic resonance imaging, etc.) and various biopsy techniques. Following this is detailed coverage of patient selection, treatment strategy, adjuvants to enhance therapy, outcomes, and patient centered interests, followed by a discussion of the strengths and limitations of various therapeutic modalities, such as cryotherapy, high intensity focused ultrasound, and photodynamic therapy, follows. The final sections of the book cover the assessment of focal therapy outcomes and look forward to the future of focal therapy for prostate cancer. Written by experts in the field and lavishly illustrated with detailed line-art and photographs, this text is designed as a comprehensive resource for urologists, radiation oncologists, medical oncologists, radiologists, uropathologists, molecular biologists, biomedical engineers, residents, fellows, nurses and allied professionals, and researchers with an interest in the diagnosis and novel targeted treatment of prostate cancer.

The book covers the various cell signaling pathways responsible for prostate cancer progression, conventional therapies used for prostate cancer treatment, new emerging therapeutics, and challenges in the treatment of cancer patients. It describes the different molecular pathways responsible for prostate cancer progression to improve readers'knowledge about the role of signaling networks, and cellular and molecular aspects of prostate cancer progression. These topics include mechanisms responsible for prostate cancer malignancy with a focus on molecular pathways. It also discusses the current challenges in prostate cancer treatment such as drug resistance and immune evasion and introduces novel therapeutics such as gene therapy and nanotherapeutics for prostate cancer. This book is completely novel and unique and covers all aspects of prostate cancer progression and challenges in therapy while presenting solutions. Written by prestigious researchers around the world, this book will be interesting to researchers and practitioners, especially those working in urological cancers.

This book comprehensively covers the techniques available for robot- assisted prostatectomy. Chapters feature detailed descriptions of how to successfully perform a variety of relevant techniques including the reconstruction of continence mechanisms and the use of the transperitoneal RALP anterior approach. Potential complications, preoperative and postoperative management strategies are also discussed, enabling the reader to develop a thorough understanding of how to apply a range of relevant methodologies into their day-to-day clinical practice and avoid commonly encountered pitfalls.Robot-Assisted Radical Prostatectomy: Advanced Surgical Techniques provides a practically applicable resource for all practicing and trainee urologists seeking a detailed overview of the latest advances in robot-assisted surgical procedures and current management strategies applicable to prostatectomy.

The nanotheranostics sector provides a very promising strategy for monitoring drug biodistribution and pathology longitudinal processes by integrating the imaging and drug delivery functions in one single nanoformulation, providing vital insights into the identification of tumour and predicting the efficacy of nanomedicine. For its unique properties, which include their small size and biocompatibility and ability to permeate the cellular membrane with carrying drugs, nanomaterials have been used for various biomedical applications. This book covers the progress made in hormone-related cancer and their management by nonmedicinal therapy for targeting the hormone regulated cancer with their clinical progress and clinical hurdles.

The only book on the market to cover palliative care for both adults and children, Pediatric and Adult Palliative Care and Support Oncology offers an easy-to-read, interdisciplinary approach to supportive oncology as well as end-of-life care. Ideal for oncologists, residents, fellows, nurse practitioners, and physician assistants, the fifth edition provides important updates for conventional topics while also featuring several brand new chapters. Covering everything from dermatologic toxicity of cancer treatment to running family meetings for setting goals of care, this unique title is a source of both help and inspiration to all those who care for patients with cancer.

This updated and expanded edition developed by the Blood and Marrow Stem Cell Transplant team at Oregon Health & Science University Knight Cancer Institute features the latest medical management guidelines and standards of care for hematopoietic stem cell transplant and cellular therapy patients. Spanning the timeline from the initial consultation throughout the transplant process, this handbook begins by providing a general overview of stem cell transplantation and goes on to outline disease-specific indications for stem cell transplantation. It then focuses on transplant complications and ongoing care, and finally explores cellular therapies for hematologic malignancies.Comprehensive and easy-to-use, Blood and Marrow Transplant Handbook: Comprehensive Guide for Patient Care, Third Edition presents a multidisciplinary approach to information for physicians and advanced practice medical providers as well as residents, fellows, and other trainees who care for patients who undergo transplant and immune effector cell therapy.

This book offers a comprehensive guide to the technical basis of laser ablation, describing and reporting in detail on the latest findings. The world of medicine is currently working to reduce the invasiveness of treatment, in order to improve patients'quality of life. Image-guided ablations are rapidly becoming an effective alternative to several surgical treatments. Among the many techniques available for ablation, laser is still not widely used, though its efficacy has been amply demonstrated. The scientific community is now showing a growing interest in laser techniques for image-guided ablations, and many physicians are willing to start using lasers in their clinical practice. The book is divided into 16 chapters, including historical notes, technical aspects, outcomes of ex-vivo experiments, and results of the application of this technique in various clinical scenarios. It will be of great interest to a broad range of physicians (interventional radiologists, surgeons, gastroenterologists, endocrinologists, urologists), from less experienced trainees to expert physicians who want to introduce a novel clinical practice.

This contributed volume emphasizes the potential of stem cells to be pertained in the urology field and attempts to disclose the history of the field up to the latest advances to date. It gathers the majority of papers that advocate utilizing stem cells as the best option for treating, diagnosing, and managing diseases related to urological system. This book covers a broad spectrum of issues, including mesenchymal stem cells, cancer stem cells, organoids, regenerative medicine, erectile dysfunction, bladder dysfunction, and kidney transplant. From several decades ago, as characteristic features of stem cells have been explored, it has attracted a great amount of interests. In view of their multiple capacity of differentiating into various lineages, many studies were conducted to assess their beneficial potential. Despite considerable progress into applying stem cells in animal models, for translating into clinical practices there are several obstacles to be resolved. However, few clinical studies have been performed in each field and outcomes were delightful. There is an ongoing hope for stem cells to someday, be the mainstream treatments of urological diseases, although stem cells treatments already exist they are not well-known. Indeed, this book is essential for anyone who is working with the purpose of employing stem cells to treat the urological diseases and discusses at length the latest advances as well as their limitations.

This book is designed to present a comprehensive and state-of the-art approach to all aspects of geriatric surgery within the broad confines of surgery in geriatrics including general surgery, neurosurgery, thoracic surgery, vascular surgery, cardiac surgery, surgical oncology, hepatobiliary and transplant surgery, plastic, colorectal, orthopedic, gynecologic, and urologic surgery. The text is split into four parts. The first part is organized under general considerations on the geriatric surgical patient and includes current trends in geriatric surgery, and a number of important general issues such as practical approaches to reversal of bleeding/anticoagulation, role of anesthetic concerns in advanced age, frailty index and measurements of physiological reserves, nutritional support in the elderly, quality of life in the elderly, drug use, and family involvement. Part two of the book focuses on surgery specific system-based problems in geriatric surgical patients. The third part addresses many other important aspects of geriatric surgery including palliative and end of life care for the elderly, religious issues and the elderly care surgery, elderly with mental health issues, and nursing care of elderly patients. The fourth and final part describes the need for geriatric surgical care education and the components that are essential for the curriculum of current and future generations of students. Written by experts in the field, Surgical Decision Making in Geriatrics addresses patient selection, pre-operative considerations, technical conduct of the most common operations, and avoiding complications.

This updated volume provides a concise evidence based overview of the field of contemporary urological practice. There are new chapters covering urologic imaging, the upper tract urothelial carcinoma, the treatment of adult male hormonal disorders, the management of urethral stricture disease, and the treatment of renal cancer. The anatomy and physiology of the urinary tract, the basis and principles for development of urologic diseases, and the evaluation and management of urologic diseases are also covered. Urologic Principles and Practice is relevant for practicing urologists, urology trainees, allied health professionals, medical students, and researchers.

This book provides a comprehensive guide for nurses practicing in any area of endocrinology and at any level of expertise. Endocrinology Nursing is a fast-developing specialty with nurses performing advanced roles and expanding their practice to run independent nurse-led services. Supported by the European Society of Endocrinology (ESE) and edited by members of the ESE Nurses Working Group, this is the first book ever published specifically for endocrine nurses. It is also an excellent resource for endocrinology specialty trainees, general practitioners, medical and nursing students, expert patients and nurses working in specialties such as fertility, osteoporosis, oncology, obesity, urology and gynaecology, who look after patients with endocrine-related disorders. This volume includes 13 sections and 69 chapters providing a comprehensive overview of adult and paediatric endocrinology but also a section on advanced practice, role development and nursing research. It has been written by an international team of more than 100 eminent nurses, physicians, surgeons, psychologists and other healthcare professionals, which makes this book a valuable resource for any multidisciplinary team. Many patient advocacy groups have contributed with case studies which emphasises the close working relationships with patients.

This book covers novel strategies and state of the art approaches for automated non-invasive systems for early prostate cancer diagnosis. Prostate cancer is the most frequently diagnosed malignancy after skin cancer and the second leading cause of cancer related male deaths in the USA after lung cancer. However, early detection of prostate cancer increases chances of patients'survival. Generally, The CAD systems analyze the prostate images in three steps: (i) prostate segmentation; (ii) Prostate description or feature extraction; and (iii) classification of the prostate status.Explores all of the latest research and developments in state-of-the art imaging of the prostate from world class experts.Contains a comprehensive overview of 2D/3D Shape Modeling for MRI data.Presents a detailed examination of automated segmentation of the prostate in 3D imaging.Examines Computer-Aided-Diagnosis through automated techniques.There will be extensive references at the end of each chapter to enhance further study.

This volume focuses on our current understanding of the molecular underpinnings of prostate cancer and their potential application for precision medicine approaches. The emergence and applications of new technologies has allowed for a rapid expansion of our understanding of the molecular basis of prostate cancer and has revealed a remarkable genetic heterogeneity that may underlie the clinically variable behavior of the disease. The book consists of five sections which provide insight about the following: (1) General principles; (2) Molecular signatures of primary prostate cancer; (3) Molecular signatures of advanced prostate cancer; (4) Key molecular pathways in prostate cancer development and progression; (5) and Precision medicine approach: Diagnosis, treatment, prognosis. Precision Molecular Pathology of Prostate Cancer is an important resource for the practicing oncologist, urologist, and pathologist, and will also be useful for researchers in the prostate cancer community.

This book presents an update on new trends and developments in broadly defined medical disciplines. The whole range of multidisciplinary topics are tackled, regarded as being important for advancing the understanding of disease pathogenicity, diagnostic methods, and patient management. The topics include a holistic approach to physiotherapy, with proprioceptive neuromuscular facilitation at the core of it, potential ways to protect kidneys during ischemic coronary interventions, and psychosocial aspects in cancer survivors. Other topics deal with growth hormone deficiency in short children and responses of molecular markers of bone metabolism to growth hormone replacement therapy and with the modern use of transcranial laser-induced photobiomodulation showing surprising benefits in autism disorder. The expert contributions take on the challenges presented to medical professionals by ever growing medical knowledge and various individual and contextual issues that require a multidisciplinary approach in patient management. The authors present a bench-to-bed clinical research to make useful additions to the knowledge on contemporary diagnostic procedures, therapy, and quality of life of patients. The book aims to provide stimulus for new research ideas and to give new perspectives on practical clinical issues. The book is intended for primary care clinicians, family physicians, medical scholars, and other clinicians who treat and manage patients.

This book will explore and explain the best diagnostic and treatment strategies for men with a big prostate. Men are living longer and the opportunity to develop significant benign prostatic hyperplasia is increasing. Men with very large prostates can often be extremely challenging to manage and all urologists and healthcare professionals carrying out general urology and managing men with prostate problems will have come across this issue. There are a number of diagnostic, interventional, and surgical management options available, with some of these being more suited to a large prostate than others. The various treatment strategies and their evidence base are discussed. Valuable tips from expert authors who are experienced in the management of the particularly large prostate are included to allow readers to be confident when managing this increasingly important and prevalent group of patients. This book is of particular use to healthcare practitioners who manage men with BPH in the outpatient or emergency setting, as well as those in the operating theatre who want further tips on how to deal with the particularly big prostate.

This book, now in an extensively revised second edition, provides an exhaustive review of the state of the art in the management of prostate cancer, from screening to treatment, with emphasis on a multidisciplinary approach. The editors are very excited about the outstanding new or updated contributions from the different expert authors. The opening chapters address basic aspects including epidemiology, pathology, biology, genetics, and chemoprevention. The role of individual and mass screening is carefully appraised, and extensive attention is devoted to diagnosis and clinical work-up by means of recently implemented investigations such as multiparametric MRI and choline PET-CT. The use of active surveillance is examined in detail. Subsequent chapters discuss the different therapies that may be employed: open and minimally invasive, including robot-assisted, radical prostatectomy, the various forms of radiation treatment, high-intensity focused ultrasound, cryotherapy, hormonal manipulations, chemotherapy, targeted therapies, and immunotherapy. Up-to-date results from practice-changing phase III randomized clinical trials are included and special insights are provided into the interpretation of results and the patient's perspective.

The announcement that we had decoded the human genome in 2000 ushered in a new and unique era in biomedical research and clinical medicine. This Third Edition of Principles of Gender-Specific Medicine focuses, as in the past two editions, on the essentials of sexual dimorphism in human physiology and pathophysiology, but emphasizes the latest information about molecular biology and genomic science in a variety of disciplines. Thus, this edition is a departure from the previous two; the editor solicited individual manuscripts from innovative scientists in a variety of fields rather than the traditional arrangement of sections devoted to the various subspecialties of medicine edited by section chiefs. Wherever it was available, these authors incorporated the latest information about the impact of the genome and the elements that modify its expression on human physiology and illness. All chapters progress translationally from basic science to the clinical applications of gender-specific therapy and suggest the most important topics for future investigation. This book is essential reading for all biomedical investigators and medical educators involved in gender-specific medicine. It will also be useful for primary care practitioners who need information about the importance of sex and gender in the prevention, diagnosis and treatment of illness. Winner of the 2018 PROSE Award in Clinical Medicine from the Association of American Publishers! - 2018 PROSE Awards - Winner, Award for Clinical Medicine: Association of American Publishers - Outlines sex-specific differences in normal human function and explains the impact of age, hormones, and environment on the incidence and outcome of illness - Reflects the latest information about the molecular basis of the sexual dimorphism in human physiology and the experience of disease - Reviews the implications of our ever-improving ability to describe the genetic basis of vulnerability to disease and our capacity to alter the genome itself - Illustrates the importance of new NIH guidelines that urge the inclusion of sex as a variable in research protocols

This book reviews different aspects of the cancer microenvironment, and its regulation and importance for tumor progression. Methodological advancements and practical applications, in terms of how biomarkers are studied and increasingly included in clinical trials and therapy protocols, are described and discussed. Biomarkers of the Tumor Microenvironment is an educational resource for students and members of the cancer research community as a whole, especially for those using morphology analysis techniques and models focusing on the cross-talk between different cell types in tumors. The textbook provides a comprehensive overview of the microenvironment in various contexts from the perspectives of experienced and accomplished cancer researchers and clinicians.

This book provides a concise yet comprehensive summary of the evolving techniques and current status of interventional urology. The book is organized by organ system with subtopics covering imaging technologies, interventional techniques, and clinical outcomes for the vast variety of interventional urologic procedures. It represents the first single text covering these topics and will help guide patient management and stimulate investigative efforts.Written by experts in the field, Interventional Urology provides a richly illustrated, image-guided, state-of-the art review of this new field, that will serve as a valuable resource for clinicians, interventional urologists, interventional radiologists, researchers, and residents with an interest in interventional urology.

Pelvic Cancer Surgery: Modern Breakthroughs and Future Advances brings together the three main pelvic specialties (Urology, Gynecological Oncology and Colorectal Surgery) into one volume. Patients have been shown to benefit from a multidisciplinary approach since it allows surgeons of different specialties to learn from one another therefore enhancing the treatment for the patient. Pelvic cancer outcomes are poor in low volume centres. These centres account for 80% of the global centres dealing with these cancers. Pelvic Cancer Surgery: Modern Breakthroughs and Future Advances is a much needed book that can focus training and assist health professionals in their care of patients with pelvic dysfunction.Pelvic Cancer Surgery: Modern Breakthroughs and Future Advance is complete with full color illustrations and schematic diagrams and makes use of key points and stepwise figures for an enhanced learning experience.

Radical Prostatectomy: Surgical Perspectives provides surgeons with a comprehensive overview of the anatomical approach to radical prostatectomy, whether done through an open (retropubic) or robotic-assisted laparoscopic approach. All chapters are structured to provide a step-by-step approach to the most technically demanding and most common oncologic procedure in urology surgery. The book includes highly practical presentations of typical surgical patients seen in the clinical practice of urology and relies heavily on illustrations and intraoperative photographs to clearly complement the text. In addition, the book includes a detailed description of the management of uncommon but potentially serious intraoperative complications, including major vascular injury, ureteral transaction, and rectotomy.Written by authors from a variety of integrated disciplines, including anesthesia, cardiology, and nursing Radical Prostatectomy: Surgical Perspectives is a unique and valuable resource in the field of urology both for those currently in training and for those already in surgical practices.

Complementary & Alternative Medicine (CAM) for Prostate/Urologic Health is designed to capture and clinically review the comprehensive database of clinical research articles that support and do not support the utilization of a variety of dietary supplements and other complementary medicines that physicians are exposed to in their daily practice. This is a critical distinction between this book and any other CAM Complementary & Alternative Medicine for Prostate and Urologic Health is designed to capture and clinically review the comprehensive database of clinical research articles that support and do not support the utilization of a variety of dietary supplements and other complementary medicines that physicians are exposed to in their daily practice. This is a critical distinction between this book and any other Complementary & Alternative Medicine (CAM) books published to date. Each section of the book provides an easy to reference guide into the topic of interest for the individual that works in urology. The various sub-specialty groups in urology are adequately represented, which allows for a physician to rapidly and thoroughly investigate their topic of interest regardless of whether it is fertility, bladder cancer, or prostate disease. Rather than having to sort through the now thousands of articles published yearly on CAM in medicine, this volume focuses first on the specialty and secondarily how it compares to the overall CAM literature. Each chapter includes a summary page that will allow the physician a rapid review of the subject with a patient, colleague or student.The practical nature of this book in urology also cannot be overstated. Chapters include a general overview of the CAM agent, whether or not it has data in medicine and urology, and a list of potential drug interactions and specific clinical scenarios where it can be utilized or discouraged in the specialty. Complementary &Alternative Medicine for Prostate and Urologic Health represents a gold standard text for use in teaching, not only for the students interested in the urologic field but for all current urologic health providers.

Prostate cancer is not only the most common genitourinary tumor but, accord­ ing to the tumor registry of Munich, the male tumor with the highest inci­ dence. The wide range of information concerning this important disease has been dealt with comprehensively. In a time when interested urologists can surf in the internet to find an article they are looking for, they usually get lost because of the flood of papers covering the same subject. Furthermore, they are still alone in deciding which scientific contribution to believe and which will serve their patients best. A well-edited book such as this, however, provi­ des quick access to all pertinent questions. These renowned authors have taken on the responsibility of writing a balanced report and producing a sort of a guideline, i. e., a diagnostic or therapeutic standard. The editors are to be congratulated on mastering such a formidable task, bringing together the leading names in prostate cancer to present their views on all the questions one might have about this disease. I trust that this book will serve urologists in practice and their patients well. J. E. Altwein Miinchen Contents Pathology and Molecular Biology of Prostate Cancer 1 Morphogenetic Aspects of Prostate Cancer H. Bonkhoff............................................ 3 2 Cytogenetics of Prostate Cancer L. Bubendorf........................................... 13 3 Molecular Dissection of the Prostate Cancer Genome V. Srikantan, S. Srivastava................................ 25 Diagnosis and Clinical Significance of Prostatic 4 Intraepithelial Neoplasia V. Ravery, L. Boccon-Gibod...............................

This book provides an exhaustive review of the current state of the art in the management of prostate cancer, from screening to treatment. A particular feature is the emphasis placed on the value of a multidisciplinary approach. The opening chapters address basic aspects including epidemiology, biology, and chemoprevention. The role of individual and mass screening is carefully appraised, and diagnosis, clinical work-up, and the role of active surveillance are discussed in detail. Subsequent chapters are devoted to each of the therapies that may be employed, including open and robotic laparoscopic radical prostatectomy, the various forms of radiation therapy, high-intensity focused ultrasound, cryotherapy, hormonal therapy, and targeted therapies and vaccination. Up-to-date data from clinical trials are included. The editors are members of the EORTC who have coordinated phase III EORTC trials and have worldwide reputations.

Introduction The prevailing model of medical care for patients with cancer emphasizes the curative efforts of medical technology toward the eradication of the disease. Yet the suffering of the patient as a result of both the disease and our efforts to treat it is often overlooked. If we are to improve the survival of patients with cancer, it will be through intensive research into the molecular under­ pinnings of the disease and clinical trials of new therapies. However, it is essen­ tial to recognize and address the suffering of cancer patients as they are being treated. It is the purpose of this book to illuminate and advance the preven­ tion and treatment of suffering as part of the continuum of care for patients with cancer. Fundamental concepts Since the time of Hippocrates in the fifth century B.c., there have been two overall goals for the physician: • Cure of disease • Relief of suffering From our vantage point in the late twentieth century looking back at previ­ ous centuries, it is easy to observe that, aside from surgery, much of the medical care administered to patients with cancer was aimed at relieving the suffering associated with illness. It wasn't until the concept of disease (as opposed to illness) was elucidated and the scientific method was applied to understand­ ing and eradicating cancer that significant strides were made to improve the physician's ability to cure cancer.

In 1996, the National Bladder Foundation (NBF) was founded by a dedicated group of physicians and researchers propeIled by the urgent need to find better treatments for bladder disease. Committed to increasing bladder disease research and to supporting its research community, the NBF coordinates and sponsors the International Bladder Symposium (IBS) in Washington, DC. Now considered to be a premier scientific assembly, the IBS brings together international leaders in bladder disease research to present and discuss their findings. It is the only international conference where all areas of bladder disease research are exclusively covered and where bladder disease researchers are provided with a unique opportunity to share their results and theories. IBS participants contributed the research papers included in this publication in 2000 and 2001. AIl substantial areas of bladder disease research are addressed, including oncology and ceIlular biology, neurophysiology, neurogenic bladder andincontinence, immunology, inflammation and infection, muscle, matrix and obstruction, and new frontiers and therapies of the bladder. Assembled in one publication, these papers and their findings demonstrate the high scientific caliber of the dedicated researchers in this field and the potential for significant discoveries in treatment options in the next decade.

The only text dealing exclusively with rare or infrequently encountered malignancies in adults and children Now in its Fourth Edition, Textbook of Uncommon Cancer is designed to help clinicians manage the treatment of uncommon cancers, for which, in many instances, there are few established guidelines for care. No longer does each new presentation of an uncommon cancer require extended periods of research. This unique and well-established book provides balanced, authoritative, and now, wherever possible, evidence-based guidance on how to address each malignancy. This Fourth Edition is thoroughly revised with new material as well as a new focus on evidence-based research and clinical practice throughout. Clinicians will find guidelines for dealing with management issues, gain insight into real-world clinical decision-making, and save themselves hours of painstaking research through the use of this widely acclaimed, comprehensive guide. Features of this new edition include: A complete revision and update, with five new chapters and extensive revisions of more than 75 percent of the existing chapters Over 100 new full-color illustrations and images Contributions by multidisciplinary teams of medical oncologists, radiation oncologists, and other specialists, reflecting day-to-day decision-making and clinical practice Textbook of Uncommon Cancer, Fourth Edition is an essential, self-contained guide for practicing oncologists who treat patients with rare or infrequently encountered malignancies. It is also an important resource for hematologists and other specialists who deal with malignancies in a particular organ system.

It is my hope that subsequent volumes of the series will join this volume in assisting in the more complete understanding of the causes, diagnosis, and cell-based treatment of major human diseases and debilitating tissue/organ injuries. There exists a tremendous, urgent demand by the public and the scientific community to address to cancer diagnosis, treatment, cure, and hopefully prevention. Stem Cells are nature's indispensable gift to multicellular organisms, including humans. The contents of the volume are divided into six subheadings: Stem Cell Culture, Bone Marrow Stem Cells, Mesenchymal Stem Cells, Reprogramming and Differentiation of Stem Cells, Treatment, and Transplantation for the convenience of the readers.

Supportive Oncology, by Drs. Davis, Feyer, Ortner, and Zimmermann, is your practical guide to improving your patients‘ quality of life and overall outcomes by integrating palliative care principles into the scope of clinical oncologic practice at all points along their illness trajectories. A multidisciplinary editorial team, representing the dual perspectives of palliative medicine and oncology, offers expert guidance on how to effectively communicate diagnoses and prognoses with cancer patients and their families, set treatment goals, and manage symptoms through pharmacological therapies, as well as non-pharmacological therapies and counselling when appropriate.Integrate complementary palliative principles as early as possible after diagnosis with guidance from a multidisciplinary editorial team whose different perspectives and collaboration provide a well-balanced approach. Effectively communicate diagnoses and prognoses with cancer patients and their families, set treatment goals, and manage symptoms through pharmacological therapies, as well as non-pharmacological therapies and counseling when appropriate. Improve patients'quality of life with the latest information on pain and symptom management including managing side effects of chemotherapy and radiotherapy, rehabilitating and counselling long-term survivors, and managing tumor-related symptoms and other complications in the palliative care setting. Prescribe the most effective medications, manage toxicities, and deal with high symptom burdens.

The average physician and even cancer care-givers are not knowledgeable about the effects of cancer treatment on sex and reproductive life. They are even less aware of the options available for treatment of such patients. Cancer and Sexual Health fills a great need for a reference work devoted to the link between cancer and human sexuality. The volume is designed to give a comprehensive and state-of-the-art review of the sexual and reproductive consequences of cancer diagnosis and treatment. It will prove an invaluable resource for those clinicians caring for cancer patients as well as acting as a reference text for the sexual medicine clinician who may not see a large number of cancer patients.

'Horizons in Cancer Research'presents original research results on the leading edge of cancer research. Each article has been carefully selected in an attempt to present substantial research results across a broad spectrum.

Knowledge about cancer genetics is rapidly expanding, and has implications for all aspects of cancer research and treatment, including molecular causation, diagnosis, prevention, screening, and treatment. Additionally, while cancer genetics has traditionally focused on mutational events that have their primary effect within the cancer cell, recently the focus has widened, with evidence of the importance of epigenetic events and of cellular interactions in cancer development. The role of common genetic variation in determining the range of individual susceptibility within the population is increasingly recognized, and is now being widely addressed using information from the Human Genome Project. These new research directions will highlight determinants of cancer that lie outside the cancer cell, suggest new targets for intervention, and inform the design of strategies for prevention in groups at increased risk. Today, the NCI is putting more and more money into research into the genetics of cancer. The very first of the NCI's stated research priorities is a project called The Cancer Genome Atlas. The Cancer Genome Atlas (TCGA) is a comprehensive and coordinated effort to accelerate the understanding of the molecular basis of cancer through the application of genome analysis technologies, including large-scale genome sequencing. The NCI and the NHGRI (National Human Genome Research Institute, where the series editor is employed) have each committed $50 million over three years to the TCGA Pilot Project. This book proposes cover the latest findings in the genetics of male reproductive cancers; specifically cancers of the prostate and testes. The volume will cover the epidemiology of these cancers; model systems, pathology, molecular genetics, and inherited susceptibility.

Cancer is a common disease with a devastating impact on the physical and psychological well being of patients. The diagnosis of cancer brings upon many clinical challenges and questions for which clear and simple answers are not always provided by modern medicine. To date, only limited therapeutic options are available for patients with advanced cancer. The recent shift toward targeted therapies has improved substantially patient's survival, however, relapses are frequent and cure remains rare. This led patients and many health care managers to shift attention to the holistic approach of traditional medicine particularly preparations from herbal products to manage and alleviate the disease.Typically, herbal preparations contain single or multiple plant ingredients, including a number of potential active components. Yet, they remain classified as food supplements and thus are exempt from regulations on quality control and proof of efficacy that govern standard pharmaceuticals. Clinical evidence for many preparations is often based on non-documented or anecdotal evidence. In consequence, several preparations with unproven efficacy are circulating in the market with the fear of interference with standard cancer therapies and/or severe toxicity that some can generate, in addition to the unjustified economical burden to patients. Despite inconsistent and conflicting clinical results single molecules have been isolated from herbal preparations and many are exploited to develop potential novel agents.This has fostered the need to organize a set of timely, in-depth and up-to-date review covering the latest developments in alternative cancer management from a scientific and clinical perspective dedicated to the medical community and health care providers, as well as to patients and their families. This book brings the latest comprehensive cancer information and practical recommendations on the best documented practice of alternativetherapies for cancer management put together by recognized experts in the fields of medical oncology, traditional medicine, and cancer pharmacology. It goes hand-in-hand with the patient's medical treatment options, quality of life issues, and more. The book is organized into four major sections: The first is an overview of the cancer syndrome by renowned medical oncologists from the USA and Europe. The second is a comprehensive description of traditional medicine by renowned experts from China and Germany. The third is an overview on the pharmacological impact of herb-based formulations on standard chemotherapy agents used in clinical practice. The fourth is a survey of cases reports from several hospitals with approved practice of alternative medicine. The book will feature simple definitions and essential information grouped in both medical and lay-term terminology, and straightforward illustrations related to human physiology, disease definition, scientific data on know and potential mechanisms of action, and preventive approaches.Finally, the book will feature collaboration of experts from China, India, USA, Canada, Germany, France, and other centres with recognized expertise in alternative/traditional medicine. This international cooperation is crucial to cover the complex topic of alternative therapies for cancer.

Rübben: Uroonkologie jetzt in 5. Auflage!Der Standard in der urologischen Onkologie ist jetzt noch besser geworden. Die „Uroonkologie'bietet dem Leser vollständige und umfassende Information zu allen Bereichen des Themas: alle erforderlichen Grundlagen für eine erfolgreiche Therapie (von Molekularbiologie über Studienplanung bis zu alternativen Therapieansätzen), alle Details zur notwendigen Diagnostik, Indikationen, Durchführung und Ergebnis der verschiedenen Therapieansätze aller urologischen Tumorerkrankungen. Und das alles unter Einbeziehung der aktuellsten Studienlage!Sämtliche Kapitel wurden neu verfasst oder zumindest intensiv überarbeitet. Eine praxisnahe, klare Sprache, viele Tabellen und instruktive Abbildungen erleichtern die Wissensaufnahme. Zahlreiche Therapieschemata sorgen für eine schnelle Orientierung Und ermöglichen die direkte Umsetzung in die tägliche Praxis. Anerkannte Experten aus ganz Deutschland stehen für maximale fachliche Kompetenz. Neue Kapitel in der 5. Auflage: Keimzelltumoren, Moderne Bildgebung.Uroonkologie: Das Buch, an dem kein onkologisch tätiger Urologe vorbeikommt!

Over recent years, there has been a dramatic increase in knowledge of the biology of the lymphomas which has been accompanied by the emergence of new treatments that offer both improvements in efficacy and reduction in toxicity. Molecular profiling of tumor tissue and other new advances have led to a better understanding of the genetic basis of lymphoma, identification of new therapeutic targets, and potentially valuable prognostic information. Monoclonal antibody therapies, radioimmunoconjugates and other new agents such as proteosome inhibitors are providing important new treatment options for patients. In this volume, an internationally recognized group of experts provides a comprehensive overview of the biology, pathology, standard treatments, and novel approaches in management of patients across the complex landscape of lymphoma subtypes. Researchers and practitioners alike will welcome this useful summary of the state of the art in this field.

This book provides a comprehensive reference and practical guide on the application of US to penile diseases and conditions. After introductory chapters on technical requirements and penile anatomy, subsequent chapters offer a systematic overview of the diverse applications of color Doppler US. The topics covered include erectile dysfunction, Peyronie's disease, priapism, trauma, tumors, the postoperative penis, inflammation, and fibrosis. Each topic is introduced by a clinical overview with the purpose of clarifying the problems and elucidating what the urologist may expect from color Doppler US. Thereafter, performance of the US study is explained and the pathological anatomy reviewed. High-quality images obtained with high-end US equipment are included. Each chapter also contains a section on the diagnostic information provided by other imaging modalities, and in particular MRI.

Das Standardwerk der urologischen Onkologie endlich in Neuauflage! Die neue'Uroonkologie'ist noch besser geworden und bietet dem Leser alles, was er von einem modernen Lehrbuch erwarten darf. Sie ist vollständig und umfassend: alle erforderlichen Grundlagen für eine erfolgreiche Therapie (von Molekularbiologie über Studienplanung bis zu alternativen Therapieansätzen) sind berücksichtigt; der Schwerpunkt liegt auf einer ausführlichen Beschreibung von Diagnostik und Therapie aller urologischen Tumorerkrankungen. Aktuell: sämtliche Kapitel wurden intensiv überarbeitet bzw. neu verfasst und sind somit auf dem letzten Stand; alle wichtigen Studien wurden berücksichtigt. Praxisnah: eine klare Sprache, viele Tabellen und instruktive Abbildungen erleichtern die Wissensaufnahme; zahlreiche Therapieschemata sorgen für eine schnelle Orientierung und ermöglichen die direkte Umsetzung in die tägliche Praxis. Zuverlässig: anerkannte Experten aus ganz Deutschland stehen für maximale fachliche Kompetenz. Neu in der 4. Auflage: Rehabilitation bei Tumorpatienten; Notfälle in der Uroonkologie; Grundlagen der Palliativmedizin; Uroonkologie beim älteren Patienten.

Endoscopic/ laparoscopic extraperitoneal radical prostatectomy (EERPE) has become established as a therapeutic option for localized prostate cancer. This book is an atlas, not a conventional textbook. Its main goal is to guide the urologist step by step through EERPE, aiming to make this highly standardized technique reproducible. Every stage of the procedure is presented with numerous endoscopic images and diagrams so that the reader can fully comprehend the different surgical steps. Complications and their management are described in detail. Special chapters are devoted to the anatomy of the prostate, anesthesiological considerations, and postoperative management and training.

Fondamenti di Oncologia Clinica si propone di fornire le conoscenze essenziali (i fondamenti) sull'oncologia con un focus sulla clinica e quindi sui problemi di comune gestione del malato oncologico. Il testo è rivolto sia a coloro che vogliono avvicinarsi all'oncologia - dai medici di famiglia che vogliono poter seguire con un minimo di cognizione di causa i loro pazienti con tumore, ai neolaureati in medicina che si avvicinano all'oncologia - sia agli specialisti che già operano in campo oncologico.Nella parte introduttiva sono trattati gli aspetti generali dell'argomento, quali epidemiologia, linguaggio della biologia molecolare, anatomia patologica, diagnostica per immagini, trial clinici e immunologia dei tumori. Vengono poi prese in esame le conoscenze essenziali, quali emato-oncologia, oncologia medica, oncologia chirurgica e radioterapia oncologica. I capitoli di approfondimento sulle singole neoplasie sono riuniti in una sezione dedicata alla patologia neoplastica d'organo. Il volume si chiude con una miscellanea su cure palliative, psico-oncologia, il nursing oncologico, counselling genetico e consenso informato. Il testo si presenta completo, generato dalla conoscenza teorica ma soprattutto dall'esperienza, redatto in un linguaggio chiaro ma non superficiale, intenzionato ad “andare al sodo”.

Written by over 250 of the world's leading urologists and uro-oncologists from the USA, Canada, UK, Austria, Belgium, Finland, France, Germany, Ireland, Italy, the Netherlands and Singapore, who tackle prostate cancer on a daily basis, this comprehensive and fully up-to-date illustrated text reference covers the etiology, pathophysiology, diagnosis

An important translational book bridging the gap between science and clinical medicine, Prostate Cancer reviews the biological processes that can be implicated in the disease, reviews current treatments, highlighting the pitfalls where relevant and examines the scientific developments that might result in novel treatments in the future.Key Features• Provides a translational resource for scientists and clinicians working on prostate cancer• Reviews current surgical interventions and highlights their related pitfalls• Presents the latest laparoscopic techniques with figures and illustrations of step-by-step procedures• Offers insight into the potential for novel approaches to treatment in the future• Includes personal perspectives from patients

This is the seventh monograph in the series Progress and Controversies in Oncologic Urology (PACIOU). Containing contributions from experts from around the globe, this book provides the most up-to-date information available on the mechanisms and treatment of prostate cancer and male sexual dysfunction. Highlighting the relationship between research