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Maximise your exam success with this essential revision guide. The fourth edition of Oxford Assess and Progress: Clinical Medicine, features over 600 Single Best Answer questions. Packed with new and updated questions written by experienced doctors, this revision tool is an authoritative guide for finals and the UKMLA. Questions on core clinical topics are accompanied by extensive feedback, which explains not only the rationale of the correct answer, but why the other options are incorrect. Further reading resources and updated cross-references to the eleventh edition of Oxford Handbook of Clinical Medicine expand your revision further. Progess to exam success with the fourth edition of Oxford Assess and Progress: Clinical Medicine.

Common Pediatric Diseases: An Updated Review informs the reader about common diseases in children that are encountered by pediatricians and family physicians. Each of the 14 chapters in the volume presents updated information for readers with the aim to give them a current perspective on the topic. This book is a handy and practical compendium for medical students and healthcare professionals involved in general practice and pediatric clinics.The text starts with a quick introduction to pediatric diseases, before progressing towards specific diseases in children. The list of topics in this book includes pediatric rheumatological diseases, common oral diseases, pediatric metabolic syndromes, pediatric epilepsy syndromes, pediatric demyelinating disorder, genetic epileptic encephalopathies (with an algorithmic diagnostic approach), Henoch-Sch amp;amp;ouml;nlein purpura, atopic dermatitis, childhood-onset systemic lupus erythematosus, Severe Combined Immunodeficiency, PFAPA, aphthous stomatitis, pharyngitis, cervical adenitis syndrome and pediatric hepatoblastoma.[Series Intro]Updates on Pediatric Health and Disease is a comprehensive series of books on infant and adolescent health and diseases. The series features volumes that update readers on current understanding in basic information and advanced clinical practice in pediatric medicine. Neonatology as well as different diseases in all subspecialties of pediatrics, including allergy and immunology, cardiology, endocrinology, gastroenterology, hematology, infectious diseases, nephrology, oncology, pulmonology, rheumatology, neurology, psychiatry and dermatology are represented in each volume.

This book summarizes the global progress in medical and scientific research toward converting traditionally chronic autoimmune diseases into a drug-free reversible illness using hematopoietic stem cell transplantation (HSCT) and other cellular therapies such as T regulatory cells (Treg), mesenchymal stromal/stem cells, and chimeric antigen receptor T (CAR T) cells in order to reintroduce sustained immune tolerance. This title provides information on different types of stem cells and immune cells; post-transplant immune regeneration; cellular regulatory requirements; ethical and economic considerations; and the advantages and disadvantages of HSCT in the treatment of a variety of autoimmune diseases versus current conventional treatments. Arranged by disease, the text provides a comprehensive guide to HSCT for all types of autoimmune/immune disorders including monogenetic autoimmune diseases; autoimmune aplastic anemia; neurologic immune diseases including multiple sclerosis, chronic inflammatory demyelinating polyneuropathy, neuromyelitis optica, and stiff person syndrome; rheumatologic diseases such as systemic sclerosis and systemic lupus erythematosus; dermatologic diseases such as pemphigus; gastrointestinal disorders such as Crohn's disease and celiac disease; and immune-mediated endocrinologic disease type I diabetes mellitus. Guidance is provided on the transplantation technique, cell collection and processing, conditioning regimens, infections, and early and late complications.Key Features Outlines therapies and techniques for HSCT for autoimmune diseases Discusses the advantages of HSCT over conventional therapies Reviews the entire process of stem cell therapy from harvest and ethics to indications, efficacy, and regulatory oversight

Medicine for MRCP provides a comprehensive review of the material that you need to pass the MRCP Parts 1 and 2 written papers. The twenty-seven chapters mapped out to the RCP syllabus, cover all areas from molecular medicine and genetics, through to medical law and ethics. Written by specialist contributors and educational experts, the content is carefully crafted to build your understanding for both papers. Each chapter begins with the basic science required for Part 1, before covering clinical medicine for Part 1, Part 2 and the PACES examinations. To ensure effective revision, material is presented in short sections with bullet lists, tables, and boxes. Over 150 drawings and photos illustrate key principles and clinical topics making them easier to retain. References to evidence-based protocols and directions to further reading allow for deeper understanding. Candidates can review their progress via the 180 end-of chapter self-assessment questions. Drawing on the authors'expertise, Medicine for MRCP is the ideal companion for the MRCP as well as a useful reference guide for practicing medical doctors.

Thoroughly updated as per the latest evidence-based guidelines as recommended by the National Institute for Health and Clinical Excellence (NICE), Royal College of Obstetricians and Gynaecologists (RCOG), Green-Top Guidelines, etc. in the field of obstetrics and gynaecology. Covers the updated figures for maternal and perinatal mortality as described by MBRRACE UK (2019). This new edition comprises of 98 chapters, distributed into 17 sections. Designed as per the current MRCOG-2 curriculum available from the RCOG website. New chapters such as thromboembolism in pregnancy, genetic disorders, postpartum collapse, Zika virus infection, etc. included. COVID-19 and its management during pregnancy has also been discussed. A new heading, titled ‘key features', has been added to all the chapters in the new edition. Addition of online content.

The reference of choice for pediatricians, residents and medical students, the newly revised and expanded 6th edition provides clear, practice-oriented guidance on the core knowledge in pediatrics. Edited by a leading primary care authority with more than one hundred contributors, the 6th edition provides comprehensive coverage of hundreds of topics ranging from temper tantrums and toilet training to adolescent depression and suicide. More than 155 (including 5 brand new) clinical chapters review pertinent epidemiology and pathophysiology, then give concise guidelines on what symptoms to look for, what alternative diagnoses to consider, what tests to order, and how to treat your patient. New in the 6th editionAll chapters have been reviewed and updated to address current issues.Five new chapters are included on the following: Health Systems SciencePopulation Health for PediatriciansSocial Determinants of Health: PrinciplesAdverse Childhood Experiences: Trauma Informed CareCommercially Exploited Children and Human TraffickingStudent worksheets corresponding to each chapter's case study questions will be posted online in a user-friendly format so that they can be completed in preparation of discussions.Case study questions have been enhanced and resources have been revised.This edition is completely reorganized into 15 sections using a systems-based approach.

MRCP Part 2: 450 BOFs, Second Edition offers a comprehensive selection of practice questions for trainees preparing for the MRCP Part 2 exam. Chapters are arranged by specialty and the weighting of questions is proportional to the exam. Thoroughly updated and featuring a wealth of practice questions that will test your ability to apply clinical understanding and make clinical judgements, this book is an essential revision tool to maximise the chances of exam success.

'The field of Biomarkers and Precision Medicine in drug development is rapidly evolving and this book presents a snapshot of exciting new approaches. By presenting a wide range of biomarker applications, discussed by knowledgeable and experienced scientists, readers will develop an appreciation of the scope and breadth of biomarker knowledge and find examples that will help them in their own work.'-Maria Freire, Foundation for the National Institutes of HealthHandbook of Biomarkers and Precision Medicine provides comprehensive insights into biomarker discovery and development which has driven the new era of Precision Medicine. A wide variety of renowned experts from government, academia, teaching hospitals, biotechnology and pharmaceutical companies share best practices, examples and exciting new developments. The handbook aims to provide in-depth knowledge to research scientists, students and decision makers engaged in Biomarker and Precision Medicine-centric drug development.Features: Detailed insights into biomarker discovery, validation and diagnostic development with implementation strategies Lessons-learned from successful Precision Medicine case studies A variety of exciting and emerging biomarker technologies The next frontiers and future challenges of biomarkers in Precision Medicine Claudio Carini, Mark Fidock and Alain van Gool are internationally recognized as scientific leaders in Biomarkers and Precision Medicine. They have worked for decades in academia and pharmaceutical industry in EU, USA and Asia. Currently, Dr. Carini is Honorary Faculty at Kings's College School of Medicine, London, UK. Dr. Fidock is Vice President of Precision Medicine Laboratories at AstraZeneca, Cambridge, UK. Prof.dr. van Gool is Head Translational Metabolic Laboratory at Radboud university medical school, Nijmegen, NL.

The Oxford Handbook of Rheumatology, 4th edition has been fully reviewed and updated to make it into an invaluable guide for students, trainees, consultant rheumatologists, and everyone caring for patients with musculoskeletal disease. With the addition of a paediatric rheumatologist to the editor team, this new edition is a fully functional rheumatology handbook for patients from childhood to adulthood. Practically structured, the handbook focuses first on presenting symptoms and then considers key diseases, emergencies, and rare diseases in detail. There is a comprehensive and updated account of assessment, guidelines, and treatment options. The text has been condensed with bullet points and summary boxes so the reader can focus on the essential information. To aid understanding over half of the images have been updated and the colour plate section has been expanded. Taking a clinical, evidence-based approach, written by experts, and presented in a clear, practical, bullet-point style for rapid reference, this handbook will be your constant companion and a joy to use.

The objective structured clinical examination (OSCE) has become widely employed in intensive care medicine (ICM) exams such as the UK Final Fellowship of Intensive Care Medicine (FFICM), the European Diploma of Intensive Care (EDIC) exam, or the Australia and New Zealand Fellowship of the College of Intensive Care Medicine (CICM). This book is not only an essential tool for the rehearsal of OSCEs in preparation for these exams, but also for American and Indian exams, and any other exams within the field of intensive care medicine. The OSCE is a style of examination that requires the candidate to present specific information in a short space of time matched to a prescriptive mark scheme. This book allows candidates preparing for an ICM OSCE to format their knowledge for this type of examination whilst practising and rehearsing against time. The 60 OSCE stations provide a broad array of topics from past exams ranging across the training ICM curriculums. The mark schemes are presented in a short, punctuated form allowing the candidate access to important points, ideal at the sharp end of an exam campaign. The 5 sets of OSCE exams are designed to run as a set of 12. Each set will have an array of clinical scenarios requiring swift assessment, diagnosis, recommendations for investigations and management, whilst also exploring aspects of pathophysiology. There are a number of data-interpretation tools that are incorporated into clinical scenarios as well as standalone stations for electrocardiogram and radiology analysis. This book is an important preparatory tool crucial to the armamentarium of any candidate preparing for an ICM exam.

Today, an increasing number of healthcare professionals (including nurses, midwives and members of many allied professions) have to conduct the vital first stage in a patient's journey – taking a clinical history and conducting an effective physical examination. This book offers clear, practical guidance on the fundamentals of clinical examination for any practitioner who wishes to understand their patient's specific needs and to plan appropriate care. Recognising that readers will come from a diverse range of clinical backgrounds and roles, the opening chapter (on consultation and the skills needed to take an accurate clinical history) underpins the systems-based approach. This, combined with the use of case study examples, allows healthcare professionals to focus on the principles of examining the system or systems that are most relevant to their specific area of practice. The book also includes a helpful glossary and list of abbreviations. This new, updated edition contains revised chapters on genitourinary assessment, obstetric assessment and mental health assessment. There is also a completely new chapter on eye, ear, nose and throat assessment, covering the EENT conditions most commonly encountered in primary healthcare.

Covering the core clinical specialties, the Oxford Handbook of Clinical Specialties contains a comprehensive chapter on each of the clinical areas you will encounter through your medical school and Foundation Programme rotations. Now updated with the latest guidelines, and developed by a new and trusted author team who have contemporary experience of life on the wards, this unique resource presents the content in a concise and logical way, giving clear advice on clinical management and offering insight into holistic care. Packed full of high-quality illustrations, boxes, tables, and classifications, this handbook is ideal for use at direct point of care, whether on the ward or in the community, and for study and revision. Each chapter is easy to read and filled with digestible information, with features including ribbons to mark your most-used pages and mnemonics to help you memorize and retain key facts, while quotes from patients help the reader understand each problem better, enhancing the doctor/patient relationship. With reassuring and friendly advice throughout, this is the ultimate guide for every medical student and junior doctor for each clinical placement, and as a revision tool. This tenth edition of the Oxford Handbook of Clinical Specialties remains the perfect companion to the Oxford Handbook of Clinical Medicine, together encompassing the entire spectrum of clinical medicine and helping you to become the doctor you want to be.

The Easy Book of Cancer Pharmacology represents the efforts of young oncologists, haematologists, pharmacists and oncology nurses who are highly motivated and encouraged by the significant development of new effective anticancer drugs. Since the discovery of antimetabolites and alkylating agents in the 1940s and 1950s, many new products have been introduced into our daily arsenal not only through chemotherapy agents, but also by means of biological or immunotherapeutic drugs whose side effects differ significantly. The idea of this book was born from a simple observation and confirmation of fact. New doctors in training experience high levels of stress and lack of confidence when confronting cancer patients and explaining a treatment or managing frequent side effects. Patients'questions will only add more nervousness, and this will lead to a failure in the doctor-patient relationship, causing the patient's mistrust and doctor's frustration. Nurses dealing with these patients will suffer pressure too, as many questions regarding antineoplastic drugs will be asked of them and patients expect them to ease their doubts. This feeling of vulnerability in front of a patient, though a part of the maturation process when becoming a professional caretaker, causes discomfort and incertitude. In this context, it is crucial to gain great knowledge about pharmacokinetic and pharmacological features of each active anticancer drug used, as well as the indications, dosages, interactions and toxicities, to be able to face the daily practice of oncology without concerns and manage daily therapeutic complications easily. This may be considered very difficult, taking into account the huge number of active agents doctors manage routinely, but doctors have accepted the challenge and designed a straightforward, comprehensible book to solve this issue. The Easy Book of Cancer Pharmacology provides the means to overcome the problem. It is conceived as an accessible, concise and yet exhaustive tool which displays a vast amounts of knowledge in a very schematic way. It is easy to consult and offers a very practical expertise to develop the ability of managing effectively each antineoplastic agent quickly. It gives the necessary insights to explain this to the patients with confidence. Each chapter reviews one active drug and shows the information with a pragmatic style, and they are divided into different sections. Each section covers distinct aspects of the agent, from general characteristics to more specific details related to clinical pharmacology. In quickly advancing fields such as oncology, such a book is necessary to help update the ever-developing and expanding knowledge of clinicians and patients in an efficient and effective manner.

Uric acid (UA) is an end-product of purine derivatives in human metabolism. Without further metabolism, it is excreted by kidneys and intestinal tract. Its serum concentration is controlled by the balance between production and excretion. High concentration of UA in human body has been discovered to be associated with various diseases, such as gout, hyperuricaemia, Lesch-Nyan disease, obesity, diabetes, high cholesterol, hypertension, kidney disease and heart disease. This book discusses the detection, applications and role in health and disease of uric acid.

Left Ventricular Hypertrophy (LVH) is defined as an increase in the left ventricular mass. Hypertrophy is a physiologic response to the increased wall stress from hemodynamic overload. The physiological changes become pathological with deleterious effects when the stress is prolonged. Genetic and infiltrative disorders have also been associated with hypertrophy. This book discusses the prevalence, risk factors and treatment options available for LVH.

This collection of articles focuses on areas of general medicine which are presented to clinicians at all levels in the profession. Some of the subjects discussed include; vitamin B12 deficiency, viral meningitis, acute altitude illnesses, assessment and management of alcohol use disorders and paracetamol poisoning, non-cardiovascular effects associated with statins and Guillain-Barre syndrome. Some of the other medical issues discussed include managing health problems in people with intellectual disabilities and adults with Down's syndrome and issues relating to sickle cell disease.

The reference of choice for pediatricians, pediatric residents, and medical students, the newly revised and expanded 5th editon provides clear, practice-oriented guidance of the core knowledge in pediatrics. Comprehensive coverage of hundreds of topics ranging from temper tantrums and thumb-sucking to diabetes and kidney disease make this an ideal reference for students, pediatric residents, pediatric nurse practitioners and nurses. More than 140 clinical chapters review pertinent epidemiology and pathophysiology, then gives concise guidelines on what symptoms to look for, what alternative diagnoses to consider, what tests to order, and how to manage your patient. Outcomes-centric focus - chapters open with a case presentation and a list of focal questions, and close with the case resolution. Quick reference organization - Signs and symptoms are grouped by body system for fast look-up; head, neck and respiratory system; cardiovascular system; hematologic, genitourinary, orthopedic, gastrointestinal, neurologic, dermatologic disorders. Consistent solution-oriented format - Steps through clinical presentation; pathophysiology; differential diagnosis; evaluation; lab tests; management; and prognosis. Illuminating visuals - Superb figures illustrate patient presentations and clinical procedures.An ideal reference for pediatricians, family physicians, medical students, residents, residency program directors, physician assistants, pediatric nurse practitioners and nurses.

Hypertension, also referred to as high blood pressure, is a disease afflicting almost 1 billion people worldwide. Some 70 million adults in the United States are affected by hypertension. The condition also affects about two million teens and children. It is called the'silent killer'due to the deleterious damaging effects, such as stroke, myocardial infarction, renal dysfunction, visual problems, among others, derived from hypertension. It is noteworthy that one-third of patients in this condition are not even aware they are hypertensive, as this disease is usually asymptomatic for many years, even decades, until it finally damages certain critical organs and the only reliable way to detect its occurrence is to regularly check blood pressure. Therefore, considerable effort has been devoted to ascertain the causes of hypertension, as well as the mechanisms damaging the organ function. Nevertheless, about 95% of cases have unknown causes and represent the primary or essential hypertension. This book presents an update of research advances contributing to a better understanding of relevant clinical models of hypertension, particularly; the involvement of the role of oxidative stress in various forms of hypertension as a still emerging subject. This paradigm could be applied to account for blood pressure elevation in the metabolic syndrome, renovascular disease, preeclampsia and chronic kidney disease, among others. These examples are discussed in the light of recent clinical and experimental studies providing a rational base for diagnosis and treatment of the diseases. Each chapter includes a synthesis of the mechanistic approach supported by the accumulated evidence to facilitate its comprehension.

Today, an increasing number of healthcare professionals (including nurses, midwives and members of many allied professions) have to conduct the vital first stage in a patient's journey – taking a clinical history and conducting an effective physical examination. This book offers clear, practical guidance on the fundamentals of clinical examination for any practitioner who wishes to understand their patient's specific needs and to plan appropriate care. Recognising that readers will come from a diverse range of clinical backgrounds and roles, the opening chapter (on consultation and the skills needed to take an accurate clinical history) underpins the systems-based approach. This, combined with the use of case study examples, allows healthcare professionals to focus on the principles of examining the system or systems that are most relevant to their specific area of practice. The book also includes a helpful glossary and list of abbreviations.

As medical technology advances and the number of users across different mediums increases, how do we continually shape medical education and practice to meet the needs of these users? Clinical Solutions and Medical Progress through User-Driven Healthcare provides comprehensive coverage and understanding of clinical problem solving in healthcare. The term'user'includes health professionals, as well as patients and anyone who uses the web with a user name. These'users'generate an information flow that'drives'the system's workflow (hence, the choice of the term'driven').'User-driven healthcare'aims at improved healthcare through clinical problem solving utilizing concerted experiential learning in conversations between multiple users and stakeholders, primarily patients, health professionals, and other actors in a care giving collaborative network across a web interface. Serving as a valuable source for information, this title is perfect for healthcare professionals, researchers, academic instructors, and students alike.

Albuminuria may not only serve as an early marker of advanced disease, but may also serve as a predictor of disease progression and poor outcome. This fact makes the current book'Albuminuria: Symptoms, Causes and Treatment Options' very crucial and timely. The book is composed of ten chapters written by experts from seven different countries. It is well classified to serve its purpose, divided in three broad sections. The first section deals with the clinical evaluation and implications of albuminuria. It also covers the molecular, cellular and biochemical basis of albuminuria. The second section is geared towards albuminuria noted in special clinical conditions; diabetic nephropathy, cardiovascular diseases, resistant hypertension and following renal transplantation and exercise. The third and final section covers albuminuria among the extremes of age; both the pediatric and the fastest growing elderly group. The book provides a reference and guide that reviews various aspects of albuminuria to cater to a wide spectrum of readers, ranging from medical students to practicing physicians.

Primary care clinicians are called on to care for adolescents in a time with increasing pharmacologic agents that are available in the management of these patients. The emphasis in this book is on the current pharmacologic treatment of common medical disorders in adolescents. Selected topics of practical relevance in adolescent medicine are covered. The goal of this book is to provide a succinct and practical guide specifically written for practicing physicians and allied health professionals who work with adolescents.

Hearing the patient’s story, asking the right questions, and doing a careful, thorough and informed physical examination are intrinsic to good medicine. It is easy to rely and become dependent on technology to diagnose and to treat our patients. Yet, no machine will ever be a match for a listening ear and the laying on of hands. These skills are core to the art of medicine and require practice. It is only by becoming familiar with the norm that we can appreciate the norm. This book is a clinical skills textbook with a third dimension – the human factor. We read about real people, real symptoms and real diagnostic problems. It doesn’t waste time on rare physical signs that will never be encountered but instead, focuses on common, important clinical skills and symptom patterns.

Pre-eclampsia is one of the leading causes of death and disability in mothers and babies. Over four million women worldwide will develop the disorder every year. This book, written by an international team of experts, focuses on both the scientific basis of pre-eclampsia and its management. The basic science section contains reviews of the most exciting research developments in pre-eclampsia. The clinical chapters provide a comprehensive review of the pertinent literature, highlighting data and ideas or developments in management. There is a section in each chapter (where relevant) that deals with practical management, giving clinicians a formulated treatment plan that they can implement directly. The book was originally published in 2007, and will have continuing relevance for all professionals interested in the reproductive sciences, and to obstetricians and physicians with an interest in pre-eclampsia.