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211 results on '"Youn, Hyun Jo"'

1. Surveillance for Distant Metastasis in Breast Cancer Patients Who Underwent Contemporary Management: A Report from the Korean Breast Cancer Society Survivor Research Group

Author

Cheun, Jong-Ho, Chung, Sooyeon, Han, Jai Hong, Lee, Young-Won, Jung, Ji-Jung, Chun, Jung Whan, Lee, Eun-Gyeong, Min, Jun Won, Kim, Zisun, Lee, Jihyoun, Jung, So-Youn, Kim, Yoo Seok, Yu, Jong Han, Kim, Eun-Kyu, Lee, Jong-Won, Hwang, Ki-Tae, Kim, Ku Sang, Youn, Hyun Jo, and Moon, Hyeong-Gon

Published
2024
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11. Dietary Isoflavone Intake and Breast Cancer Prognosis: A Prospective Analysis and Meta-Analysis

Author

Song, Sihan, primary, Cheun, Jong-Ho, additional, Moon, Hyeong-Gon, additional, Noh, Dong-Young, additional, Jung, So-Youn, additional, Lee, Eun Sook, additional, Kim, Zisun, additional, Youn, Hyun Jo, additional, Cho, Jihyoung, additional, Yoo, Young Bum, additional, Jun, Shinyoung, additional, Joung, Hyojee, additional, and Lee, Jung Eun, additional

Published
2023
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23. Dietary Isoflavone Intake and Breast Cancer Prognosis: A Prospective Analysis and Meta-Analysis.

Author

Song, Sihan, Cheun, Jong-Ho, Moon, Hyeong-Gon, Noh, Dong-Young, Jung, So-Youn, Lee, Eun Sook, Kim, Zisun, Youn, Hyun Jo, Cho, Jihyoung, Yoo, Young Bum, Jun, Shinyoung, Joung, Hyojee, and Lee, Jung Eun

Subjects
BREAST cancer prognosis, THERAPEUTIC use of isoflavones, ONLINE information services, META-analysis, CONFIDENCE intervals, MEDICAL information storage & retrieval systems, FOOD consumption, SYSTEMATIC reviews, CANCER relapse, CANCER patients, COMPARATIVE studies, DESCRIPTIVE statistics, RESEARCH funding, MEDLINE, LONGITUDINAL method, PROPORTIONAL hazards models
Abstract

We aimed to examine the association between dietary isoflavone intake and the risk of breast cancer recurrence and summarize evidence on the role of dietary isoflavone intake in breast cancer prognosis. This prospective study included 592 breast cancer survivors who completed a dietary assessment. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models. Of the studies published until May 31, 2023, that were searched in PUBMED and EMBASE databases, 14 studies were selected. Adjusted HRs were combined using fixed- or random-effects models. During the median follow-up of 4.3 years, 47 recurrences were identified. The HR (95% CI) for recurrence comparing the highest versus the lowest tertile of isoflavones intake was 1.29 (0.60–2.78). In a meta-analysis of previously published data and ours, dietary isoflavone intake was associated with a better breast cancer prognosis. The combined HRs (95% CIs) comparing the extreme categories were 0.81 (0.67–0.98) for recurrence and 0.85 (0.76–0.96) for all-cause mortality. A nonlinear inverse association was observed between isoflavone intake and the risk of recurrence and all-cause mortality. Our study suggests that dietary isoflavone intake is associated with a favorable prognosis in breast cancer survivors and warrants further investigation. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Multidisciplinary Shared Decision Making for Fertility Preservation in Young Women With Breast Cancer

Author

Baek, Soo Yeon, primary, Kim, Hong-Kyu, additional, Park, Seho, additional, Yu, Jong Han, additional, Lee, Min Hyuk, additional, Youn, Hyun Jo, additional, Kim, Hyun-Ah, additional, Han, Jai Hong, additional, Choi, Jung Eun, additional, Lee, Jung Ryeol, additional, Lee, Kyung-Hun, additional, Chung, Seockhoon, additional, Chae, Hee Dong, additional, Kim, Seonok, additional, Yoo, Soyoung, additional, Hahm, Sang Keun, additional, and Kim, Hee Jeong, additional

Published
2023
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27. Epidemiology of Second Non-breast Primary Cancers among Survivors of Breast Cancer: A Korean Population-based Study by the SMARTSHIP group

Author

Kim, Haeyoung, primary, Kim, Su SSan, additional, Lee, Ji Sung, additional, Yoon, Jae Sun, additional, Youn, Hyun Jo, additional, Shin, Hyukjai, additional, Lee, Jeong Eon, additional, Lee, Se Kyung, additional, Chung, Il Yong, additional, Jung, So-Youn, additional, Choi, Young Jin, additional, Cho, Jihyoung, additional, and Woo, Sang Uk, additional

Published
2022
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31. The Risk Factors, Incidence and Prognosis of Postpartum Breast Cancer: A Nationwide Study by the SMARTSHIP Group

Author

Park, Sungmin, primary, Lee, Ji Sung, additional, Yoon, Jae Sun, additional, Kim, Nam Hyoung, additional, Park, Seho, additional, Youn, Hyun Jo, additional, Lee, Jong Won, additional, Lee, Jung Eun, additional, Lee, Jihyoun, additional, Hur, Ho, additional, Jeong, Joon, additional, Kim, Kweon-Cheon, additional, and Bae, Soo Youn, additional

Published
2022
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34. Associations of body mass index and weight change with circulating levels of high‐sensitivity C‐reactive protein, proinflammatory cytokines, and adiponectin among breast cancer survivors.

Author

Cho, Hyun Jeong, Song, Sihan, Kim, Zisun, Youn, Hyun Jo, Cho, Jihyoung, Min, Jun Won, Kim, Yoo Seok, Choi, Sang‐Woon, and Lee, Jung Eun

Subjects
BODY mass index, C-reactive protein, CANCER survivors, BREAST cancer, ADIPONECTIN
Abstract

Aim: This study examined the associations of body mass index (BMI) and weight change with inflammatory markers among breast cancer survivors in Korea. Methods: A total of 495 women were included who had been diagnosed with primary breast cancer and survived for at least 6 months since the surgery. Information on the body weight and height of the participants was collected both at the study enrollment and diagnosis. The plasma levels of inflammatory markers were measured, including high‐sensitivity C‐reactive protein, interleukin (IL)‐6, IL‐8, tumor necrosis factor‐α, and adiponectin. A summary z‐score was calculated by summing up the z‐scores of each biomarker. The least‐square means and 95% confidence intervals (CIs) were calculated using a generalized linear model and odds ratios (ORs) and 95% CIs for the elevated levels of inflammatory markers with a multivariate logistic regression model. Results: Participants with a BMI ≥27.5 kg/m2 at the study enrollment and at diagnosis were significantly associated with elevated summary z‐scores compared to those with a BMI < 23 kg/m2; the ORs (95% CIs) were 5.42 (2.15–13.71) for current BMI and 3.66 (1.68–7.98) for BMI at diagnosis, respectively. Additionally, a weight loss > 5% since diagnosis was associated with a lower prevalence of high summary z‐scores; the OR (95% CI) was.20 (.08–.52) compared to a stable weight. Conclusions: A high BMI at diagnosis and current BMI with a greater degree were associated with unfavorable levels of inflammatory markers among breast cancer survivors. Additionally, weight loss since diagnosis was inversely associated with these markers. [ABSTRACT FROM AUTHOR]

Published
2023
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39. CORRIGENDUM: Correction of the first author’s affiliation. Low incidence of lymph node metastasis in patients with microinvasive breast cancer: a Korean nationwide study

Author

Paik, Pill Sun, primary, Paik, Nam Sun, additional, Lee, Eun Sook, additional, Choi, Jung Eun, additional, Jeong, Joon, additional, Youn, Hyun Jo, additional, Yoon, Chang Ik, additional, Bae, Soo Youn, additional, Yoo, Tae-Kyung, additional, and Society, Korean Breast Cancer, additional

Published
2022
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42. Role of NOX1 and NOX5 in protein kinase C/reactive oxygen species‑mediated MMP‑9 activation and invasion in MCF‑7 breast cancer cells.

Author

Song, Hyun-Kyung, Kim, Jeong-Mi, Noh, Eun-Mi, Youn, Hyun Jo, and Lee, Young-Rae

Subjects
PROTEIN kinase C, REVERSE transcriptase polymerase chain reaction, SMALL interfering RNA, EXTRACELLULAR matrix proteins, MEMBRANE proteins
Abstract

NADPH oxidases (NOXs) are a family of membrane proteins responsible for intracellular reactive oxygen species (ROS) generation by facilitating electron transfer across biological membranes. Despite the established activation of NOXs by protein kinase C (PKC), the precise mechanism through which PKC triggers NOX activation during breast cancer invasion remains unclear. The present study aimed to investigate the role of NOX1 and NOX5 in the invasion of MCF-7 human breast cancer cells. The expression and activity of NOXs and matrix metalloprotease (MMP)-9 were assessed by reverse transcription-quantitative PCR and western blotting, and the activity of MMP-9 was monitored using zymography. Cellular invasion was assessed using the Matrigel invasion assay, whereas ROS levels were quantified using a FACSCalibur flow cytometer. The findings suggested that NOX1 and NOX5 serve crucial roles in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MMP-9 expression and invasion of MCF-7 cells. Furthermore, a connection was established between PKC and the NOX1 and 5/ROS signaling pathways in mediating TPA-induced MMP-9 expression and cellular invasion. Notably, NOX inhibitors (diphenyleneiodonium chloride and apocynin) significantly attenuated TPA-induced MMP-9 expression and invasion in MCF-7 cells. NOX1- and NOX5-specific small interfering RNAs attenuated TPA-induced MMP-9 expression and cellular invasion. In addition, knockdown of NOX1 and NOX5 suppressed TPA-induced ROS levels. Furthermore, a PKC inhibitor (GF109203X) suppressed TPA-induced intracellular ROS levels, MMP-9 expression and NOX activity in MCF-7 cells. Therefore, NOX1 and NOX5 may serve crucial roles in TPA-induced MMP-9 expression and invasion of MCF-7 breast cancer cells. Furthermore, the present study indicated that TPA-induced MMP-9 expression and cellular invasion were mediated through PKC, thus linking the NOX1 and 5/ROS signaling pathways. These findings offer novel insights into the potential mechanisms underlying their anti-invasive effects in breast cancer. [ABSTRACT FROM AUTHOR]

Published
2024
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48. Nutrient intakes from supplement and factors associated with supplement use among breast cancer survivors: A cross‐sectional study

Author

Youn, Jiyoung, primary, Park, Sihyun, additional, Song, Sihan, additional, Moon, Hyeong‐Gon, additional, Noh, Dong‐Young, additional, Jung, So‐Youn, additional, Lee, Eunsook, additional, Kim, Zisun, additional, Youn, Hyun Jo, additional, Cho, Jihyoung, additional, Yoo, Young Bum, additional, Lee, Se Kyung, additional, Hyun, Taisun, additional, and Lee, Jung Eun, additional

Published
2021
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49. Clinical Outcomes Following Letrozole Treatment according to Estrogen Receptor Expression in Postmenopausal Women: LETTER Study (KBCSG-006)

Author

Ahn, Sung Gwe, primary, Nam, Seok Jin, additional, Ahn, Sei Hyun, additional, Jung, Yongsik, additional, Park, Heung Kyu, additional, Lee, Soo Jung, additional, Kang, Sung Soo, additional, Han, Wonshik, additional, Park, Kyong Hwa, additional, Park, Yong Lai, additional, Lee, Jihyoun, additional, Youn, Hyun Jo, additional, Kim, Jun Hyun, additional, Yoo, Youngbum, additional, Song, Jeong-Yoon, additional, Ko, Byung Kyun, additional, Gwak, Geumhee, additional, Chung, Min Sung, additional, Kim, Sung Yong, additional, Cho, Seo Heon, additional, Kim, Doyil, additional, Chang, Myung-Chul, additional, Moon, Byung In, additional, Kim, Lee Su, additional, Kim, Sei Joong, additional, Park, Min Ho, additional, Kim, Tae Hyun, additional, Cho, Jihyoung, additional, Lim, Cheol Wan, additional, Bae, Young Tae, additional, Gong, Gyungyub, additional, Bae, Young Kyung, additional, Lee, Ahwon, additional, and Jeong, Joon, additional

Published
2021
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