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Este libro es una introducción al aprendizaje relacionado con las neoplasias que se presentan en la mujer en sus diferentes etapas de la vida que servirá, a todos los profesionales en cuidados primarios de salud de la mujer; como revisión actualizada, didáctico o como material de referencia ayudará a los conocimientos especializados necesarios para la detección y manejo de los diferentes procesos oncológicos en las mujeres. La lectura de esta obra instruye dentro de los conocimientos científicos del cáncer de la mujer, muchos de ellos ocultos en la vida cotidiana, pero aquí, en calidad de consulta, lleva de la mano a resolver mucho de lo que se hemos perdido y a consultar e instruir en lo que no sabemos. Este tratado, dividido en 16 secciones, incluye temas actualizados relacionados con la oncología de la mujer, una bibliografía actualizada nacional e internacional, en medio de una basta información que esta al día; el manejo oncológico se describe en varias áreas, para lograr una mejor calidad de vida, la cirugía conservadora de cáncer y profiláctica se indican para diferentes canceres, así como la descripción e indicaciones en cirugía vaginal, laparoscópica, oncoplástica; además exenterativa y de reconstrucción todas estas áreas se analizan en este libro, así como la técnica de ganglio centinela; los autores han contribuido en gran medida al desarrollo nacional e internacional para el establecimiento de las normas actuales del tratamiento de los cánceres.

This book provides a practical overview of a central topic in cervical cancer concerning human papillomavirus (HPV), prevention, cervical cancer screening, diagnosis, and treatment. Since the finding of human papillomavirus (HPV) being the cause of cervical cancer and its precursor symptoms, effective screening based on HPV DNA testing and prevention methods by HPV vaccination are established. Furthermore, new surgical methods, radiation therapy, and drug therapy are developed. To summarize the history and the recent advancement, this book is presented in five attractive parts: pathogenesis and epidemiology, cancer screening and prevention strategies, diagnosis and clinical management of cervical intraepithelial neoplasia (CIN), surgical treatments, and multimodal therapy. Recent Topics on Prevention, Diagnosis, and Clinical Management of Cervical Cancer is an appealing source for gynecologists, gynecologic surgeons, gynecologic pathologists, and gynecologic, clinical, and radiation oncologists. Also, primary care doctors, public health nurses, nurses, and pharmacists involved in cancer and other medical personnel will find the information and challenges presented tempting.

This book is a case-based resource detailing the latest diagnostic and management strategies applicable to a number of carefully selected situations in clinical gynecological oncology. It emphasizes the importance of a holistic approach to tackling difficult and unique clinical presentations. Each chapter presents a specific pathology and features descriptions of clinical scenarios and presentations that are both commonly and rarely encountered. Techniques and strategies for ovarian, cervical and endometrial cancer are discussed in accordance with the latest evidence-based knowledge on the topic. Relevant'tips and tricks'are identified in each chapter to assist the reader in developing a thorough understanding of the topics discussed and enhance their decision making skills.Case-Based Gynecological Oncology is a practical guide to clinical presentations of a range of conditions encountered in the field, making it a valuable resource for all clinicians who encounter these patients in their day-to-day practice.

HOLLAND-FREI CANCER MEDICINE The latest edition of the gold-standard in cancer science and clinical oncology references In the newly revised Tenth Edition of Holland-Frei Cancer Medicine, a team of distinguished researchers and practitioners delivers a comprehensive and up-to-date discussion of cancer science and clinical oncology practice. The book contains timely and indispensable information on epidemiology, etiology, cancer biology, immunology, prevention, screening, clinical presentation, pathology, imaging, and therapy. Grounded in a fundamental understanding of cancer biology, Holland-Frei Cancer Medicine combines scientific principles with clinical practice. It contains hundreds of full-color illustrations and photographs, tables, graphs, and algorithms that complement and enhance the complex topics discussed within the book. This book is an invaluable clinical tool that provides readers with overview boxes, additional references, and other pedagogic features designed to make the content easy to access and comprehend. Readers will also find: A translational and integrated approach throughout the book that combines cancer biology with cancer management A strong emphasis on multidisciplinary, research-driven patient care that improves outcomes and allows for the optimal use of all clinically appropriate therapies Discussions of the most current personalized cancer care, including molecular diagnostics and therapeutics Perfect for medical oncologists, radiation oncologists, and internists, Holland-Frei Cancer Medicine, Tenth Edition will also earn a place in the libraries of allied health professionals involved in the treatment of cancer patients. This book is published in collaboration with the American Association for Cancer Research: https://www.aacr.org/

For more than 40 years, DiSaia and Creasman Clinical Gynecologic Oncology has been the leading reference for diagnosis and treatment of gynecologic cancers, providing physicians and trainees alike with expert guidance on clinical presentations and management. The fully revised 10th Edition remains the most readable, most comprehensive text in the field. Under outstanding editorial leadership from Dr. William Creasman and featuring a'who's who list of expert contributing authors, this authoritative reference is a must-have resource for improving outcomes and providing effective patient care. - Emphasizes practical clinical presentations and management of commonly seen problems, making this text an excellent resource for daily decision making. - Provides in-depth explanations of major topics supplemented with up-to-date references. - Features a new chapter on Immunotherapy in Gynecologic Malignancies, updated information on invasive cervical cancer, and significantly revised content on vulvar cancer, with new guidance on micro-staging for sentinels. - Covers key topics such as precision medicine and new biomarker-driven targeted therapies, cancer staging, targeted therapy, and immunotherapy. - Includes quick-reference features such as key point boxes with bulleted lists, highlighted key text, enhanced chapter outlines, clinical algorithms that review recommended treatment and management options, and additional references online. - Contains useful appendices covering staging, screening, nutritional therapy, toxicity criteria, blood component therapy, and radiation therapy. - An ideal comprehensive resource for clinical practice, personal study, and exam review. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Offering a one-stop guide to recognition and therapeutic decision making, Diagnosis and Treatment of Rare Gynecologic Cancers fills a gap in the medical literature on uncommon ovarian, uterine, cervical, and vulvovaginal cancers and trophoblastic diseases. This authoritative text, edited by Drs. Michael Frumovitz, Mario Leitao, and Preetha Ramalingam, has been authored by internationally recognized experts from top institutions such as MD Anderson Cancer Center and Memorial Sloan Kettering Cancer Center. Each chapter covers different cancer subtypes and has been reviewed by an oncologist and a pathologist. - Provides up-to-date clinical guidance on assessment and therapeutic options for patients with rare gynecologic malignancies. - Presents information in a templated, easy-to-read format. Each chapter includes an introductory clinical case followed by epidemiology of disease, pathologic assessment, basic science/molecular/translational research, work-up of newly diagnosed disease, staging, treatment of newly diagnosed disease, treatment of recurrent disease, potential therapeutic targets, and a case resolution. - Includes diagnostic and treatment algorithms for each form of cancer. - Contains numerous anatomical figures, radiographs, photographs, and tables for quick visual reference.

The standard-setting text in oncology for 40 years, DeVita, Hellman and Rosenberg's Cancer: Principles and Practice of Oncology, 12th Edition, provides authoritative guidance and strategies for managing every type of cancer by stage and presentation. Drs. Vincent T. DeVita, Jr., Theodore S. Lawrence, and Steven A. Rosenberg oversee an outstanding team of expert contributing authors who keep you up to date and fully informed in this fast-changing field. This award-winning reference is also continually updated on Health Library and VitalSource platforms for the life of the edition.

This book is a complete representation of all the gynecological cancers covering from the anatomical details of the individual gynecological organs along with the epidemiological pathophysiological aspects of the various gynecological cancers. It also covers the diagnostic workup of various gynecological cancers with recent evidence based treatment protocols. All the major gynecological oncological surgeries are described in a simple way along with photographs for easy understanding in all the chapters. In addition, numerous flowcharts and management algorithms are included in every chapters, as a ready reference for the benefits of the trainees and practitioners. This book includes chapters such as critical care in oncology, oncology nursing, benign and malignant breast disease, hormones and gynecological cancer, cancer infections and vaccines, palliative care which are not often found in many text books. Apart from these, this book has also included chapters like principlesand practice of Radiation oncology, surgical oncology and medical oncology, recent advances and imaging in gynecological malignancy to make it a complete package. Thus, it will serve as an excellent reference book for surgical oncologists, general gynecologists, medical and radiation oncologists fellows and trainees.

Single best answers to 500+ questions covering all of the key exam topics Perfect preparation and practice for the medical oncology SCE and a valuable tool for the FRCR (Oncology) and ESMO exams Produced in partnership with the Association of Cancer Physicians (ACP) Written by senior trainees and consultants and verified by experienced medical oncology consultants in the style of the specialty certificate exam, this collection of 500 single best answers offers an ideal preparation for success. The aim of 500 SBAs for the Medical Oncology Specialty Certificate Exam is to provide an important evidence-based resource for trainees and non-trainees in preparation for the SCE in Medical Oncology. The practice questions enable learners to assess their own knowledge and identify gaps for further learning. Single-best answer (SBA) questions are accompanied with a description of the answer that highlights important trial data, NICE/other national guidelines and resources. The question number and layout closely mirrors that of the SCE blueprint. Topics covered follow the blueprint of the exam closely, and include: Scientific basis of malignancy, Systemic anti-cancer therapy, Acute oncology, Supportive therapies and palliative care, Breast cancer, Upper GI cancer, Colorectal and anal cancer, Lung and thoracic cancer, Gynaecological cancers, Urological and germ cell cancers, Haematological cancers, Skin cancer, Sarcoma. Less common cancers (Head and neck, CNS cancers, Endocrine), Carcinoma of unknown primary, Professional skills and ethics. Make this book the last thing you use before you take the exam.

Bösartige Tumoren der Geschlechtsorgane machen etwa 15 Prozent der malignen Erkrankungen bei Frauen aus. Wer Patientinnen mit jenen betreuen möchte, muss in der gynäkologischen Onkologie bewandert sein. In diesem Kompendium beschreiben erfahrene Kliniker die entsprechenden Krankheiten und geben einen Überblick über die derzeitigen Standards in Diagnostik und Therapie – unter Berücksichtigung der Leitlinien sowie der wissenschaftlichen Literatur.

Comprehensive, authoritative, and up to date, Oncologic Imaging: A Multidisciplinary Approach, 2nd Edition, covers every aspect of radiographic imaging for the diagnosis, treatment, and management of the cancer patient. Dr. Paul M. Silverman and an expert author team from MD Anderson Cancer Center provide all the current, practical information available, while incorporating their unique experience based upon extensive, daily clinical care of patients with cancer. In one convenient volume, this definitive, one-of-a-kind text discusses new diagnostic imaging and surgical approaches as well as therapeutic cutting-edge treatments from radiation and medical oncology, focusing on best practices and the newest standards for personalized medicine. - Brings together a unique multidisciplinary team of authors including clinical radiologists, medical oncologists, radiation oncologists, and surgical oncologists who reflect team-based practice. - Features an all-new chapter on head and neck imaging, authored by world experts in this complex area. - Contains extensive updates throughout, including transformational state-of-the-art imaging modalities such as PET/CT, and the full range of traditional modalities, including multidetector CT (MDCT), ultrasound, and MR in conjunction with the latest advances in genetics, molecular oncology, and targeted therapies. - Distills practical, up-to-date information into a concise and consistent format with key point summaries, algorithms, clear drawings, and full-color staging diagrams. - Includes emerging options for care based on practice recommendations and evidence in the literature. - Provides updated tumor staging information based on the AJCC Classification of Malignant Tumors, 8th edition. - Highlights the text with 1,000 high-quality radiographic images: CT, MR, hybrid imaging (PET/CT, PET/MR), mammography, and ultrasound, as well as clear line anatomic drawings, graphs, and algorithms.

Treatment of Cancer is a multi-author work and comprehensive guide on modern cancer treatment that aims to give clinician and student alike the framework for an integrated approach to patient care, including radiotherapy, chemotherapy, and surgery. Much information is presented in tables and charts for easy assimilation, and clear algorithms for patient pathways are included to make decisions straightforward while allowing for sound clinical judgement.

Evidence-based, superbly illustrated, and easy to read, Berek & Hacker's Gynecologic Oncology, Seventh Edition, remains your reference of choice for authoritative information on every aspect of gynecologic malignancies. Templated chapters provide quick access to guidance on everything from general principles through diagnosis and medical and surgical management. This fully revised edition offers the practical, state-of-the-art coverage you need when caring for women with preinvasive disease; ovarian, breast, uterine, cervical, vulvar, and vaginal cancers; and gestational trophoblastic disease.

Sarcomas: Evidence-Based Diagnosisand Management is the most comprehensive clinical reference on sarcomas available to oncologists and trainees. Presenting a compilation of the current knowledge of specific soft tissue and bone sarcomas, this accessible resource on diagnosis and management is the most practical in the market. Led by the world's foremost sarcomas experts in medical oncology, surgical oncology, radiation oncology, gynecologic oncology, orthopedic surgery, radiology, and pathology, the book addresses the general principles of each major medical discipline, provides details on each major sarcoma subtype, and presents the evidence for standard frontline, adjuvant, and novel treatment approaches such as immunotherapy, cellular therapies, and more.The book begins with general principles of diagnosis and management for each discipline in the field, covering specialties from medical oncology to radiology. Following the chapters on general principles, are chapters characterizing the most prevalent subtypes of sarcoma including their estimated incidence, common presenting symptoms, diagnostic approach, radiographic features and essential imaging, key diagnostic features, molecular characteristics, approaches to treatment, recommended follow up, the metastatic potential as well as evidence-based therapeutic approaches. Each chapter ends with a summary of caveats, clinical pearls, pitfalls, and solutions as well as a case study from the clinician's point of view. The book ends with chapters focusing on new approaches to treatment and the development of therapeutics to combat sarcoma using immunotherapy, cellular therapy, and interventional radiology. Numerous tables and disease-based images support the text and provide key information for quick reference. Presenting detailed evidence and authoritative clinical guidance throughout, Sarcomas is a “one-stop” guide for any clinician diagnosing, treating, or managing patients suffering from these heterogenous diseases.Key Features:Provides the standards of care and evidence base for treatment of each major sarcoma subtypeCovers all new treatment paradigms and FDA approvalsIncludes numerous quick reference tables and high-quality color imagesPresents over 20 practical case studies from leading clinicians in the field

This book covers some well-known and some unexplored pathological aspects of management of peritoneal metastases and should be read by both surgeons and pathologists involved in the management of peritoneal surface malignancies. The evaluation of cytoreductive surgery specimens is explored for the prognostic information it can provide and recommendations for evaluation of such specimens are provided. The pathways and patterns of peritoneal dissemination and their clinical implications on the extent of surgery performed and other aspects of management are discussed for some common peritoneal tumours. The exploratory studies presented here provide a new perspective on the surgical resection of peritoneal metastases. Other important aspects of pathological evaluation like pathological response to chemotherapy, diagnosis and classification of rare peritoneal tumors have also been covered in different chapters. Keeping in sync with the progress in molecular oncology, the role ofmolecular oncology in the current and future management of peritoneal metastases is addressed for different tumors.

This practical book focuses on the most recent advances in fertility preservation in oncological and non-oncological patients. It presents the steps that need to be followed prior to treatment for successful fertility preservation, and describes in detail the medical conditions requiring fertility preservation, including precise information on the risk of fertility loss, prognosis, risk of ovarian metastasis and other possible risks. The book also provides information on how to perform the preservation techniques (success rates, risks, etc.) and on what to do after the treatment (in cases of bleeding during chemotherapy, menopause, wish to conceive, etc.). Written by experts in the field, including members of the globally known network FertiPROTEKT and leading oncologists and specialists, this practical and easy-to-use book is a valuable resource for all clinicians involved in fertility preservation for patients with specific diseases

Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. Now updated online for the life of the edition, DeVita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology, 11th Edition keeps you up to date in this fast-changing field. Every quarter, your eBook will be updated with late-breaking developments in oncology, including new drugs, clinical trials, and more.

This book discusses in detail the recent advances in the management of endometrial cancer, including the latest therapies and diagnostic methods. The book focuses on treatment-oriented topics such as the role of lymphadenectomy and sentinel node dissection, surgical complications, radiation techniques, and chemotherapy in endometrial cancer, and also explores treatment options in advanced disease stages, including hormonal therapy and targeted therapy. Providing insights into the evidence-based management guidelines for endometrial cancer, this book is a valuable resource for students, trainees and practitioners in the field of gynecology and gyne-oncology.

This volume provides a comprehensive and up-to-date account of the use of MRI and CT to identify and characterize developmental anomalies and acquired diseases of the female genital tract. Both benign and malignant diseases are considered in depth, and detailed attention is also paid to normal anatomic findings and variants. Further individual chapters focus on the patient with pelvic pain and the use of MRI for pelvimetry during pregnancy and the evaluation of fertility. Compared with the first edition, chapters have been either newly written by different authors or updated to reflect intervening progress; in addition, imaging of the placenta is now covered. Throughout, emphasis is placed on the most recent diagnostic and technical advances, and the text is complemented by many detailed and informative illustrations. All of the authors are acknowledged experts in diagnostic imaging of the female pelvis, and the volume will prove an invaluable aid to everyone with an interest in this field.

Latin America represents about 10% of the global population distributed in 33 countries. There is huge social and economic heterogeneity even within and beyond the same country, particularly Brazil being the largest country, where Portuguese is the official language rather than Spanish. Furthermore, several ranking systems have considered Brazil a unique country within the 10 world highest economies. In view of the diversity in Latin America with different possibilities and realities, we have found it essential to develop a textbook with focus on the Management of Cancer in Latin America, describing our daily reality, problems to overcome and our huge possibilities. In this volume, we discuss various cancers from nasopharyngeal to renal cancer. We hope that this book will serve as a valuable resource of information for health care professionals, practitioners and policy makers.

The 3rd edition of this text entails a comprehensive review of endometrial pathophysiology, including the recognition of physiologic conditions (i.e. normal phases and pregnancy), as well as the accurate interpretation of pathologic entities (i.e. polyps, endometritis, gestational trophoblastic diseases, endometrial hyperplasia, carcinoma, etc). The book will maintain a compact size with numerous illustrations and tables. Although, in its essence, the table of contents remains unaltered from the previous edition, we intend to incorporate significant updates related to the expansion of our knowledge of old and newer entities, use of immunohistochemical and molecular ancillary techniques to assist in the correct diagnosis, as well as two new chapters - one with recommendations/suggestions of appropriate terminology for a pathology report (sign out templates) and another one focusing on specific pitfalls/mimickers/confounding factors in the diagnosis of endometrial samples (surface metaplasias, cytoplasmic changes, endocervical contaminants). The complicated subject of hyperplasia and cancer precursors will include expanded commentary on the application of endometrial intraepithelial neoplasia (EIN) and how it relates to the traditional classification of endometrial hyperplasia. Additionally, a substantial number of new, all color images, some of which will be available in electronic format, will aid readers to fully understand and confidently classify such complex specimens. This text will continue to serve as a useful resource not only for pathologists in training and practicing pathologists, but also to experienced physicians, other health care providers and researchers dealing with, and interested in endometrial pathology. At the end of each chapter, a comprehensive summary - tables with key diagnostic bullets - will provide an additional tool for the readers interested in a quick review of the chapter's information. This text will remain concise yet a comprehensive reference that will help pathologists use the most updated terminology, recognize potential pitfalls in the diagnosis of endometrial biopsies/curettages, as well as apply the most current tools in immunohistochemistry and molecular ancillary techniques available in the field at the moment.From the reviews of the second edition:'...extremely useful for the practicing pathologist because it outlines criteria for diagnosis, helps in solving diagnostic dilemmas, and clarifies controversial issues.'Modern Pathology

Sarcoma Oncology: A Multidisciplinary Approach is a comprehensive textbook that addresses the entire spectrum of the subject from epidemiology to laboratory research in the biology of sarcomas. Chapters contributed by an international group of highly regarded specialists cover the epidemiology and pathology of sarcomas; diagnostic imaging and biopsy techniques; staging and prognosis: surgery of sarcomas in extremity soft tissue, abdominal wall and trunk, and skeletal bone; hyperthermia in sarcoma treatment; isolated limb perfusion; surgery for metastases; reconstructive surgery; radiation therapy; systemic chemotherapy; multidisciplinary care; treatment-induced sarcoma; pain management in sarcoma; and basic research including molecular biology and mouse models.

Endometrial cancer is the most common gynecological cancer and the sixth cause of cancer in developed countries. The findings that EC is a heterogeneous group of tumors with distinct risk factors and histopathological features, together with our improved understanding of its molecular mechanism has paved the way to the investigation of new surgical and medical therapies. The aim of this book is to give a complete overview on risk factors, pre-operative methods and management of endometrial cancer. The authors hope that this book will be a useful tool for any health provider involved in gynecological cancer care.

This updated edition provides clinicians from various backgrounds and levels of training the information needed to optimally diagnose and manage neurologic complications of the nervous system. Organized into seven sections, this comprehensive volume begins with an overview of diagnostic studies for neurologic complications involving the nervous system. That is followed by sections on metastatic and non-metastatic complications of cancer involving the nervous system, and the interpretation, diagnosis, and management of common neuro-oncologic symptoms. The next section reviews the neurologic complications of cancer therapy, including corticosteroids, radiation therapy, chemotherapy, targeted molecular therapies, immunotherapies, hematopoietic stem cell transplantation, and infections involving the nervous system. The final section focuses on the most important neurologic complications in cancers arising from specific organs. In addition to capturing the latest advancements in the rapidly evolving fields of oncology and cancer neurology, the goal of this resource is to lead clinicians toward prompt diagnosis and intervention in order to improve patient quality of life.'This textbook is a valuable resource for medical oncologists and radiation oncologists, as well as neurologists and neuro-oncologists dealing with these patients. … Overall, the chapters are well organized, clearly written, fairly balanced, and reasonably up to date. … I would recommend it as a learning tool to physicians in training (medical students, residents, and fellows) and for more experienced physicians as both a review/ update and a way to gain more in-depth knowledge and insight into the neurologic problems of cancer patients.'(John C. Flickinger, International Journal of Radiation Oncology Biology Physics, Vol. 73 (2), 2009)'The general organization of the book is logical and facilitates its practical and everyday use. … Overall this textbook is very comprehensive and encompasses main neuro-oncological challenges. … Schiff, Kesari and Wen have edited a very elegant and highly practical textbook, written by recognized authorities in their respective fields, which will be used by a wide range of medical and surgical specialists who are confronted on a daily basis with neurological manifestations of cancer in their practice.'(I. Radovanovic and G. Zadeh, British Journal of Cancer, Vol. 100 (6), 2009)

There are more than 63,000 new cases of uterine and endometrial cancer each year in the United States, up from approximately 41,000 when the first edition of Uterine Cancer was published in 2009. A book focusing on these cancers was timely, with emergent sophistication in diagnosis increasingly impacting clinical decision-making. However, five years later, the need for an updated book on this topic is even stronger as oncologists recognize opportunities to impact the outcome on women that are increasingly diagnosed with these malignancies. Uterine Cancer: Screening, Diagnosis, and Treatment, Second Edition, ​part of the Current Clinical Oncology series, enhances the awareness on this somewhat neglected area of therapeutics, helping to integrate targeted therapies into the management of women with uterine cancer. Written by experts in the field in a highly practical and comprehensive manner, it is a must-have for all gynecological residents and fellows, as well as gynecological oncologists, medical oncologists, radiation oncologists, and family practice doctors who wish to provide their patients with the best possible care.

This revised and updated second edition contains multiple microscopic illustrations of all diagnostic entities and ancillary techniques, providing a comprehensive, authoritative guide to all aspects of serous effusions. It now includes the many new antibodies which have been tested since the previous edition, as well as a discussion on next-generation sequencing and molecularly targeted therapy.Section one covers diagnosis for benign and malignant effusions while section two discusses biology, therapy, and prognosis highlighting clinical approaches that may be of value.Serous Effusions provides an indispensable guide to all aspects of current practice for cytopathologists, cytotechnicians, pathologists, clinicians and researchers in training and practice.

This is the second edition of a well-received book that reflects the state of the art in cancer medical therapies and their side-effects, including immunotherapy and chemotherapeutic drugs. All chapters have been fully updated to include all the latest progress in drug discovery such as targeted therapies for each cancer type. From issues such as preservation of fertility to antiemetic therapy the book provides a very comprehensive overview of the field. The book includes a new chapter on immuno-oncology drugs. Organised by organ system, it lists the toxicity, side-effects and measures of prevention pertaining to each type of drug used in cancer therapy. The most dangerous side-effects are priority so as to alert the reader to their importance.Designed for quick reference in the clinical setting this book is primarily aimed at established medical oncologists but will also appeal to junior doctors, trainees, pharmacistsand nurses.

Developed by the American Cancer Society this new textbook designed for a wide range of learners and practitioners comprehensively addresses all aspects of clinical management for cancer taking a balanced, authoritative and, -where possible- evidence-based stance and may be used in conjunction with the book, The American Cancer Society's Principles of Oncology: Prevention to Survivorship. Edited by leading clinicians in the field and a stellar contributor list from the US and Europe, this book is written in an easy to understand style by multidisciplinary teams of medical oncologists, radiation oncologists and other specialists, reflecting day-to-day decision-making and clinical practice. Input from pathologists, surgeons, radiologists, and other specialists is included wherever relevant and comprehensive treatment guidelines are provided by expert contributors where there is no standard recognized treatment. This book is an ideal resource for anyone seeking a practical understanding of the field of oncology.

Dieses kompakte und praxisrelevante Standardwerk richtet sich alle Ärzte in Klinik und Praxis, die Patientinnen mit bösartigen Tumoren des Genitales und der Mamma behandeln. Die 5. Auflage wurde komplett aktualisiert und auf der Basis internationaler Leitlinien und Empfehlungen auf den neuesten Wissensstand gebracht. Sie finden einfach umsetzbare Handlungsanweisungen zum diagnostischen und therapeutischen Vorgehen und profitieren in bewährter Weise von der Expertise und dem reichen klinischen Erfahrungsschatz der Herausgeber und Autoren.

The widespread acceptance among the oncology community at large of cytoreductive surgery and HIPEC as a potentially curative treatment for peritoneal metastases has paved the way for innovative new therapies that could benefit a larger proportion of patients. Much has been and continues to be published on this subject.This book provides comprehensive reviews on the various aspects of managing peritoneal metastases. The authors highlight essential practical issues that surgical oncologists encounter in their day-to-day practice, and try to before provide evidence based answers to address them. All chapters were written and/or reviewed by leading experts in this field.

The latest edition of An Atlas of Gynecologic Oncology continues its coverage of the innovative techniques in investigation and surgery on the brink of becoming established as part of the gynecologic surgeon's repertoire, now including the exciting developments in uterine transplantation.

Essentials of Clinical Radiation Oncology is a comprehensive, user-friendly clinical review that summarizes up-to-date cancer care in an easy-to-read format. Each chapter is structured for straightforward navigability and information retention beginning with a “quick-hit” summary that contains an overview of each disease, its natural history, and general treatment options. Following each'quick-hit'are high-yield summaries covering epidemiology, risk factors, anatomy, pathology, genetics, screening, clinical presentation, workup, prognostic factors, staging, treatment paradigms, and medical management for each malignancy. Each treatment paradigm section describes the current standard of care for radiation therapy including indications, dose constraints, and side effects. Chapters conclude with an evidence-based question and answer section which summarizes practice-changing data to answer key information associated with radiation treatment outcomes. Flow diagrams and tables consolidate information throughout the book that all radiation oncologists and related practitioners will find extremely useful when approaching treatment planning and clinical care. Essentials of Clinical Radiation Oncology has been designed to replicate a'house manual'created and used by residents in training and is a'one-stop'resource for practicing radiation oncologists, related practitioners, and radiation oncology residents entering the field. Key Features: Offers digestible information as a learning guide for general practice Examines essential clinical questions which are answered with evidence-based data from important clinical studies Places clinical trials and data into historical context and points out relevance in current practice Provides quick reference tables on treatment options and patient selection, workup, and prognostic factors by disease site

This book initiates the descriptions of the practical performance of different hysterectomies with conventional and robotically assisted laparoscopy, laparotomy and vaginal surgery. Laparoscopic hysterectomy has been out as an additional technique for hysterectomies for the last couple of decades. As the necessary light, augmentation and advanced skill has only been introduced into this already 200 year old surgical procedure within the last few decades by laparoscopy, the editors aim to look at the laparoscopic procedures followed by the traditional techniques of hysterectomy with laparotomy and vaginal surgery.

This text provides a comprehensive review for practicing pathologists to understand the molecular biology, diagnostics, and predictive markers and implications for therapy of uterine cancer. While molecular based therapeutic strategies for uterine cancer are not as well developed as for some other organ sites, these are the most common gynecologic malignancies and there have been many important recent developments that are discussed in this volume. Comprehensive chapters address essential information about endometrial carcinoma, uterine mesenchymal tumors, and cervical carcinoma and include the pathogenesis of carcinoma and discuss molecular based classification, biomarkers, therapy, prevention, and hereditary cancers of the uterus. Precision Molecular Pathology of Uterine Cancer is a unique and one of a kind resource for practicing pathologists, pathologists in training and gynecologists.

This volume presents the latest advances and the current status of our understanding regarding ovarian cancer, addressing both the basic and clinical aspects of the disease. In terms of basic medicine, the WHO Classification of Tumors of Female Reproductive Organs was revised in 2014, and that version addresses several new concepts and histopathological classifications not previously included. One of the most revolutionary breakthroughs concerns the genesis of epithelial ovarian tumors, shifting the focus from the ovarian surface epithelium to serous tubal intraepithelial carcinomas. Clinically, the mortality rate of epithelial ovarian cancer has gradually increased over the past few decades, making it essential to pursue multidisciplinary treatment and apply novel techniques such as neoadjuvant chemotherapy in daily clinical practice. The primary clinical task is the effective treatment of recurrent ovarian cancer with early palliative medicine. Fertility-sparing surgery may also be pursued depending on histologic subtypes, stage, extent of disease, and preexisting ovarian reserve with the concept of oncofertility. On the basis of the considerations described above, each expert author elucidates the science of ovarian cancer in detail, thus providing a collection that will benefit young medical oncologists and seasoned gynecologists and obstetricians alike.

The fifth edition of the only comprehensive text dealing exclusively with rare or infrequently encountered malignancies in adults and children is an essential resource for any clinical oncologist. Encompasses all the information needed to diagnose and manage uncommon cancers, an area where advice and guidance is typically scarce Fully revised with new material and an evidence-based, teach-by-example approach Provides insight on real-world decision making in the clinical setting Edited and authored by a highly experienced and senior team of medical oncologists, radiation oncologists, and other specialists, giving a balanced and complete overview Extensively illustrated in full color throughout, including heat maps to show gene expression

This comprehensive text provides a much-needed review of a disease that is currently garnering the interest of molecular biologists, translational scientists, and clinicians. The volume includes emerging developments in the molecular genetics of endometrial carcinoma. In addition to covering the basic genetics of endometrial carcinoma, chapters also cover a wide range of signaling pathways implicated in endometrial carcinoma. A section of the book includes a number of genetically engineered mouse models, which contribute to understanding the role of various genetic alterations in the development and progression of endometrial carcinoma. These models also provide preclinical models for developing effective targeted therapeutic approaches. Endometrial carcinoma is the most common malignancy of the female genital tract in the United States and the number of cases continues to increase around the world. This book is a meant to serve as a resource for a wide range of scientists,from molecular geneticists to signal transduction biologists, as well as to both clinicians and scientists interested in developing targeted therapeutic approaches for women with endometrial carcinoma.

This book has been designed to provide the full description of the comprehensive management of peritoneal surface malignancies which have originated from different primaries, such as breast cancer, small bowel cancers and imatinib resistant GISTosis and sarcomas and pseudomyxoma. The book provides the most up-to-date information on current approaches such as cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. Given the increasing evidence that the patients who may benefit from this treatment modality avoid potential lethal course of these diseases, the book explores the application of these approaches to a number of types of malignancy. The first chapters explore Benign Multicystic Mesothelioma and Pseudomyxoma Peritonei arising from unusual primaries. Among other explored topics are peritoneal metastases from serous papillary uterine carcinoma, sarcoma and from unusual origins. This book is valuable for surgical oncologists who deal with the management of peritoneal surface malignancies.

This book provides an overview of the latest developments in the concepts and management of ovarian cancer. The new data presented throughout opens the way to radically different therapeutic approaches. Surgery remains the core of ovarian cancer treatment, but its ultimate goal and the standard surgical procedure have evolved, giving rise to the question of how to label expert centers for debulking surgery. Neo-adjuvant chemotherapy is becoming more popular and is also a new field for testing novel drug combinations.Over recent years, ovarian cancer management has embraced molecular biology. It is now more correct to talk about cancers of the ovary rather than ovarian cancer, since it is not a unique disease but several entities with different molecular drivers. The significant advances in drugs targeting the microenvironment or the tumor cell DNA repair mechanisms are presented in detail together with exciting future perspectives.All these advances would not have been possible without collaborative groups such as the GINECO group in France and their integration in wider clinical research networks at the European (ENGOT) and international (GCIG) level.

Management of Soft Tissue Sarcoma, 2nd Edition provides the most comprehensive analysis of demographics and natural history currently available for these lesions, based on the authors'experience with over 10,000 patients. Sections regarding radiation therapy not found in the previous text have been expanded, as have updates on molecular characteristics of sarcomas and chemotherapy studies published since the prior edition. Clinical and molecular diagnoses are addressed, and tumor histopathology is employed as the basis of treatment recommendations including surgery, radiation and systemic therapy. This is the first book to provide specific chemotherapy opinions for every sarcoma subtype. Written by four world-renowned experts, this book gives a practical, up-to-date approach to managing the many subtypes of adult soft tissue sarcoma.Reviews from the first edition:“This is an impressive book. Written by a surgeon, a pathologist and an oncologist, the book draws heavily on the Memorial Sloan-Kettering Cancer Center soft tissue sarcoma (STS) database. … it is a book that should be in the library of any sarcoma unit and will appeal to the sub-specialist in Orthopaedic Oncology.” (Robert U. Ashford, European Journal of Orthopaedic Surgery & Traumatology, Vol. 24, 2014)“The book is laid out in 27 chapters, with an impressive inclusion of a wide array of sarcoma histology. One of the real strengths of the book is the quality and number of images, figures, tables, and graphs. … The overall outline of the text is well done. … This book is a unique and important addition to the sarcoma literature. … this edtion should find itself on every medical oncologist's bookshelf ….” (Larry C. Daugherty and Sanjay P. Bagaria, Journal of Radiation Oncology, Vol. 3, 2014)

The reader will discover a comprehensive and multifaceted overview of the history of the development of anticancer drugs deeply influenced by the cell concept of cancer and future directions for the development of new anticancer drugs. First, this book documents the scientific progress in biological science over the last 70 years and the influence this progress had in cancer research. Summaries and charts of important discoveries complete this overview. Furthermore, this book outlines the process of anticancer drug development with a focus on the characteristic drug groups of each era, related to advancements of chemistry and biological sciences. This book also provides brief mechanism of action of drugs, illustrated by comprehensive timelines and conceptual cartoons. This book finally sums up the limitations of the current anticancer drug development and seeks new directions for anticancer drug discovery, considering under the systemic view of cancer.

In der komplett überarbeiteten und deutlich erweiterten zweiten Auflage des nun zweibändigen Buches werden die Sarkome, Mischtumoren und andere seltene mesenchymale Tumoren des weiblichen Genitale und retroperitonealen Beckenraumes dargestellt. Die genitalen Sarkome und malignen Mischtumoren sind aufgrund erheblicher diagnostischer Probleme mehrheitlich ein Zufallsbefund. Neben nur wenigen aussagekräftigen Studien existieren keine definierten Therapiestandards und Leitlinien. Wegen der schwierigen differentialdiagnostischen Abgrenzung und therapeutischen Unsicherheiten wurden auch die mesenchymalen Tumoren mit auffälligen klinischen Eigenschaften sowie einem unsicherem malignen Potential und gutartige Mischtumoren in die Publikation aufgenommen. Für jede Entität erfolgt eine detaillierte Besprechung zur Epidemiologie, Ätiologie und Pathogenese. Auf die makro- und mikroskopische Charakterisierung, die Prognose, die klinische und bildgebende Diagnostik sowie Differenzialdiagnose wird besonderer Wert gelegt. Der Fertilität und Schwangerschaft ist ein eigenständiges Kapitel in Band 2 gewidmet. Die klar formulierten Therapieempfehlungen beziehen sich jeweils auf die auf das Organ begrenzte sowie auf fortgeschrittene, rezidivierte und metastasierte Tumoren. Die Möglichkeiten der Operation, der Bestrahlung, der neoadjuvanten, adjuvanten, sowie palliativen Hormon- und Chemotherapie und Empfehlungen zur Nachsorge werden umfassend und kritisch dargestellt. Das Buch, mit einer Vielzahl an hochwertigen vierfarbigen Abbildungen und einem umfassenden aktuellen Literaturverzeichnis, soll für den klinisch und ambulant tätigen Gynäkologen und Onkologen ein Leitfaden zur Entscheidungsfindung sein und kann gleichfalls für den Pathologen von Nutzen sein. Das repräsentative aussagekräftige Bildmaterial ist auch das Resultat einer umfassenden Mithilfe durch zahlreiche Gynäkologen aus ganz Deutschland. Für die aufgeführten Tumorgruppen existiert gegenwärtig keine anderweitige zusammenfassende Monographie. Ebenfalls erhältlich:Sarkome des weiblichen GenitaleBand 1: Glattmuskuläre und stromale Tumoren ISBN 978-3-11-025317-7e-ISBN 978-3-11-025318-4

This volume provides a concise yet comprehensive overview of precancerous lesions and gynecologic tract cancers. Each section discusses the historic evolution of a precancerous lesion, its epidemiology, the nature of the published evidence that supports its characterization as a precancerous lesion, and gives a detailed description of morphologic, immunophenotypic and molecular properties, and patient outcomes. The volume also features 2 separate chapters on the clinical management of precancerous lesions of the gynecologic tract as a well as the cytopathology of cervical precancerous lesions.Lavishly illustrated and written by some of the foremost experts in the field, Precancerous Lesions of the Gynecologic Tract: Diagnostic and Molecular Genetic Pathology is a definitive account of precancerous lesions of the gynecologic tract and is a valuable resource for pathologists, oncologists, and gynecologists.

Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

In der komplett überarbeiteten und deutlich erweiterten zweiten Auflage des nun zweibändigen Buches werden die Sarkome, Mischtumoren und andere seltene mesenchymale Tumoren des weiblichen Genitale und retroperitonealen Beckenraumes dargestellt. Die genitalen Sarkome und malignen Mischtumoren sind aufgrund erheblicher diagnostischer Probleme mehrheitlich ein Zufallsbefund. Neben nur wenigen aussagekräftigen Studien existieren keine definierten Therapiestandards und Leitlinien. Wegen der schwierigen differentialdiagnostischen Abgrenzung und therapeutischen Unsicherheiten wurden auch die mesenchymalen Tumoren mit auffälligen klinischen Eigenschaften sowie einem unsicherem malignen Potential und gutartige Mischtumoren in die Publikation aufgenommen. Für jede Entität erfolgt eine detaillierte Besprechung zur Epidemiologie, Ätiologie und Pathogenese. Auf die makro- und mikroskopische Charakterisierung, die Prognose, die klinische und bildgebende Diagnostik sowie Differenzialdiagnose wird besonderer Wert gelegt. Der Fertilität und Schwangerschaft ist ein eigenständiges Kapitel in Band 2 gewidmet. Die klar formulierten Therapieempfehlungen beziehen sich jeweils auf die auf das Organ begrenzte sowie auf fortgeschrittene, rezidivierte und metastasierte Tumoren. Die Möglichkeiten der Operation, der Bestrahlung, der neoadjuvanten, adjuvanten, sowie palliativen Hormon- und Chemotherapie und Empfehlungen zur Nachsorge werden umfassend und kritisch dargestellt. Das Buch, mit einer Vielzahl an hochwertigen vierfarbigen Abbildungen und einem umfassenden aktuellen Literaturverzeichnis, soll für den klinisch und ambulant tätigen Gynäkologen und Onkologen ein Leitfaden zur Entscheidungsfindung sein und kann gleichfalls für den Pathologen von Nutzen sein. Das repräsentative aussagekräftige Bildmaterial ist auch das Resultat einer umfassenden Mithilfe durch zahlreiche Gynäkologen aus ganz Deutschland. Für die aufgeführten Tumorgruppen existiert gegenwärtig keine anderweitige zusammenfassende Monographie. Ebenfalls erhältlich:Sarkome des weiblichen GenitaleBand 2: Andere seltene Sarkome, Mischtumoren, genitale Sarkome und Schwangerschaft ISBN 978-3-11-044994-5e-ISBN 978-3-11-045133-7

Perfect for radiation oncology physicians and residents needing a multidisciplinary, treatment-focused resource, this updated edition continues to provide the latest knowledge in this consistently growing field. Not only will you broaden your understanding of the basic biology of disease processes, you'll also access updated treatment algorithms, information on techniques, and state-of-the-art modalities. The consistent and concise format provides just the right amount of information, making Clinical Radiation Oncology a welcome resource for use by the entire radiation oncology team.Content is templated and divided into three sections -- Scientific Foundations of Radiation Oncology, Techniques and Modalities, and Disease Sites – for quick access to information. Disease Sites chapters summarize the most important issues on the opening page and include a full-color format, liberal use of tables and figures, a closing section with a discussion of controversies and problems, and a treatment algorithm that reflects the treatment approach of the authors. Chapters have been edited for scientific accuracy, organization, format, and adequacy of outcome data (such as disease control, survival, and treatment tolerance). Allows you to examine the therapeutic management of specific disease sites based on single-modality and combined-modality approaches.Features an emphasis on providing workup and treatment algorithms for each major disease process, as well as the coverage of molecular biology and its relevance to individual diseases. Two new chapters provide an increased emphasis on stereotactic radiosurgery (SRS) and stereotactic body irradiation (SBRT).New Associate Editor, Dr. Andrea Ng, offers her unique perspectives to the Lymphoma and Hematologic Malignancies section.Key Points are summarized at the beginning of each disease-site chapter, mirroring the template headings and highlighting essential information and outcomes.Treatment algorithms and techniques, together with discussions of controversies and problems, reflect the treatment approaches employed by the authors.Disease Site Overviews allow each section editor to give a unique perspective on important issues, while online updates to Disease Site chapters ensure your knowledge is current.Disease Site chapters feature updated information on disease management and outcomes.Thirty all-new anatomy drawings increase your visual understanding.Medicine eBook is accessible on a variety of devices.

Uterine cancers are the commonest malignancies of the female genital tract in the developed world, and are increasing in numbers world over because of obesity and other life-style changes. Many of these malignancies are hereditary and thus, a better understanding of the genetic and molecular biology is needed. This would lead to appropriate treatment plan for improving the quality of life and long-term survival. This book addresses, in depth, all aspects of uterine malignancies covering both carcinomas and sarcomas. The book is divided into seven sections; the first two sections deal with epidemiology, molecular aspects, familial cancers and pathology and the later sections focus on diagnosis, imaging techniques and comprehensive management of both early stage and advanced cancers. Surgical techniques, adjuvant chemotherapy and radiotherapy have been covered in detail. Apart from the open surgical methods, role of laparoscopy and emerging role of robotic surgery in the contemporary management of endometrial cancers have been discussed. Written by authors with expertise in the field of gynecologic oncology from premier institutes, this book provides up-to-date information on best practice management of uterine malignancies.

During this age of advanced technology, there is an incredible amount of dynamic literature surrounding the diagnosis and treatment of gynecologic cancers. Despite this information surplus, house officers and junior faculty studying gynecologic oncology indicate a need for a reliable, easily accessible, streamlined resource for everyday use. Gynecologic Oncology: A Pocketbook is a collaborative effort that combines the perspectives of expert faculty and fellows in training in the field of gynecologic oncology. Not only is it incredibly portable, but the format in which the information is presented (bullet point, outline, tables and diagrams) allows for rapid access to valuable information and is unique amongst existing texts. This distinct pocketbook will provide the information needed to care for patients with gynecologic malignancies appropriately and will promote critical thinking throughout treatment.

This book provides a state-of-the-art review of the role of radiation therapy in various pelvic malignancies as well as the consequences of the radiation in the pelvic tissues. With sections covering the role of radiation therapy in the various pelvic malignancies, the pathophysiology of radiation related injury and the risk factors that increase the possibility of such an injury, and the latest in medical, endoscopic and surgical therapies for these radiation related complications the text offers a concise yet comprehensive overview of radiation therapy in the human pelvis, its role and the adverse effects on the pelvic organs. Written by experts in the field with readers in mind, Radiation Therapy for Pelvic Malignancy and its Consequences is the first of its kind standalone reference on the subject. Radiation Therapy for Pelvic Malignancy and its Consequences is of great value to urologists, medical radiation and gynecological oncologists, and gastroenterologists.

This textbook addresses themes ranging from the molecular issues of cancer sciences to clinical practice in medical oncology. It clarifies many topics, including molecular oncology, chemotherapy pharmacology and practical issues for clinicians. Systemic treatments in many areas of oncology feature, such as breast cancer, gastrointestinal, thoracic, urological oncology, head and neck tumors, bone tumors, sarcomas and palliative care.An excellent source for young physicians and researchers in the field of oncology, this book furthers understanding of medical oncology practice and facilitates professionals'treatment of cancer patients. It sets the direction for future research in the field, and will become the readers'regular working tool.