11 results on '"Ulaf, Raisa G."'
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2. Evaluation of the efficacy and safety of icatibant and C1 esterase/kallikrein inhibitor in severe COVID-19: study protocol for a three-armed randomized controlled trial
- Author
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Mansour, Eli, Bueno, Flávia F., de Lima-Júnior, José C., Palma, Andre, Monfort-Pires, Milena, Bombassaro, Bruna, Araujo, Eliana P., Bernardes, Ana Flavia, Ulaf, Raisa G., Nunes, Thyago A., Ribeiro, Luciana C., Falcão, Antônio Luís E., Santos, Thiago Martins, Trabasso, Plinio, Dertkigil, Rachel P., Dertkigil, Sergio S., Maia, Rafael P., Benaglia, Tatiana, Moretti, Maria Luiza, and Velloso, Licio A.
- Published
- 2021
- Full Text
- View/download PDF
3. SARS-CoV-2 uses CD4 to infect T helper lymphocytes
- Author
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Brunetti, Natalia S, primary, Davanzo, Gustavo G, primary, de Moraes, Diogo, primary, Ferrari, Allan JR, primary, Souza, Gabriela F, primary, Muraro, Stéfanie Primon, primary, Knittel, Thiago L, primary, Boldrini, Vinicius O, primary, Monteiro, Lauar B, primary, Virgílio-da-Silva, João Victor, primary, Profeta, Gerson S, primary, Wassano, Natália S, primary, Nunes Santos, Luana, primary, Carregari, Victor C, primary, Dias, Artur HS, primary, Veras, Flavio P, additional, Tavares, Lucas A, additional, Forato, Julia, additional, Castro, Icaro MS, additional, Silva-Costa, Lícia C, additional, Palma, André C, additional, Mansour, Eli, additional, Ulaf, Raisa G, additional, Bernardes, Ana F, additional, Nunes, Thyago A, additional, Ribeiro, Luciana C, additional, Agrela, Marcus V, additional, Moretti, Maria Luiza, additional, Buscaratti, Lucas I, additional, Crunfli, Fernanda, additional, Ludwig, Raissa G, additional, Gerhardt, Jaqueline A, additional, Munhoz-Alves, Natália, additional, Marques, Ana Maria, additional, Sesti-Costa, Renata, additional, Amorim, Mariene R, additional, Toledo-Teixeira, Daniel A, additional, Parise, Pierina Lorencini, additional, Martini, Matheus Cavalheiro, additional, Bispos-dos-Santos, Karina, additional, Simeoni, Camila L, additional, Granja, Fabiana, additional, Silvestrini, Virgínia C, additional, de Oliveira, Eduardo B, additional, Faca, Vitor M, additional, Carvalho, Murilo, additional, Castelucci, Bianca G, additional, Pereira, Alexandre B, additional, Coimbra, Laís D, additional, Dias, Marieli MG, additional, Rodrigues, Patricia B, additional, Gomes, Arilson Bernardo SP, additional, Pereira, Fabricio B, additional, Santos, Leonilda MB, additional, Bloyet, Louis-Marie, additional, Stumpf, Spencer, additional, Pontelli, Marjorie C, additional, Whelan, Sean, additional, Sposito, Andrei C, additional, Carvalho, Robson F, additional, Vieira, André S, additional, Vinolo, Marco AR, additional, Damasio, André, additional, Velloso, Licio, additional, Figueira, Ana Carolina M, additional, da Silva, Luis LP, additional, Cunha, Thiago Mattar, additional, Nakaya, Helder I, additional, Marques-Souza, Henrique, additional, Marques, Rafael E, additional, Martins-de-Souza, Daniel, additional, Skaf, Munir S, additional, Proenca-Modena, Jose Luiz, additional, Moraes-Vieira, Pedro MM, additional, Mori, Marcelo A, additional, and Farias, Alessandro S, additional
- Published
- 2023
- Full Text
- View/download PDF
4. Author response: SARS-CoV-2 uses CD4 to infect T helper lymphocytes
- Author
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Brunetti, Natalia S, primary, Davanzo, Gustavo G, primary, de Moraes, Diogo, primary, Ferrari, Allan JR, primary, Souza, Gabriela F, primary, Muraro, Stéfanie Primon, primary, Knittel, Thiago L, primary, Boldrini, Vinicius O, primary, Monteiro, Lauar B, primary, Virgílio-da-Silva, João Victor, primary, Profeta, Gerson S, primary, Wassano, Natália S, primary, Nunes Santos, Luana, primary, Carregari, Victor C, primary, Dias, Artur HS, primary, Veras, Flavio P, additional, Tavares, Lucas A, additional, Forato, Julia, additional, Castro, Icaro MS, additional, Silva-Costa, Lícia C, additional, Palma, André C, additional, Mansour, Eli, additional, Ulaf, Raisa G, additional, Bernardes, Ana F, additional, Nunes, Thyago A, additional, Ribeiro, Luciana C, additional, Agrela, Marcus V, additional, Moretti, Maria Luiza, additional, Buscaratti, Lucas I, additional, Crunfli, Fernanda, additional, Ludwig, Raissa G, additional, Gerhardt, Jaqueline A, additional, Munhoz-Alves, Natália, additional, Marques, Ana Maria, additional, Sesti-Costa, Renata, additional, Amorim, Mariene R, additional, Toledo-Teixeira, Daniel A, additional, Parise, Pierina Lorencini, additional, Martini, Matheus Cavalheiro, additional, Bispos-dos-Santos, Karina, additional, Simeoni, Camila L, additional, Granja, Fabiana, additional, Silvestrini, Virgínia C, additional, de Oliveira, Eduardo B, additional, Faca, Vitor M, additional, Carvalho, Murilo, additional, Castelucci, Bianca G, additional, Pereira, Alexandre B, additional, Coimbra, Laís D, additional, Dias, Marieli MG, additional, Rodrigues, Patricia B, additional, Gomes, Arilson Bernardo SP, additional, Pereira, Fabricio B, additional, Santos, Leonilda MB, additional, Bloyet, Louis-Marie, additional, Stumpf, Spencer, additional, Pontelli, Marjorie C, additional, Whelan, Sean, additional, Sposito, Andrei C, additional, Carvalho, Robson F, additional, Vieira, André S, additional, Vinolo, Marco AR, additional, Damasio, André, additional, Velloso, Licio, additional, Figueira, Ana Carolina M, additional, da Silva, Luis LP, additional, Cunha, Thiago Mattar, additional, Nakaya, Helder I, additional, Marques-Souza, Henrique, additional, Marques, Rafael E, additional, Martins-de-Souza, Daniel, additional, Skaf, Munir S, additional, Proenca-Modena, Jose Luiz, additional, Moraes-Vieira, Pedro MM, additional, Mori, Marcelo A, additional, and Farias, Alessandro S, additional
- Published
- 2023
- Full Text
- View/download PDF
5. SARS-CoV-2 uses CD4 to infect T helper lymphocytes
- Author
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Brunetti, Natalia S, Davanzo, Gustavo G, de Moraes, Diogo, Ferrari, Allan JR, Souza, Gabriela F, Muraro, Stéfanie Primon, Knittel, Thiago L, Boldrini, Vinicius O, Monteiro, Lauar B, Virgílio-da-Silva, João Victor, Profeta, Gerson S, Wassano, Natália S, Nunes Santos, Luana, Carregari, Victor C, Dias, Artur HS, Veras, Flavio P, Tavares, Lucas A, Forato, Julia, Castro, Icaro MS, Silva-Costa, Lícia C, Palma, André C, Mansour, Eli, Ulaf, Raisa G, Bernardes, Ana F, Nunes, Thyago A, Ribeiro, Luciana C, Agrela, Marcus V, Moretti, Maria Luiza, Buscaratti, Lucas I, Crunfli, Fernanda, Ludwig, Raissa G, Gerhardt, Jaqueline A, Munhoz-Alves, Natália, Marques, Ana Maria, Sesti-Costa, Renata, Amorim, Mariene R, Toledo-Teixeira, Daniel A, Parise, Pierina Lorencini, Martini, Matheus Cavalheiro, Bispos-dos-Santos, Karina, Simeoni, Camila L, Granja, Fabiana, Silvestrini, Virgínia C, de Oliveira, Eduardo B, Faca, Vitor M, Carvalho, Murilo, Castelucci, Bianca G, Pereira, Alexandre B, Coimbra, Laís D, Dias, Marieli MG, Rodrigues, Patricia B, Gomes, Arilson Bernardo SP, Pereira, Fabricio B, Santos, Leonilda MB, Bloyet, Louis-Marie, Stumpf, Spencer, Pontelli, Marjorie C, Whelan, Sean, Sposito, Andrei C, Carvalho, Robson F, Vieira, André S, Vinolo, Marco AR, Damasio, André, Velloso, Licio, Figueira, Ana Carolina M, da Silva, Luis LP, Cunha, Thiago Mattar, Nakaya, Helder I, Marques-Souza, Henrique, Marques, Rafael E, Martins-de-Souza, Daniel, Skaf, Munir S, Proenca-Modena, Jose Luiz, Moraes-Vieira, Pedro MM, Mori, Marcelo A, Farias, Alessandro S, Brunetti, Natalia S, Davanzo, Gustavo G, de Moraes, Diogo, Ferrari, Allan JR, Souza, Gabriela F, Muraro, Stéfanie Primon, Knittel, Thiago L, Boldrini, Vinicius O, Monteiro, Lauar B, Virgílio-da-Silva, João Victor, Profeta, Gerson S, Wassano, Natália S, Nunes Santos, Luana, Carregari, Victor C, Dias, Artur HS, Veras, Flavio P, Tavares, Lucas A, Forato, Julia, Castro, Icaro MS, Silva-Costa, Lícia C, Palma, André C, Mansour, Eli, Ulaf, Raisa G, Bernardes, Ana F, Nunes, Thyago A, Ribeiro, Luciana C, Agrela, Marcus V, Moretti, Maria Luiza, Buscaratti, Lucas I, Crunfli, Fernanda, Ludwig, Raissa G, Gerhardt, Jaqueline A, Munhoz-Alves, Natália, Marques, Ana Maria, Sesti-Costa, Renata, Amorim, Mariene R, Toledo-Teixeira, Daniel A, Parise, Pierina Lorencini, Martini, Matheus Cavalheiro, Bispos-dos-Santos, Karina, Simeoni, Camila L, Granja, Fabiana, Silvestrini, Virgínia C, de Oliveira, Eduardo B, Faca, Vitor M, Carvalho, Murilo, Castelucci, Bianca G, Pereira, Alexandre B, Coimbra, Laís D, Dias, Marieli MG, Rodrigues, Patricia B, Gomes, Arilson Bernardo SP, Pereira, Fabricio B, Santos, Leonilda MB, Bloyet, Louis-Marie, Stumpf, Spencer, Pontelli, Marjorie C, Whelan, Sean, Sposito, Andrei C, Carvalho, Robson F, Vieira, André S, Vinolo, Marco AR, Damasio, André, Velloso, Licio, Figueira, Ana Carolina M, da Silva, Luis LP, Cunha, Thiago Mattar, Nakaya, Helder I, Marques-Souza, Henrique, Marques, Rafael E, Martins-de-Souza, Daniel, Skaf, Munir S, Proenca-Modena, Jose Luiz, Moraes-Vieira, Pedro MM, Mori, Marcelo A, and Farias, Alessandro S
- Abstract
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the agent of a major global outbreak of respiratory tract disease known as Coronavirus Disease 2019 (COVID-19). SARS-CoV-2 infects mainly lungs and may cause several immune-related complications, such as lymphocytopenia and cytokine storm, which are associated with the severity of the disease and predict mortality. The mechanism by which SARS-CoV-2 infection may result in immune system dysfunction is still not fully understood. Here, we show that SARS-CoV-2 infects human CD4+ T helper cells, but not CD8+ T cells, and is present in blood and bronchoalveolar lavage T helper cells of severe COVID-19 patients. We demonstrated that SARS-CoV-2 spike glycoprotein (S) directly binds to the CD4 molecule, which in turn mediates the entry of SARS-CoV-2 in T helper cells. This leads to impaired CD4 T cell function and may cause cell death. SARS-CoV-2-infected T helper cells express higher levels of IL-10, which is associated with viral persistence and disease severity. Thus, CD4-mediated SARS-CoV-2 infection of T helper cells may contribute to a poor immune response in COVID-19 patients.
- Published
- 2023
6. Plasma Angiotensin II Is Increased in Critical Coronavirus Disease 2019
- Author
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Camargo, Rafael L., primary, Bombassaro, Bruna, additional, Monfort-Pires, Milena, additional, Mansour, Eli, additional, Palma, Andre C., additional, Ribeiro, Luciana C., additional, Ulaf, Raisa G., additional, Bernardes, Ana Flavia, additional, Nunes, Thyago A., additional, Agrela, Marcus V., additional, Dertkigil, Rachel P., additional, Dertkigil, Sergio S., additional, Araujo, Eliana P., additional, Nadruz, Wilson, additional, Moretti, Maria Luiza, additional, Velloso, Licio A., additional, and Sposito, Andrei C., additional
- Published
- 2022
- Full Text
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7. Circulating Levels of Ang/Tie2 and VEGF-a Pathway Mediators Are Associated with Clinical Severity, Endothelial Barrier Disruption and Coagulation Activation in COVID-19
- Author
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de Moraes, Carla Roberta Peachazepi, primary, de Borba Junior, Ivanio Teixeira, additional, de Lima, Franciele, additional, Barbosa, Mayck Silva, additional, Huber, Stephany Cares, additional, Palma, Andre C., additional, Nunes, Thyago A., additional, Ulaf, Raisa G., additional, Ribeiro, Luciana C., additional, Bernandes, Ana Flavia, additional, Bombassaro, Bruna, additional, Dertkigil, Sergio S., additional, Moretti, Maria Luiza, additional, Bizzacchi, Joyce Annichino, additional, Mansour, Eli, additional, Velloso, Lício Augusto, additional, Maranhão Costa, Fábio Trindade, additional, Orsi, Fernanda Andrade, additional, and De Paula, Erich V, additional
- Published
- 2021
- Full Text
- View/download PDF
8. Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis
- Author
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Codo, Ana Campos, Davanzo, Gustavo Gastão, Monteiro, Lauar de Brito, de Souza, Gabriela Fabiano, Muraro, Stéfanie Primon, Virgilio-da-Silva, João Victor, Prodonoff, Juliana Silveira, Carregari, Victor Corasolla, de Biagi Junior, Carlos Alberto Oliveira, Crunfli, Fernanda, Jimenez Restrepo, Jeffersson Leandro, Vendramini, Pedro Henrique, Reis-de-Oliveira, Guilherme, Bispo dos Santos, Karina, Toledo-Teixeira, Daniel A., Parise, Pierina Lorencini, Martini, Matheus Cavalheiro, Marques, Rafael Elias, Carmo, Helison R., Borin, Alexandre, Coimbra, Laís Durço, Boldrini, Vinícius O., Brunetti, Natalia S., Vieira, Andre S., Mansour, Eli, Ulaf, Raisa G., Bernardes, Ana F., Nunes, Thyago A., Ribeiro, Luciana C., Palma, Andre C., Agrela, Marcus V., Moretti, Maria Luiza, Sposito, Andrei C., Pereira, Fabrício Bíscaro, Velloso, Licio Augusto, Vinolo, Marco Aurélio Ramirez, Damasio, André, Proença-Módena, José Luiz, Carvalho, Robson Francisco, Mori, Marcelo A., Martins-de-Souza, Daniel, Nakaya, Helder I., Farias, Alessandro S., and Moraes-Vieira, Pedro M.
- Published
- 2020
- Full Text
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9. Safety and Outcomes Associated with the Pharmacological Inhibition of the Kinin–Kallikrein System in Severe COVID-19
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Mansour, Eli, primary, Palma, Andre C., additional, Ulaf, Raisa G., additional, Ribeiro, Luciana C., additional, Bernardes, Ana Flavia, additional, Nunes, Thyago A., additional, Agrela, Marcus V., additional, Bombassaro, Bruna, additional, Monfort-Pires, Milena, additional, Camargo, Rafael L., additional, Araujo, Eliana P., additional, Brunetti, Natalia S., additional, Farias, Alessandro S., additional, Falcão, Antônio Luís E., additional, Santos, Thiago Martins, additional, Trabasso, Plinio, additional, Dertkigil, Rachel P., additional, Dertkigil, Sergio S., additional, Moretti, Maria Luiza, additional, and Velloso, Licio A., additional
- Published
- 2021
- Full Text
- View/download PDF
10. SARS-CoV-2 Uses CD4 to Infect T Helper Lymphocytes
- Author
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Brunetti, Natália S., primary, Davanzo, Gustavo G., additional, de Moraes, Diogo, additional, Ferrari, Allan J. R., additional, de Souza, Gabriela F., additional, Muraro, Stefanie P., additional, Knittel, Thiago L., additional, Boldrini, Vinícius O., additional, Monteiro, Lauar B., additional, Virgilio-da-Silva, João Victor, additional, Profeta, Gerson S., additional, Wassano, Natália S., additional, Santos, Luana N., additional, Carregari, Victor C., additional, Dias, Artur H. S., additional, Veras, Flavio P., additional, Tavares, Lucas A., additional, Forato, Julia, additional, Castro, Ícaro, additional, Silva-Costa, Lícia C., additional, Palma, Andre, additional, Mansour, Eli, additional, Ulaf, Raisa G., additional, Bernardes, Ana F., additional, Nunes, Thyago A., additional, Ribeiro, Luciana C., additional, Agrela, Marcus V., additional, Moretti, Maria Luiza, additional, Buscaratti, Lucas I., additional, Crunfli, Fernanda, additional, Ludwig, Raissa G., additional, Gerhardt, Jaqueline A., additional, Munhoz-Alves, Natália, additional, Marques, Ana M., additional, Sesti-Costa, Renata, additional, Amorim, Mariene R., additional, Texeira, Daniel A. T., additional, Parise, Pierina L., additional, Martini, Matheus C., additional, Bispo-dos-Santos, Karina, additional, Simeoni, Camila L., additional, Granja, Fabiana, additional, Silvestrini, Virginia C., additional, de Oliveira, Eduardo B., additional, Faça, Vitor M., additional, Carvalho, Murilo, additional, Castelucci, Bianca G., additional, Pereira, Alexandre B., additional, Coimbra, Laís D., additional, Dias, Marieli M. G., additional, Rodrigues, Patricia B., additional, S. P. Gomes, Arilson Bernardo, additional, Pereira, Fabricio B., additional, Santos, Leonilda M. B., additional, Bloyet, Louis-Marie, additional, Stumpf, Spencer, additional, Pontelli, Marjorie C., additional, Whelan, Sean P. J., additional, Sposito, Andrei C., additional, Carvalho, Robson F., additional, Vieira, Andre S., additional, Vinolo, Marco A. R., additional, Damasio, André, additional, Velloso, Licio A., additional, M. Figueira, Ana Carolina, additional, da Silva, Luis L. P., additional, Cunha, Thiago M., additional, Nakaya, Helder I., additional, Marques-Souza, Henrique, additional, Marques, Rafael E., additional, Martins-de-Souza, Daniel, additional, Skaf, Munir S., additional, Proença-Modena, José Luiz, additional, Moraes-Vieira, Pedro M., additional, Mori, Marcelo A., additional, and Farias, Alessandro S., additional
- Published
- 2020
- Full Text
- View/download PDF
11. Pharmacological inhibition of the kinin-kallikrein system in severe COVID-19 – A proof-of-concept study
- Author
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Mansour, Eli, primary, Palma, Andre C., additional, Ulaf, Raisa G., additional, Ribeiro, Luciana C., additional, Bernardes, Ana Flavia, additional, Nunes, Thyago A., additional, Agrela, Marcus V., additional, Bombassaro, Bruna, additional, Monfort-Pires, Milena, additional, Camargo, Rafael L., additional, Araujo, Eliana P., additional, Brunetti, Natalia S., additional, Farias, Alessandro S., additional, Falcão, Antônio Luís E., additional, Santos, Thiago Martins, additional, Trabasso, Plinio, additional, Dertkigil, Rachel P., additional, Dertkigil, Sergio S., additional, Moretti, Maria Luiza, additional, and Velloso, Licio A., additional
- Published
- 2020
- Full Text
- View/download PDF
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