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The electronic structure of high-quality van der Waals multiferroic CuCrP$_2$S6 crystals was investigated applying photoelectron spectroscopy methods in combination with DFT analysis. Using X-ray photoelectron and near-edge X-ray absorption fine structure (NEXAFS) spectroscopy at the Cu L2,3 and Cr L2,3 absorption edges we determine the charge states of ions in the studied compound. Analyzing the systematic NEXAFS and resonant photoelectron spectroscopy data at the Cu/Cr L2,3 absorption edges allowed us to assign the CuCrP$_2$S6 material to a Mott-Hubbard type insulator and identify different Auger-decay channels (participator vs. spectator) during absorption and autoionization processes. Spectroscopic and theoretical data obtained for CuCrP$_2$S6 are very important for the detailed understanding of the electronic structure and electron-correlations phenomena in different layered materials, that will drive their further applications in different areas, like electronics, spintronics, sensing, and catalysis.

Recombinant adeno-associated virus (rAAV) vectors have revolutionized gene therapy, but their broad tropism and suboptimal transduction efficiency limit their clinical applications. To overcome these limitations, researchers have focused on designing and screening capsid libraries to identify improved vectors. However, the large sequence space and limited resources present challenges in identifying viable capsid variants. In this study, we propose an end-to-end diffusion model to generate capsid sequences with enhanced viability. Using publicly available AAV2 data, we generated 38,000 diverse AAV2 viral protein (VP) sequences, and evaluated 8,000 for viral selection. The results attested the superiority of our model compared to traditional methods. Additionally, in the absence of AAV9 capsid data, apart from one wild-type sequence, we used the same model to directly generate a number of viable sequences with up to 9 mutations. we transferred the remaining 30,000 samples to the AAV9 domain. Furthermore, we conducted mutagenesis on AAV9 VP hypervariable regions VI and V, contributing to the continuous improvement of the AAV9 VP sequence. This research represents a significant advancement in the design and functional validation of rAAV vectors, offering innovative solutions to enhance specificity and transduction efficiency in gene therapy applications.

In extending fast digital clock synchronization to the bounded-delay model, the expected constant time Byzantine pulse resynchronization problem is investigated. In this problem, the synchronized state of the system should not only be deterministically maintained but be reached from arbitrary states with expected constant time in the presence of Byzantine faults. An intuitive geometric representation of the problem is introduced, with which the classical approximate agreement, randomized Byzantine agreement, and random walk are integrated with some geometric operations. Efficient realizations are also provided for practical uses. Compared with the state-of-the-art solutions, the assumed common pulses need not be regularly generated, the message complexity can be lowered as approximate agreement, and the expected stabilization time is optimal. With this, the provided solution can efficiently convert irregularly generated common pulses to self-stabilizing Byzantine pulse synchronization., Comment: 9 pages, 4 figures, submitted to Elsevier

For reaching dependable high-precision clock synchronization (CS) upon IoT networks, the distributed CS paradigm adopted in ultra-high reliable systems and the master-slave CS paradigm adopted in high-performance but unreliable systems are integrated. Meanwhile, traditional internal clock synchronization is also integrated with external time references to achieve efficient stabilization. Low network connectivity, low complexity, high precision, and high reliability are all considered. To tolerate permanent failures, the Byzantine CS is integrated with the common CS protocols. To tolerate transient failures, the self-stabilizing Byzantine CS is also extended upon open-world IoT networks. With these, the proposed intro-stabilizing Byzantine CS solution can establish and maintain synchronization with arbitrary initial states in the presence of permanent Byzantine faults. With the formal analysis and numerical simulations, it is shown that the best of the CS solutions provided for the ultra-high reliable systems and the high-performance unreliable systems can be well integrated upon IoT networks to derive dependable high-precision CS even across the traditional closed safety-boundary., Comment: 26 pages, 18 figures

For reaching fast and efficient self-stabilizing Byzantine pulse synchronization (SSBPS) upon the bounded-delay message-passing networks, we consider the peaceable SSBPS problem where the resource occupation in the stabilized system is required to be as sparse as possible and the stabilization of the system is required to be as fast as possible. To solve it, the decoupled absorption process and emergency process are investigated under a general framework. The constant-time two-stage absorption process and more than one kind of emergency process are provided in integrating the merits of temporal trails, approximate agreements, deterministic and randomized Byzantine agreements, and self-stabilizing protocols. With this, not only SSBPS but self-stabilizing Byzantine clock synchronization can be fast established and efficiently maintained. In the optimal-resilient basic solutions, the deterministic linear stabilization time and the stabilized resource occupation are all optimized to those of the underlying primitives, which is optimal in the presence of Byzantine faults under the classical static adversary. In the hybrid solutions, faster stabilization can be expected with a worst-case deterministic stabilization time. In all solutions, the stabilized resource occupation is at most at the order of approximate agreement, which is a good property in considering real-world ultra-high-reliable hard-real-time applications where pulse synchronization is expected to be established before all upper-layer functions and to be efficiently maintained when the upper-layer functions are in service., Comment: 23 pages, 3 figures

Robust pulse synchronization is fundamental in constructing reliable synchronous applications in wired and wireless distributed systems. In wired systems, self-stabilizing Byzantine pulse synchronization aims for synchronizing fault-prone distributed components with arbitrary initial states in bounded-delay message-passing systems. In wireless systems, fault-tolerant synchronization of pulse-coupled oscillators is also built for a similar goal but often works under specific system restrictions, such as low computation power, low message complexity, and anonymous physical pulses whose senders cannot be identified by the receivers. These restrictions often prevent us from constructing high-reliable wireless synchronous applications. This paper tries to break barriers between bounded-delay message-passing systems and classical pulse-coupled oscillators by introducing a new fault-tolerant synchronization scheme for the so-called anonymous bounded-delay pulsing systems in the presence of indeterministic communication delays and inconsistent faults. For low computation power and low message complexity, instead of involving in consensus-based primitives, the proposed synchronization scheme integrates the so-called discrete mean-fields, planar random walks, and some additional easy operations in utilizing only sparsely generated anonymous pulses. For fault-tolerance, we show that a square-root number of faulty oscillators can be tolerated by utilizing planar random walks in anonymous pulse synchronization. For self-stabilization, we show that the stabilization can be reached in an expected constant number of observing windows in anonymous bounded-delay pulsing systems with the pulsing-frequency restriction., Comment: 19 pages, 5 figures

For reaching efficient deterministic synchronous Byzantine agreement upon partially connected networks, the traditional broadcast primitive is extended and integrated with a general framework. With this, the Byzantine agreement is extended to fully connected bipartite networks and some bipartite bounded-degree networks. The complexity of the Byzantine agreement is lowered and optimized with the so-called Byzantine-levers under a general system structure. Some bipartite simulation of the butterfly networks and some finer properties of bipartite bounded-degree networks are also provided for building efficient incomplete Byzantine agreement under the same system structure. It shows that efficient real-world Byzantine agreement systems can be built with the provided algorithms with sufficiently high system assumption coverage. Meanwhile, the proposed bipartite solutions can improve the dependability of the systems in some open, heterogeneous, and even antagonistic environments., Comment: 24 pages, 5 figures

For tolerating Byzantine faults of both the terminal and communication components in self-stabilizing clock synchronization, the two-dimensional self-stabilizing Byzantine-fault-tolerant clock synchronization problem is investigated and solved. By utilizing the time-triggered (TT) stage provided in the underlying networks as TT communication windows, the approximate agreement, hopping procedure, and randomized grandmasters are integrated into the overall solution. It is shown that with partitioning the communication components into $3$ arbitrarily connected subnetworks, efficient synchronization can be achieved with one such subnetwork and less than $1/3$ terminal components being Byzantine. Meanwhile, the desired stabilization can be reached for the specific networks in one or several seconds with high probabilities. This helps in developing various distributed hard-real-time systems with stringent time, resources, and safety requirements., Comment: 8 pages, 3 figures

To improve the overall efficiency and reliability of Byzantine protocols in large sparse networks, we propose a new system assumption for developing multi-scale fault-tolerant systems, with which several kinds of multi-scale Byzantine protocols are developed in large sparse networks with high system assumption coverage. By extending the traditional Byzantine adversary to the multi-scale adversaries, it is shown that efficient deterministic Byzantine broadcast and Byzantine agreement can be built in logarithmic-degree networks. Meanwhile, it is shown that the multi-scale adversary can make a finer trade-off between the system assumption coverage and the overall efficiency of the Byzantine protocols, especially when a small portion of the low-layer small-scale protocols are allowed to fail arbitrarily. With this, efficient Byzantine protocols can be built in large sparse networks with high system reliability., Comment: 8 pages, 1 figure

The authenticated broadcast is simulated in the bounded-degree networks to provide efficient broadcast primitives for building efficient higher-layer Byzantine protocols. A general abstraction of the relay-based broadcast system is introduced, in which the properties of the relay-based broadcast primitives are generalized. With this, fault-tolerant propagation is proposed as a building block of the broadcast primitives. Meanwhile, complementary systems are proposed in complementing fault-tolerant propagation and localized communication. Analysis shows that efficient fault-tolerant propagation can be built with sufficient initiation areas. Meanwhile, by integrating fault-tolerant propagation and localized communication, efficient broadcast primitives can be built in bounded-degree networks., Comment: 8 pages, 2 figures

Message propagation is fundamental in constructing distributed systems upon sparsely connected communication networks. For providing easy message propagation primitives, the mutual-exclusive propagation (MEP) of one-bit messages is investigated with a simplified discrete system model. Inspired by natural propagation systems, efficient self-stabilizing periodic MEP processes are proposed with the MEP systems. For handling the worst-case scenarios, the MEP systems are generally analyzed with formal proofs upon arbitrarily connected networks. It shows that the MEP systems can be stabilized with arbitrary initial system states within a short bounded time. Meanwhile, the numeric simulation shows that the propagation errors can be significantly reduced if the message delays are randomly distributed. Propagation patterns are also discussed in further deriving finer propagation results in the MEP systems. It shows that bounded clock drifts and some benign faults can be well handled in the MEP systems. Featured by its very simple mechanism, the proposed MEP primitive can be employed as a practical building block of upper-layer self-stabilizing synchronous systems., Comment: 12 pages, 7 figures