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Associated Particle Imaging (API) is a nuclear technique that allows for the nondestructive determination of 3D isotopic distributions. The technique is based on the detection of the alpha particles associated with the neutron emitted in the deuteriumtritium (DT) fusion reaction, which provides information regarding the direction and time of the emitted 14 MeV neutron. Inelastic neutron scattering leads to characteristic gamma-ray emission from certain isotopes, for example 12C, that can be correlated with the neutron interaction location. An API system consisting of a sealed-type neutron generator, gamma detectors, and a position-sensitive alpha detector is under development for the nondestructive quantification of carbon distribution in soils. This paper describes the design of the alpha detector, detector response simulations, and first experimental results. The alpha detector consists of an Yttrium Aluminum Perovskite (YAP) scintillator mounted on the inside of a neutron generator tube. The scintillation light propagates through a sapphire window to a position-sensitive photomultiplier tube mounted on the outside. The 16 × 16 output signals are connected through a resistive network for a 4-corner readout. The four readout channels are amplified, filtered, and then digitized for the calculation of the alpha interaction in the detector. First test results demonstrate that an excellent alpha position resolution, better than the 1mm FWHM required by the application, can be achieved with this detector design.

The database at http://www.radiopurity.org is the world's largest public database of material radio-purity mea-surements. These measurements are used by members of the low-background physics community to build experiments that search for neutrinos, neutrinoless double-beta decay, WIMP dark matter, and other exciting physics. This paper summarizes the current status and the future plan of this database.

The Majorana Collaboration is searching for the neutrinoless double-beta decay of the nucleus 76Ge. The Majorana Demonstrator is an array of germanium detectors deployed with the aim of implementing background reduction techniques suitable for a tonne scale 76Ge-based search (the LEGEND collaboration). In the Demonstrator, germanium detectors operate in an ultra-pure vacuum cryostat at 80 K. One special challenge of an ultra-pure environment is to develop reliable cables, connectors, and electronics that do not significantly contribute to the radioactive background of the experiment. This paper highlights the experimental requirements and how these requirements were met for the Majorana Demonstrator, including plans to upgrade the wiring for higher reliability in the summer of 2018. Also described are requirements for LEGEND R&D efforts underway to meet these additional requirements.

Time-resolved experimental techniques are increasingly abundant at storage ring facilities. Recent developments in accelerator technology and beamline instrumentation allow for simultaneous operation of high-intensity and timing-based experiments. The MAX IV facility is a state-of-the-art synchrotron light source in Lund, Sweden, that will come into operation in 2016. As many storage ring facilities are pursuing upgrade programs employing strong-focusing multibend achromats and passive harmonic cavities (HCs) in high-current operation, it is of broad interest to study the accelerator and instrumentation developments required to enable timing-based experiments at such machines. In particular, the use of hybrid filling modes combined with pulse picking by resonant excitation or pseudo single bunch has shown promising results. These methods can be combined with novel beamline instrumentation, such as choppers and instrument gating. In this paper we discuss how these techniques can be implemented and employed at MAX IV.

The maximum entropy principle is a powerful tool for solving underdeterminedinverse problems. This paper considers the problem of discretizing a continuousdistribution, which arises in various applied fields. We obtain theapproximating distribution by minimizing the Kullback-Leibler information(relative entropy) of the unknown discrete distribution relative to an initialdiscretization based on a quadrature formula subject to some momentconstraints. We study the theoretical error bound and the convergence of thisapproximation method as the number of discrete points increases. We prove that(i) the theoretical error bound of the approximate expectation of any boundedcontinuous function has at most the same order as the quadrature formula westart with, and (ii) the approximate discrete distribution weakly converges tothe given continuous distribution. Moreover, we present some numerical examplesthat show the advantage of the method and apply to numerically solving anoptimal portfolio problem.

Two hydrodynamic effects are introduced in the standard transmission-line formalism, the focusing of the pressure and fluid velocity fields near the basilar membrane and the viscous damping at the fluid-basilar membrane interface, which significantly affect the cochlear response in the short-wave region. In this region, in which the wavelength is shorter than the cochlear duct height, only a layer of fluid of order of the wavelength is effectively involved in the traveling wave. This has been interpreted [8] as a reduced fluid contribution to the system inertia in the peak region, which is a viewpoint common to the 3-D FEM solutions. In this paper we propose an alternative approach, from a slightly different physical viewpoint. Invoking the fluid flux conservation along the traveling wave propagation direction, we can derive a rigorous propagation equation for the pressure integrated along the vertical axis. Consequently, the relation between the average pressure and the local pressure [4] at the fluid-BM interface can be written. The local pressure is amplified by a factor dependent on the local wavenumber with respect to the average pressure, a phenomenon we refer to as "fluid focusing", which plays a relevant role in the BM total amplification gain. This interpretation of the hydrodynamic boost to the pressure provides a physical justification to the strategy [10] of fitting the BM admittance with a polynomial containing both a conjugated pole and a zero. In the short-wave region, the sharp gradients of the velocity field yield a second important effect, a damping force on the BM motion, proportional to the local wavenumber, which stabilizes active models and shifts the peak of the response towards the base, with respect to the resonant place. This way, the peaked BM response is not that of a proper resonance, corresponding to a sharp maximum of the admittance, but rather a focusing-driven growth toward the resonant place, which is "aborted" before reaching it by the sharply increasing viscous losses. The large values of the wavenumber that ensure strong focusing are ultimately fueled, against viscosity, by the nonlinear OHC mechanism, hence the otherwise puzzling observation of a wide nonlinear gain dynamics with almost level-independent admittance.

Intermittent high intensity ultrasound pulses with circulating contrast agent microbubbles can induce scattered microlesions of potential value for myocardial reduction therapy. This paper presents an in vitro setup imitating the treatment for monitoring development. A preclinical imaging system with a single element transducer, synchronization and receive-only imaging transducer array has been implemented on a research platform. Contrast agent microbubbles pumped in a dialysis tubing setup were exposed to high intensity focused ultrasound at 1.0/3.5 MHz center frequencies. Polystyrene spheres were employed as linear scatterers compared to contrast agents for system transfer function equalization. A cavitation mapping technique was employed to spatially locate and depict microbubble activity during treatment. For high acoustic pressure amplitudes a 5 dB difference between contrast agent and solid spheres was observed and spatially mapped. The in-plane resolution was 4.5 mm for axial and 1.5 mm laterally. In the future, this cavitation detection scheme will be applied to monitor in vivo microlesioning in real-time.

Acoustic radiation force is a nonlinear acoustic effect caused by the transfer of wave momentum to absorbing or scattering objects. This phenomenon is exploited in modern ultrasound metrology for measurement of the acoustic power radiated by a source and is used for both therapeutic and diagnostic sources in medical applications. To calculate radiation force an acoustic hologram can be used in conjunction with analytical expressions based on the angular spectrum of the measured field. The results of an experimental investigation of radiation forces in two different cases are presented in this paper. In one case, the radiation force of an obliquely incident ultrasound beam on a large absorber (which completely absorbs the beam) is considered. The second case concerns measurement of the radiation force on a spherical target that is small compared to the beam diameter.

Human immunodeficiency virus and acquired immune deficiency syndrome (HIV/AIDS) is pandemic. It has affected nearly 60 million people since the detection of the disease in 1981 to date. In this paper basic deterministic HIV/AIDS model with mass action incidence function are developed. Stability analysis is carried out. And the disease free equilibrium of the basic model was found to be locally asymptotically stable whenever the threshold parameter (RO) value is less than one, and unstable otherwise. The model is extended by introducing two optimal control strategies namely, CD4 counts and treatment for the infective using optimal control theory. Numerical simulation was carried out in order to illustrate the analytic results.