Search

Past quantitative studies have shown that most media coverage is of men. Here we ask if the scarce coverage that women get is qualitatively different from that of men. We use computer-coded sentiment scores for 14 million person names covered in 1,323 newspapers to investigate the three-way relationship between gender, fame, and sentiment. Additional large-scale data on occupational categories allow us to compare women and men within the same profession and rank. We propose that as women's fame increases their media coverage becomes negative more quickly when compared to men (a "paper cut"), because their violation of gender hierarchies and social expectations about typical feminine behavior evokes disproportionate scrutiny. We find that while overall media coverage is much more positive for women than for men, this difference disappears and even reverses at higher levels of fame. In encyclopedic sentiment data we find no biographic basis for women's disproportionate decline in media coverage sentiment at high fame, consistent with the conjectured double standard in media discourse. [ABSTRACT FROM AUTHOR]

Throughout its serial run, Charles Dickens's Pickwick Papers (1836–7), was repurposed hundreds of times by the provincial press. From acting as innocuous filler material to making strategic political statements, provincial newspaper editors evoked, excerpted and adapted Pickwick as quickly as Dickens was penning the instalments, showing a keen responsiveness to political topicalities relevant to their reading communities. This article contends that these types of journalistic re-use benefit from being read collectively as a form of remediation, defined by Jay David Bolter and Richard Grusin as 'the formal logic by which new media refashion prior media forms'. It argues that these remediations are vital to understanding the politics of the provincial press because they became one method through which provincial newspapers articulated a localised response to the national political debates that raged following the 1832 Reform Act. As well as reflecting the political priorities of specific communities, these remediations nuance our understanding of Pickwick 's popularity by drawing attention to aspects of its construction that lent themselves to re-use. While explicit engagement with party politics is conspicuously absent from Pickwick , provincial editors capitalised upon this generality and imbued their re-workings of the serial with a partisanship that Dickens himself avoided, while using his name to substantiate and authorise their own pieces. In this respect, these remediations invite us to place Pickwick at the heart of political debate in the papers, by foregrounding the close relationship between newspaper politics, serial literature, and provincial identity in the 1830s. [ABSTRACT FROM AUTHOR]

Purpose: The purpose of this white paper is to educate health care professionals about the evolution of telemedicine (TM) and to propose a hybrid model that leverages the strengths of traditional in-person medicine as well as virtual medicine while maximizing the safety and quality of men's sexual health care. Literature Search Strategy: A literature search focused on the use of TM in urology and men's health was performed through PubMed/MEDLINE, Embase, and Web of Science (January 1, 2012–April 26, 2022). Keywords included all known permutations of the terminology used to refer to virtual health, care as well as the terminology used to refer to urologic diseases, issues specific to men's health, and men's sexual health concerns. Publications that emerged after the literature search that met this criterion also were incorporated. Opinion pieces, letters to the editor, meeting abstracts, and conference proceedings were excluded. Additional resources were retrieved, such as governmental technical reports, legislative updates and reviews, and blogs. This search strategy yielded 1684 records across databases after removal of duplicates. Abstracts from the retrieved records were reviewed for relevance. Relevant publications were defined as those that reported data on any aspect of TM use specific to urology, men's health, and/or men's sexual health. If relevance was unclear from the abstract, then the full text of the article was retrieved for a more detailed review. In addition, the published evidence-based practice guidelines relevant to care for erectile dysfunction, Peyronie's disease, ejaculatory dysfunction, and hypogonadism were retrieved. The most common reasons for article exclusions were a focus on TM use in disciplines other than urology and the absence of data (ie, opinion pieces). After exclusions, a total of 91 publications remained and constituted the evidence base for this paper. [ABSTRACT FROM AUTHOR]

Previous research has evaluated the extent to which cocaine and other drugs were detectable on currency in the USA. The literature was in agreement that the majority of bills exhibited some degree of contamination. With the increase of fentanyl in the illicit drug supply, this study was designed to evaluate the extent that fentanyl, cocaine, methamphetamine and other substances were present on circulating currency in 2022. A quantitative assay using liquid chromatography–triple quadrupole mass spectrometry was developed and validated to detect six analytes: fentanyl, 4-anilino- N -phenethylpiperidine, acetylfentanyl, benzylfentanyl, cocaine and methamphetamine. One-dollar bills were collected from 13 cities across the country. Sample preparation consisted of soaking the bills in methanol followed by liquid–liquid extraction. Chromatographic separation was achieved using a C18 analytical column and gradient elution with ammonium formate in water (5 mM, pH 3) and 0.1% formic acid in acetonitrile. The quantitative working range for this assay was 0.1 μg to 1.0 μg per bill (equivalent to 1 ng/mL to 100 ng/mL of extract). Fentanyl was detected on the majority (63%) of samples, with 61% of samples having ≥0.1 μg of fentanyl and 4% of samples having ≥1.0 μg. Cocaine and methamphetamine were detected on 100% and 98% of bills, respectively, typically in amounts >1.0 μg. The remaining fentanyl-related substances were detected in 15% of samples in amounts no >0.69 μg per bill and exclusively in the presence of fentanyl. Unsurprisingly, areas of the country with higher incidence of fentanyl use yielded higher frequency of contaminated bills and higher concentrations. Human exposure to drugs on currency is unlikely to have any significant impacts toxicologically or pharmacologically; however, our research findings suggest that paper currency could serve as a useful substrate for surveillance of drug trends regionally, nationally and/or internationally. [ABSTRACT FROM AUTHOR]

We present the analysis of the stellar population and star formation history of 181 MIRI selected galaxies at z  = 0 − 3.5 in the massive galaxy cluster field SMACS J0723.3–7327, commonly referred to as SMACS0723, using the JWST Mid-Infrared Instrument (MIRI). We combine the data with the JWST Near Infrared Camera (NIRCam) catalogue, in conjunction with the Hubble Space Telescope (HST) WFC3/IR and ACS imaging. We find that the MIRI bands capture PAH features and dust emission, significantly enhancing the accuracy of photometric redshift and measurements of the physical properties of these galaxies. The median photo- z 's of galaxies with MIRI data are found to have a small 0.1 per cent difference from spectroscopic redshifts and reducing the error by 20 per cent. With MIRI data included in SED fits, we find that the measured stellar masses are unchanged, while the star formation rate is slightly lower by 0.1 dex. We also fit the median SED of active galactic nuclei (AGNs) and star-forming galaxies (SFG) separately. MIRI data provides tighter constraints on the AGN contribution, reducing the typical AGN contributions by ∼15 per cent. In addition, we also compare the median SED obtained with and without MIRI, and we find that including MIRI data yields steeper optical and UV slopes, indicating bluer colours, lower dust attenuation, and younger stellar populations. In the future, MIRI/MRS will enhance our understanding by providing more detailed spectral information and allowing for the study of specific emission features and diagnostics associated with AGN. [ABSTRACT FROM AUTHOR]

This article studies the contested legal–political dynamics around forced migration flows to and through an unrecognized state: the Turkish Republic of Northern Cyprus (TRNC). We adopt an analytical perspective drawn from the literature on performative politics and the legal anthropology of documents to explore how migration dynamics interact with the contested legal status of the TRNC. Our two main questions are: What practical shape do the human rights of refugees and asylum seekers take in an interstitial legal space, where the foundation of law is itself subject to ambiguity, suspension, and contestation? And what implications—opportunities and hazards—does this constellation have for refugees and asylum-seekers? Drawing on interviews, lived experience and fieldwork observations, we make two arguments. First, we contend that the interstitial status of the TRNC represents both an opportunity for refugees and a threat. Secondly, we argue that a purely legal or technical understanding of legal identity and concurrent rights is inadequate; we must subject these phenomena to a politically informed analysis of the everyday practices through which legal norms and spaces are continuously shaped and reshaped. [ABSTRACT FROM AUTHOR]

Introduction Roll-your-own (RYO) tobacco is a popular choice in Australia, with some people who smoke finding these products more attractive than factory-made cigarettes (FMC). Differences in visual and tactile properties and in the feel and taste of the smoke may contribute to this attractiveness. These differences may be driven by variation in tobacco constituents and wrapping paper permeability. However, to date, there has been no comparison of RYO and FMC products on the Australian market. Aims and Methods Chemical constituents, pH, flavorants, and paper permeability were compared in unburned RYO tobacco and tobacco from FMC. RYO and FMC products from matched brands were compared, as were products from the most popular FMC and RYO brands on the Australian market in 2018. Results RYO tobacco had higher moisture and humectant content (glycerol and propylene glycol) than FMC tobacco. RYO tobacco also had higher amounts of total and reducing sugars and lower nicotine when comparing the most popular brands. RYO papers were less permeable than FMC papers. Both RYO and FMC tobacco contained many chemicals identified as flavorants, including fourteen with known potential health risks. For most measured constituents and flavorants, RYO tobaccos had more in common with other RYO than FMC, with the commonalities remaining even when matched brands were compared. Conclusions Higher levels of moisture, humectants, and sugars in Australian RYO tobacco compared to FMC may be increasing attractiveness of RYO by reducing the harsh taste of the smoke and increasing the moist feel of the tobacco. Implications While price is the main factor driving the use of RYO tobacco, some people who smoke find these products more attractive. This study has shown that Australian RYO tobacco contains higher amounts of glycerol, propylene glycol, and sugars than FMC. These chemicals may be improving the taste of the tobacco, as well as creating a moist feel that is falsely perceived as indicating that the tobacco is "fresh" and "less chemically." Ironically, it may be that higher amounts of some added chemicals in RYO contribute to false perceptions of a more natural and less harmful product. [ABSTRACT FROM AUTHOR]

The Centers for Medicare & Medicaid Services (CMS) introduced the Severe Sepsis/Septic Shock Management Bundle (SEP-1) as a pay-for-reporting measure in 2015 and is now planning to make it a pay-for-performance measure by incorporating it into the Hospital Value-Based Purchasing Program. This joint IDSA/ACEP/PIDS/SHEA/SHM/SIPD position paper highlights concerns with this change. Multiple studies indicate that SEP-1 implementation was associated with increased broad-spectrum antibiotic use, lactate measurements, and aggressive fluid resuscitation for patients with suspected sepsis but not with decreased mortality rates. Increased focus on SEP-1 risks further diverting attention and resources from more effective measures and comprehensive sepsis care. We recommend retiring SEP-1 rather than using it in a payment model and shifting instead to new sepsis metrics that focus on patient outcomes. CMS is developing a community-onset sepsis 30-day mortality electronic clinical quality measure (eCQM) that is an important step in this direction. The eCQM preliminarily identifies sepsis using systemic inflammatory response syndrome (SIRS) criteria, antibiotic administrations or diagnosis codes for infection or sepsis, and clinical indicators of acute organ dysfunction. We support the eCQM but recommend removing SIRS criteria and diagnosis codes to streamline implementation, decrease variability between hospitals, maintain vigilance for patients with sepsis but without SIRS, and avoid promoting antibiotic use in uninfected patients with SIRS. We further advocate for CMS to harmonize the eCQM with the Centers for Disease Control and Prevention's (CDC) Adult Sepsis Event surveillance metric to promote unity in federal measures, decrease reporting burden for hospitals, and facilitate shared prevention initiatives. These steps will result in a more robust measure that will encourage hospitals to pay more attention to the full breadth of sepsis care, stimulate new innovations in diagnosis and treatment, and ultimately bring us closer to our shared goal of improving outcomes for patients. [ABSTRACT FROM AUTHOR]

Objective The primary aim of this paper is to review evidence and clinical implications related to lifestyle activities associated with promoting brain and cognitive health. Our review targets four key lifestyle factors: physical activity and exercise, social engagement, cognitively stimulating activity, and consuming Mediterranean-style diets. Method We conducted a critical review of the lifestyle factor literature in the four domains listed earlier. We contextualize this literature review by translating findings, when possible, into evidence-based recommendations to consider when providing neuropsychological services. Results There is significant current evidence supporting the role of physical activity and exercise, social engagement, cognitively stimulating activity, and consuming Mediterranean-style diets on positive brain and cognitive health outcomes. While some null findings are present in all four areas reviewed, the weight of the evidence supports the notion that engaging in these activities may promote brain and cognitive functioning. Conclusions Clinical neuropsychologists can have confidence in recommending engagement in physical activity, social activity, and cognitively stimulating activity, and adhering to a Mediterranean-style diet to promote brain and cognitive health. We discuss limitations in existing lifestyle factor research and future directions to enhance the existing evidence base, including additional research with historically underrepresented groups and individuals with neurological conditions. [ABSTRACT FROM AUTHOR]

The ecological relationships among antimicrobial producing, resistant, and sensitive strains have been proposed to follow rock-paper-scissors dynamics, but evidence is mainly based on Gram-negative bacteriocins in vitro. The ecological relevance of antimicrobials in vivo or in situ has not been systematically studied. This study therefore aimed to analyze binary and ternary competitions among reutericyclin-producing strain Limosilactobacillus reuteri TMW1.656, its reutericyclin-resistant, nonproducing isogenic derivative L. reuteri TMW1.656 ∆rtcN , and the reutericyclin-sensitive, nonproducing L. reuteri TMW1.656 ∆rtcN∆rtcT in vitro (liquid culture and static plate), in situ (sourdough fermentation), and in vivo (gut of germ-free mice). In liquid culture, L. reuteri TMW1.656 had a higher fitness than TMW1.656 ∆rtcN and TMW1.656 ∆rtcN∆rtcT. Limosilactobacillus reuteri TMW1.656 ∆rtcN∆rtcT had a higher fitness than TMW1.656 ∆rtcN. On agar plates, L. reuteri TMW1.656 had a higher fitness than TMW1.656 ∆rtcN∆rtcT. In situ , reutericyclin production and resistance had no influence on the fitness of the strains. In vivo , TMW1.656 had an advantage over TMW1.656 ∆rtcN and TMW1.656 ∆rtcN∆rtcT. Ternary competitions showed reutericyclin production was ecologically beneficial in all ecosystems. The findings support the ecological importance of reutericyclin in a variety of environments/niches, providing an explanation for the acquisition of the reutericyclin gene cluster in L. reuteri and its contribution to the ecological fitness of Streptococcus mutans. [ABSTRACT FROM AUTHOR]

Direct alcohol biomarkers are of growing interest for the assessment of alcohol consumption, with particular interest in phosphatidylethanol (PEth) in recent years. PEth is only formed when alcohol is present in the body. However, there is no statement about how much the PEth concentration increases after single moderate alcohol consumption. This study was conducted to determine the increase in PEth concentrations after a single drinking event. Additionally, a new volumetric sampling device (volumetric dried blood spot cards (DBSV)) was evaluated, which was designed to simplify further sampling processes and to allow for easy self-sampling. Dried blood samples from 31 volunteers were collected before and after single alcohol consumption with a mean maximum breath alcohol concentration of 0.4 mg/L (range: 0.30–0.55 mg/L). PEth concentrations were determined after automated extraction by liquid chromatography--tandem mass spectrometry. PEth 16:0/18:1 and PEth 16:0/18:2 concentrations increased to an average of 45 ng/mL each in patients starting below 20 ng/mL (range: 25.0–57.0 ng/mL for PEth 16:0/18:1; range 26.8–62.3 ng/mL for PEth 16:0/18:2). PEth concentrations in patients starting above 20 ng/mL increased by a mean of 30 ng/mL (range: 6.2–71.3 ng/mL for PEth 16:0/18:1; range 8.8–65.3 ng/mL for PEth 16:0/18:2). In addition, the comparison of the new sampling device DBSV with a standard filter paper card (with volumetrically applied 20 µL of blood samples) yielded a close agreement for the determined PEth concentrations in 24 forensic samples and three external controls. Therefore, the sampling device DBSV proved to be suitable for the determination of PEth concentrations in blood. [ABSTRACT FROM AUTHOR]

Digital technology has broadened the research methods in the field of cultural heritage protection, and promoted the online organization and utilization of different resources. New digital technology is used to further explore the resources related to traditional Chinese handmade paper (TCHP) in order to comprehensively and systematically realize the knowledge association of different types of handmade paper. In this article, the characteristics of TCHP are combined to existing mature and generic ontologies to design a new ontology model of TCHP, and Protégé software is used to construct the visual ontology. The model is verified by analyzing the digital resources of Kaihua paper. Constructing the ontology of TCHP can realize the knowledge organization and visual presentation of related resources, and also promote the further utilization of the resources and wider spread of the culture of TCHP. [ABSTRACT FROM AUTHOR]

A significant amount of researcher and practitioner effort has focused on developing new chemical controls for the parasitic Varroa destructor mite in beekeeping. One outcome of that has been the development and testing of "glycerol–oxalic acid" mixtures to place in colonies for extended periods of time, an off-label use of the otherwise legal miticide oxalic acid. The majority of circulated work on this approach was led by practitioners and published in nonacademic journals, highlighting a lack of effective partnership between practitioners and scientists and a possible failure of the extension mandate in beekeeping in the United States. Here, we summarize the practitioner-led studies we could locate and partner with a commercial beekeeper in the Southeast of the United States to test the "shop towel–oxalic acid–glycerol" delivery system developed by those practitioners. Our study, using 129 commercial colonies between honey flows in 2017 split into 4 treatment groups, showed no effectiveness in reducing Varroa parasitism in colonies exposed to oxalic acid–glycerol shop towels. We highlight the discrepancy between our results and those circulated by practitioners, at least for the Southeast, and the failure of extension to support practitioners engaged in research. [ABSTRACT FROM AUTHOR]

Packaging waste makes up more than 10% of the landfilled waste in the United States. While consumers often want to make environmentally friendly product choices, we find that their perceptions of the environmental friendliness of product packaging may systematically deviate from its objective environmental friendliness. Eight studies (N = 4,103) document the perceived environmental friendliness (PEF) bias whereby consumers judge plastic packaging with additional paper to be more environmentally friendly than identical plastic packaging without the paper. The PEF bias is driven by consumers' "paper = good, plastic = bad" beliefs and by proportional reasoning, wherein packaging with a greater paper-to-plastic proportion is judged as more environmentally friendly. We further show that the PEF bias impacts consumers' willingness to pay and product choice. Importantly, this bias can be mitigated by a "minimal packaging sticker" intervention, which increases the environmental friendliness perceptions of plastic-only packaging, rendering plastic-packaged products to be preferable to their plastic-plus-paper-packaged counterparts. This research contributes to the packaging literature in marketing and to research on sustainability while offering practical implications for managers and public policy officials. [ABSTRACT FROM AUTHOR]

In this work, we update and develop algorithms for KMTNet tender-love care (TLC) photometry in order to create a new, mostly automated, TLC pipeline. We then start a project to systematically apply the new TLC pipeline to the historic KMTNet microlensing events, and search for buried planetary signals. We report the discovery of such a planet candidate in the microlensing event MOA-2019-BLG-421/KMT-2019-BLG-2991. The anomalous signal can be explained by either a planet around the lens star or the orbital motion of the source star. For the planetary interpretation, despite many degenerate solutions, the planet is most likely to be a Jovian planet orbiting an M or K dwarf, which is a typical microlensing planet. The discovery proves that the project can indeed increase the sensitivity of historic events and find previously undiscovered signals. [ABSTRACT FROM AUTHOR]

Spermatozoa vary in quantity, quality and design across species and individuals. Here, we reported the first detailed analysis of sperm traits in two primitively eusocial paper wasps, Polistes dominula and Polistes gallicus , which differ in their nuptial strategies and body size as follows: lek-territoriality of the large P. dominula males, defending exclusive territories at landmarks; scramble competition of the small P. gallicus , where serial mating may occur because males interfere with rivals and replace them during copulation. We compared the number, viability, and length of sperm, and its coefficient of variation, between these sympatric paper wasps patrolling and marking the same landmarks during the same summer: a good opportunity to analyse sperm across species while controlling for environmental variables. Spermatozoa were more numerous and longer in P. dominula than in P. gallicus males. Viability was similar in both species and positively covaried with male body size. Intra-male variation in sperm length was significantly reduced in P. gallicus , as predicted in the case of selection for an optimal sperm design. We hypothesized that precopulatory sexual selection (lek-territoriality vs. scramble competition) may affect sperm traits. [ABSTRACT FROM AUTHOR]

Background and Aims Cress seeds release allelochemicals that over-stimulate the elongation of hypocotyls of neighbouring (potentially competing) seedlings and inhibit their root growth. The hypocotyl promoter is potassium, but the root inhibitor was unidentified; its nature is investigated here. Methods Low-molecular-weight cress-seed exudate (LCSE) from imbibed Lepidium sativum seeds was fractionated by phase partitioning, paper chromatography, high-voltage electrophoresis and gel-permeation chromatography (on Bio-Gel P-2). Fractions, compared with pure potassium salts, were bioassayed for effects on Amaranthus caudatus seedling growth in the dark for 4 days. Key Results The LCSE robustly promoted amaranth hypocotyl elongation and inhibited root growth. The hypocotyl inhibitor was non-volatile, hot acid stable, hydrophilic and resistant to incineration, as expected for K+. The root inhibitor(s) had similar properties but were organic (activity lost on incineration). The root inhibitor(s) remained in the aqueous phase (at pH 2.0, 6.5 and 9.0) when partitioned against butan-1-ol or toluene, and were thus hydrophilic. Activity was diminished after electrophoresis, but the remaining root inhibitors were neutral. They became undetectable after paper chromatography; therefore, they probably comprised multiple compounds, which separated from each other, in part, during fractionation. On gel-permeation chromatography, the root inhibitor co-eluted with hexoses. Conclusions Cress-seed allelochemicals inhibiting root growth are different from the agent (K+) that over-stimulates hypocotyl elongation and the former probably comprise a mixture of small, non-volatile, hydrophilic, organic substances. Abundant components identified chromatographically and by electrophoresis in cress-seed exudate fitting this description include glucose, fructose, sucrose and galacturonic acid. However, none of these sugars co-chromatographed and co-electrophoresed with the root-inhibitory principle of LCSE, and none of them (in pure form at naturally occurring concentrations) inhibited root growth. We conclude that the root-inhibiting allelochemicals of cress-seed exudate remain unidentified. [ABSTRACT FROM AUTHOR]

This study aimed to evaluate the filter paper as a means to transport inactivated Gram‐negative non‐fermentative (GNNF) bacteria and Haemophilus spp. for analysis using MALDI‐TOF MS. A total of 133 isolates were evaluated and the analysis of each isolate was performed directly from original bacterial colony and in filter paper after the processing. To evaluate the agreement between the identification performed directly from the colony and after impregnation in filter paper, we assign the scores: >2·3 as excellent (E); 2·0 to 2·3 as very good (VG); 1·7–1·99 as good (G); <1·7 as unidentified (U). The divergences were classified as: Minor Divergence, Intermediate Divergence and Major Divergence. A total of 80 isolates transported in the filter paper disks presented full category concordance; 39 isolates presented Minor Divergence; 4 isolates present Intermediate Divergence; 4 isolates present Major Divergence and 6 isolates present better results after impregnation in filter paper. The proposed methodology of bacteria transportation presented a sensitivity of 96·9% and a specificity of 100%. The filter paper as a means to transport and storage of inactivated GNNF and Haemophilus spp. may be considered a potential tool for faster, more accurate, biosafe and less‐expensive identification. [ABSTRACT FROM AUTHOR]

We present relativistic magnetohydrodynamic modelling of jets running into hydrostatic, spherically symmetric cluster atmospheres. For the first time in a numerical simulation, we present model cluster atmospheres based upon the universal pressure profile (UPP), incorporating a temperature profile for a 'typical' self-similar atmosphere described by only one parameter – M 500. We explore a comprehensive range of realistic atmospheres and jet powers and derive dynamic, energetic, and polarimetric data which provide insight into what we should expect of future high-resolution studies of AGN outflows. From the simulated synchrotron emission maps which include Doppler beaming we find sidedness distributions that agree well with observations. We replicated a number of findings from our previous work, such as higher power jets inflating larger aspect-ratio lobes, and the cluster environment impacting the distribution of energy between the lobe and shocked regions. Comparing UPP and β-profiles we find that the cluster model chosen results in a different morphology for the resultant lobes with the UPP more able to clear lobe material from the core; and that these different atmospheres influence the ratio between the various forms of energy in the fully developed lobes. This work also highlights the key role played by Kelvin–Helmholtz instabilities in the formation of realistic lobe aspect ratios. Our simulations point to the need for additional lobe-widening mechanisms at high jet powers, for example jet precession. Given that the UPP is our most representative general cluster atmosphere, these numerical simulations represent the most realistic models yet for spherically symmetric atmospheres. [ABSTRACT FROM AUTHOR]

The Healthcare Nutrition Council (HNC) represents manufacturers of enteral nutrition formulas and oral nutrition supplements, including those categorized as medical foods and parenteral nutrition. HNC member companies, Abbott's Nutrition Division, Nestlé Health Science, and Nutricia North America, a subsidiary of Danone S.A., manufacture a majority of the medical foods consumed in the United States. HNC is proposing a modernized interpretation of the medical food framework to reflect the evolution of nutrition science and health care. The medical food category was first defined in 1988 as part of the Orphan Drug Act. Since then, the scientific community's understanding of nutrition and the role it can play in disease management has progressed. HNC believes that a patient-centric approach is needed to foster research and innovation and to position medical foods as a viable solution in the dietary management of disease. HNC proposes that distinctive nutritional requirements refer to the clinical need for a specific nutritional intake (compared with the intake of healthy populations), which may exist by reason of abnormal physiologic manifestation or physical impairment associated with a disease or condition. The dietary management of these diseases and conditions results in clinically meaningful improvements, including but not limited to nutritional status, health outcomes, or quality of life. HNC believes that abnormal physiologic manifestation or physical impairment would include a limited, impaired, or disturbed capacity to ingest, digest, absorb, metabolize, or excrete ordinary food or certain nutrients or metabolites or other medically determined requirements for nutrients or other food substances of biological value. HNC recommends our position be considered as we build consensus across the industry. We request that the Food and Drug Administration modify and codify the current definition to reflect this. Patients and the health care system will benefit from a strong regulatory interpretation of the medical foods framework. [ABSTRACT FROM AUTHOR]

A recent study published in the British Journal of Dermatology discusses the use of beremagene geperpavec (B-VEC) gene therapy for the treatment of cutaneous wounds in patients with dystrophic epidermolysis bullosa (DEB). DEB is a rare inherited skin disease characterized by blistering and slow-to-heal wounds. The study found that B-VEC treatment resulted in significantly higher rates of wound healing compared to a placebo. The therapy has received approval from the US Food and Drug Administration and is expected to provide a new treatment option for patients with DEB. [Extracted from the article]

This paper explores the connections between archival research and teaching as an adjunct faculty member and mother. The form of the essay is an example of the "I-Search paper," a first-person account of the research process. In I-Search papers, authors start with the "search story," where they explain their initial research questions, then describe their "search results" in detail, including the primary sources they found, and end with a reflection on the research process. This essay is two I-Search papers in one—bringing together the experience of reading about students' historical research experiences with the author's own version of a research story. The essay is about teaching and research and their intersections, and especially what teaching has taught the author about research. The account of the individual research experience touches on the archival experiences of frustration and boredom, and the tension between wanting to find something in the archives and coming away with something else, and ends with a reflection on how our personal circumstances can impact our research. [ABSTRACT FROM AUTHOR]

Host immune activation is common under a pathogen invasion. This physiological response can promote changes in the body surface compounds, thus providing chemical cues related to health that might be useful to conspecifics. By recognizing the current immunological status of social partners, individuals can modulate their behavior to minimize the risk of infection. Tegument wounding, an immune elicitor, is a required step for many parasites to become established in a host. By using the neotropical eusocial paper wasp Mischocyttarus metathoracicus as a model organism, we first performed a lure presentation experiment in the field to test if wasps discriminate conspecific immunological status (experimentally manipulated by wounding) during on nest social interactions. Then, we performed gas chromatography–mass spectrometry analyses to test if immunostimulation by wounding alters the wasps' cuticular hydrocarbon profile. We found that wasps reduce the duration of aggressive physical contact when interacting with wounded lures, despite displaying a similar frequency of inspective and aggressive behaviors toward both the wounded and the control lures. Besides, we found a subtle increase in a single cuticular hydrocarbon in the wounded wasps. Thus, wasps recognize conspecific immunological status, likely by chemical cues, and modulate their behavior in order to defend the colony against intruders while minimizing the personal risk of infection. [ABSTRACT FROM AUTHOR]

Peer review is a key gatekeeper for academic journals, attempting to block inadequate submissions or correcting them to a publishable standard, as well as improving those that are already satisfactory. The three key aspects of research quality are rigour, significance, and originality but no prior study has assessed whether journal reviewers are ever able to judge these effectively. In response, this article compares reviewer scores for these aspects for theoretical articles in the SciPost Physics journal. It also compares them with Italian research assessment exercise physics reviewer agreement scores. SciPost Physics theoretical articles give a nearly ideal case: a theoretical aspect of a mature science, for which suitable reviewers might comprehend the entire paper. Nevertheless, intraclass correlations between the first two reviewers for the three core quality scores were similar and moderate, 0.36 (originality), 0.39 (significance), and 0.40 (rigour), so there is no aspect that different reviewers are consistent about. Differences tended to be small, with 86% of scores agreeing or differing by 1 on a 6-point scale. Individual reviewers were most likely to give similar scores for significance and originality (Spearman 0.63), and least likely to for originality and validity (Spearman 0.38). Whilst a lack of norm referencing is probably the biggest reason for differences between reviewers, others include differing background knowledge, understanding, and beliefs about valid assumptions. The moderate agreement between reviewers on the core aspects of scientific quality, including rigour, in a nearly ideal case is concerning for the security of the wider academic record. [ABSTRACT FROM AUTHOR]

There are a few results about the global nonlinear stability of nontrivial large solution to quasilinear wave equations. Time-like extremal surface in Minkowski space is an important model of quasilinear wave equation. There are two folds in this paper. Firstly, we get the existence of traveling wave solution to the time-like extremal hypersurface in |$\mathbb {R}^{1+(n+1)}$|⁠ , which can be considered as the generalized Bernstein theorem. For |$n=2$|⁠ , we are also concerned with global stability of traveling wave solutions with speed of light to time-like extremal hypersurface equation in |$1+(2+1)$| dimensional Minkowski space, which is corresponding with quasilinear wave equation in two space dimensions. [ABSTRACT FROM AUTHOR]

During social interactions, the behavior of an individual often depends on the sex of its social partner. Many animal societies have males and females that play very different behavioral roles, although they coexist and interact non-sexually. At specific phases of the colony cycle, social wasp females and males are contemporaries within a nest, they often interact, although mating occurs mostly off the nest, therefore providing an opportunity to test sex discrimination in contexts other than classical sexual ones. We performed a lure presentation experiment to test if Mischocyttarus metathoracicus discriminate between conspecifics of the 2 sexes during on-nest social interactions. Female wasps discriminated conspecific sex during experimentally simulated nest intrusions. Visual and chemical cues may account for this sex discrimination. Despite sex discrimination (evidenced by differential inspective behavior from the nest females toward the female and the male lures), female wasps were as aggressive toward lures of both sexes. In the female-dominated hymenopteran societies, males are often subordinate and not aggressive on nest, resulting in females directing less aggression to them compared to other females. Instead, M. metathoracicus males and females are both aggressive toward nestmates, so they might be perceived as similar threat during on-nest social interactions. [ABSTRACT FROM AUTHOR]

Hasan reads the poems as a 'picture of an inept state, one in which the king and his officials are reckless and indifferent and there is a total breakdown of law and order' (p. 75). Hasan notes that although two witnesses were required for property deeds, documents often bear a much larger, and quite heterogeneous, list of witnesses. [Extracted from the article]

Paper spray mass spectrometry (PS-MS) has been shown to be a rapid, simple and inexpensive alternative to traditional forensic drug screening methods. It can address the limitations of both immunoassays and chromatography-based techniques due to its non-reliance on sample preparation and its ability to rapidly screen for a wide array of compounds. In this study, an automated PS-MS system was employed to semi-quantitatively screen for 40 commonly abused drugs and metabolites in urine after a 15-min glucuronidase reaction. The target compounds included common prescription opioids, fentanyl and norfentanyl, stimulants including methamphetamine and cocaine, benzodiazepines and antidepressants. The enzyme, buffer and internal standard solution were combined in one spiking solution to minimize sample handling. Analysis was carried out using a commercially available automated paper spray system coupled to a triple quadrupole mass spectrometer. This method may prove useful for clinical and forensic toxicology laboratories as it allows for automated screening of complex samples for drugs without extraction, separation and sample cleanup. [ABSTRACT FROM AUTHOR]

When toilet paper disappeared from store shelves across Japan in November 1973, the housewives who searched their neighborhood markets and stood in long lines for the scarce packs were described as unwitting perpetrators of a "toilet paper panic." The word "panic" evoked well-established notions of a social frenzy, irrational and overwrought. This article overturns a conception of panic laden with condescension and adopts, instead, a more empathetic approach to examining why a run on toilet paper and other daily necessities occurred in late 1973, and why it resonated so deeply across Japan as a "panic." In the broader context of the early 1970s, the toilet paper scare and its characterization as a "panic" can be understood as responses to sweeping and multifaceted economic challenges that destabilized daily life and threatened to upend middle-class lifestyles. After more than fifteen years of high economic growth, that sense of middle-class comfort and security was shaken by shortages and inflation as well as mounting evidence of government ineptitude and corporate profiteering. Buffeted by insecurity and uncertainty, Japanese "middle-classness" as both an experience and an ideal had never seemed as vulnerable as it did in the early 1970s. [ABSTRACT FROM AUTHOR]

Summary: Numerous studies are published on the benefits of electric hand dryers vs paper towels (PT) for drying hands after washing. Data are conflicting and lacking key variables needed to assess infection risks. We provide a rapid scoping review on hand‐drying methods relative to hygiene and health risks. Controlled vocabulary terms and keywords were used to search PubMed (1946–2018) and Embase (1947–2018). Multiple researchers independently screened abstracts for relevance using predetermined criteria and created a quality assessment scoring system for relative study comparisons. Of 293 papers, 23 were included in the final analysis. Five studies did not compare multiple methods; however, 2 generally favoured electric dryers (ED); 7 preferred PT; and 9 had mixed or statistically insignificant results (among these, 3 contained scenarios favourable to ED, 4 had results supporting PT, and the remaining studies had broadly conflicting results). Results were mixed among and within studies and many lacked consistent design or statistical analysis. The breadth of data does not favour one method as being more hygienic. However, some authors extended generalizable recommendations without sufficient scientific evidence. The use of tools in quantitative microbial risk assessment is suggested to evaluate health exposure potentials and risks relative to hand‐drying methods. We found no data to support any human health claims associated with hand‐drying methods. Inconclusive and conflicting results represent data gaps preventing the advancement of hand‐drying policy or practice recommendations. [ABSTRACT FROM AUTHOR]

Background: Fragrance allergens (FAs) refer to these volatile or semi-volatile fragrance compounds that can induce sensitization, and they are widely used in household goods. Objective: In this work, a method combining solid-liquid extraction (SLE) and dispersive liquid-liquid microextraction (DLLME) with gas chromatography-mass spectrometry (GC-MS) has been developed and applied in the analysis of 19 FAs (including hydrocarbons, alcohols, aldehydes, esters, and phenols) in paper household goods. Method: The samples (infant or personal paper hygiene products) were cut into small pieces and underwent SLE with methanol as solvent. The supernatant was taken, and ultrapure water, sodium chloride, and trichloromethane (extractant) were added, which was mixed with vortex. After centrifugation, the bottom chloroform layer was taken for GC-MS detection. Results: Under optimized conditions, a good linearity was achieved (r≥0.9985) in the range of 0.01-128.0 mg/kg with relative standard deviations lower than 15%. The method showed limits of detection (LODs) within the range of 0.96-12.0 mg/kg and recoveries from 70.6% to 128.9%, except furfuryl alcohol with low recoveries (53.8-64.6%). Twenty kinds of paper household goods samples were analyzed by this method; nine FAs were detected. The linalool detected in one sample was more than 10 mg/kg, and the contents of other analytes in this sample and all analytes in other samples were less than 10 mg/kg. Conclusions: The performance evaluation of the method met the requirements of the analysis of trace components. The established method was successfully applied to the detection of FAs in paper household goods samples. The proposed method could provide a basis for the establishment of relevant detection standards in the future. Highlights: The LODs were found between 0.96 and 12.0 mg/kg. A simple, economical, and sensitive method was established for the determination of 19 FAs in paper household goods. [ABSTRACT FROM AUTHOR]

This article focuses on the Royal Manuscript 18 B II which is the earliest and most complete surviving witness to the Middle English prose "Melusine." The article discusses the single-text codex and its features including the number and placement of capitula and explores the hypothesis that the manuscript was translated from the first edition of writer Jean d'Arras's "Mélusine" printed by Adam Steinschaber in Geneva, Switzerland in August 1478.

Background The Medical Certificate of Stillbirth (MCS) records data about a baby's death after 24 weeks of gestation but before birth. Major errors that could alter interpretation of the MCS were widespread in two UK-based regional studies. Methods A multicentre evaluation was conducted, examining MCS issued 1 January 2018 to 31 December 2018 in 76 UK obstetric units. A systematic case-note review of stillbirths was conducted by Obstetric and Gynaecology trainees, generating individual 'ideal MCSs' and comparing these to the actual MCS issued. Anonymized central data analysis described rates and types of error, agreement and factors associated with major errors. Results There were 1120 MCSs suitable for assessment, with 126 additional submitted data sets unsuitable for accuracy analysis (total 1246 cases). Gestational age demonstrated 'substantial' agreement [K = 0.73 (95% CI 0.70–0.76)]. Primary cause of death (COD) showed 'fair' agreement [K = 0.26 (95% CI 0.24–0.29)]. Major errors [696/1120; 62.1% (95% CI 59.3–64.9%)] included certificates issued for fetal demise at <24 weeks' gestation [23/696; 3.3% (95% CI 2.2–4.9%)] or neonatal death [2/696; 0.3% (95% CI 0.1–1.1%)] or incorrect primary COD [667/696; 95.8% (95% CI 94.1–97.1%)]. Of 540/1246 [43.3% (95% CI 40.6–46.1%)] 'unexplained' stillbirths, only 119/540 [22.0% (95% CI 18.8–25.7%)] remained unexplained; the majority were redesignated as either fetal growth restriction [FGR: 195/540; 36.1% (95% CI 32.2–40.3%)] or placental insufficiency [184/540; 34.1% (95% CI 30.2–38.2)]. Overall, FGR [306/1246; 24.6% (95% CI 22.3–27.0%)] was the leading primary COD after review, yet only 53/306 [17.3% (95% CI 13.5–22.1%)] FGR cases were originally attributed correctly. Conclusion This study demonstrates widespread major errors in MCS completion across the UK. MCS should only be completed following structured case-note review, with particular attention on the fetal growth trajectory. [ABSTRACT FROM AUTHOR]

While we have the tools to achieve this goal, the persistent barriers to healthcare services experienced by too many individuals will need to be addressed to make significant progress and improve the health and quality of life of all people with human immunodeficiency virus (HIV). The necessary structural changes require actions by federal, state, and local policymakers and range from ensuring universal access to healthcare services to optimizing care delivery to ensuring a robust and diverse infectious diseases and HIV workforce. In this article, we outlines 10 key principles for policy reforms that, if advanced, would make ending the HIV epidemic in the United States possible and could have much more far-reaching effects in improving the health of our nation. [ABSTRACT FROM AUTHOR]

Despite significant advances in the diagnosis and treatment of cardiovascular diseases, recent calls have emphasized the unmet need to improve precision-based approaches in cardiovascular disease. Although some studies provide preliminary evidence of the diagnostic and prognostic potential of circulating coding and non-coding RNAs, the complex RNA biology and lack of standardization have hampered the translation of these markers into clinical practice. In this position paper of the CardioRNA COST action CA17129, we provide recommendations to standardize the RNA development process in order to catalyse efforts to investigate novel RNAs for clinical use. We list the unmet clinical needs in cardiovascular disease, such as the identification of high-risk patients with ischaemic heart disease or heart failure who require more intensive therapies. The advantages and pitfalls of the different sample types, including RNAs from plasma, extracellular vesicles, and whole blood, are discussed in the sample matrix, together with their respective analytical methods. The effect of patient demographics and highly prevalent comorbidities, such as metabolic disorders, on the expression of the candidate RNA is presented and should be reported in biomarker studies. We discuss the statistical and regulatory aspects to translate a candidate RNA from a research use only assay to an in-vitro diagnostic test for clinical use. Optimal planning of this development track is required, with input from the researcher, statistician, industry, and regulatory partners. [ABSTRACT FROM AUTHOR]

The Society of Toxicology has awarded the Paper of the Year to a study titled "Increased renal expression of complement components in patients with liver diseases: nonalcoholic steatohepatitis, alcohol-associated, viral hepatitis, and alcohol-viral combination." The study examined the impact of liver dysfunction on renal physiology and identified overlapping renal expression changes across different liver disease etiologies. The findings provide insight into the mechanisms of renal dysfunction associated with chronic liver disease. Two other papers received Honorable Mention, one exploring the impact of particulate matter exposure on foam cell formation in atherosclerosis and the other investigating the effects of developmental exposure to environmental chemicals on CD8+ T cell function during influenza A virus infection. These studies contribute to our understanding of toxicological effects and offer potential strategies for intervention. [Extracted from the article]

Paper wasps are a model system for the study of social evolution due to a high degree of inter- and intraspecific variation in cooperation, aggression, and visual signals of social status. Increasing the taxonomic coverage of genomic resources for this diverse clade will aid comparative genomic approaches for testing predictions about the molecular basis of social evolution. Here, we provide draft genome assemblies for two well-studied species of paper wasps, Polistes exclamans and Mischocyttarus mexicanus. The P. exclamans genome assembly is 221.5 Mb in length with a scaffold N50 of 4.11 Mb. The M. mexicanus genome assembly is 227 Mb in length with a scaffold N50 of 1.1 Mb. Genomes have low repeat content (9.54–10.75%) and low GC content (32.06–32.4%), typical of other social hymenopteran genomes. The DNA methyltransferase gene, Dnmt3  , was lost early in the evolution of Polistinae. We identified a second independent loss of Dnmt3 within hornets (genus: Vespa). [ABSTRACT FROM AUTHOR]

Background A crisis in pain management persists, as does the epidemic of opioid overdose deaths, addiction, and diversion. Pain medicine is meeting these challenges by returning to its origins: the Bonica model of multidisciplinary pain care. The 2018 Academic Consortium White Paper detailed the historical context and magnitude of the pain crisis and the evidence base for nonpharmacologic strategies. More than 50% of chronic opioid use begins in the acute pain care setting. Acupuncture may be able to reduce this risk. Objective This article updates the evidence base for acupuncture therapy for acute pain with a review of systematic reviews and meta-analyses on postsurgical/perioperative pain with opioid sparing and acute nonsurgical/trauma pain, including acute pain in the emergency department. Methods To update reviews cited in the 2018 White Paper, electronic searches were conducted in PubMed, MEDLINE, CINAHL, and the Cochrane Central Register of Controlled Trials for "acupuncture" and "acupuncture therapy" and "acute pain," "surgery," "peri-operative," "trauma," "emergency department," "urgent care," "review(s) ," "systematic review," "meta-analysis," with additional manual review of titles, links, and reference lists. Results There are 22 systematic reviews, 17 with meta-analyses of acupuncture in acute pain settings, and a review for acute pain in the intensive care unit. There are additional studies of acupuncture in acute pain settings. Conclusion The majority of reviews found acupuncture therapy to be an efficacious strategy for acute pain, with potential to avoid or reduce opioid reliance. Future multicenter trials are needed to clarify the dosage and generalizability of acupuncture for acute pain in the emergency department. With an extremely low risk profile, acupuncture therapy is an important strategy in comprehensive acute pain care. [ABSTRACT FROM AUTHOR]

Subject to various restrictive requirements on project application and completion, funded projects are often affected by funding policies for the selection of research objects. This study explored the impact of scientific research funding policies on the funding and research by comparing the topic distribution of awards and papers. A total of 1,870 awards and 16,491 papers of the National Social Science Foundation of China (NSSFC) in library and information science (LIS) were collected from a Chinese research project database. According to the results, the growth rate of awards on most topics is higher than that of papers, while the growth rate of papers on the relevant topics to users, technology, and metrology is higher than that of awards. It was found out in the study that the topics funded by NSSFC were imbalanced. NSSFC provides much more funding to traditional topics rather than emerging topics. As indicated by the funding provided to the projects on traditional topics for research on a large number of papers on emerging topics, however, the innovation and diversity of academic research have yet to be restricted. This study demonstrated that the effect of funding policies on the research topics in LIS is significant. Topic suggestions and funding structure of NSSFC have more impacts on award topics than on paper topics. The influence of NSSFC-recommended topics on paper topics is declining year by year. Additionally, awards with high funding intensity are more susceptible to topic suggestions. [ABSTRACT FROM AUTHOR]

Aims: The utilization of micro‐organisms in pulp and paper industries has proved biobleaching technology as an environmentally friendly alternative to the conventional approach. In this paper, the effect of actinobacterial fermentation broth on pulp biobleaching has been investigated. Methods and Results: Actinobacterial colonies were isolated from lignocellulose‐rich soil samples and screened for xylanase production and bleaching activity. The most efficient isolate in bleaching activity showed 100% similarity to Streptomyces rutgersensis. Pulp treatment with 5‐day fermentation broth of this strain showed up to 7% increase in brightness (30°C for 6 h, pH (5–7)) compared to untreated (control) pulp. Also, after 60 min biotreatment, significant reduction (12·5%) in consumption of bleaching chemicals was achieved to obtain final brightness of 55%. Conclusion: Actinobacterial fermentation broth can be considered as a rich source of effective biobleaching agents which may be considered as environmental friendly and cost‐effective technique in comparison with traditional method. Significance and Impact of the Study: Our findings showed ability of S. rutgersensis UTMC 2445 in bleaching chemomechanical paper pulp. Also, two strains of Saccharothrix, a rare actinobacterium, with biobleaching activity were introduced. In the proposed method, there is no need to use purified enzymes, and biobleaching process can be done using the fermentation broth. [ABSTRACT FROM AUTHOR]

Here, we use a variety of microscopic imaging techniques, including scanning electron microscopy, 3D visible light microscopy, and portable microscopy to capture the topography of rough paper. Paper coated with a model soot was cleaned with either a firm vinyl eraser or softer, putty-like kneaded eraser and reimaged to characterize the disposition of remaining soot. Although both methods remove soot from the upper-most surface of the paper, only the kneaded eraser can conform to the complex topography to remove soot from the interstices between paper fibers. [ABSTRACT FROM AUTHOR]

The human gut microbiota is the microbial ecosystem in the small and large intestines of humans. It has been naturally preserved and evolved to play an important role in the function of the gastrointestinal tract and the physiology of its host, protecting from pathogen colonization, and participating in vitamin synthesis, the functions of the immune system, as well as glucose homeostasis and lipid metabolism, among others. Mounting evidence from animal and human studies indicates that the composition and metabolic profiles of the gut microbiota are linked to the pathogenesis of cardiovascular disease, particularly arterial hypertension, atherosclerosis, and heart failure. In this review article, we provide an overview of the function of the human gut microbiota, summarize, and critically address the evidence linking compositional and functional alterations of the gut microbiota with atherosclerosis and coronary artery disease and discuss the potential of strategies for therapeutically targeting the gut microbiota through various interventions. [ABSTRACT FROM AUTHOR]

Larger animals studied during ontogeny, across populations, or across species, usually have lower mass-specific metabolic rates than smaller animals (hypometric scaling). This pattern is usually observed regardless of physiological state (e.g. basal, resting, field, and maximally active). The scaling of metabolism is usually highly correlated with the scaling of many life-history traits, behaviors, physiological variables, and cellular/molecular properties, making determination of the causation of this pattern challenging. For across-species comparisons of resting and locomoting animals (but less so for across populations or during ontogeny), the mechanisms at the physiological and cellular level are becoming clear. Lower mass-specific metabolic rates of larger species at rest are due to (a) lower contents of expensive tissues (brains, liver, and kidneys), and (b) slower ion leak across membranes at least partially due to membrane composition, with lower ion pump ATPase activities. Lower mass-specific costs of larger species during locomotion are due to lower costs for lower-frequency muscle activity, with slower myosin and Ca++ ATPase activities, and likely more elastic energy storage. The evolutionary explanation(s) for hypometric scaling remain(s) highly controversial. One subset of evolutionary hypotheses relies on constraints on larger animals due to changes in geometry with size; for example, lower surface-to-volume ratios of exchange surfaces may constrain nutrient or heat exchange, or lower cross-sectional areas of muscles and tendons relative to body mass ratios would make larger animals more fragile without compensation. Another subset of hypotheses suggests that hypometric scaling arises from biotic interactions and correlated selection, with larger animals experiencing less selection for mass-specific growth or neurolocomotor performance. An additional third type of explanation comes from population genetics. Larger animals with their lower effective population sizes and subsequent less effective selection relative to drift may have more deleterious mutations, reducing maximal performance and metabolic rates. Resolving the evolutionary explanation for the hypometric scaling of metabolism and associated variables is a major challenge for organismal and evolutionary biology. To aid progress, we identify some variation in terminology use that has impeded cross-field conversations on scaling. We also suggest that promising directions for the field to move forward include (1) studies examining the linkages between ontogenetic, population-level, and cross-species allometries; (2) studies linking scaling to ecological or phylogenetic context; (3) studies that consider multiple, possibly interacting hypotheses; and (4) obtaining better field data for metabolic rates and the life history correlates of metabolic rate such as lifespan, growth rate, and reproduction. [ABSTRACT FROM AUTHOR]

The release of millions of financial documents, which has been known as the 'WikiLeaks' of the financial world (a.k.a. 'Panama Papers'), has dragged global attention in how highly structured means applied by some of the elite to conceal their financial assets. Consequently, significant financial corruption allegations were raised. We concentrate on a somewhat overlooked region, the Middle East and North Africa (MENA) region. This study aims to use social network analytics to study the information contained in these documents. We are checking the major players in the MENA's trends and patterns to determine if it matches the known economic powers. The analysis reveals that while the constructed network enjoys some typical characteristics, many interesting observations and properties are worth discussing. Specifically, using the extracted network consisting of 62 987 nodes and 84 692 edges, our social network analysis finding shows that, perhaps surprisingly, the nodes or the social network are not necessarily directly correlated with perceived economic influence. [ABSTRACT FROM AUTHOR]

Circadian rhythms are internal regulatory processes controlled by molecular clocks present in essentially every mammalian organ that temporally regulate major physiological functions. In the cardiovascular system, the circadian clock governs heart rate, blood pressure, cardiac metabolism, contractility, and coagulation. Recent experimental and clinical studies highlight the possible importance of circadian rhythms in the pathophysiology, outcome, or treatment success of cardiovascular disease, including ischaemic heart disease. Disturbances in circadian rhythms are associated with increased cardiovascular risk and worsen outcome. Therefore, it is important to consider circadian rhythms as a key research parameter to better understand cardiac physiology/pathology, and to improve the chances of translation and efficacy of cardiac therapies, including those for ischaemic heart disease. The aim of this Position Paper by the European Society of Cardiology Working Group Cellular Biology of the Heart is to highlight key aspects of circadian rhythms to consider for improvement of preclinical and translational studies related to ischaemic heart disease and cardioprotection. Applying these considerations to future studies may increase the potential for better translation of new treatments into successful clinical outcomes. [ABSTRACT FROM AUTHOR]

The article looks at the "The Aspern Papers in reverse': A Note on the Emily Hale Letters" by Paul Keers. It mentions that in 1960 T. S. Eliot wrote a Statement, which was revised in 1963, sealed, and subsequently stored by the Houghton Library, Harvard University. It explores several similarities between the situation of T. S. Eliot and Emily Hale, and the characters in James's tale.

The article calls for papers on genomic data analyses in biobanks by highlighting the opportunities and challenges stemming from the heterogeneity between biobanks worldwide. Topics include population structures, selection bias effects, clinical observations, ethical considerations, and technological advancements in data generation for omics studies.

The Genetics Society of America is calling for submissions of papers on biobank-scale genomic data analyses. Biobanks, which are large collections of biological, medical, and genetic data on the same individuals, have revolutionized human genomics research. However, there is substantial heterogeneity between biobanks worldwide, creating both challenges and opportunities for data analysis. The series will focus on various topics, including population structures, selection bias, measurement errors, clinical observations, linkage with external data sources, meta-analysis, computational analysis methods, family-based analyses, ethical and privacy-related issues, and technological considerations. Manuscripts can be submitted until May 31, 2024, and the series will be an ongoing resource in this area. [Extracted from the article]

Moreover, Willis was not the critic of Locke's views in the I Reasonableness of Christianity i as expressed in I The Occasional Paper: Number I i , and the "Post-Script" to I The Occasional Paper: Number V i . The stylometric evidence from the Delta analysis conflicts with the clear indications that the author of I The Occasional Paper: Number I i also wrote the "Post-Script" to I The Occasional Paper: Number V i . I The Occasional Paper i was a series of anonymous pamphlets covering a diverse range of topics, published in quarto by Matthew Wotton and running for ten numbers from 1697 to 1698.[1] The I Paper i was intended to provide a moderate Anglican perspective through a regular publication rather than one-off pamphlets.[2] It is remembered primarily for its criticisms of Locke, Toland, and its contribution to the Collier controversy.[3] It has always been attributed to Richard Willis ( I bap i . 1664, d. 1734), successively bishop of Gloucester (1715-21), Salisbury (1721-3) and Winchester (1723-34). We were unable to source any published texts for the ascribed author of I The Occasional Paper: Number X i , Mr Hodges, "fellow of Wadham College", and no ascription was provided for I The Occasional Paper: Number VII i ; hence, it was not possible to provide com- parison texts for these two I Occasional Papers i . [Extracted from the article]