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This book provides a comprehensive review of current knowledge on the pathophysiology, diagnostic techniques, and therapeutic strategies for salivary gland disorders. It highlights new evidence-based developments that are widely supported in the literature. In 28 chapters, the volume addresses a wide range of topics, including embryological development and anomalies, histology, surgical anatomy, and applied physiology of the salivary glands. Parotid gland topics include assessment and evaluation, traumatic injuries and fistulae, calculi, sialadenosis (sialosis), sialadenitis, cysts, tumors of the parotid gland, various techniques and potential complications of parotidectomy, including Frey's syndrome, and extra-temporal facial nerve reconstruction procedures. Likewise, topics of the submandibular gland cover evaluation, sialolithiasis, inflammatory disorders, sialadenosis, tumors, and different techniques and complications of submandibular sialadenectomy. In addition, two chapters discuss surgery of the sublingual gland and minor salivary glands. The book is structured to facilitate quick reference and to serve as a practical manual for clinicians of many specialties who treat patients with salivary gland disorders. Head and neck surgeons, maxillofacial surgeons, endocrinologists, oncologists, pediatricians, and clinicians from other specialties will find this book to be a useful and indispensable resource as they face the most challenging salivary gland disorders, helping to provide individual patients with the best possible outcomes.

The book provides a comprehensive overview of the challenges and debates on the diagnosis and treatment of midline neck swellings to clarify some uncertainties, make suggestions for resolving others, and establish strategies for achieving therapeutic success. In addition to information on the surgical anatomy of the neck with particular emphasis on midline cervical regions, and the classification and clinical approach for diagnosis and management of neck swellings, the chapters explore cervical lymphadenopathy, swellings of the submental region, swellings of the hyoid bone region, swellings of the laryngeal/pharyngeal region, swellings of the tracheal region, and swellings of the supra-space of Burns. The last chapter emphasizes the importance of scheduling regular follow-ups as well as patient counselling and education.The volume, enriched with color images and flowcharts, will be a key resource for head and neck surgeons, maxillofacial surgeons, orthopedic surgeons,endocrinologists, oncologists, pediatricians, and clinicians of other specialties as they face the most challenging midline neck swellings and work towards providing each patient with the best possible outcome.

This easy-to-use pocket book covers all aspects of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA), a preferred diagnostic procedure for many pulmonary and mediastinal conditions. Chapters include topics ranging from anatomy and lymph node stations to detailed insights on endobronchial ultrasound instrumentation. The book discusses the indications and contraindications of EBUS, patient preparation, the technical aspect of scope insertion into airways, manipulation and sampling, and complications. Additionally, it provides the latest EBUS-related guidelines and serves as a handy clinical reference for practitioners. The book is relevant for postgraduate students of general and pulmonary medicine, thoracic surgeons, radiologists, nurses, EBUS technicians, and practitioners alike performing EBUS-TBNA.

In the vast landscape of medical literature, we now have a groundbreaking book that unveils the intricate details of our body's inner workings. In Vivo Microscopy takes readers on a captivating journey through the microscopic realms of organs and systems, offering unprecedented insights into the new technologies that allow the visualization of tissues at a cellular level.Authored by leading experts in the field, this comprehensive guide delves into the cellular mechanisms of various organs, shedding light on the microscopic events underpinning the full spectrum of disease processes, especially inflammatory conditions and cancer. In vivo microscopy allows the visualization of living tissues in real-time. This allows us to explore the dynamic interaction of cells and their microenvironment, providing a profound understanding of the manifestations of each of these conditions.In Vivo Microscopy not only educates but also inspires. Its rich visuals, coupled with compelling narratives, make it an enthralling read for anyone with an interest in the microanatomy of the human body and the novel technologies the book details. It also serves as a valuable resource for healthcare professionals seeking to deepen their understanding of the pathologic basis of disease, as well as for researchers aiming to uncover novel therapeutic targets.As we continue to unravel the complexities of our body, this book serves as a guiding light, encouraging us to investigate the microscopic universe within and paving the way for advancements in the diagnosis, treatment, and prevention of disease.

This book provides comprehensive and practical guidance for the management of esophageal cancer. It presents a detailed review of the pathophysiology, clinical staging, treatment, and outcomes of patients with esophageal cancer. Chapters cover the epidemiology of the disease, latest diagnostic and staging tools, systemic therapies, and the current open and minimally invasive surgical techniques including transhiatal, Ivor Lewis and McKeown esophagectomy. Esophageal Cancer: Diagnosis and Treatment compiles experience gained across a variety of medical disciplines, with contributions from world renowned surgeons, gastroenterologists, and medical oncologists. Thanks to its multidisciplinary authorship, this book represents a unique resource for anybody who takes care of patients with esophageal cancer.

This book provides a comprehensive yet succinct update for the clinician in the diagnosis, staging, and treatment of lung cancer. Lung cancer is a leading cause of death in the US and worldwide and its prevention, screening, and treatment is a large part of clinical practice across specialties. Frequent updates in recommendations and guidelines in screening, diagnosis, staging, treatment, and management are vital, and it can be difficult for the busy clinician to stay up to date. This book provides a comprehensive update for the chest clinician across the continuum of lung cancer care. Each of the thirteen chapters covers a specific component of lung cancer care and is written by experts in the field who are practicing clinicians. The objectives are to provide an organized and easily-referenced resource for the chest clinician; to provide comprehensive evidence-based information on the following topics: lung cancer screening and prevention, approach to lung nodules, diagnosis and staging of lung cancer, treatment of lung cancer, pleural disease in lung cancer, and treatment complications; and to provide source information for clinicians so they can stay up-to-date on any new guidelines or recommendations related to lung cancer screening, tobacco treatment, staging, and diagnosis. This book is written specifically for the busy clinician that focuses on clinically relevant and evidence-based principles around lung cancer while providing references for ease of finding source information to enable clinicians to stay updated as guidelines change. This is an ideal guide for practicing pulmonary clinicians, practicing general practice clinicians, trainees in chest and general medicine, as well as some advanced practice providers who need a refresher.

This book is a case-based resource detailing the latest diagnostic and management strategies applicable to a number of carefully selected situations in clinical gynecological oncology. It emphasizes the importance of a holistic approach to tackling difficult and unique clinical presentations. Each chapter presents a specific pathology and features descriptions of clinical scenarios and presentations that are both commonly and rarely encountered. Techniques and strategies for ovarian, cervical and endometrial cancer are discussed in accordance with the latest evidence-based knowledge on the topic. Relevant'tips and tricks'are identified in each chapter to assist the reader in developing a thorough understanding of the topics discussed and enhance their decision making skills.Case-Based Gynecological Oncology is a practical guide to clinical presentations of a range of conditions encountered in the field, making it a valuable resource for all clinicians who encounter these patients in their day-to-day practice.

This textbook includes 70 chapters contributed by an exceptional group of experts in all areas of hepato-pancreato-biliary diseases, bringing a multi-disciplinary approach to treatments. The book is designed to cover all aspects of the liver and pancreatic anatomy and pathology, as well as therapy. The topics are comprehensively reviewed, and as well as summarizing the previous works, the authors provide discussions of practice-changing techniques and approaches to therapy of HBP cancers. Treating the diseases in hepato-pancreato-biliary regions is particularly difficult due to the complex anatomy, aggressive biological behavior, and poor prognosis. Therefore, ample illustrations are included to tackle these challenges.The IASGO Textbook of Multi-Disciplinary Management of Hepato-Pancreato-Biliary Diseases aims to update the academic and non-academic medical professionals, such as surgeons, radiation oncologists, medical oncologists, gastroenterologists, interventional radiologists, radiologists, basic scientists. In collaboration with the International Association of Surgeons, Gastroenterologists and Oncologists (IASGO), delivers a valuable and well-organized textbook for medical professionals.

This book is a comprehensive reference work on the multidisciplinary team (MDT) management of colorectal cancer (CRC) patients that will meet the needs of all members of CRC MDTs and those training in the field. Important, up-to-date knowledge is provided on organization of MDTs, early intervention, surgery, oncology, imaging, pathology, and palliation, with special focus on controversies. This second edition has been thoroughly revised. It includes an entirely new section on the principles of treatment of significant polyps and early cancers and a total of 14 new chapters, including one on the early integration of palliative care. Every effort has been made to ensure that each specialty-specific chapter will be approachable for all team members, thereby facilitating an effective interdisciplinary approach to teamwork. The authors are leading European doctors and scientists who have influenced the development of the MDT concept as well as other aspects of individualized treatment ofCRC patients.

This textbook combines essential information on clinical cancer medicine with a guide to the latest advances in molecular oncology and tumor biology. Providing a systematic overview of all types of solid tumors, including epidemiology and cancer prevention, genetic aspects of hereditary cancers, differential diagnosis, typical signs and symptoms, diagnostic strategies and staging, and treatment modalities, it also discusses new and innovative cancer treatments, particularly targeted therapy and immunotherapy. Expert commentaries at the end of each chapter highlight key points, offer insights, suggest further reading and discuss clinical application using case descriptions. This textbook is an invaluable, practice-oriented tool for medical students just beginning their clinical oncology studies, as well as for medical oncology residents and young professionals.

This book provides a comprehensive and up-to-date overview of current endoscopic ultrasound use in all aspects of pancreatology, from diagnosis to therapy, i.e., from tissue acquisition, with standard fine-needle aspiration and the newer biopsy needles, to less invasive techniques such as contrast-enhanced ultrasound and elastography. It also covers novel therapeutic strategies, with a particular focus on ablative treatments and lumen-apposing stents, and describes techniques developed by the editors, in particular combined celiac plexus neurolysis with pancreatic tumor ethanol ablation and elastography-guided fine-needle aspiration. All topics are developed by pursuing an evidence-based approach and several recent meta-analyses, the majority of which were published by the authors. Due to several recent advances in the field, endoscopic ultrasound has taken on a pivotal role in the diagnosis, staging, and treatment of pancreatic lesions; as such, the present volume offers an invaluable tool for staying abreast of the state-of-the-art in this field.

This comprehensive book presents the latest evidence-based data on pancreatobiliary malignancies, including the epidemiology, examination, treatment and endoscopic management. It explores a range of topics, such as risk factors, detection strategies, and novel treatment approaches like precision medicine and immunotherapy.Although there have been rapid improvements in the management of these diseases, the survival period has not yet reached a satisfactory level. This book will help those doctors needing to share the latest information with the patients and their families. It provides a wealth of practical information to help surgeons, endoscopists and oncologists as well as physicians, basic researchers and professionals at medical device and pharmaceutical companies broaden their understanding of the current treatment and management strategies for pancreatobiliary malignancies.

This book provides a comprehensive, state-of-the-art overview of cholangiocarcinoma (CCA). The text is structured to effectively present a broad yet concise overview of bile duct cancer, its relevant definitions, classification schemata, clinical management tenets, translational (including molecular and cellular) facets, and future directions. The book features numerous high-yield illustrations and is authored by an eclectic range of renowned experts in various areas of CCA, reflecting the multidisciplinary nature of the field.Filling a critical gap in the field, Diagnosis and Management of Cholangiocarcinoma: A Multidisciplinary Approach is a valuable resource for clinicians and practitioners who treat patients with bile duct cancer.

This book provides a comprehensive, state-of-the-art overview of imaging modalities used in the diagnosis, staging, and management of pancreatic cancer. In addition to profiling the most commonly-used imaging modalities for pancreatic cancer, the text reviews recent advances in endoscopic ultrasound, staging characteristics utilized in determining appropriate treatment options, and reviews the role of imaging in pancreatic cancer screening in specialized patient populations. The book also spotlights the use of radiation therapy for pancreatic cancer in patients who cannot have surgery, as well as when fiducial marker placement should be considered in targeting a malignancy. Written by experts in the field, Imaging Diagnostics in Pancreatic Cancer: A Clinical Guide is a valuable resource for gastroenterologists, surgeons, oncologists, radiologists, and other practitioners who manage patients with pancreatic cancer.

Endoscopy in Early Gastrointestinal Cancers, Volume 2: Treatment covers the detailed information of the indications, techniques and perioperative management of endoscopic resection including endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD). Carcinoma of the gastrointestinal tract remained a major health issue worldwide, which is, however notoriously difficult to treat. Endoscopic resection for early neoplasia of the gastrointestinal tract had been developed for more than 25 years. Endoscopic submucosal dissection (ESD) is a recently developed technique pioneer by Japanese endoscopists. The principle of ESD is to achieve a complete resection of gastrointestinal neoplasia limited to mucosa with adequate circumferential margins. This novel endoscopic technique not only allows the achievement of en-bloc resection for early GI cancers, it also conveys a significantly lower rate of local recurrence as compared to EMR for early gastric cancers. There isan urge for the knowledge in applying these novel technologies for the treatment of early GI neoplasia worldwide. This book on the endoscopic treatment of early GI neoplasia, containing lots of illustrations, artwork and numerous short video clips, serves as a bridge between the recent development in endoscopy and the knowledge of gastroenterologist, endoscopist and surgeons.

Endoscopy in Early Gastrointestinal Cancers, Volume 1: Diagnosis provides detailed information of the technique of novel endoscopic diagnostic tools including magnifying endoscopy, narrow band imaging system (NBI), autofluorescence endoscopy (AFI), endocytoscopy, FICE and confocal endomicroscopy. Carcinoma of the gastrointestinal tract remained a major health issue worldwide, which is, however notoriously difficult to treat. One of the major reasons for such a poor result is that these cancers are diagnosed at advanced stage. There is a recent increase in the number of gastrointestinal cancers diagnosed at early stage. This is attributed to an increasing recognition of these early stage cancers through a recent development in the technology of endoscopy. This book on the endoscopic diagnosis of early GI neoplasia, containing lots of illustrations, artwork and numerous short video clips, serves as a bridge between the recent development in endoscopy and the knowledge of gastroenterologist, endoscopist and surgeons.

This thoroughly revised and extended second edition of the book clearly explains the nature of colon polyps and their relationship to colorectal cancer in light of new developments. It discusses in detail new topics, including polyp development, risk factors and prevention measures, and also describes surgical, medical oncology and radiotherapy treatments of colon cancer. In cases of advanced colon cancer, it clearly demonstrates how to perform surgical interventions in the presence of urinary tract metastases and gynecologic organ metastases. The book also includes chapters on medical treatment and radiotherapy in distant metastases of colorectal cancer. Further, it presents resection of liver metastases and transplantation options. Carefully examining the risk factors, and the treatment of colon cancer from the early to the advanced stages, the book is invaluable not only for medical specialists and students, but also for general readers and patients.

This textbook provides a practically applicable resource for understanding the surgical oncology management of pancreatic cancer. It discusses relevant aspects of anatomy and pathophysiology along with the latest diagnostic techniques. Insightful descriptions are then provided detailing how to perform critical surgical procedures when treating these patients. Relevant perioperative management strategies and emerging themes in cancer biology critical to understanding and treating the disease are also described. The need for cross-discipline collaboration to facilitate and enhance innovation within the discipline is reinforced throughout the text. Each chapter presents the relevant current clinical standards along with areas of controversy in both research and clinical practice within “pearls and pitfalls” sections. Textbook of Pancreatic Cancer: Principles and Practice of Surgical Oncology is a detailed work covering the basic material important to trainees as well as advanced curriculum for established specialists in the field from a multi-disciplinary perspective. Therefore, it is crucial resource for all practicing and trainee professionals who encounter these patients in their day-to-day clinical practice.

​This book incorporates a multi-disciplinary approach to present how research results can be translated into clinical trials. The first part begins with a chapter on variants of pancreatic cancer, precursor lesions and groups of people at risk to developing the disease. There is a particular focus on intraductal papillary mucinous neoplasia as a large-scale clinical challenge in pancreatology. The next two parts focus on diagnosis, biomarkers and stratification that emphasize how various approaches to biomarker development are important as both prognostic and predictive tools. The final part consists of personalized treatment approaches that include preclinical models of pancreatic cancer and stromal, epigenetic and metabolism targeting as promising approaches to be translated into early phase clinical trials. Chapters within this part also deal with approaches that are close to being implemented in clinical practice or are already being tested in (early) clinical trials, such asthose that targeting the immune systems and strategies to overcome immunotherapy resistance; phase 1 clinical trials and translational approaches in surgical treatment. Written by experts in their fields, Translational Pancreatic Cancer Research provides an outlook towards future directions by integrating information both from basic and clinical research and though demonstrating pathways to better understanding pancreatic cancer and current approaches to translating these into clinical practice.

First published in 1989, this easy, quick reference details the ongoing clinical trials, their rationale and some early results in surgical oncology. Each chapter covers a major tumor site from epidemiology, etiology, screening, diagnostic methods, prognosis, staging, the various therapeutic approaches for each disease, and the follow up of the patients. The surgical options available in the management of cancer patients, the preoperative decisions and preparations, operative and postoperative management, the value of adjuvant therapy, chemotherapy, hormonal manipulation, and immunotherapy in the primary management of each disease are presented. The palliative management by various disciplinary approaches is also discussed. In addition, the book details the management of some hematologic disorders. All medical disciplines involved in the care of cancer patients will find this a valuable publication.

This book provides an up-to-date and comprehensive primer on image-guided interventions for cancer. Image-guided interventional oncology is gaining popularity as it is a minimally invasive and more precisely targeted approach that both proves more effective and results in fewer side effects. This book's aim is to provide a clinical guide to interventional oncology for the entire oncology team. Chapters are approached with the same interdisciplinary perspective that is used in the care itself, with each chapter written by an interventional radiologist with contributions from medical, surgical and/or radiation oncologists. Chapters cover the major cancers that can benefit from interventional oncology treatment (including lung, liver, kidney, and bone), as well as some of the physics and physiology behind these interventional modalities. This is an ideal guide for interventional radiologists, medical oncologists, surgical oncologists, radiation oncologists, as well as relevant trainees.

This comprehensive, ground-breaking title presents, in simplifying style, the driving and organizing principles of cancer, making this multidimensional, highly complex disease easily understandable for readers. Developed out of the renowned author's many years of teaching a widely popular, several-hundred-student college course, this 12-chapter book begins with an account of the history of cancer as a medical and public health problem, as well as the major milestones and setbacks in the ongoing quest to understand the wide variety of cancers that continue to impact the world. Subsequent chapters then address pathogenesis, incidence and mortality statistics, risk factors, causal factors, screening challenges and victories, treatment strategies, and disease prevention approaches. This wealth of clinical information is further supplemented with socioeconomic discussions on the financial, social, ethical, technological, regulatory, political, and logistical challenges thatlimit progress in cancer research. A soon to be gold-standard text that thoroughly and expertly describes cancer as a composite, adaptive system, Cancer: The Enemy from Within equips and empowers all undergraduate students and graduate students to better understand this continually perplexing disease. Clinicians across all disciplines may also find this work of great interest.

The second edition of this very successful book documents the latest progress in the prevention, diagnosis and treatment of esophageal cancer and includes additional sections covering novel targeted therapeutic approaches, immunotherapy and palliative and nutritional support for patients. Furthermore, the sections covering epidemiology, molecular biology, pathology, staging and radiologic and endoscopic assessments have been thoroughly updated and expanded. The principles of surgical resection, radiation therapy and systemic therapy are reviewed and attention is paid to the multidisciplinary approaches to the management of early stage cervical, thoracic, distal and junctional tumors. Updated information is also provided on the treatment of metastatic and recurrent disease as well as approaches that may impact future care, such as chemoprevention. Esophageal Cancer: Prevention, Diagnosis and Therapy will assist specialists from various disciplines, including surgery,radiation therapy, gastroenterology, medical oncology and palliative medicine, in delivering optimal, up-to-date care to the benefit of patients.

This third edition manual provides a comprehensive, insightful, evidenced-based review of general surgical oncology and serves as a valuable resource for general surgeons in training, practicing general surgeons, and surgical oncologists. The volume describes a multidisciplinary approach that integrates clinical, radiologic, and pathologic data in formulating practical clinical management, and offers a practical approach to the most common situations when treating cancer patients. Each chapter focuses on an individual malignancy and describes the presentation of the malignancy, integrated management based on stage, landmark trials, and suggestions for who to discuss at multidisciplinary cancer conferences. Multiple tables in each chapter provide a concise yet comprehensive summary of the current status of the field. Clinical “pearls” or tips and tricks from high volume surgeons at the University of Toronto are also discussed. The third edition of the Surgical Oncology Manual will serve as a critical resource for general surgeons in training and practicing surgeons dealing with this challenging field.

Handbook of Gastrointestinal Cancers is a practical guide to the management of colorectal, pancreatic, hepatocellular, gastric, and esophageal cancers as well as other cancers of the upper and lower gastrointestinal tract. Edited by a multidisciplinary group of oncologists from leading institutions, this book is an essential day-to-day reference for evidence-based treatment and patient care. The handbook focuses on treatment strategies and approaches to cancerous gastrointestinal tumors that are transforming the recent oncological landscape, including expert-given guidance on methods such as neoadjuvant and adjuvant chemotherapy, surgical transplant, radiation therapy, molecular diagnostic testing leading to molecularly targeted therapy, and immunotherapy.With so many advances in the current field, it is increasingly difficult for early-career practitioners to grasp the entirety of practices and for seasoned oncologists to keep up with newly approved therapies, side effects to treatments, and special clinical management considerations, but this handbook addresses it all. Organized by major gastrointestinal disease sites and featuring “How I Treat” case vignettes from world experts for common and uncommon management considerations, the handbook brings an experience-based perspective to these tough-to-treat areas. The treatment strategies and applications set forth in the chapters are pertinent to situations and decision-making encountered in practice. Handbook of Gastrointestinal Cancers is a valuable resource for medical oncologists, radiation oncologists, and surgeons treating and managing gastrointestinal cancers as well as trainees in medical, radiation, and surgical oncology programs needing an accessible point of care resource.KEY FEATURES:Provides treatment plans and recommendations for each stage of a range of gastrointestinal cancers, including colorectal, pancreatic, and hepatocellular cancers plus moreIncludes “How I Treat” patient vignettes told from the physician's point of view within each clinical chapterOutlines special considerations for the elderly and for survivors of gastrointestinal cancersHighlights important clinical guidance on nutritional and palliative concerns commonly seen in patients with gastrointestinal cancers

This book presents various cases of upper GI tract neoplasms, discussing endoscopic diagnostic procedures and treatment strategies, such as white light endoscopy (WLE), magnified endoscopy with narrow band imaging (NBI) and endoscopic ultrasonography (EUS). Focusing on the esophagus, stomach and duodenum, it provides user-friendly, practical information on these innovative approaches, and explores treatments, pathological insights, including target biopsy, and therapies for specific cases. Endoscopic Treatment Strategy for Upper GI Tract Neoplasms appeals to a wide readership, from trainees to experienced gastroenterologists. It presents research evidence to broaden readers'understanding and enable them to optimize outcomes for patients.

This major reference work is the most comprehensive resource on oncologic critical care. The text reviews all significant aspects of oncologic ICU practices, with a particular focus on challenges encountered in the diagnosis and management of the critically ill cancer patient population. Comprised of over 140 chapters, the text explores such topics as the organization and management of an oncologic ICU, diseases and complications encountered in the oncologic ICU, multidisciplinary care, surgical care, transfusion medicine, special patient populations, critical care procedures, ethics, pain management, and palliative care. Written by worldwide experts in the field, Oncologic Critical Care is a valuable resource for intensivists, advance practice providers, nurses, and other healthcare providers, that will help close significant knowledge and educational gaps within the realm of medical care for critically ill cancer patients.

Cancer is a very aggressive disease and currently it has been considered a challenge to oncologists and cancer patients worldwide. Nowadays, several therapeutic strategies had improved toward last decades. Surgery is many times still the best curative treatment, mainly in early stage disease. However, Radiotherapy and chemotherapy acquired a main role in this scenario. Target therapies were introduced for medical oncology practice and are demonstrating a hallmark of a new era in cancer treatment. More recently, immunotherapy has been considered the novel cornerstone in cancer treatment. The 2nd edition of the International Manual of Oncology Practice (iMOP) emerged after the great success of the iMOP 1st edition as a reference for medical oncologists and medical residents in the field. In this edition, several chapters were revised and its addresses from the molecular issues of cancer sciences to the clinical practice in medical oncology. In addition, multiplechoice questions and clinical cases were included in the main chapters in order to improve the reader learning. The book focuses systemic treatments in many areas of medical oncology, such as breast cancer, gastrointestinal, thoracic, urological oncology, head and neck tumors, bone tumors, sarcomas and palliative care. The topics herein discussed will provide the readers a step forward in the medical oncology practice understanding and give facilities for help in cancer patient treatments.

Durch die rasante Entwicklung bildgebender Verfahren in der Pneumologie und der Möglichkeit einer sehr sensitiven Gewinnung zytologischen Untersuchungsmaterials, hat sich die qualitative wie quantitative Anforderung an zytologische Untersuchungen weltweit erhöht. Dieses Buch ermöglicht sehr praxisorientiert die zytologischen Befundung aller relevanten Erkrankungen des Lungen-und Bronchialsystems, einschließlich thorakaler Lymphknoten, Pleura und Mediastinum. Diagnostische Kriterien sind kompakt in Tabellenform zusammengestellt und in den meisten Fällen durch eine oder mehrere Abbildungen belegt. Diese Darstellung erleichtert dem Kliniker das Verständnis für die Pathogenese und die Gewichtung eines klinischen Befundes.

This text presents comprehensive review of the recommendations of the Papanicolaou Society of Cytopathology for reporting results of respiratory cytology specimens along with advances in diagnostic, prognostic, and predictive immunohistochemical and molecular techniques which can be performed on cytology specimens.The majority of the text focuses on the standardized terminology and nomenclature for respiratory cytology as recommended by the Papanicolaou Society of Cytopathology. Each of the diagnostic categories are described in depth and formal definitions for each category are given along with cytologic criteria. Explanatory notes are given discussing limitations of the category as well as its malignancy risk and reproducibility. Management recommendations are supplied for each category. Sample reports documenting the preferred reporting format are also given. Each category is associated with a reference list establishing the evidence based nature of the categories.An in depth discussion of ancillary testing is provided, including the utilization of microbiologic culture, immunohistochemistry, and molecular techniques. Substantial emphasis is placed on molecular diagnostics necessary for optimization of personalized testing and the appropriate use of targeted therapies. The text represents a comprehensive resource for the state of the science of the cytologic diagnosis of respiratory lesions.

Colorectal Surgery has continued to experience tremendous growth in both the community and academic settings over the past few years. The recent increase in demand for colorectal specialists has been fueled by an overwhelming number of applications to fellowship training programs, resulting in some of the most coveted and competitive positions. Furthermore, the accumulation of experience, knowledge, and wisdom from pioneers in the field, combined with major recent technological advances, has transformed the clinical management of diseases of the colon and rectum. Colorectal Surgeons have embraced advances ranging from minimally invasive approaches for complex problems to novel training methods for future generations. Additionally, we have spearheaded innovations in the management of colorectal cancer, pelvic floor disorders, diverticulitis, inflammatory bowel disease, and anorectal conditions. Despite these improvements, there remains a seemingly never-ending mixture of complex patient disease processes and complications resulting from the care of these patients. Even in cases where the technical challenges were managed successfully, complications or poor function may result in dramatic life-long consequences, reduced quality of life, as well as having economic implications. The American Society of Colon and Rectal Surgeons (ASCRS) is the premiere professional organization of Colon and Rectal Surgeons. Three editions of the ASCRS Textbook of Colon and Rectal Surgery have been published and have proved to be extremely valuable for their wealth of general information and knowledge, providing not only background information, but also specifics regarding the more complex situations that surgeons who treat patients with colorectal disease experience on a regular basis. An ASCRS manual was produced in in 2009 and 2014, each accompanying their original textbooks. This has been formed by abstracting the textbook into a bullet format;all figures and most tables were retained. The 3rd edition of the Textbook (published by Springer) included completely new chapters and authors. This 3rd edition of the Manual is indicated to conform to the new edition of the Textbook and incorporate newer information in the field of colon and rectal surgery. This Manual will serve as a very useful resource for physicians and researchers dealing with diseases of the colon and rectum. It will provide a concise yet comprehensive summary of the current status of the field that will help guide education, patient management and stimulate investigative efforts. All chapters were written and abstracted by experts in their fields and will include the most up to date scientific and clinical information.

This book focuses on Barrett's Esophagus (BE), a clinical condition that must be evaluated in all patients affected by chronic GERD, and with an important link to esophageal cancer. Divided into four sections (morphological background, epidemiology and natural history, diagnosis, and treatments), this handy volume provides the latest indications regarding endoscopic approaches (first level and advanced endoscopy), pathological studies (pathology and molecular biology), and state-of-the-art therapeutic options (medical, endoscopic, and surgical) for BE. As such, it offers a valuable reference guide for all professionals involved in the management of BE (gastroenterologists, endoscopists, pathologists and surgeons), offering them a comprehensive overview and deeper understanding of this seemingly superficial disease.

This text provides a comprehensive, state-of-the art review of this field, and will serve as a valuable resource for clinicians, pathologists and researchers with an interest in GVHD and its mimickers. The book reviews new data about risk factors affecting outcomes, pathologic features, and profiles the new WHO guidelines as well as current practices. The richly illustrated text covers the gamut of gross and histologic presentations of acute GVHD in skin, gut, liver, and additional organs affected by chronic GVHD. An engaging aspect of this book is the format of patient based cases as the focus for the major chapters teaching points. The case presentations include both infectious and toxic complications that mimic GVHD, or displaying similar morphologies. Recent up to date references on clinical investigations and pathogenesis make the reading and teaching resonant with the readers. Pathology of Graft vs. Host Disease will serve as a very useful resource for physicians and researchers dealing with, and interested in, this challenging disease. It provides a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts. All chapters were written by experienced transplant physicians with expertise in their fields.

This book provides essential insights into the various pathogeneses, diagnoses and therapies for patients with gastric cancer. Special attention is given to trending topics: endoscopic diagnosis, cancer screening and eradication of H. pylori as prevention of the disease. A dedicated section focuses on risk classification and cancer screening/diagnosis, and is intended for practical use in clinical doctors'day-to-day management of patients. Since cancer screening and prevention is currently only practiced in Japan, this book is intended to disseminate new findings and serve as a point of departure for further research. Abundant color illustrations of the enhanced endoscopic imaging are also included, making it a valuable resource for GI medical doctors, medical students and those seeking detailed information on H. pylori.​

This book provides a comprehensive, state-of-the art review of current and new therapies in treating pancreatic cancer. In addition to discussing the current landscape for treating various stages of pancreatic cancer, the text highlights several standard and emerging approaches, with a particular emphasis on novel endoscopic, surgical, chemotherapeutic, radiotherapeutic, targeted, and immunotherapeutic strategies. The volume also features concepts on the potential economic effects associated with the development and implementation of new treatments in pancreatic cancer. Written by experts from a variety of integrative disciplines, Current and Emerging Therapies in Pancreatic Cancer is a valuable resource for oncologists, gastroenterologists, surgeons, and other professionals who treat and manage patients with pancreatic cancer.

This book offers a comprehensive yet concise overview of immunoprofile of tumors and antibodies used in contemporary surgical pathology, and provides diagnostic algorithms for approaching tumor diagnostics.Immunohistochemistry has become the most important ancillary technique in diagnostic pathology in the last 20 years, and unlike most books on tumor diagnostics, this volume discusses in details immunohistochemical biomarkers, diagnostic approaches and their pitfalls, as well as the immunoprofile of common tumors throughout all systems of human body. With numerous color figures and detailed flowcharts, it appeals to all pathologists be they young residents in training who want a brief introduction to this technique, or specialists in need of a reliable and comprehensive reference resource in tumors diagnostics.

This book introduces oncoplastic surgery as an interdisciplinary branch of oncological surgery that integrates theories and technologies in oncological surgery, plastic surgery and microsurgery with characteristics of planned radical resection of tumors and one-stage repair and reconstruction of surgical defects on the basis of multidisciplinary treatment (MDT) of tumors. Consisting of 23 chapters, the book covers a range of surgical topics related to oncoplastic surgery in clinical disciplines, with a focus on oncology surgery, plastic surgery, microsurgery, vascular surgery, otolaryngology-head and neck surgery, neurosurgery, oral and maxillofacial surgery, breast surgery, urinary surgery, gynecologic oncology, bone surgery, thoracic surgery and abdominal surgery. In most of the surgical cases oncology surgery is combined with plastic surgery. The book summarizes the basic theories and clinical experiences in oncoplastic surgery, focusing on repair and aesthetic reconstruction after tumor removal, which increases patients'survival rate and significantly improves their quality of life. It is a valuable reference resource for tumor surgeons, plastic surgeons, head and neck surgeons, breast surgeons as well as surgeons in other relevant fields.

This book presents state of the art knowledge and guidance on the use of therapeutic colonoscopy for all of the usual indications, including hemostasis for colorectal bleeding, resection of benign and malignant lesions, and decompression and recanalization of obstructed bowel. Technical aspects are covered in detail, with advice on indications and instrumentation and provision of tips and tricks of proven practical value. With respect to polypectomy, separate chapters focus on technique for pedunculated polyps and the choice between endoscopic piecemeal mucosal resection and endoscopic submucosal dissection for large sessile polyps. The closing chapter looks to the future of therapeutic colonoscopy. The clearly written text is supported by numerous helpful illustrations. Over the years, technological developments have markedly increased the therapeutic, as opposed to the diagnostic, role of endoscopy. This book will be an invaluable aid in clinical practice for all who are involved inthe performance of therapeutic colonoscopy.

Global experts, in conjunction with the International Association for the Study of Lung Cancer, bring you up to date with today's best approaches to lung cancer diagnosis, treatment, and follow-up. IASLC Thoracic Oncology, 2nd Edition, keeps you abreast of the entire scope of this fast-changing field, from epidemiology to diagnosis to treatment to advocacy. Written in a straightforward, practical style for the busy clinician, this comprehensive, multidisciplinary title is a must-have for anyone involved in the care of patients with lung cancer and other thoracic malignancies. - Offers practical, relevant coverage of basic science, epidemiology, pulmonology, medical and radiation oncology, surgery, pathology, palliative care, nursing, and advocacy. - Provides authoritative guidance from the IASLC – the only global organization dedicated to the study of lung cancer. - Includes new content on molecular testing, immunotherapy, early detection, staging and the IASLC staging system, surgical resection for stage I and stage II lung cancer, and stem cells in lung cancer. - Features a new full-color design throughout, as well as updated diagnostic algorithms. - Expert Consult™ eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, Q&As, and references from the book on a variety of devices.

Pancreatic cancer is a very aggressive carcinoma with a poor prognosis. From all options currently available for pancreatic cancer patients, surgical resection offers the only potential for a cure. The high mortality rate of pancreatic cancer is related to the advanced stage of disease at the time of diagnosis. However, it is extraordinarily difficult to make an early diagnosis of pancreatic adenocarcinoma based on clinical signs and symptoms only. Due to the nonspecific characteristics of the early symptoms and their insidious nature, pancreatic cancer is often mistaken for other diseases. Moreover, the pancreas is a relatively inaccessible organ for physical examination. This book reviews important literature about pancreatic cancer. Chapter One of this book describes the etiology and pathology of pancreatic cancer. Chapter Two presents up-to-date possibilities in the diagnosis of pancreatic cancer. Chapter Three describes the surgical treatment of pancreatic cancer and postoperative surgical complications in detail. This chapter describes the standard and extended lymphadenectomy performed during radical pancreatic resection for pancreatic cancer. Chapter Four describes borderline pancreatic cancer and brings new knowledge concerning vascular reconstruction during radical surgical resection. Chapter Five discusses systemic therapy for patients with pancreatic cancer.

Developed by the American Cancer Society this new textbook designed for a wide range of learners and practitioners comprehensively addresses all aspects of clinical management for cancer taking a balanced, authoritative and, -where possible- evidence-based stance and may be used in conjunction with the book, The American Cancer Society's Principles of Oncology: Prevention to Survivorship. Edited by leading clinicians in the field and a stellar contributor list from the US and Europe, this book is written in an easy to understand style by multidisciplinary teams of medical oncologists, radiation oncologists and other specialists, reflecting day-to-day decision-making and clinical practice. Input from pathologists, surgeons, radiologists, and other specialists is included wherever relevant and comprehensive treatment guidelines are provided by expert contributors where there is no standard recognized treatment. This book is an ideal resource for anyone seeking a practical understanding of the field of oncology.

This book aims to equip the reader to make optimal decisions on the use of mechanical ventilatory support in critically ill cancer patients with acute respiratory failure (ARF) and to implement the different strategies effectively. Detailed information is provided on the rationale for invasive and non-invasive ventilation, the different modes of ventilation, indications and contraindications, prognostic factors, and outcomes. The role of postoperative mechanical ventilation following various forms of surgery is extensively addressed, and key aspects of withdrawal from ventilatory support are discussed. Attention is also devoted to mechanical ventilation in the palliative care context. The concluding part of the book focuses on healthcare resource utilization and organizational support in cancer critical care. ARF is the most common reason for hospital and intensive care admission among oncological patients, and there is growing evidence that outcome following mechanical ventilation isimproving. Readers will find this book to be an invaluable aid when selecting and executing a strategy for management of ARF in individual cancer patients.

This book provides a comprehensive and up-to-date overview of current polypectomy techniques and describes new perspectives in the field. A wide variety of topics are covered, including classification of colon polyps, established polypectomy techniques and related controversies, advanced endoscopic resection, endoscopic submucosal dissection, the use of submucosal injection solutions, management of complications, management of anticoagulant and antiplatelet medications, and post-polypectomy endoscopic surveillance. Information is also provided on a novel risk calculation score for adenoma recurrence after polypectomy, developed by the editors of the book and their colleagues. In acquainting readers with the state of the art in the field, Colon Polypectomy will serve as a valuable reference and practical tool for all who perform the procedure, which is of ever-increasing importance given the recent success of colon cancer screening campaigns in leading to earlier detection ofcolon polyps.

This book provides a unique and comprehensive overview of minimally invasive (MI) surgical options for the treatment of pancreatic diseases. The opening chapters present the state of the art of MI pancreatic resection according to the 2016 IHPBA Conference, offer information on the safe dissemination of MI pancreatic surgical techniques, and discuss preoperative evaluations protocols and surgical planning options. The book subsequently investigates the full range of currently available minimally invasive techniques, which includes: biliary and gastric bypass, ampullectomy, central and distal pancreatectomy, laparoscopic and robotic pancreatoduodenectomy, and robotic pancreas transplantation. Combining the acknowledged expertise of the Italian school in pancreatic surgery and the contributions of many leading international experts, the book offers a valuable guide for all surgeons who perform this complex surgery, as well as for residents and fellows-in-training.

This book is designed to present readers with comprehensive, high-quality research results on almost all aspects of this carcinoma in clinical management, from correct determination of the esophagogastric junction, issues on cardiac mucosa, epidemiology, and natural history, to clinical, endoscopic, and histopathologic features and diagnostic pitfalls of this carcinoma at both early and advanced stages. Once diagnosed and correctly staged, clinical management of this carcinoma at the early stage is addressed primarily with endoscopic therapy employing the latest endoscopic technology such as endoscopic submucosal dissection, in which detailed technical topics of the endoscopic therapy are written by experts in the field with sections from pre-resection staging and patient preparation to post-resection complications and management. Subsequently, clinical management of gastric cardiac carcinoma at advanced stages is discussed at length with a personalized, multidiscipline approach with strategies from surgical resections with various methods, to pre-, peri- and post-resection chemoradiation therapies as well as the most advanced immunotherapy. A state-of-art approach with the results of meta-analyses and large-scale randomized double-blinded clinical trials are employed throughout these chapters. For patients at the terminal ill stage, the appropriate palliative care plan is presented by experienced clinicians armed with the latest clinical practice guidelines to better manage and help those patients in the last period of their lives.

In organizing the second edition of this renowned Handbook, Dr. Neoptolemos and his co-editors have produced and updated a revised edition to the distinguished Major Reference Work devoted to pancreatic cancer. Like its preceding edition, the second edition continues to have a widespread appeal among clinicians, pathologists and basic scientists, who are now struggling to understand this complex and rapidly expanding field. Because of the recent and vast growth in both the clinical and scientific research being done in pancreatic cancer, (there is currently an unprecedented investment by academia and industry in this field), each research's knowledge of other specialty areas outside his or her own is often quite limited. The aim of the new edition is to place the tangible advances, including new developments in surgical approaches with regards to resection techniques, the state of laparoscopic approaches, the growing impact of surgical approaches in the management of recurrent pancreatic cancer, controversies in the management of IMPN as the precursor lesion for PDAC and others – readily at hand. The second edition focuses on advances that will not become dated, and the editors have chosen authors, who are the very best in each area.

Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. For more than 30 years, Perez and Brady's Principles and Practice of Radiation Oncology has been the must-have standard reference for radiation oncologists and radiation oncology residents who need a comprehensive text covering both the biological and physical science aspects of this complex field as well as disease site-specific information on the integrated, multidisciplinary management of patients with cancer. The book has established itself as the discipline's'text-of-record,'belonging on the shelf of all of those working in the field. The Seventh Edition continues this tradition of excellence with extensive updates throughout, many new chapters, and more than 1,400 full-color illustrations that highlight key concepts in tumor pathogenesis, diagnosis, and targeted radiation therapy.

The fifth edition of the only comprehensive text dealing exclusively with rare or infrequently encountered malignancies in adults and children is an essential resource for any clinical oncologist. Encompasses all the information needed to diagnose and manage uncommon cancers, an area where advice and guidance is typically scarce Fully revised with new material and an evidence-based, teach-by-example approach Provides insight on real-world decision making in the clinical setting Edited and authored by a highly experienced and senior team of medical oncologists, radiation oncologists, and other specialists, giving a balanced and complete overview Extensively illustrated in full color throughout, including heat maps to show gene expression

Durch die rasante Entwicklung bildgebender Verfahren in der Gastroenterologie und der damit verbundenen Möglichkeit einer sehr sensitiven Gewinnung zytologischen Untersuchungsmaterials, hat sich die qualitative wie quantitative Anforderung an zytologische Untersuchungen weltweit erhöht. Während die'Klassiker'der klinischen Zytologie in ihrer Anwendung, z.B. in der Hämatologie, Pneumologie, Urologie u.a. als etabliert gelten, fehlen für die gastroenterologische Zytologie vergleichbare diagnostische Standards. Dieses Buch erklärt Internisten und insbesondere Gastroenterologen und Onkologen, wie auch Morphologen die diagnostische Wertigkeit zytologischer Befunde klinisch relevanter Organe. Darüber hinaus soll dem Kliniker die Möglichkeit einer eigenständigen zytologischen Befundung vor Ort vorgestellt werden.

This book provides a detailed overview of the latest innovations in respiratory endoscopy, from both diagnostic and therapeutic perspectives; each chapter focuses on one disease and the techniques for early diagnosis as well as treatment. It comprehensively covers treatment and procedures, including simultaneous X-ray fluoroscopy and its use during bronchoscopic procedures. This fast-developing technology is essential for the medical management of non-malignant and malignant diseases of the chest, especially lung cancer. Respiratory Endoscopy describes the cooperation between all the members of the healthcare team, and as such is a valuable resource not only for medical staff, but also for radiological technicians and nursing staff who contribute significantly in the care of the patients undergoing these invasive procedures. By promoting teamwork and providing practical know-how, it will improve the success and safety of respiratory endoscopy procedures.