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Background: Various studies on prevalence of celiac disease in patients with irritable bowel syndrome in Iran is available that Chiefly, the prevalence of this disease and its association with several factors have been investigated. In order to gain a better perspective of Iran and spread across the heterogeneity, all studies included in the systematic review, the findings were analyzed and used a meta-analysis. Materials and Methods: All articles published in Iranian journals and international research project, related papers presented at the Congress, and the Student thesis, in this study used standard and sensitive keyword. All the articles published in this field in the country, where inclusion criteria for assess quality control using random effect, and the meta-analysis were entered. Results: In 7 studies, minimum and maximum prevalence of celiac disease in patients with irritable bowel syndrome, 2/59 % and 13/5 % was calculated, and total prevalence of this disease based on fix effect model 6/26 %, with the heterogeneity index equals Q =13/74 (t2=52/05 and P=56) and reliability 99% (x2= l6/8) was estimated and because of the high heterogeneity based on random effect model, total and final prevalence of the celiac disease in IBS patients 7/59%, with the heterogeneity index equals Q=2/05 (t2=0 and I2=19) and confidence 95% (Cl =8/07-7/23) were counted. Also by using method of meta-regression, main factors causing heterogeneity, variable location, time, and gender of patients were identified. (p<0/01). Conclusion: Considering that the prevalence of celiac disease in patients with irritable bowel syndrome in the country is high, with knowledge and research-centered measures, total level of health in the country should be raised and daily, in the direction to the horizon landscape of civil and global health charter progressed. [ABSTRACT FROM AUTHOR]