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The book aims to summarise the technical steps of several difficult, complex and lesser-known minimally invasive surgery (MIS) resections in cancer. It serves as an extensive practical resource for a surgeon interested in MIS for cancer. An accompanying approximately 8 min narrated video with each chapter demonstrates the personal techniques and innovations used by the author. Chapters are contributed by global experts working in this field who have shared their views and personal techniques in a “how I do it” manner, supplemented by high-quality illustrations, both diagrammatic and actual operative photographs. Chapters cover a variety of MIS procedures in cancer of the head and neck, thyroid, breast, lung, esophagus, stomach, colon, rectum, liver, pancreas as well as MIS radical hysterectomy and inguinal lymph node dissection. It also includes a few chapters covering the history of MIS in cancer, pros and cons of MIS, fluorescence imaging and an expert commentary. Each chapter is well-structured and includes - a brief history of the procedure, patient positioning and operating room setup, list of specific instruments/ gadgets used, the operative technique in a detailed stepwise manner, postoperative course and management, complications and personal experience. The book provides an up-to-date, practical guide for both young and experienced surgeons/ surgical oncologists/surgical gastroenterologists interested in MIS for cancer.

The sixth edition of this internationally successful text includes the many positive advances in radiation oncology that have occurred over the past decade, and which continue to keep radiation at the cutting edge of cancer therapy. As previously, a multi-national authorship includes some of the top radiation oncologists, biologists, and physicists from North America and Europe, who highlight the core principles of radiobiology.

Gastrointestinal cancers are among the most prevalent malignancies worldwide, with high rate of global cancer incidence and cancer-related death. Gastrointestinal cancers include esophageal cancer, gastric cancer, colorectal cancer, pancreatic cancer, and liver cancer, which all, except the last one, are covered in this volume. The fourth volume of the “Interdisciplinary Cancer Research” series, entitled “Gastrointestinal Cancers: An Interdisciplinary Approach” publishes comprehensive volumes on mechanisms of gastrointestinal cancers and novel immunotherapy opportunities and presents the most updated and peer-reviewed chapters on gastrointestinal cancers therapy. This interdisciplinary series is of special value to researchers working on cell biology, immunology, biochemistry, genetics, and practitioners working on oncology and gastroenterology. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN). This interdisciplinary book will be of special value for researchers, oncologists, and gastroenterologists who wish to extend their knowledge on gastrointestinal cancers.

This book provides updated knowledge on esophageal cancer diagnosis and treatment options. Esophageal cancer has become one of the cancers that can be detected early with the widespread use of endoscopy. Combinations of chemotherapy, radiotherapy and surgical treatment are used in the treatment. Depending on the planning of the surgery, operation is performed in two or three anatomical areas such as abdomen, thorax or cervical region. A good preoperative evaluation and postoperative follow-up and treatment are very important. In the book each stage of the disease is explained by different branches with a multidisciplinary approach. The book addresses professionals in oncology, radiology and surgery.

The book covers the concepts, techniques and strategies of oncoplastic breast surgery and reconstruction for breast cancer patients. It includes contemporary surgical procedures with step-by-step illustrations, pre-operative and post-operative considerations, pearls and pitfalls shared from the personal experiences and surgical practices of the individual authors. Experienced authors with diverse backgrounds and an in-depth understanding of the domains are involved in curating the content of the book. This book mainly focuses on practical tips and surgical techniques to reach a broad spectrum of surgeons practicing breast surgery from low and middle-income countries. It provides both the scientific basis and practical tips from experienced surgeons in the field. Breast cancer is an emerging major public health problem in low and middle-income countries. While the surgical approach to breast cancer has witnessed a major shift from mastectomy to breast conservation, oncoplasty and reconstruction in western countries, the field of breast surgery is still evolving in low and middle-income countries. Barriers to adopting newer surgical approaches include socio-cultural factors, disease-related factors, resource-related factors and availability of expertise. This book fills the gap and helps surgeons in low and middle-income countries in adapting contemporary breast surgical techniques into their day-to-day practice. This book will be relevant for surgical oncologists, breast and endocrine surgeons, general surgeons practicing breast surgery and plastic surgeons. Additionally, it will serve as a resource book for residents and fellows from general surgery, surgical oncology, breast surgery and plastic surgery streams.

This book provides comprehensive and practical guidance for the management of esophageal cancer. It presents a detailed review of the pathophysiology, clinical staging, treatment, and outcomes of patients with esophageal cancer. Chapters cover the epidemiology of the disease, latest diagnostic and staging tools, systemic therapies, and the current open and minimally invasive surgical techniques including transhiatal, Ivor Lewis and McKeown esophagectomy. Esophageal Cancer: Diagnosis and Treatment compiles experience gained across a variety of medical disciplines, with contributions from world renowned surgeons, gastroenterologists, and medical oncologists. Thanks to its multidisciplinary authorship, this book represents a unique resource for anybody who takes care of patients with esophageal cancer.

This book intends to report new concept of onco-spheres in cancer ecosystem. Onco-spheres are defined as where cancer cells (living organisms) dynamically interact with nontumor cellular (other living organisms) and noncellular components (non-living environmental factors) in the ‘host'internal environment (habitat) to construct a self-sustainable cancer ecosystem, which can be scoped at three different levels: primary/regional, distal and systemic onco-spheres. Cancer cells should be conceived as ‘living organisms', interacting with cellular or noncellular components in the host internal environment, not only with the local tumor microenvironment (TME) but also constantly communicating with a distant organ niche as well interacting with the host's nervous, endocrine and immune systems, to construct a self-sustainable ‘biosphere', as we termed the tumor ecosystem. By looking at theinteraction of cancer and host as a unique ecosystem, we will use ecology principles to further delineate the features of the dynamics of the tumor ecosystem. As the pioneer in proposing this concept, we feel that this full-scale overview of the tumor ecosystem is able to inform the readers about this concept, and to pave the way for designing novel therapeutic strategies on actionable targets within tumor ecosystem. The book is likely to be of interest to immunologist, biologist, medical students, researchers and general public who wish to learn more on this new concept of tumor ecosystem, and how this could be applied in many fields of research.

The book provides a comprehensive overview of the challenges and debates on the diagnosis and treatment of lateral neck swellings to clarify some uncertainties, make suggestions for resolving others, and establish strategies for achieving therapeutic success. In addition to information on the surgical anatomy of the neck, and the classification and clinical approach for diagnosis and management of neck swellings, the chapters explore solid swellings and cystic swellings of the anterior and posterior triangles. The last chapter emphasizes the importance of scheduling regular follow-ups as well as patient counselling and education.The volume, enriched with colour images and flowcharts, will be an indispensable resource for head and neck surgeons, maxillofacial surgeons, endocrinologists, oncologists, pediatricians, and clinicians in other specialties as they face the most challenging lateral neck swellings and work towards providing each patient with the best possible outcome.

The standard-setting text in oncology for 40 years, DeVita, Hellman and Rosenberg's Cancer: Principles and Practice of Oncology, 12th Edition, provides authoritative guidance and strategies for managing every type of cancer by stage and presentation. Drs. Vincent T. DeVita, Jr., Theodore S. Lawrence, and Steven A. Rosenberg oversee an outstanding team of expert contributing authors who keep you up to date and fully informed in this fast-changing field. This award-winning reference is also continually updated on Health Library and VitalSource platforms for the life of the edition.

This book aims to examine all immunohistochemical and molecular pathological biomarkers that can be useful and effective in patient diagnosis, prognosis and treatment decision, especially when faced with a carcinoma of unknown primary. For this purpose, epithelial malignancies of all systems and related biomarkers are examined one by one, and to look at the subject through the metastatic regions window, biomarkers that can be used to determine the primary focus for carcinomas seen in the areas most frequently metastasized are emphasized. With this bi-directional perspective, the reader is able to find biomarkers of any type of carcinoma on a system basis, as well as access to which biomarkers can be used when faced with a metastatic carcinoma. The importance of biomarkers in patient follow-up and treatment is also conveyed through the clinician's eye, and so biomarkers are handled with a holistic approach in all aspects. This book primarily targets pathologists, as well as clinicians (oncologists and surgeons) who manage cancer patients.

Comprehensive, authoritative, and up to date, Oncologic Imaging: A Multidisciplinary Approach, 2nd Edition, covers every aspect of radiographic imaging for the diagnosis, treatment, and management of the cancer patient. Dr. Paul M. Silverman and an expert author team from MD Anderson Cancer Center provide all the current, practical information available, while incorporating their unique experience based upon extensive, daily clinical care of patients with cancer. In one convenient volume, this definitive, one-of-a-kind text discusses new diagnostic imaging and surgical approaches as well as therapeutic cutting-edge treatments from radiation and medical oncology, focusing on best practices and the newest standards for personalized medicine. - Brings together a unique multidisciplinary team of authors including clinical radiologists, medical oncologists, radiation oncologists, and surgical oncologists who reflect team-based practice. - Features an all-new chapter on head and neck imaging, authored by world experts in this complex area. - Contains extensive updates throughout, including transformational state-of-the-art imaging modalities such as PET/CT, and the full range of traditional modalities, including multidetector CT (MDCT), ultrasound, and MR in conjunction with the latest advances in genetics, molecular oncology, and targeted therapies. - Distills practical, up-to-date information into a concise and consistent format with key point summaries, algorithms, clear drawings, and full-color staging diagrams. - Includes emerging options for care based on practice recommendations and evidence in the literature. - Provides updated tumor staging information based on the AJCC Classification of Malignant Tumors, 8th edition. - Highlights the text with 1,000 high-quality radiographic images: CT, MR, hybrid imaging (PET/CT, PET/MR), mammography, and ultrasound, as well as clear line anatomic drawings, graphs, and algorithms.

This third edition manual provides a comprehensive, insightful, evidenced-based review of general surgical oncology and serves as a valuable resource for general surgeons in training, practicing general surgeons, and surgical oncologists. The volume describes a multidisciplinary approach that integrates clinical, radiologic, and pathologic data in formulating practical clinical management, and offers a practical approach to the most common situations when treating cancer patients. Each chapter focuses on an individual malignancy and describes the presentation of the malignancy, integrated management based on stage, landmark trials, and suggestions for who to discuss at multidisciplinary cancer conferences. Multiple tables in each chapter provide a concise yet comprehensive summary of the current status of the field. Clinical “pearls” or tips and tricks from high volume surgeons at the University of Toronto are also discussed. The third edition of the Surgical Oncology Manual will serve as a critical resource for general surgeons in training and practicing surgeons dealing with this challenging field.

This well-illustrated book covers the full range of lung and pleural diseases from the pathologic standpoint. It has been updated from the first edition by including the most recent molecular data for the different lung diseases, tumor as well as non-tumor ones. New diagnostic tests are included, new aspects for the understanding of diseases have been added. Both diseases of adults and pediatric lung diseases are presented. The chapter on lung development has been expanded due to the many new findings being reported since the first edition.The book will serve as an excellent guide to the diagnosis of these diseases, but in addition it explains the disease mechanisms and etiology. Genetics and molecular biology are also discussed whenever necessary for a full understanding. The author is an internationally recognized expert who runs courses on lung and pleural pathology attended by participants from all over the world. In compiling this book, he has drawn on more than 30 years'experience in the field.

This is the second edition of the book, covering a wide spectrum of the latest information relevant to diagnosis and treatment of esophageal squamous cell carcinoma (ESCC). In recent years the incidence rate of esophageal cancer has been increasing; however, the background characteristics of the cancer treatment are significantly different between Asian and Western countries. In tumor histology, ESCC associated with smoking and alcohol consumption is overwhelmingly prevalent in Asia, whereas adenocarcinoma associated with Barrett's metaplasia is remarkably prevalent in the West. In Asia, especially in Japan, surgeons play a significant role in the management of esophageal cancer patients, while medical and radiation oncologists as well as surgeons are important in the West. Considering these East–West differences in management of esophageal cancer, evidence originating in Asia should be more widely disseminated globally. The contributing authors, who have great expertise in their areas of specialization, discuss details in terms of treatment of ESCC, including basic science, diagnosis, surgery, other treatment modalities, Japanese guidelines, and also valuable experiences from other Asian countries. Accordingly, this excellent collection of texts benefits not only oncologists, but all medical and biological researchers involved in the latest ESCC research.

The second edition of this very successful book documents the latest progress in the prevention, diagnosis and treatment of esophageal cancer and includes additional sections covering novel targeted therapeutic approaches, immunotherapy and palliative and nutritional support for patients. Furthermore, the sections covering epidemiology, molecular biology, pathology, staging and radiologic and endoscopic assessments have been thoroughly updated and expanded. The principles of surgical resection, radiation therapy and systemic therapy are reviewed and attention is paid to the multidisciplinary approaches to the management of early stage cervical, thoracic, distal and junctional tumors. Updated information is also provided on the treatment of metastatic and recurrent disease as well as approaches that may impact future care, such as chemoprevention. Esophageal Cancer: Prevention, Diagnosis and Therapy will assist specialists from various disciplines, including surgery,radiation therapy, gastroenterology, medical oncology and palliative medicine, in delivering optimal, up-to-date care to the benefit of patients.

In the new edition of this very successful book, European and North American experts present the state of the art in diagnostic and therapeutic radionuclide procedures. The aim is to examine established and emerging clinical applications in detail, rather than to consider everything included in the comprehensive texts already available within the field. This “practical” approach ensures that the book will be a valuable guide for nuclear medicine physicians, technologists, students, and interested clinicians alike. This edition of Clinical Nuclear Medicine has been extensively revised to take account of recent developments. The roles of SPECT/CT, PET/CT, and PET/MRI are clearly explained and illustrated, and the coverage extended to encompass, for example, novel PET tracers and therapeutic radionuclides, advanced techniques of brain imaging, and the development of theranostics. Readers will be fully persuaded of the ever-increasing value of nuclear medicine techniques in depicting physiology and function and complementing anatomic modalities such as CT, MRI, and ultrasound.

Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. Now updated online for the life of the edition, DeVita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology, 11th Edition keeps you up to date in this fast-changing field. Every quarter, your eBook will be updated with late-breaking developments in oncology, including new drugs, clinical trials, and more.

This book focusing on the immunopathology of cancers is published as part of the three-volume Springer series Cancer Immunology, which aims to provide an up-to-date, clinically relevant review of cancer immunology and immunotherapy. Readers will find detailed descriptions of the interactions between cancerous cells and various components of the innate and adaptive immune system. The principal focus, however, is very much on clinical aspects, the aim being to educate clinicians in the clinical implications of the latest research and novel developments in the field. In the new edition of this very well received book, first published in 2015, the original chapters have been significantly updated and additional chapters included on, for example, current knowledge on the roles of T-helper cells and NK cells in tumor immunity, the part played by oncoviruses in the development of various cancers, and the applications of fluorescent in situ hybridization, bioluminescence, and cancer molecular and functional imaging. Cancer Immunology: A Translational Medicine Context will be of special value to clinical immunologists, hematologists, and oncologists.

Im vorliegenden Band werden nicht-hereditäre Tumorerkrankungen behandelt, deren Häufigkeit zwischen 85% und 95% liegt und damit ungleich höher ist als die der hereditären Tumorerkrankungen. Auch den nicht-hereditären Tumoren liegen Mutationen von DNS-Basenpaaren zugrunde, jedoch ohne Veränderungen der Keimbahn. Der pleiotrope Charakter dieser Erkrankungen erfordert zur Erkennung ihrer Ursachen eine komplizierte Diagnostik. Besonders betroffen sind Organe, die einer Einwirkung von Schadstoffen in besonderem Maße ausgesetzt sind. Diese Belastungen spiegeln sich in den insgesamt 13 Kapiteln dieses Bandes wider. Sie reichen von Hirn-, Brust- und Lungentumoren, über Tumoren der Leber, des Ösophagus und Magens, des Pankreas, des Darmes, der Blase und Niere, der Prostata und der Keimdrüsen bis zu Tumoren der Knochen und Weichteile.

This second updated volume on breast cancer provides a comprehensive overview of its clinical management and current therapies. Updated to reflect the changes in breast cancer staging, the progress in immunotherapy approaches, as well as the latest guidelines for therapies, this book brings readers up to speed with the latest therapeutic regimens in breast cancer and provides an in-depth account of current and new therapeutic approaches. The most important phase III trials, high quality meta-analysis, consensus reports and guidelines are extensively discussed in this new edition and provide the reader with the most up-to-date information.Divided in themed parts, the book examines invasive breast cancer, pre-operative systemic therapy surgical management and recurrence among others, thus providing an in-depth account of breast cancer at the clinical stage. Among the themed parts are a section dedicated to special therapeutic problems, such as breast cancer in older women, Paget'sdisease and phyllodes tumors and a section on supportive and follow-up care. By adopting a multidisciplinary approach to breast cancer, this book is a must-have for breast cancer practitioners. With a high number of colored illustrations and edited by highly experienced clinicians, this work enables readers to gain an interdisciplinary perspective on breast diseases. Contributions from an international team of experts present invaluable insight into clinical practice across different settings. Covering both theoretical and practical aspects of breast cancer, this is a highly informative and carefully presented book which will appeal to an international audience of medical, radiation and surgical oncologists.

The 25th volume of this highly successful series covers a range of interesting topics, including biological therapy in inflammatory bowel disease, recent surgical approaches in rectal cancer, tumor markers in HPB and GI malignancies, bridging therapy for hepatocellular carcinoma, adjuncts to liver resection, IgG-related HPB diseases, ERCP-induced perforations and superior mesenteric artery syndrome. As in the previous volumes, the chapter on advances in GI surgery reviews the important new developments in the field. The GI Surgery Annual 25th Volume provides up-to-date information on current hot topics.

Chemotherapy and radiotherapy for cancer can have devastating side effects on the skin of a patient. This innovative guide for both dermatologists and oncologists gives a good introduction both to therapy regimes and to dermatological management for medical professionals treating their patients.

This book is an evidence-based guide to current use of radiation therapy for the treatment of malignancies at major disease sites. It is designed to meet the needs of residents, fellows, and practicing radiation oncologists and will assist in selection and delineation of tumor volumes/fields and dose prescription for intensity-modulated radiation therapy, including volumetric modulated arc therapy for stereotactic radiosurgery or stereotactic body radiotherapy. Each tumor site-related chapter presents, from the perspective of an academic expert, informative cases at different stages in order to clarify specific clinical concepts. The coverage includes case presentation, a case-related literature review, patient preparation, simulation, contouring, treatment planning, image-guided treatment delivery, follow-up, and toxicity management. The text is accompanied by illustrations ranging from slice-by-slice delineations on planning CT images to finalized plan evaluations based on detailed acceptance criteria. The expert knowledge and evidence contained in this comprehensive book will give readers the confidence to manage common cancers without outside referral and to meet the clinical challenges faced in everyday practice.

This book demonstrates why oncoplastic and reconstructive surgery represents such an exciting tool for surgeons who undertake breast surgery. Fundamental principles and basic concepts are clearly outlined, and numerous techniques are presented by acknowledged experts from across the world. The emphasis is very much on a “how to do” approach, with detailed guidance and advice on the various techniques. The informative text is supported by a wealth of color illustrations, and accompanying videos of procedures can be accessed via the publisher's website. This second edition of Oncoplastic and Reconstructive Breast Surgery has been completely revised and updated. More than 25 additional chapters have been included, and new videos of surgeries made available, with the aim of making this already very successful book truly comprehensive, and the most complete reference on the subject – a true classic. The new edition entails close collaboration betweensome of the most important centers for breast cancer treatment and research worldwide. It will be an ideal resource for surgical fellows and specialists wishing to learn about indications and the selection of patients, to master technical skills, and to manage complications effectively.

This book clearly describes the surgical procedures employed in patients with gastric cancer. The techniques used in the various types of gastrectomy are presented step by step, and the roles of endoscopic treatment and chemotherapy are also discussed. A distinctive practical feature is the provision of accompanying online videos of standard surgical procedures, which will serve as excellent learning aids for novice practitioners and provide ideal teaching material for experienced surgeons. Surgery remains the mainstay in the treatment of gastric cancer. With advances in tumor biology and technical developments, gastric cancer surgery has become more diverse and its outcomes have steadily improved. However, further improvement of certain aspects of surgical procedures and techniques is still required. Surgery for Gastric Cancer will acquaint readers with the state of the art in the field and prove a valuable tool in the quest for optimal practice.

This book provides the most comprehensive and up-to-date knowledge of lymph node micrometastasis (LMM) and sentinel node navigation surgery (SNNS) in gastrointestinal cancers. Lymph node metastasis is a critically important prognostic factor in gastrointestinal tract cancers such as tumors of the esophagus, stomach, and colorectum. An understanding of the basic aspects of lymphatics and lymph nodes, including anatomy, histology, physiology, immunology, and molecular biology, is fundamental for physicians who are involved in cancer treatment. Furthermore, owing to the development of molecular and biological methodology, the precise recognition of LMM and its clinical significance have been clarified recently. At the same time, SNNS has actually been anticipated in treatment of breast tumors, and it is now being introduced in gastrointestinal tract cancer. For the application of SNNS, the detection of lymph node metastasis including LMM is extremely significant, because the presence of LMM determines the direction for surgery and chemo and/or radiation therapy. With these considerations in mind, the expert contributors to this book review basic and clinical approaches for LMM and SNNS including methodology for gastrointestinal cancers. Thus this volume benefits not only surgeons who treat gastrointestinal cancers but also clinical oncologists and medical scientists such as physiologists and pathologists.

This book focuses on Barrett's Esophagus (BE), a clinical condition that must be evaluated in all patients affected by chronic GERD, and with an important link to esophageal cancer. Divided into four sections (morphological background, epidemiology and natural history, diagnosis, and treatments), this handy volume provides the latest indications regarding endoscopic approaches (first level and advanced endoscopy), pathological studies (pathology and molecular biology), and state-of-the-art therapeutic options (medical, endoscopic, and surgical) for BE. As such, it offers a valuable reference guide for all professionals involved in the management of BE (gastroenterologists, endoscopists, pathologists and surgeons), offering them a comprehensive overview and deeper understanding of this seemingly superficial disease.

Für 15 wichtige viszeralchirurgische Indikationen bei malignen Erkrankungen ermöglicht dieses Buch eine gezielte evidenzbasierte Therapiewahl. Grundlagen sind die weltweit publizierten aktuellen Behandlungsergebnisse zu operativen Eingriffen und konservativem Vorgehen: was empfehlen die nationalen und internationalen Leitlinien? Welche wichtigen Informationen stehen nicht in den Leitlinien? Welche Behandlungsergebnisse wurden in Metaanalysen und Cochrane-Reviews und weiteren randomisierten Studien veröffentlicht, und wie sind diese zu bewerten? Wie sehen die Ergebnisse in Zentren und in der Fläche aus?Die Analyse der Daten führt zu gut begründeten, differenzierten Therapieempfehlungen, die unmittelbar in Klinik und Praxis angewandt werden können.

Los tumores malignos están ocupando hoy en día los primeros lugares dentro de la morbi-mortalidad del país. A medida que ha aumentado la expectativa de vida aumenta la probabilidad de tener esta patología y esto está pasando en nuestra población. Por esta razón es fundamental que los estudiantes tengan conocimiento (al menos elemental) sobre algunos aspectos de la oncología como la epidemiología, la prevención, la historia natural, el seguimiento e igualmente cómo hacer el diagnóstico, el tratamiento y el pronóstico de algunos de los tumores más frecuentes de la oncología. Acordes con los compromisos curriculares en salud se deben tener textos básicos sobre temas que respondan a la epidemiología más prevalente de la comunidad y este es el objetivo de este libro que es el primero en la Universidad sobre el tema. El texto está dirigido a estudiantes de pre y postgrado que en cualquier momento de su formación requieran alfabetizarse en oncología. Por esta razón es fundamental que los estudiantes tengan conocimiento (al menos elemental) sobre algunos aspectos de la oncología como la epidemiología, la prevención, la historia natural, el seguimiento e igualmente cómo hacer el diagnóstico, el tratamiento y el pronóstico de algunos de los tumores más frecuentes de la oncología. Acordes con los compromisos curriculares en salud se deben tener textos básicos sobre temas que respondan a la epidemiología más prevalente de la comunidad y este es el objetivo de este libro que es el primero en la Universidad sobre el tema. El texto está dirigido a estudiantes de pre y postgrado que en cualquier momento de su formación requieran alfabetizarse en oncología. Acordes con los compromisos curriculares en salud se deben tener textos básicos sobre temas que respondan a la epidemiología más prevalente de la comunidad y este es el objetivo de este libro que es el primero en la Universidad sobre el tema. El texto está dirigido a estudiantes de pre y postgrado que en cualquier momento de su formación requieran alfabetizarse en oncología.

This book presents the morphology, possible mechanisms of formation, and clinical relevance of tumor deposits (TDs) in different organs and parts of the body. It also describes the diagnostic features that are currently available for TDs and discusses the prognostic impact of TDs. The poor prognostic and predictive values of TDs were found to be as strong as distant metastasis in different series. TDs, best characterized by colorectal cancer, are irregular discrete tumor masses that are discontinuous from the leading edge of the tumor. However, even in colorectal cancers, the place of TDs in tumor staging (tumor, lymph node and distant metastasis categories) remains controversial. This book presents the possible mechanisms of TD formation, including neurotrophic and angiotrophic extravascular migratory metastasis, in comparison with the well-known mechanisms of metastasis. It also shows that TDs were identified in esophageal, gastric, salivary gland, head and neck, andbreast carcinomas. The possible mechanisms leading to the frequent association of TDs and peritoneal carcinomatosis are discussed. This is a valuable resource for pathologists, oncologists, and surgeons who are looking for detailed information on the latest scientific insights into the pathology and prognostic implications of TDs.

This is the second edition of a well-received book reflecting the state of the art in oncologic imaging research and promoting mutual understanding and collaboration between radiologists and clinical oncologists. It presents all currently available imaging modalities and covers a broad spectrum of oncologic diseases for most organ systems. Today, oncologic imaging faces the challenge of improving and refining concepts for precise tumor delineation and biologic/functional tumor characterization, as well as for purposes of creating individual treatment plans. The concept of radiomics has further advanced the conversion of images into mineable data and subsequent analysis of said data for decision-making support. Since the release of the book's first edition, radiomics has been introduced in oncology studies and can be performed with tomographic images from CT, MRI and PET/CT studies. The combination of radiomic data with genomic features is known as radiogenomics, and can potentially offer additional decision-making support. This book will be of interest to clinical oncologists with regard to the diagnosis, staging, treatment and follow-up on various tumors affecting the CNS, chest, abdomen, urogenital and musculoskeletal systems.

The 24th volume of this highly successful series includes new contemporary topics such as corrosive injuries of the oesophagus, post-gastrectomy complications, advances in imaging of inflammatory bowel disease, unusual presentations of gallstones, gall bladder cancer with jaundice, minimally invasive pancreatic surgery, and enhanced recovery after surgery. Finally, the chapter on advances in GI surgery, like in each past volume, reviews important new developments in the field. The GI Surgery Annual 24th Volume provides an overall roundup of selected topics that were deemed particularly relevant and topical by the series editors.

Medicine has become highly specialized so that thoracic oncology is not a subspecialty of medical oncology and thoracic surgery. The field of thoracic oncology is a specialized area within oncology which is rapidly evolving making it difficult to keep comprehensive textbooks up to date. This thoracic oncology textbook has recruited international experts to write concise focused sections about their area of specialization.Comprehensive discussions about the basics of thoracic oncology and each specific tumor are discussed in detail in terms of biology, presentation, staging, pathology, treatment including surgery, radiation, chemotherapy as well as targeted/gene therapies and their complications.This is the only concise comprehensive textbook on the subject that includes all chest malignancies.

This book presents an update on new trends and developments in broadly defined medical disciplines. The whole range of multidisciplinary topics are tackled, regarded as being important for advancing the understanding of disease pathogenicity, diagnostic methods, and patient management. The topics include a holistic approach to physiotherapy, with proprioceptive neuromuscular facilitation at the core of it, potential ways to protect kidneys during ischemic coronary interventions, and psychosocial aspects in cancer survivors. Other topics deal with growth hormone deficiency in short children and responses of molecular markers of bone metabolism to growth hormone replacement therapy and with the modern use of transcranial laser-induced photobiomodulation showing surprising benefits in autism disorder. The expert contributions take on the challenges presented to medical professionals by ever growing medical knowledge and various individual and contextual issues that require a multidisciplinary approach in patient management. The authors present a bench-to-bed clinical research to make useful additions to the knowledge on contemporary diagnostic procedures, therapy, and quality of life of patients. The book aims to provide stimulus for new research ideas and to give new perspectives on practical clinical issues. The book is intended for primary care clinicians, family physicians, medical scholars, and other clinicians who treat and manage patients.

This book focuses on the biological mechanisms of minimal residual disease (MRD) and recurrence. It integrates this biology in solid cancers and in hematological malignancies. It reports also on technological advancements for monitoring MRD, derived from mechanistic insights. Chapters in solid and hematological malignancies address stem cell biology, genetics, epigenetics and micro-environmental regulation of dormant MRD. Novel insight into technologies for molecular phenotyping of MRD and monitoring of CTCs, DTCs and cell free RNA and DNA are also addressed extensively. Five chapters explore the above concepts in solid cancers such as prostate, breast, melanoma, head and neck and esophageal. Two chapters also explore the basic mechanisms of vascular biology targeting and epigenetic mechanisms regulating pluripotency programs during dormancy. Similar biology is explored in hematological malignancies such as T-ALL, CML, AML and multiple myeloma in additional four chapters. This book is edited and prefaced by Dr. Julio Aguirre-Ghiso, an expert in dormancy and recurrence. The chapters are written by world-recognized experts Drs. Ravi Bahtia, Samir Parekh, Russel Taichman, Monica Guzman, David Hoon, Denis Schewe, Irmela Jeremias, Cyrus Ghajar, Maria Soledad Sosa and Nicholas Stoecklein. The topic of this book is of particular interest to both basic cancer cell biologists and physician scientists that are working to provide a more integrated view of the biology of MRD and to those interested in working on or learning about this paradigm. The integrated and cross-disciplinary focus of the book from biology to medicine seeks to help bridge gaps to improve cancer care and prevent recurrences.

This invaluable book provides an introduction to the development and application of molecular biology with a focus on translational research development in a variety of gastrointestinal cancers.Multidisciplinary Management of Gastrointestinal Cancers will emphasize the multidisciplinary aspects of GI cancer diagnosis, treatment and management, introduce the application of new techniques in GI cancer therapy; guide clinicians/experts to use newly developed evidence-based information and knowledge in patient care.This book will also discuss the role of supportive care and quality of life issues in patients with GI malignancies.

Kanker is de belangrijkste doodsoorzaak in Nederland. Door preventie, verbetering in diagnostiek en behandeling, is de levensverwachting voor patiënten met kanker toegenomen. Het is van het grootste belang dat de patiënt, nogal eens met meer dan een ziekte in een gespecialiseerd multidisciplinair team besproken wordt waarbij precisie diagnostiek leidt tot precisie behandeling, optimaal gericht op de individuele patiënt met specifieke tumoreigenschappen. Deze nieuwe ontwikkeling in de multidisciplinaire aanpak van kanker is het leidend thema van het Leerboek oncologie. De auteurs zijn top expert binnen hun vakgebied in Nederland en internationaal. Leerboek oncologie biedt een helder inzicht in de diversiteit van oncologische problematiek, algemene aspecten, organisatie, begeleiden en palliatie krijgen aandacht naast de orgaan gerichte diagnostiek en behandeling van kanker. Leerboek oncologie is bedoeld als leerboek voor studenten geneeskunde enverpleegkunde. Maar is ook bedoeld als naslagwerk voor (huis)artsen en verpleegkundigen die in de praktijk met oncologische vraagstukken te maken hebben en onderdeel zijn van een multidisciplinair team.

This Atlas presents a state-of-the-art review of VATS and robotic approaches to managing lung and esophageal cancers. It discusses cancer staging, physiological evaluation of patients, and patient selection for minimally invasive surgery. The atlas offers detailed descriptions of individual operations accompanied by anatomic drawings, intraoperative images, and 3-dimensional anatomic reconstructions. Written by recognized experts in the field, it provides readers with an unparalleled resource for advancing their skills in managing these cancers. It is a valuable reference work for thoracic surgeons in training as well as in practice who want to pursue minimally invasive surgery. It is unique in offering fully illustrated, step-by-step descriptions of the operative procedures.

This new edition offers comprehensive coverage of all areas of interventional pulmonology, a minimally invasive endoscopic method for diagnosing and treating lung disorders. The text is divided into eight sections on the major areas of interventional pulmonology, including basic endoscopy, lung cancer staging, and interventional bronschoscopy in asthma and emphysema. Chapters then explore specific procedures and techniques, including medical thoracoscopy, flexible and rigid bronchoscopy, endobronchial ultrasound, and electromagnetical navigation with coverage of history, indications and contraindications, and up-to-date evidence-based reviews. In recent years there have been many advances in interventional pulmonology, the most significant relating to lung cancer early diagnosis and late-stage treatment. Two new chapters on lung cancer epidemiologic changes and personalized lung cancer treatment explore new methods for maximizing patient care for an increasingly prevalent disease. Thisinclusive volume concludes with a look towards the future of interventional pulmonology and experimental techniques currently being tested. Interventions in Pulmonary Medicine, Second Edition, is a must have for pulmonologists, endoscopists, pulmonary oncologists, ENT physicians, thoracic surgeons, anesthesiologists, and intensive care specialists and their teams.

This well-illustrated textbook covers the full range of lung and pleural diseases from the pathologic standpoint. Both diseases of adults and pediatric lung diseases are presented. The book will serve as an excellent guide to the diagnosis of these diseases, but in addition it explains the disease mechanisms and etiology. Genetics and molecular biology are also discussed whenever necessary for a full understanding. The author is an internationally recognized expert who runs courses on lung and pleural pathology attended by participants from all over the world. In compiling this book, he has drawn on more than 30 years'experience in the field.

The 23rd volume of this highly successful series includes new contemporary topics such as PET in HPB diseases, short gut syndrome, current status of extended lymphadenectomy in esophageal cancer, splenectomy for haematological disorders, postoperative liver failure, HIPEC, and current issues in surgery of pancreatic cancer. Finally, the chapter on advances in GI surgery, like in each volume in the past, reviews the important new developments in the field.The GI Surgery Annual 23rd Volume provides an overall round up of selected topics that are considered relevant and contemporary by the editors of the series.

This book discusses the latest molecular targeted therapy of lung cancer including its evaluation and future directions. It clearly illustrates the initial dramatic effectiveness of molecular targeted therapy, recurrence of the disease, overcoming the wide variety of resistance mechanisms using new-generation molecular targeted agents and potential novel approaches. It also outlines the increasing necessity for new diagnostic technology and strategies for managing different adverse effects and novel methods for evaluating effectiveness and safety. Edited and authored by opinion leaders, Molecular Targeted Therapy of Lung Cancer provides a comprehensive overview of the disease and its treatments. It is a valuable resource for graduate students, post-doctoral fellows and faculty staff, as well as researchers involved in clinical and translational research on lung cancer, helping promote new ideas for further advances.

This book offers up-to-date and comprehensive coverage of the diagnosis and therapy of adenocarcinoma of the esophagogastric junction (EGJ). As is appropriate in the era of multidisciplinary and multimodal treatment, the contributions of all the various specialists involved cooperatively in the treatment of EGJ cancer are thoroughly described. Detailed attention is also paid to the significance of preneoplastic lesions, such as Barrett esophagus. The final part of the book represents a surgical atlas documenting the techniques used in the EGJ region, with superb color images and stepwise description of procedures. Against the background of the rapidly increasing incidence in EGJ cancer, especially evident in Western countries, there is a need for greater uniformity in management strategies, which currently vary significantly across the world. This book provides appropriate guidance that will assist all practitioners involved in the diagnosis and treatment of EGJ cancers, including surgeons, oncologists, and radiotherapists.

This book is a pocket guide to the science and practice of PET/CT imaging of esophageal and gastric malignancies. The scientific principles of PET/CT, the radiopharmaceuticals used in this context, the role of PET/CT, the characteristic PET/CT findings, and limitations and pitfalls are all clearly described. In addition, information is provided on epidemiology, clinical presentation, diagnosis, staging, pathology, management, and radiological imaging. The book is published within the Springer series Clinicians'Guides to Hybrid Imaging, which is aimed at referring clinicians, nuclear medicine/radiology physicians, radiographers/technologists, and nurses who routinely work in nuclear medicine and participate in multidisciplinary meetings. Compiled under the auspices of the British Nuclear Medicine Society, the series is the joint work of many colleagues and professionals worldwide who share a common vision and purpose in promoting and supporting nuclear medicine as an important imaging specialty for the diagnosis and management of oncological and non-oncological conditions.

This text is intended as a practical guide for physicians and surgeons who treat diseases of the breast, both benign and malignant. Thus, general surgeons, internists, family practitioners, gynecologists, surgical oncologists, radiation oncologists, and medical oncologists will find this book useful. The management of breast diseases requires a multidisciplinary approach, and this textbook therefore includes the views of a wide range of specialists from throughout the world. Today the treatment of breast diseases is largely predicated on the results of randomized prospective trials. The results of many clinical trials are discussed in detail, and readers will find this book to be a useful guide to the evidence-based treatment of breast diseases.The revised edition provides a comprehensive update of the previous version of the book. Specifically, it contains 2 new chapters: “Molecular Classification of Breast Cancer” and “Breast Cancer Molecular Testing for Prognosis and Prediction”. In addition, since publication of the previous edition, the results of numerous adjuvant systemic therapy and neo-adjuvant systemic therapy trials have been published, and this edition provides a comprehensive overview of these trials and discusses how they have changed the management of breast cancer. Similarly, there have been, in the last few years, important new developments in the local therapy of breast cancer. This edition discusses these new developments and particularly recent developments and controversies concerning the management of the axilla in patients with primary breast cancer. New guidelines with respect to radiotherapy are also reviewed and discussed. Finally, all chapters in the book are thoroughly revised and updated to provide readers with current understanding of the biology and treatment of breast cancer.

Perfect for radiation oncology physicians and residents needing a multidisciplinary, treatment-focused resource, this updated edition continues to provide the latest knowledge in this consistently growing field. Not only will you broaden your understanding of the basic biology of disease processes, you'll also access updated treatment algorithms, information on techniques, and state-of-the-art modalities. The consistent and concise format provides just the right amount of information, making Clinical Radiation Oncology a welcome resource for use by the entire radiation oncology team.Content is templated and divided into three sections -- Scientific Foundations of Radiation Oncology, Techniques and Modalities, and Disease Sites – for quick access to information. Disease Sites chapters summarize the most important issues on the opening page and include a full-color format, liberal use of tables and figures, a closing section with a discussion of controversies and problems, and a treatment algorithm that reflects the treatment approach of the authors. Chapters have been edited for scientific accuracy, organization, format, and adequacy of outcome data (such as disease control, survival, and treatment tolerance). Allows you to examine the therapeutic management of specific disease sites based on single-modality and combined-modality approaches.Features an emphasis on providing workup and treatment algorithms for each major disease process, as well as the coverage of molecular biology and its relevance to individual diseases. Two new chapters provide an increased emphasis on stereotactic radiosurgery (SRS) and stereotactic body irradiation (SBRT).New Associate Editor, Dr. Andrea Ng, offers her unique perspectives to the Lymphoma and Hematologic Malignancies section.Key Points are summarized at the beginning of each disease-site chapter, mirroring the template headings and highlighting essential information and outcomes.Treatment algorithms and techniques, together with discussions of controversies and problems, reflect the treatment approaches employed by the authors.Disease Site Overviews allow each section editor to give a unique perspective on important issues, while online updates to Disease Site chapters ensure your knowledge is current.Disease Site chapters feature updated information on disease management and outcomes.Thirty all-new anatomy drawings increase your visual understanding.Medicine eBook is accessible on a variety of devices.

This book is a comprehensive understanding of the evolution of pre-malignant disease, emphasizing common themes in the field, including stem cell biology and histologic modes of cancer progression between the distal esophagus and stomach. Its sixteen chapters discuss metaplastic tissue change in the upper GI, clonalexpansion of early neoplasia, stem cell dynamics in experimental models, pathology of early esophageal squamous cell carcinoma, therapeutic modalities for esophageal squamous cell carcinoma, pathology of Barrett's esophagus, screening, early detection and novel diagnostic tools for Barrett's esophagus, clonal evolution of Barrett's esophagus, endoscopic therapeutic modalities of early esophageal cancer, pathology of early gastric cancer, and experimental models for gastric cancer. Stem Cells, Pre-neoplasia and Early Cancer of the Upper Gastrointestinal Tract is an integrative text on both the current state of translational research on every cancer development of the upper gastrointestinal tract as well as on novel clinical diagnostic and therapeutic modalities. It highlights a rapidly growing field within cancer research and is essential reading for oncologists, biochemists and advanced graduate students alike. Springer's Advances in Experimental Medicine and Biology series presents multidisciplinary and dynamic findings in the broad fields of experimental medicine and biology. The wide variety in topics it presents offers readers multiple perspectives on a variety of disciplines including neuroscience, microbiology, immunology, biochemistry, biomedical engineering and cancer research.

This second volume of the handbook on breast disease provides a comprehensive overview of its clinical management and current therapies. It brings readers up to speed with the latest guidelines and therapeutic regimens in breast cancer and provides and in-depth account of current and new therapeutic approaches. Divided in themed parts, the book examines invasive breast cancer, pre-operative systemic therapy surgical management and recurrence among others, thus providing an in-depth account of breast cancer at the clinical stage. Among the themed parts are a section dedicated to special therapeutic problems, such as breast cancer in older women, Paget's disease and phyllodes tumors, and a section on supportive and follow-up care. By adopting a multidisciplinary approach to breast cancer, this book is a must- have for breast cancer practitioners. With a high number of colored illustrations and edited by highly experienced clinicians, this work enables readers to gain aninterdisciplinary perspective on breast diseases. Contributions from an international team of experts present invaluable insight into clinical practice across different settings. Covering both theoretical and practical aspects of breast cancer, this is a highly informative and carefully presented book which will appeal to an international audience of medical, radiation and surgical oncologists.

Written and edited by internationally recognised leaders in the field, the new edition of the Oxford Textbook of Oncology has been fully revised and updated, taking into consideration the advancements in each of the major therapeutic areas, and representing the multidisciplinary management of cancer. Structured in six sections, the book provides an accessible scientific basis to the key topics of oncology, examining how cancer cells grow and function, as well as discussing the aetiology of cancer, and the general principles governing modern approaches to oncology treatment. The book examines the challenges presented by the treatment of cancer on a larger scale within population groups, and the importance of recognising and supporting the needs of individual patients, both during and after treatment. A series of disease-oriented, case-based chapters, ranging from acute leukaemia to colon cancer, highlight the various approaches available for managing the cancer patient, including the translational application of cancer science in order to personalise treatment. The advice imparted in these cases has relevance worldwide, and reflects a modern approach to cancer care. The Oxford Textbook of Oncology provides a comprehensive account of the multiple aspects of best practice in the discipline, making it an indispensable resource for oncologists of all grades and subspecialty interests.

Selected from the world's leading comprehensive cancer textbook, this tightly focused resource provides you with the practical, cutting-edge information you need to provide the best cancer care to each patient. Colon and Other Gastrointestinal Cancers: Cancer: Principles & Practice of Oncology, 10th Edition, offers a comprehensive and balanced view of this rapidly changing field, meeting the needs of oncology practitioners, fellows, and others who need an in-depth understanding of colon and GI cancer. The print reference gives you the solid, dependable guidance you've come to expect from this outstanding title, and the Inkling version features new quarterly updates written by a team of experts selected by the authors.