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6. Reduction of the oxidative damage to H 2O 2-induced HepG2 cells via the Nrf2 signalling pathway by plant flavonoids Quercetin and Hyperoside

Author

Zhang, Meijing, primary, Zhang, Gaoshuai, additional, Meng, Xiangxing, additional, Wang, Xinxin, additional, Xie, Jiao, additional, Wang, Shaoshu, additional, Wang, Biao, additional, Wang, Jilite, additional, Liu, Suwen, additional, Huang, Qun, additional, Yang, Xu, additional, Li, Jing, additional, and Wang, Hao, additional

Published
2024
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9. Ursolic Acid Inhibited Cholesterol Esterase and Pancreatic Lipase Activities and Decreased Micellar Cholesterol Solubility In Vitro

Author

Jiang, Wenjing, primary, Huang, Qun, additional, Meng, Xiangxing, additional, Rehman, Rizwan-ur, additional, Qian, Kun, additional, Yang, Xu, additional, Liu, Xiaozhi, additional, Chen, Jingnan, additional, Zhang, Ye, additional, Li, Jing, additional, Wang, Jilite, additional, Guo, Qingbin, additional, Liu, Suwen, additional, and Wang, Hao, additional

Published
2023
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11. Reduction of the oxidative damage to H2O2-induced HepG2 cells via the Nrf2 signalling pathway by plant flavonoids Quercetin and Hyperoside

Author

Zhang, Meijing, Zhang, Gaoshuai, Meng, Xiangxing, Wang, Xinxin, Xie, Jiao, Wang, Shaoshu, Wang, Biao, Wang, Jilite, Liu, Suwen, Huang, Qun, Yang, Xu, Li, Jing, and Wang, Hao

Abstract

Hyperoside and quercetin are similar in molecular structures. In this study, the antioxidant regulatory targets of hyperoside and quercetin are mainly in the nuclear factor (erythroid-2-derived)-related factor 2 (Nrf2) pathway predicted by network pharmacology. And the antioxidant effect and mechanism of hyperoside and quercetin were measured and compared in H2O2-induced HepG2 cells and Caenorhabditis elegans. The findings indicated that quercetin was more effective than hyperoside in reducing oxidative damage, which was proved by improved cell viability, decreased reactive oxygen species (ROS) production, decreased cellular apoptosis, and alleviated mitochondrial damage. In addition, quercetin was more efficient than hyperoside in enhancing the expression of Nrf2-associated mRNAs, increasing the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT), and reducing the cellular malondialdehyde (MDA) content. Quercetin was superior to hyperoside in prolonging the lifespan of worms, decreasing the accumulation of lipofuscin, inhibiting ROS production, and increasing the proportion of skn-1 in the nucleus. With the Nrf2 inhibitor ML385, we verified that quercetin and hyperoside primarily protected the cells against oxidative damage via the Nrf2 signalling pathway. Furthermore, molecular docking and dynamics simulations demonstrated that the quercetin- Kelch-like ECH-associated protein 1 (Keap1) complex was more stable than the hyperoside-Keap1 complex. The stable structure of the complex might hinder the binding of Nrf2 and Keap1 to release Nrf2 and facilitate its entry into the nucleus to play an antioxidant role. Overall, quercetin had a better antioxidant than hyperoside.

Published
2024
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13. Structural characterization of different starch–fatty acid complexes and their effects on human intestinal microflora.

Author

Li, Dan, Wang, Xin, Wang, Jilite, Wang, Mingchun, Zhou, Jiaping, Liu, Suwen, Zhao, Juan, Li, Jing, and Wang, Hao

Subjects
CORNSTARCH, STARCH, GUT microbiome, GINKGO, SHORT-chain fatty acids, LAURIC acid, FATTY acids, STEARIC acid
Abstract

Resistant starch type 5 (RS5), a starch–lipid complex, exhibited potential health benefits in blood glucose and insulin control due to the low digestibility. The effects of the crystalline structure of starch and chain length of fatty acid on the structure, in vitro digestibility, and fermentation ability in RS5 were investigated by compounding (maize, rice, wheat, potato, cassava, lotus, and ginkgo) of different debranched starches with 12–18C fatty acid (lauric, myristic, palmitic, and stearic acids), respectively. The complex showed a V‐type structure, formed by lotus and ginkgo debranched starches, and fatty acid exhibited a higher short‐range order and crystallinity, and lower in vitro digestibility than others due to the neat interior structure of more linear glucan chains. Furthermore, a fatty acid with 12C (lauric acid)‐debranched starches complexes had the highest complex index among all complexes, which might be attributed to the activation energy required for complex formation increased with the lengthening of the lipid carbon chain. Therefore, the lotus starch–lauric acid complex (LS12) exhibited remarkable ability in intestinal flora fermentation to produce short‐chain fatty acid (SCFAs), reducing intestinal pH, and creating a favorable environment for beneficial bacteria. [ABSTRACT FROM AUTHOR]

Published
2023
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15. Lutein attenuated methylglyoxal‐induced oxidative damage and apoptosis in PC12 cells via the PI3K/Akt signaling pathway.

Author

Chen, Wei, Zhang, Hua, Liu, Guishan, Kang, Ji, Wang, Biao, Wang, Jilite, Li, Jing, and Wang, Hao

Subjects
LUTEIN, GLYOXALASE, PI3K/AKT pathway, CELLULAR signal transduction, WESTERN immunoblotting, REACTIVE oxygen species, APOPTOSIS
Abstract

Methylglyoxal (MGO), a cytotoxic byproduct of glycolysis, causes neuro oxidative damage and apoptosis, and plays key roles in diabetic encephalopathy (DE). The goal of this research was to evaluate the roles of lutein attenuated MGO‐induced damage in PC12 cells as well as the underlying mechanisms. The findings of this study showed that lutein has a significant impact on reducing the generation of reactive oxygen species (ROS) and oxidative stress in MGO‐induced PC12 cells, which may be attributed to the increased antioxidant enzymes activity and the decreased MDA levels. Moreover, treatment with lutein also alleviated cell apoptosis and mitochondrial damage. Real‐time PCR and western blot analysis showed that lutein enhanced the Bcl‐2:Bax ratio, inhibited the expression of caspase‐3 and caspase‐9, and increased the protein level of phosphorylated Akt. The network pharmacology and molecular docking prediction results suggested that the phosphoinositide 3‐kinase/protein kinase B (PI3K/Akt) signaling pathway was a potential mechanism of lutein in DE treatment. Furthermore, LY294002, a specific PI3K inhibitor, partially abolished the protective effect of lutein. These results presented that lutein attenuated oxidative damage and apoptosis triggered by MGO in PC12 cells via the PI3K/Akt signaling pathway. Practical applications: Lutein is a common carotenoid dispersed in fruits and vegetables. This article confirmed a protective effect of lutein on oxidative damage and apoptosis in PC12 cells after MGO damage. These results indicated that lutein could potentially be developed as a nutraceutical or functional food in the prevention of diabetic‐related neurodegenerative diseases. [ABSTRACT FROM AUTHOR]

Published
2022
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28. Tianjin University of Science and Technology (TUST) Reports Findings in Obesity, Fitness and Wellness (Wolfberry water extract attenuates blue light-emitting diode damage to ARPE-19 cells and mouse retina by activating the NRF2 signaling pathway)

Subjects
Light-emitting diodes -- Reports -- Research, Obesity -- Research, Circuit components -- Reports -- Research, Physical fitness -- Research -- Reports, Semiconductor device, Electronics, Tianjin University -- Reports
Abstract

2023 APR 25 (VerticalNews) -- By a News Reporter-Staff News Editor at Electronics Newsweekly -- New research on Obesity, Fitness and Wellness is the subject of a report. According to [...]

Published
2023

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