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An epiretinal membrane (ERM) is a fibrocellular proliferation on the inner surface of the retina causing blurred and distorted central vision. Surgery is the only effective method for ERM removal. This paper investigated the mechanical properties of ERM peeling using the finite element (FE) method. A FE model of ERM formation on the retina surface was constructed. The failure criterion was applied to the attachment pegs to represent the adhesive force between the ERM and retina. The simulation results were consistent with the experimental data in published research. The maximum peeling force was 4.1 mN at a peeling velocity of 2 mm/s and an angle of 30°. The peeling force was minimum at the peeling angle of 45° and increased with the increase in peeling velocity and Young's modulus of the membrane. The outcome of this paper can improve the safety and efficiency of ERM removal. [ABSTRACT FROM AUTHOR]

The tilting of the cab seat when the tractor is in deep ploughing operation changes the sitting position of the driver, which may accelerate lumbar spine injury. This paper adopts the musculoskeletal model and the finite element model of the lumbar L4–L5 segment to predict the maximum Von-Mises stress and maximum strain of the driver's lumbar L4–L5 segment intervertebral disc. In this study, we used 3D motion capture to obtain the driver's spine position spatial data when the tractor tilted at different angles. A tractor-driver musculoskeletal model and a finite element model of the lumbar spine L4–L5 segments were created in AnyBody™ and Abaqus, respectively. The tractor-driver musculoskeletal model was used to calculate the load of the driver's lumbar spine L4–L5 segment at different angles of tractor tilt, which was used as the load condition of the finite element model of the lumbar spine L4–L5 segment, and then the influence of tractor tilt angle and vibration on the driver's lumbar spine L4–L5 disc was studied. The results show that the maximum Von-Mises stress and maximum strain of the driver's lumbar L4–L5 intervertebral disc will increase due to the tilt. The maximum Von-Mises stress occurs in the annulus II, and the maximum strain occurs in the upper end plate of the intervertebral disc. With the occurrence of tilt, the position of the maximum Von-Mises stress changes, which can lead to disc injury to the driver, and vibration may exacerbate this injury. [ABSTRACT FROM AUTHOR]

The bone lacunar-canalicular system (LCS) is a unique complex 3D microscopic tubular network structure within the osteon that contains interstitial fluid flow to ensure the efficient transport of signaling molecules, nutrients, and wastes to guarantee the normal physiological activities of bone tissue. The mass transfer laws in the LCS under microgravity and hypergravity are still unclear. In this paper, a multi-scale 3D osteon model was established to mimic the cortical osteon, and a finite element method was used to numerically analyze the mass transfer in the LCS under hypergravity, normal gravity and microgravity and combined with high-intensity exercise conditions. It was shown that hypergravity promoted mass transfer in the LCS to the deep lacunae, and the number of particles in lacunae increased more significantly from normal gravity to hypergravity the further away from the Haversian canal. The microgravity environment inhibited particles transport in the LCS to deep lacunae. Under normal gravity and microgravity, the number of particles in lacunae increased greatly when doing high-intensity exercise compared to stationary standing. This paper presents the first simulation of mass transfer within the LCS with different gravity fields combined with high-intensity exercise using the finite element method. The research suggested that hypergravity can greatly promote mass transfer in the LCS to deep lacunae, and microgravity strongly inhibited this mass transfer; high-intensity exercise increased the mass transfer rate in the LCS. This study provided a new strategy to combat and treat microgravity-induced osteoporosis. [ABSTRACT FROM AUTHOR]

In order to understand the distribution of streaming potentials in cartilage pores, this paper established finite element model to analyze. The results showed that the streaming potential in cartilage micro-pores increased along the axis. The electric potential in 5 μm straight micro-pore was about 50 μV, and the electric potential of curved bifurcation model was about 30 μV. The pressure and Zeta potential had a linear growth relationship with the streaming potential. The streaming potential decreased with the increase of ion concentration until ion concentration was saturated. These results could provide a theoretical basis for cartilage research. [ABSTRACT FROM AUTHOR]

In the intervention with stent implantation for iliac vein compression syndrome (IVCS), it remains unclear about the influencing mechanism of the structure and implantation position of the stent for the hemodynamics of the affected site. In this paper, an iliac vein model was established. Besides, the computational fluid dynamics (CFD) was utilized to analyze the time-averaged wall shear stress (TAWSS) and oscillatory shear index (OSI) in a sine period after stent implantation based on the three different implantation positions of two iliac vein stents (the left branch outlet, contralateral disturbed flow and main iliac vein). The influence of the structure and implantation position of the stent on blood flow was revealed. These findings were verified by the particle image velocimetry (PIV) experiment. The results indicated that the maximum blood flow velocity of the iliac vein decreased after the stent implantation. Among the three positions, the influence of stent implantation on the iliac vein blood flow was the least when the stent implantation was performed at the left branch outlet; the influence of stent implantation on the iliac vein blood flow was the greatest when the stent implantation was performed at the contralateral disturbed flow. Moreover, there was little influence of Venastent implantation on the blood flow. These results could provide a scientific foundation for implantation treatment and stent design related to IVCS. [ABSTRACT FROM AUTHOR]

Finite element simulation is used to analysis stent designs, extension as well as interaction between a stent and a vessel. In this paper, two different stents with different geometries have been simulated. One is Zilver stent and the other one is Navalis stent. The aim of this study is to determine the effect of stents deployment with various designs that are made of shape memory alloy (SMA) on the distribution of vessel wall stresses by using computational modeling approach. The constitutive model which described the behavior of SMA is based on Microplane model. In addition, SMA stents have been simulated under torsion loading to compare the flexibility of various designs under different conditions. The superelastic behavior and shape memory effect of SMA stents are investigated in this paper. The numerical simulation results show the different geometries of stents have significant effect on the arterial wall. The results show the Navalis stent causes less stress on the arterial wall and it is more flexible than the Zilver stent under the same torsion loading. [ABSTRACT FROM AUTHOR]

This paper aimed to investigate the biomechanical changes during the talus impact with the calcaneus at varying velocities. Various three-dimensional reconstruction software was utilized to construct a finite element model that consisted of the talus, calcaneus, and ligaments. The explicit dynamics method was used to explore the process of the talus impacting on the calcaneus. The velocity of impact was altered from 5 m/s to 10 m/s with a 1 m/s interval. Stress readings were collected from the posterior, intermediate, and anterior subtalar articular (PSA, ISA, ASA), calcaneocubic articular (CA), Gissane Angle (GA), calcaneal base (BC), medial wall (MW), and lateral wall (LW) of the calcaneus. The changes in the amount and distribution of stress in the different regions of the calcaneus that varied with velocity were analysed. The model was validated through comparison with findings from the existing literature. During the process of impact between the talus and calcaneus, the stress in the PSA reached its peak first. Notably, stress was concentrated mainly in the PSA, ASA, MW, and LW of the calcaneus. At varying impact velocities of the talus, the mean maximum stress of the PSA, LW, CA, BA, and MW exhibited statistically significant differences (P values were 0.024, 0.004, <0.001, <0.001, and 0.001, respectively). However, the mean maximum stress of the ISA, ASA, and GA was not statistically significant (P values were 0.289, 0.213, and 0.087, respectively). In comparison with the velocity at 5 m/s, the mean maximum stress increases in each region of the calcaneus at a velocity of 10 m/s were as follows: PSA 73.81%, ISA 7.11%, ASA 63.57%, GA 89.10%, LW 140.16%, CA 140.58%, BC 137.67%, MW 135.99%. The regions of stress concentration were altered, and the magnitude and sequence of peak stress in the calcaneus also varied according to the velocity of the talus during impact. In conclusion, the velocity of the talus during impact had a significant influence on the magnitude and distribution of stress within the calcaneus, which was a crucial factor in the development of calcaneal fractures. It was possible that the magnitude and sequence of stress peaks played a vital role in determining the emergence of fracture patterns. [ABSTRACT FROM AUTHOR]

This paper discussed the size of 3 D-printed personalized titanium plates that can gain maximum stability of mandibular fracture and minimize stress shielding through finite element analysis. A 3 D virtual model of mandible with mandibular angle fracture was created from the CT data of patient. 3 D-printed personalized titanium plates varying in length and thickness were designed, and finite element analysis was performed under different loading conditions and fracture healing periods. After that, the stress distribution and deformation of the mandible with gonial fracture could be observed, and the stress shielding rate could be obtained. Finally, SPSS21.0 was used for statistical analysis. The results of finite element analysis indicated that as the thickness of titanium plates and the healing time decreased, the maximum displacement increased, under a certain condition in which the pore size, the width, the hole distance and the bridge spacing were 2.0 mm, 4.0 mm, 6.0 mm, 12.0 mm, respectively. What's more, in this condition, the thicker the titanium plate and the shorter the healing time were, the higher the stress shielding was at central occlusion. When the thickness of the personalized 3 D-printed titanium plate was 1.0 mm, the maximum displacement tended to be stable and the stress shielding was minimized. It can not only improve the bone stability after tension band fixation, but also minimize the stress shielding, which is expected to expand the indications of tension band fixation. [ABSTRACT FROM AUTHOR]

The objective of this paper is to elucidate the response to contact stresses of Polymer Infiltrated Ceramic Network (PICN) using the microscopic viscoplastic finite elements, validated by clinically relevant in vitro tests. A feldspathic ceramic material, namely Vita Mark II, is an interconnected structure infiltrated with the polymer (PMMA). Axisymmetric finite element microstructure models are reconstructed from two-dimensional images of a PICN microstructure. Viscoplastic finite element analysis (FEA) with various degrees of microscopic damages occurring over contact is performed. The force-displacement responses obtained from FEA are validated with Hertzian contact tests. Finite element results for force-displacement, stresses and strains in each phase are discussed. We hypothesize that the resistance to fracture of PICN can be further improved by microstructural tailoring. The experimental evidence suggests that a composite material is both more resistant to displacement under load and more resistant to crack initiation and propagation, as hypothesized. Further parametric study on the effects of various volume fractions of two phases in PICN is done to provide some insight on increased contact damage resistance of PICN as well as potential optimization of microstructures. [ABSTRACT FROM AUTHOR]

In this paper, two mathematical models have been formulated by extending the basic reaction–diffusion model, along with suitable initial and boundary conditions to study the drug delivery and its diffusion in biological tissues from multi-layered capsules/tablets and other drug delivery devices (DDDs), respectively. These devices are either taken orally or through other drug-administration routes. The formulated models are solved using the variational finite element method followed by the fundamental matrix method, to study the drug delivery and its diffusion more efficiently. The main aim of this work is to provide an effective model, using optimal mathematical techniques to help researchers and biologists in medicine in decreasing the endeavours and expenses in designing DDDs. The outcomes obtained are compared with the experimental data to demonstrate the validity and the feasibility of the proposed work. [ABSTRACT FROM AUTHOR]

In endoscopic surgery, the surgical navigation system needs to calculate the deformation of soft tissue by biomechanical model which requires elastic properties and boundary conditions. However, patient-specific elastic parameters and boundary conditions of soft tissue are hard to measure accurately from the preoperative images, especially the boundary conditions will change during the operation due to the ligament cutting. In addition, simple boundary conditions such as fixed constraints and free-force constraints are not physically adequate to simulate the elastic effect of ligaments attached to the liver. In this paper, we present a novel method to identify the Young's modulus and equivalent spring constraint boundary conditions of a locally observed soft tissue. Based on the spring constraint boundary condition, a two-step inverse algorithm is developed based on the finite element method (FEM) with integration of energy regularized Gauss-Newton (GN) method and l 1 -regularized method, which takes external forces and displacements of observable nodes as inputs. A series of numerical simulations and physical hydrogel phantom experiments were conducted. The results of simulation and physical experiments show that the Young's modulus and equivalent spring constraint boundary conditions identified by the proposed method agree well with their setup true values. [ABSTRACT FROM AUTHOR]

Tear force of the capsulotomy edge is a paramount parameter to affect the surgical safety in cataract surgery. This paper aimed to investigate the stretch force of the capsulotomy edge using finite element (FE) method. A FE model of capsule bag was developed to simulate dynamic response of the lens capsule to the stretch of retractors. The failure criterion based on the distortion energy theory was applied to predict the rupture of the anterior capsule. The simulation results showed a good agreement with the experimental data reported in the literature. Sensitivity studies were then conducted to evaluate the effect of the various parameters on tear force, including the stretching velocity, capsulorhexis dimension, age, retractor width and shape, and rim morphology. The rupture force was proportional to the stretching velocity, capsulorhexis dimension and retractor width, while the age showed the opposite trend. In addition, the retractor shape has a greatly effect on the tear force and the rim of continuous curvilinear capsulorhexis (CCC) has the higher tear resistance. This work can contribute to the understanding of the regularity for capsule rupture. [ABSTRACT FROM AUTHOR]

Osteoporosis occurs in astronauts after long-term space flight owing to the lack of gravity. The mechanical microenvironment of osteocytes in load-bearing bone are changed during resistance exercise, which prevents massive bone loss in the human body. A cylindrical fluid-structure coupling finite element model for osteons with a two-stage pore structure (i.e., Haversian canal, lacunar-canalicular system) was established with the software COMSOL. In the Earth's gravity field and in microgravity, considering the effects of pulsating pressure of arterioles, a comparative study was performed on the changes in hydrodynamic microenvironment of osteocytes during human body high-intensity exercise at different frequencies (defined as causing bone to produce 3000 με) and the body is at rest. Positive and negative liquid pressure (with respect to one atmosphere pressure) alternately acted on osteocytes during human exercising, but only positive pressure acted on osteocytes during human resting. The variation range of liquid pressure acted on osteocytes during human exercising was significantly higher than that during resting. The liquid flow velocity around osteocytes during body exercise was about four orders of magnitude higher than that during resting. In microgravity, moderate physical exercise can obviously improve the hydrodynamic microenvironment of osteocytes in load-bearing bone, which could compensate for the lack of mechanical stimulation to osteocytes caused by the lack of gravity, thereby promoting the normal physiological function of osteocytes. To a certain extent, these results revealed the biomechanical mechanism by which exercise has an effect in fighting osteoporosis in astronauts. [ABSTRACT FROM AUTHOR]

Spinal injuries are a concern for automotive applications, requiring large parametric studies to understand spinal injury mechanisms under complex loading conditions. Finite element computational human body models (e.g. Global Human Body Models Consortium (GHBMC) models) can be used to identify spinal injury mechanisms. However, the existing GHBMC detailed models (with high computational time) or GHBMC simplified models (lacking vertebral fracture prediction capabilities) are not ideal for studying spinal injury mechanisms in large parametric studies. To overcome these limitations, a modular 50th percentile male simplified occupant model combining advantages of both the simplified and detailed models, M50-OS + DeformSpine, was developed by incorporating the deformable spine and 3D neck musculature from the detailed GHBMC model M50-O (v6.0) into the simplified GHBMC model M50-OS (v2.3). This new modular model was validated against post-mortem human subject test data in four rigid hub impactor tests and two frontal impact sled tests. The M50-OS + DeformSpine model showed good agreement with experimental test data with an average CORrelation and Analysis (CORA) score of 0.82 for the hub impact tests and 0.75 for the sled impact tests. CORA scores were statistically similar overall between the M50-OS + DeformSpine (0.79 ± 0.11), M50-OS (0.79 ± 0.11), and M50-O (0.82 ± 0.11) models (p > 0.05). This new model is computationally 6 times faster than the detailed M50-O model, with added spinal injury prediction capabilities over the simplified M50-OS model. [ABSTRACT FROM AUTHOR]

This study investigates the effect of PID controller gains, reaction time, and initial muscle activation values on active human model behavior while comparing three different control strategies. The controller gains and reaction delays were optimized using published experimental data focused on the upper extremity. The data describes the reaction of five male subjects in four tests based on two muscle states (relaxed and tensed) and two states of awareness (open and closed eye). The study used a finite element model of the left arm isolated from the Global Human Body Models Consortium (GHBMC) average male simplified occupant model for simulating biomechanical simulations. Major skeletal muscles of the arm were modeled as 1D beam elements and assigned a Hill-type muscle material. Angular position control, muscle length control, and a combination of both were used as a control strategy. The optimization process was limited to 4 variables; three Proportional-Integral-Derivative (PID) controller gains and one reaction delay time. The study assumed the relaxed and tensed condition require distinct sets of controller gains and initial activation and that the closed-eye simulations can be achieved by increasing the reaction delay parameter. A post-hoc linear combination of angle and muscle length control was used to arrive at the final combined control strategy. The premise was supported by variation in the controller gains depending on muscle state and an increase in reaction delay based on awareness. The CORA scores for open-eye relaxed, closed-eye relaxed, open-eye tensed, and closed-eye tensed was 0.95, 0.90, 0.95, and 0.77, respectively using the combined control strategy. [ABSTRACT FROM AUTHOR]

Uterine prolapse (UP) seriously affects the quality of life and physical and mental health of elderly women, which can easily be caused by ligament injury or intra-abdominal pressure (IAP) increasing. The objective of this manuscript was to study the influence of IAP and ligament injury on uterus and its surrounding ligaments using the finite element method. First, the three-dimensional (3D) models of retroverted uterus and its surrounding ligaments were established, and loads and constraints were set in ABAQUS software, then the stress and deformation of uterine ligaments and uterine displacement were calculated. The study found that the uterine displacement and the stress and deformation of the ligaments increased when IAP and ligament injury increased alone or simultaneously. Then, the stress and sensitivity of the ligaments to the changes of IAP or ligament injury were in the order of uterosacral ligament (USL), broad ligament (BL), cardinal ligament (CL) and round ligament (RL), while the deformation and sensitivity the changes of the ligaments were in the order of BL > RL > USL > CL. Moreover, the ligament injury had a greater influence on the uterus and uterine ligaments than IAP. The results of this study can provide guidance for optimization of surgical scheme of uterus prolapsed in clinic and exploration of pathogenesis. [ABSTRACT FROM AUTHOR]

There has been a systematic review of studies that used FEA in dental sciences, but no adequate risk of bias (RoB) analysis technique has been developed. Therefore, the development and validation process of RoB in studies using the finite element analysis in dentistry (ROBFEAD) tool is described. In the first phase of development, the scope of the tool and possible modifications were covered, and validation was done in the second phase. The developed tool comprised 6 domains and a total of 22 guiding questions in these domains. This article proposes the development and validation of ROBFEAD, a tool for measuring RoB in finite element research in dentistry. [ABSTRACT FROM AUTHOR]

The objective of this study is to use the finite element (FE) method to predict the mechanical signals (interstitial fluid velocity, strain, pore pressure, and pore fluid velocity) produced by osteocyte during physiological activities. The model predicts that the amplitude and distribution of the mechanical signals are mainly affected by the loading rate. The magnitude of mechanical signals in the lacunar-canalicular system increases as the amplitude, frequency and amount of direction of load increase. Collagen hillocks can effectively amplify strain signals at the process. The established model can be used for studying the mechanism of bone mechanotransduction at the micro-level. [ABSTRACT FROM AUTHOR]

Astrocyte cells play a critical role in the mechanical behaviour of the brain tissue; hence understanding the properties of Astrocytes is a big step toward understanding brain diseases and abnormalities. Conventionally, atomic force microscopy (AFM) has been used as one of the most powerful tools to characterize the mechanical properties of cells. However, due to the complexities of experimental work and the complex behaviour of living cells, the finite element method (FEM) is commonly used to estimate the cells' response to mechanical stimulations. In this study, we developed a finite element model of the Astrocyte cells to investigate the effect of two key parameters that could affect the response of the cell to mechanical loading; the properties of the underlying substrate and the nucleus. In this regard, the cells were placed on two different substrates in terms of thickness and stiffness (gel and glass) with varying properties of the nucleus. The main achievement of this study was to develop an insight to investigate the response of the Astrocytes to mechanical loading for future studies, both experimentally and computationally. [ABSTRACT FROM AUTHOR]

We analyzed and compared the effectiveness of the rotating seat of autonomous vehicles and that of an airbag in traditional vehicles as head protection measures in a frontal crash. Driver frontal crash models of traditional and autonomous vehicles and a head finite element model were established. Four evaluation indexes were used for comparison. The airbag proved more effective than seat rotation in terms of injury criteria and brain tissue injury risk under frontal crash conditions with and without brake involvement. A segmented protection measure based on crash acceleration values is proposed to improve crash safety in future autonomous vehicles. [ABSTRACT FROM AUTHOR]

The purpose of this investigation was to assess the effects of changing the Nitinol stent's geometrical characteristics on the superelastic behavior of the stent using the finite element method. Four different geometrical parameters were considered and analyzed in sixteen stents. These geometrical parameters consisted of stent length, number of stent's meanders, inside diameter of the stent and wire diameter. Results showed that decreasing either stent length or the number of stent meanders and increasing either the inside diameter of the stent or wire diameter generally result in more sensible superelastic behavior exposure. The effect of changing stent length is independent of the inside diameter and number of the stent's meanders. Effects of changing inside diameter and number of stent's meanders were exactly dependent together. In addition, increasing wire diameter has a great effect on the maximum force. In conclusion, the results of this study may serve as guidelines for future stent design. [ABSTRACT FROM AUTHOR]

This study compared the biomechanical characteristics of different treatment strategies based on finite element analysis. Posterior tilt and valgus angle were measured on X-ray from ten valgus-impacted femoral neck fractures, and 7 finite element models that were generated to compare the stress and displacement. The results showed that in the intact femur, von Mises stress was concentrated at the medial and inferior sides of the femoral neck. In valgus-impacted femoral neck fractures, von Mises stress was at the same locations but was 5.66 times higher than that in the intact femur. When 3 cannulated screws were used for internal fixation, anatomic reduction diminished the stress at the fracture end from 140.6 to 59.14 MPa, although displacement increased from 0.228 to 0.450 mm. When the fracture was fixed with a sliding hip screw (SHS) + cannulated screw, there was less stress at the fracture end and greater displacement with anatomic reduction than that without reduction (stress: 15.9 vs 37.9 MPa; displacement: 0.329 vs 0.168 mm). Therefore, the SHS + cannulated screw has superior biomechanical stability than 3 cannulated screws, and is recommended following anatomic reduction to treat valgus-compacted femoral neck fractures. [ABSTRACT FROM AUTHOR]

The injury conditions of the sitting position occupant inside the military equipment are highly related to the vertical impact environments. In this study, a detailed three-dimensional finite element (FE) model of pelvis-lumbar spine of seated human with nonlinear material property and strain failure criterion was developed and validated. A series of sinusoidal accelerations with a constant peak speed of 8 m/s and frequencies ranging from 10 Hz to 90 Hz were loaded on the FE model to investigate the injury conditions under different high loading rates. The results indicated that the injury patterns mainly include wedge fracture of the junction between lumbar spine and pelvis, and comminuted fracture of ischial tuberosity. The bending moment caused by the large angle deflection of pelvis under 10 Hz case (low rate) and the acting force caused by the excessive curvature of lumbar spine under 30 Hz–70 Hz cases (medium and high rate) cause the junction wedge fractured, while the high impact force under 30 Hz–50 Hz cases (medium rate) leads to comminuted fracture of the ischial tuberosity. The associated mechanism that the shorter the time interval between the peak of seat loading speed and the peak of hip muscle compression, the more serious dynamic responses of pelvis-lumbar spine is revealed for the first time. [ABSTRACT FROM AUTHOR]

Enamel possesses ingenious hierarchical structure that gives rise to superior fracture resistance. Despite considerable efforts devoted to characterization of fracture behavior of enamel, the role of rod decussation in fracture of enamel is largely unknown. In this study, the features of rod decussation in the inner enamel are experimentally identified, and analyses of crack growth in enamel are carried out using a micromechanical model of enamel, in which the structural features of the outer enamel and rod decussation of the inner enamel are incorporated. We carry out calculations within a framework based on the extended finite element method, and the crack growth and crack path selection are natural outcomes of imposed loading. We show that crack deflection in enamel is controlled by rod decussation. For crack growth in the parazone, the crack path is oriented along the axis of enamel rods, leading to gross crack deflection. The microstructure of inner enamel with intermediate inclination angle enables multiple crack deflections, giving rise to enhanced toughness. For crack growth in the diazone, the transition in orientation of crack deflection occurs as inclination angle increases. The relatively straight crack path emerges in the case of the microstructure of enamel with intermediate inclination angle, leading to weak fracture resistance. It is further found that compared with the diazone, the gross crack deflection in the parazone provides greater contribution to fracture resistance of enamel. The findings of this study provide a good mechanistic understanding of the role of rod decussation in enamel. [ABSTRACT FROM AUTHOR]

Multiphysics models have become a key tool in understanding the way different phenomenon are related in bone remodeling and various approaches have been proposed, yet, to the best of the author's knowledge there is no model able to link a cell population model with a mechanical stimulus model using a discrete approach, which allows for an easy implementation. This article couples two classical models, the cell population model from Komarova and the Nackenhorst model in a 2D domain, where correlations between the mechanical loading and the cell population dynamics can be established, furthermore the effect of different paracrine and autocrine regulators is seen on the overall density of a portion of trabecular bone. A discretization is performed using frame 1D finite elements, representing the trabecular structure. The Nackenhorst model is implemented by using the finite element method to calculate the strain energy as the main mechanical stimulus that determines the bone mass density evolution in time. This density is normalized to be added to the bone mass percentage proposed by the Komarova model, where coupling terms have been added as well that guarantee a stable response. In the simulations, the equations were solved employing the finite element method with a user subroutine implemented in ABAQUS (2017) and by applying a direct formulation. The methodology presented can model the cell dynamics occurring in bone remodelling in accordance with the asynchronous nature of this process, yet allowing to differentiate zones with higher density, the main trabecular groups are obtained for the proximal femur. Finally, the model is tested in pathological cases, such as osteoporosis and osteopetrosis, yielding results similar to the pathology behavior. Furthermore, the discrete modelling technique is shown to be of use in this particular application. [ABSTRACT FROM AUTHOR]

The conduction, perfusion and metabolic heat generation based partial differential equation has been used to study the heat transfer in human head. The main objective of this study is to predict the temperature distribution at the multi-layered human head that results in hypothermic condition. The temperature profiles have been estimated at the interface points of brain, skull and scalp with respect to various parameters including atmospheric temperature, arterial temperature and metabolic heat generation. The variational finite element method and analytical method based on Laplace transform has been employed to establish the solution of the formulated model, and the resulting outcomes are illustrated graphically. Under cold exposure, the blood capillaries around scalp exchange core heat with the external cold environment and experience lowering in the tissue temperature of the blood in the scalp. It is reflected in the graphical view of the model that the prolonged exposure to cold transmits its effect into the deep brain capillaries, wherein the temperature gradually lowers down below the normal body temperature that results hypothermia and hence abnormal body homoeostasis. [ABSTRACT FROM AUTHOR]

Vascular stent implantation has become an important choice for the treatment of severe cardiovascular and cerebrovascular blockage. Rational design is vital to ensure the mechanical properties of the vascular stents, which are important both to the implantation and service as for clinical treatment of coronary heart disease. Therefore we proposed a wholly new non-uniform honeycomb stent E and compared with an inverted honeycomb-like shaped stent F and a honeycomb-like shaped stent G. To evaluate their properties, a finite element method (FEM) was used to simulate the implantation process (crimp, crimp recoil, expand, and expand recoil) of these three different kinds of stents. Results showed that the stent E exhibits better mechanical behaviour than the other two stents F and G as far as radial strength and axial shortening performances and that the distribution of equivalent stress among the stent E is more uniform than that among the other two stents F and G. After that, a three-point bending method was used to study the bending flexibility of these three vascular stents. Stent E shows high bending stiffness compared with stents F and G due to the existence of additional support bridges in its structure. This study can be helpful to the rational design of optimizable PLA stents for its practical clinical performance and therefore possibly improve the prognosis of patients. [ABSTRACT FROM AUTHOR]

Bone remodelling is a complex biomechanical process, which has been studied widely based on the restrictions of local continuum theory. To provide a nonlocal bone remodelling framework, we propose, for the first time, a peridynamic formulation on the macroscale. We illustrate our implementation with a common benchmark test as well as two load cases of the proximal femur. On the one hand, results of our peridynamic model with diminishing nonlocality measure converge to the results of a local finite element model. On the other hand, increasing the neighbourhood size shows to what extent the additional degree of freedom, the nonlocality, can influence the density evolution. [ABSTRACT FROM AUTHOR]

Research on carbon-fiber-reinforced polyetheretherketone (CF-PEEK/CFR-PEEK) as a bone tumor joint prosthesis remains limited. Herein we numerically determine the feasibility of CF-PEEK material containing 30% Wt carbon fiber (CF30-PEEK) as a material for the dual-action tumor-type distal femoral prosthesis. Use CT scan method to build a complete finite element model of the knee joint. Simulate the resection of the distal femoral tumor, and then reconstruct it with the dual-action tumor-type distal femoral prosthesis. The femoral condyle and extension rod components were simulated with cobalt chromium molybdenum (CoCrMo), PEEK and CF30-PEEK materials respectively. When simulating the standing state, a vertical stress of 700 N is applied to the femoral head. When simulating the squatting state, a vertical stress of 2800 N is applied to the femoral head. The displacement and rotation angle of each node of the distal tibia are fully restrained in three directions (X-axis, Y-axis, Z-axis). We examined the stress magnitude, stress distribution, and stability of the prosthesis and each of its components by means of finite element analysis (FE analysis). The FE analysis results show: after replacing the distal femur and the extension rod with CF30-PEEK material, the stress is still evenly distributed, and the average stress is significantly reduced. In addition, the stability is similar to CoCrMo material. Therefore, CF30-PEEK is an appropriate material for this type of prosthesis. [ABSTRACT FROM AUTHOR]

Eleven Crash Injury Research and Engineering Network (CIREN) frontal crashes were reconstructed using a novel, time-efficient methodology involving a simplified vehicle model. Kinematic accuracy was assessed using novel kinematic scores between 0-1 and chest injury was assessed using literature-defined injury metric time histories. The average kinematic score across all simulations was 0.87, indicating good kinematic accuracy. Time histories for chest compression, rib strain, shoulder belt force, and steering column force discerned the most causative components of chest injury in all cases. Abbreviated Injury Scale (AIS) 2+ and AIS 3+ chest injury risk functions using belt force identified chest injury with 81.8% success. [ABSTRACT FROM AUTHOR]

The mobility of pelvic organs is the result of an equilibrium called Pelvic Static characterizing the balance between the properties and geometries of organs, suspensions and support system. Any imbalance in this complex system can cause of pelvic static disorder. Genital prolapse is a common hypermobility pathology which is complex, multi factorial and its surgical management has high rate of complications. The use of 3 D numerical models and simulation enables the role of the various suspension structures to be objectively studied and quantified. Fascias are connective tissues located between organs. Although their role are described as important in various descriptions of pelvic statics, their influence and role has never been quantitatively objectified. This article presents a refine Finite Element (FE) model for a better understanding of biomechanical contribution of inter-organ fascia. The model is built from MRI images of a young volunteer, the mechanical properties derived from literature data to take into account the age of the patient and new experimental results have enabled an order of magnitude of the mechanical properties of the fascias to be defined. The FE results allows to quantify the biomechanical role of the fascia on pelvic mobility quantified by an analysis of dynamic MRI images and a local mapping of the gap between calculated and measured displacements. This improved numerical model integrating the fascias makes it possible to describe pelvic mobilities with a gap of 1 mm between numerical simulations and measurements, whereas without taking them into account this gap locally reaches 20 mm. [ABSTRACT FROM AUTHOR]

This research intends to investigate the effects of a new intraoral device, VomPress, combined with a Right Angle Maxillary Protraction Appliance (RAMPA) extraoral device on the treatment of maxillary hypoplasia. To this end, finite element (FE) method has been employed and a skull model, including all sutures, has been investigated. In addition, the effects of VomPress combined with RAMPA on a seven-year-old girl with the malocclusion and other side problems were monitored. The results of both FE simulations and the clinical data revealed that VomPress combined with RAMPA effectively improved the malocclusion and straight neck problem by creating more space in the patient's mouth and anterosuperior protraction effects. [ABSTRACT FROM AUTHOR]

A two dimensional finite element model of upper airway respiratory function was developed emphasizing the effects of dilator muscular activation on the human retro-lingual airway. The model utilized an upright mid-sagittal computed tomography of the human head and neck to reconstruct relevant structures of the tongue, mandible, and the hyoid-related soft tissues, along with the retro-lingual airway. The reconstructed geometry was divided into fluid and solid domains and discretized into finite element (FE) meshes used for the computational model. Three cases were investigated: standing position; supine position; and supine position coupled with dilator muscle activation. Computations were performed for the inspiration stage of the breathing cycle, utilizing a fluid-structure interaction (FSI) method to couple structural deformation with airflow dynamics. The spatio-temporal deformation of the structures surrounding the airway wall were predicted to be in general agreement with known changes from upright to supine posture on luminal opening, as well as the distribution of airflow. The model effectively captured the effects of muscular stimulation on the upper airway anatomical changes, the flow characteristics relevant to airway reduction in the supine position and airway enlargement with muscle activation. The smallest airway opening in the retro-lingual section is predicted to occur at the epiglottic region in all the three cases considered, an unexpected vulnerable location of airway obstruction. The model also predicted that hyoid displacement would be associated with recovery from airway collapse. This information may be useful for building more complex models relevant to mechanisms and clinical interventions for obstructive sleep apnea. [ABSTRACT FROM AUTHOR]

We present a 3-D finite element (FE) model of the chinchilla's inner ear consisting of the entire cochlea structure and the vestibular system. The reaction of the basilar membrane to the head rotation and the reaction of ampulla to the stapes movement were investigated. These results demonstrate the existence of hearing-vestibular system interaction. They provide an explanation to the clinical finding on the coexistence between hearing loss and equilibration dysfunction. It is a preliminary, yet critical step toward the development of a comprehensive FE model of an entire ear for mechano-acoustic analysis. [ABSTRACT FROM AUTHOR]

Studies on the deformation characteristics and stress distribution in loaded skeletal muscles are of increasing importance. Reliable prediction of hyperelastic material parameters requires an inverse process, which possesses challenges. This work proposes two inverse procedures to identify the hyperelastic material parameters of skeletal muscles. The first one integrates nonlinear finite element method (FEM), random forest (RF) model, and Bayesian optimization (BO) algorithm. The other one integrates FEM, RF and hybrid Grid Search (GS), and Random Search (RS) algorithm. FEM models are first established to simulate nonlinear deformation of skeletal muscles subject to compression based on nonlinear mechanics principals. A dataset of nonlinear relationship between the nominal stress and principal stretch of skeletal muscles is created using our FEM models and the nonlinear relationship is learned through RF model. The BO, hybrid GS and RS algorithms are used to adjust the major model parameters in RF. Then the optimized RF is utilized to predict hyperelastic material parameters of skeletal muscles, with the help of uniaxial compression experiments. Intensive studies also have been carried out to compare the RF-BO approach with RF-Search approach, and the comparison results show that RF-BO approach is an effective and accurate approach to identify the hyperelastic material parameters of skeletal muscles. The present RF-BO model can be further extended for the predictions of constitutive parameters of other types of nonlinear soft materials. [ABSTRACT FROM AUTHOR]

For internal fixation of proximal femoral fractures, a screw is commonly placed into the femoral head; therefore, mechanical matching of the femoral head and screw is important. This article proposes an elastoplastic numerical model of the femoral head that takes nonlinear deformation and cancellous bone heterogeneity into account. Force–depth curves from finite element analysis based on the model were compared with those from macroindentation experiments. The maximum difference between the indentation depth shown by the finite element model and that found with macroindentation testing was 5.9%, which demonstrates that the model is valid. [ABSTRACT FROM AUTHOR]

Two contemporary finite element Human Body Models (HBMs) were subjected to five lateral impact scenarios to investigate the sensitivity of thorax response to impact scenario and pre-crash arm position. The greatest increase in chest compression (UW-HBM: +140%, GHBMC-HBM: +100%) and Viscous Criterion (UW-HBM: +467%, GHBMC-HBM: +245%) occurred when the arm was aligned with the thorax in a full vehicle impact, moderate change for sled impacts, and only a minor change in response for pendulum impacts. This study highlights the importance of including full vehicle impact boundary conditions in parametric studies of occupant response in side impacts and assessing side-impact protection. [ABSTRACT FROM AUTHOR]