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Im vorliegenden Band werden nicht-hereditäre Tumorerkrankungen behandelt, deren Häufigkeit zwischen 85% und 95% liegt und damit ungleich höher ist als die der hereditären Tumorerkrankungen. Auch den nicht-hereditären Tumoren liegen Mutationen von DNS-Basenpaaren zugrunde, jedoch ohne Veränderungen der Keimbahn. Der pleiotrope Charakter dieser Erkrankungen erfordert zur Erkennung ihrer Ursachen eine komplizierte Diagnostik. Besonders betroffen sind Organe, die einer Einwirkung von Schadstoffen in besonderem Maße ausgesetzt sind. Diese Belastungen spiegeln sich in den insgesamt 13 Kapiteln dieses Bandes wider. Sie reichen von Hirn-, Brust- und Lungentumoren, über Tumoren der Leber, des Ösophagus und Magens, des Pankreas, des Darmes, der Blase und Niere, der Prostata und der Keimdrüsen bis zu Tumoren der Knochen und Weichteile.

Molecular Approach to Cancer Management discusses molecular mechanisms of cancer initiation, growth and secondary spread, emphasizing how this information can be used to devise new modes of treatment of cancer, especially in combatting secondary spread. The book addresses the basic concepts relating to cancer biology, the genetic determinants, and the signal transduction cascades associated with tumor growth, EMT, stem cell maintenance and propagation, and invasion and metastasis. The salient features of the signaling systems that are amenable to targeted manipulation are emphasized to facilitate research and development in the design of novel therapies and for the planning of new trials. This book is the only unique volume with coverage of topics that target therapy. As such, it is a valuable source for cancer researchers, molecular oncologists and members of the biomedical field who are interested in knowing more about molecular approaches to cancer therapy. - Covers all relevant topics with a defined aim of targeted therapy - Encompasses the basic aspects of cancer invasion and metastasis - Discusses signaling systems operating in normal cells and their deregulation in cancer cells - Directs attention to the foci in signaling systems that can be targeted with a new and conventional drug-based approach

This book provides readers an extensive overview of recent progress in basic and clinical research on cancer immunotherapy. Thanks to rapid advances in molecular biology and immunology, it has become increasingly evident that cancer growth is influenced by host immune responses. With the success of a number of clinical trials, immunotherapy has become a promising treatment modality of cancer. This book covers five major topics, including monoclonal antibodies, biological response modifiers, cancer vaccines, adoptive cellular therapy and oncolytic viruses. It also examines the combination of different immune strategies as well as the combination of immunotherapy with other treatments to increase anti-tumor effects. Through the comprehensive discussion of the topic, the book sheds valuable new light on the treatment of tumors.

•Hepatocellular carcinoma (HCC) used to be regarded as a rare disease. However, the increasing numbers of chronic HCC carriers in the U.S. and subsequent increased incidences of HCC seen in most large medical centers means that it is no longer an uncommon disease for gastroenterologists or oncologists to encounter and its incidence and epidemiology are changing. During this exciting time in the field of HCC basic science and clinical management, many changes are simultaneously occurring at multiple levels of our understanding and management of the disease. Suddenly, there are several new choices of therapy to offer patients. Hepatocellular Carcinoma, 3rd edition addresses this fast-changing disease and gives the reader a clearer understanding of the many mechanisms involved in carcinogenesis of the liver. This comprehensive and detailed review of how to diagnose and treat hepatocellular carcinoma is written by international leaders in the field, covering both clinical treatment choices and the basic science underlying HCC development. Updated and enhanced from the last edition in 2009, Hepatocellular Carcinoma, 3rd edition features 12 new chapters including discussion of molecular markers, molecular hepatocarcinogenesis, microenvironment, heterogeneity, the new and exciting contributions of immunotherapy, and updates on the major effective hepatitis therapies that will transform HCC incidence and perhaps also the therapy. This cutting-edge text is a vital resource and must-have for today's hepatologists and medical and surgical oncologists.'This is a well written text and should be a good reference book for those who see patients with HCC..'- Practical Gastroenterology'...a useful tool for both physicians and surgeons with a specific interest in the management of patients with HCC.'- Digestive and Liver Disease

Twenty years have passed since I became a professor in the First Department of Pathology, Hiroshima University School of Medicine. It is my great pleas­ ure that Molecular Pathology o[ Gastroenterological Cancer-Application to Clinical Practice has been published by Springer-Verlag Tokyo to commemo­ rate the 20th anniversary of my professorship. Seeing the academic achievements of our department during these 20 years, I am confident that we could establish a department of oncology to research the pathogenesis of human cancer through systemic application of a variety of molecular techniques. We have demonstrated that the develop­ me nt and progression of esophageal, gastric, and colon cancer require mul­ tiple alterations affecting DNA mismatch repair genes, oncogenes, and tumorsuppressor genes, and that common and uncommon genetic changes exist for esophageal, gastric, and colorectal carcinomas. In addition to these genetic changes, the majority of gastrointestinal cancers express telomerase activity, with overexpression of telomerase RNA, indicating a powerful addi­ tional tool for early detection of gastrointestinal cancer. By transferring these basic observations to the clinic, we now are able to make accurate cancer diagnoses, thus determing the grade of malignancy and patient prognosis. We also can identify patients at high risk for developing cancer and create new therapeutic approaches. In fact, we have routinely implemented a new molecular diagnosis strategy at the Hiroshima City Medi­ cal Association Clinical Laboratory since August 1993.

Practical and clinically focused, Abeloff's Clinical Oncology is a trusted medical reference book designed to capture the latest scientific discoveries and their implications for cancer diagnosis and management of cancer in the most accessible manner possible. Abeloff's equips everyone involved - from radiologists and oncologists to surgeons and nurses - to collaborate effectively and provide the best possible cancer care.Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Select the most appropriate tests and imaging studies for cancer diagnosis and staging of each type of cancer, and manage your patients in the most effective way possible by using all of the latest techniques and approaches in oncology.Enhance your understanding of complex concepts with a color art program that highlights key points and illustrates relevant scientific and clinical problems. Stay at the forefront of the latest developments in cancer pharmacology, oncology and healthcare policy, survivorship in cancer, and many other timely topics.See how the most recent cancer research applies to practice through an increased emphasis on the relevance of new scientific discoveries and modalities within disease chapters.Streamline clinical decision making with abundant new treatment and diagnostic algorithms as well as concrete management recommendations.Take advantage of the collective wisdom of preeminent multidisciplinary experts in the field of oncology, including previous Abeloff's editors John E. Niederhuber, James O. Armitage, and Michael B. Kastan as well as new editors James H. Doroshow from the National Cancer Institute and Joel E. Tepper of Gunderson & Tepper: Clinical Radiation Oncology.Quickly and effortlessly access the key information you need with the help of an even more user-friendly, streamlined format.Access the complete contents anytime, anywhere at Expert Consult, and test your mastery of the latest knowledge with 500 online multiple-choice review questions.

Stimulation of the immune system's ability to control and destroy tumors cont- ues to be the goal of cancer immune therapy; but the scope has rapidly expanded; approaches are constantly updated; new molecules are continually introduced; and immune mechanisms are becoming better understood. This book has no intention of covering every aspect of immune therapy but rather focuses on the novelty of cancer immune therapy in an attempt to give readers an opportunity to absorb the new aspects of immune therapy from a single source. In this regard, three areas were selected: cytokine immune therapy, cell-based immune therapy, and targeted immune therapy. In each of these three sections, only the novel aspects of immune therapy were described instead of attempting to cover any historical achievement. In the first section, Cytokine Immune Therapy, the IL12 family, IL18, IL21, IL24, IL28, and IL29 were emphasized in regard to the an- tumor function and application in treating tumors. Most of these selected cyt- ines were discovered in last 10 years. In the second section, Cell-based Immune Therapy, the focus was engineering potent immune regulatory or effector cells such as dendritic cells, T cells, and stem cells. Cell engineering design is primarily based on the increased understanding of the interaction of tumor antigen-presenting cells, antigen- specific effector cells, and the tumor microenvironment.

Carrying on the tradition established by its founding editor, the late Dr. Martin Abeloff, the 4th Edition of this respected reference synthesizes all of the latest oncology knowledge in one practical, clinically focused, easy-to-use volume. It incorporates basic science, pathology, diagnosis, management, outcomes, rehabilitation, and prevention – all in one convenient resource – equipping you to overcome your toughest clinical challenges. What's more, you can access the complete contents of this Expert Consult title online, and tap into its unparalleled guidance wherever and whenever you need it most!Equips you to select the most appropriate tests and imaging studies for diagnosing and staging each type of cancer, and manage your patients most effectively using all of the latest techniques and approaches. Explores all of the latest scientific discoveries'implications for cancer diagnosis and management. Employs a multidisciplinary approach - with contributions from pathologists, radiation oncologists, medical oncologists, and surgical oncologists - for well-rounded perspectives on the problems you face. Offers a user-friendly layout with a consistent chapter format • summary boxes • a full-color design • and more than 1,445 illustrations (1,200 in full color), to make reference easy and efficient.Offers access to the book's complete contents online – fully searchable – from anyplace with an Internet connection. Presents discussions on cutting-edge new topics including nanotechnology, functional imaging, signal transduction inhibitors, hormone modulators, complications of transplantation, and much more. Includes an expanded color art program that highlights key points, illustrates relevant science and clinical problems, and enhances your understanding of complex concepts.

This superb text gives a concise, systematic account of what is currently known about the epidemiology and primary prevention for most forms of human cancer. Part 1 provides an introduction to basic concepts in epidemiology, a description of the global burden of cancer, definitions and characterizations of the various measures used, and approaches used to reveal genetic determinants of cancer risk and integrate biologic markers in the epidemiogic research process. Part 2 contains chapters of uniform structure on over 20 types of cancer, providing clinical and pathological outlines, descriptive epidemiology, and a comprehensive account of risk factors and their etiological importance. Specific sections address somatic and germ cell mutations that play a role in the occurrence of particular forms of cancer.

The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics including Molecular Mechanisms in Gliomagenesis; Activation of AKT Kinases in Cancer: Implications for Therapeutic Targeting; Mitochondria as Functional Targets of Proteins Coded by Human Tumor Viruses; Apoptotic Pathways and Therapy Resistance in Human Malignancies; Endostatin Signaling and Regulation of Endothelial Cell-Matrix Interactions; Molecular Mechanisms and Clinical Development.

In 74 chapters, Gastrointestinal Oncology brings together a diverse group of specialists to provide the most authoritative, up-to-date and encyclopedic volume currently available on the subject. The first part of this text introduces a series of concepts and topics taht are important to gastrointestinal malignancies in general. These topics include epidemiologic principles, prevention, screening, familial GI cancers, developmental and molecular biology, pathobiology, general therapeutic principles, emerging therapies, and palliative care. The second part of the book covers each of the specific cancers affecting the human gastrointestinal tract. These chapters are introduced by state of the art discussions outlining our current understanding of the pathobiology and molecular biology relevant to each cancer. Subsequent sections describe the multidisciplinary management of specific clinical situations. By organizing the treatment-related chapters around clinical scenarios, the reader will readily find the information necessary to effectively manage the complex clinical situations encountered by patients with gastrointestinal malignancies.

Title from e-book title screen (viewed on Feb. 23, 2004.)

There has been an explosion of knowledge and enormous progress in the fundamental understanding of the biology of cancer in recent years. This has included the realisation that cancer occurs when normal cellular functions are disturbed leading to a malignant phenotype. Much research has focussed on understanding the types of disturbances that can occur, the contribution that these abnormalities can make to the development and behaviour of particular cancers and more recently, the recognition that these cellular and genetic abnormalities can provide rational targets for new therapeutic approaches. Information about the biology of cancers that occur in children has increased in parallel with these more general advances and this book is intended to provide a focus for readers who wish to have an understanding of our current state of knowledge. A international group of editors and contributors provide guidelines on the molecular biology and pathology of paediatric oncology, aimed at clinicians and scientists working in the specialty who wish to understand current developments in molecular pathology as applied to their field. The book is a broad ranging review focusing on the impact of molecular and cytogenetic techniques on our understanding of the aetiology, clinical behaviour, diagnosis and management of paediatric cancer. The first section outlines the laboratory handling of tissue samples, theory and methodology of cytogenetic and molecular techniques and discusses predisposition syndromes. The second section highlights the application of cytogenetic and molecular methods in diagnosis and treatment of the major paediatric cancers.

Advances in Cancer Research

This book covers the concepts of molecular medicine and personalized medicine. Subsequent chapters cover the topics of genomics, transcriptomics, epigenomics, and proteomics, as the tools of molecular pathology and foundations of molecular medicine. These chapters are followed by a series of chapters that provide overviews of molecular medicine as applied broadly to neoplastic, genetic, and infectious diseases, as well as a chapter on molecular diagnostics. The volume concludes with a chapter that delves into the promise of molecular medicine in the personalized treatment of patients with complex diseases, along with a discussion of the challenges and obstacles to personalized patient care.The Molecular Basis of Human Cancer, Second Edition, is a valuable resource for oncologists, researchers, and all medical professionals who work with cancer.

The Roundtable on Environmental Health Sciences, Research, and Medicine wanted to address the link between environmental factors and the development of cancer in light of recent advances in genomics. They asked what research tools are needed, how new scientific information can be applied in a timely manner to reduce the burden of cancer, and how this can be flexible enough to treat the individual.

Molecular Genetics of Cancer, Second Edition provides an authoritative and up to date review of the key genes known to be critical in the development or progression of cancer. Throughout the book, scientific advances and their clinical relevance are covered in detail, particularly in the light of findings concerning the inheritance of genes predisposing to tumorigenesis. The book is therefore a valuable source of reference for clinicians and genetic counsellors as well as researchers.

Internationally renowned basic and clinical scientists provide an account of our best current understanding of the genetics of cancer. These authoritative contributors describe in detail each of the known molecular mechanisms governing neoplastic transformation in the breast, prostate, lung, liver, colon, and skin, and in the leukemias and lymphomas. Their discussion illuminates both recent developments and established concepts in epidemiology, molecular techniques, oncogenesis, and mutation mechanisms, as well as the chemical, viral, and physical mechanisms in cancer induction.

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics, including nitric oxide-induced apoptosis in tumor cells, detection of minimal residual disease, immunity to oncogenetic human papilloma viruses, and modeling prostate cancer in the mouse.

James J. Goedert and a team of leading experimental and clinical researchers provide critical, integrating surveys of those viruses, bacteria, and parasites that are now known to play a major role in cancer-work that opens the way toward novel therapeutic targets. The contributors focus on five types of human carcinogenic infection-herpesviruses, retroviruses, papillomaviruses, hepatitis viruses, and H. pylori-and review in depth the associated malignancies, as well as how these new diagnostic and therapeutic technologies may be implemented. Cutting-edge and cross-disciplinary, Infectious Causes of Cancer: Targets for Intervention provides clinical oncologists and infectious disease specialists, as well as clinical researchers, with insightful reviews of cancer induction by infectious diseases and the high promise of closely targeted new therapeutics and vaccines.

Advances in molecular characterization and novel gene-isolation techniques have vigorously expanded our understanding of hepatocellular carcinoma (HCC), a form of liver cancer that affects one million people annually, and generated many new therapeutic possibilities. In Hepatocellular Carcinoma: Methods and Protocols, Nagy Habib and a team of basic and clinical researchers describe the wide variety of powerful new laboratory-based molecular methods currently being used for investigating and treating this disease. The book focuses on gene therapy approaches, including the use of such vectors as lipids, adenovirus, and baculovirus, and virus detection assessment using electron microscopy. It also provides preclinical and clinical data on the killing of cancer cells using tumor-suppressor genes, antisense compounds to growth factors, immunotherapy (remove gene), and virus-directed enzyme prodrug therapy. A perspective on future treatment of the failing liver is given, along with a clinical protocol for p53 gene therapy. Hepatocellular Carcinoma: Methods and Protocols offers experimental and clinical investigators a rich source of both basic science and clinical information on today's optimal use of gene therapy to treat and manage patients suffering from hepatocellular carcinoma.

The book is edited by a multidisciplinary team, with an international group of contributors. After discussing the basic and clinical aspects of HCC the main focus of the book is on diagnosis and therapy. The book is both authoritative and practical, providing expert guidance on the various techniques used in diagnosis, such as ultrasound, CT and MRI and the appropriate therapeutic options, for example, surgical resection, transcatheter therapies and radiofrequency ablation. It is fully illustrated throughout in both colour and black and white.