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2. Does an electronic pathology ordering system change the volume and pattern of routine testing in hospital? An interrupted time series analysis.

Author

de Carle, Madeleine, Macnab, Brooke, Utainrat, Jenewa, Herkes-Deane, Jessica, Attia, John, de Malmanche, Theo, Teber, Erdahl, Palazzi, Kerrin, Scowen, Craig, and Hure, Alexis

Subjects
PICTURE archiving & communication systems, COVID-19 pandemic, BLOOD cell count, CORONARY care units, HEALTH information exchanges, COST estimates
Published
2024
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3. Effectiveness of HealthTracker for post-caesarean section surgical site infection surveillance: An intervention study.

Author

Se Ok Ohr, Ball, Jean, Teber, Erdahl, Ferguson, John K., Petherbridge, Rachael, and Giles, Michelle

Subjects
CESAREAN section, POSTOPERATIVE care, PUBLIC health surveillance, MOBILE apps, HUMAN services programs, RESEARCH funding, INFECTION control, EVALUATION of human services programs, CLINICAL trials, QUESTIONNAIRES, DESCRIPTIVE statistics, PRE-tests & post-tests, SURGICAL site infections, DATA analysis software, CONFIDENCE intervals, COMMUNITY-based social services
Abstract

This intervention study aimed to implement and evaluate the effectiveness of Health-Tracker, a post-discharge surgical site infection surveillance system. Participants were 730 women birthing by caesarean section at a large hospital over a 6-month period. Data were downloaded from clinical data systems and HealthTracker. Receiver operating characteristics were used to assess HealthTracker. Over a 6-month period, 382 women completed HealthTracker, with 83 scoring >6, indicating signs and symptoms of surgical site infection. Of this 83, 58 sought advice from health professionals, 29 returned to hospital, and 45 received antibiotics. A total of 20 infections from a total population of 730 were confirmed, with 14 out of 382 respondents confirmed via HealthTracker. Receiver operating characteristics identified HealthTracker as an excellent indicator of surgical site infection. HealthTracker is a feasible mHealth option for monitoring post-discharge surgical site infection post-caesarean section. In addition, by providing alerts, advising women to monitor their symptoms and seek treatment if necessary, HealthTracker has the potential to enhance self-efficacy for surgical wound monitoring at home. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Differentiation of brain and retinal organoids from confluent cultures of pluripotent stem cells connected by nerve-like axonal projections of optic origin

Author

Fernando, Milan, primary, Lee, Scott, additional, Wark, Jesse R., additional, Xiao, Di, additional, Lim, Benjamin Y., additional, O’Hara-Wright, Michelle, additional, Kim, Hani J., additional, Smith, Grady C., additional, Wong, Ted, additional, Teber, Erdahl T., additional, Ali, Robin R., additional, Yang, Pengyi, additional, Graham, Mark E., additional, and Gonzalez-Cordero, Anai, additional

Published
2022
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12. Differentiation of cortical brain organoids and optic nerve-like structures from retinal confluent cultures of pluripotent stem cells

Author

Fernando, Milan, primary, Lee, Scott, additional, Wark, Jesse R., additional, Xiao, Di, additional, Kim, Hani J., additional, Smith, Grady C., additional, Wong, Ted, additional, Teber, Erdahl T., additional, Ali, Robin R., additional, Yang, Pengyi, additional, Graham, Mark E., additional, and Gonzalez-Cordero, Anai, additional

Published
2021
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17. Telomerase promotes formation of a telomere protective complex in cancer cells

Author

Perera, Omesha N., primary, Sobinoff, Alexander P., additional, Teber, Erdahl T., additional, Harman, Ashley, additional, Maritz, Michelle F., additional, Yang, Sile F., additional, Pickett, Hilda A., additional, Cesare, Anthony J., additional, Arthur, Jonathan W., additional, MacKenzie, Karen L., additional, and Bryan, Tracy M., additional

Published
2019
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19. Djinn Lite: a tool for customised gene transcript modelling, annotation-data enrichment and exploration

Author

Van Dyk Derek, Bolton Kent B, Crawford Edward, Teber Erdahl T, Schofield Peter R, Kapoor Vimal, and Church W Bret

Subjects
Computer applications to medicine. Medical informatics, R858-859.7, Biology (General), QH301-705.5
Abstract

Abstract Background There is an ever increasing rate of data made available on genetic variation, transcriptomes and proteomes. Similarly, a growing variety of bioinformatic programs are becoming available from many diverse sources, designed to identify a myriad of sequence patterns considered to have potential biological importance within inter-genic regions, genes, transcripts, and proteins. However, biologists require easy to use, uncomplicated tools to integrate this information, visualise and print gene annotations. Integrating this information usually requires considerable informatics skills, and comprehensive knowledge of the data format to make full use of this information. Tools are needed to explore gene model variants by allowing users the ability to create alternative transcript models using novel combinations of exons not necessarily represented in current database deposits of mRNA/cDNA sequences. Results Djinn Lite is designed to be an intuitive program for storing and visually exploring of custom annotations relating to a eukaryotic gene sequence and its modelled gene products. In particular, it is helpful in developing hypothesis regarding alternate splicing of transcripts by allowing the construction of model transcripts and inspection of their resulting translations. It facilitates the ability to view a gene and its gene products in one synchronised graphical view, allowing one to drill down into sequence related data. Colour highlighting of selected sequences and added annotations further supports exploration, visualisation of sequence regions and motifs known or predicted to be biologically significant. Conclusion Gene annotating remains an ongoing and challengingtask that will continue as gene structures, gene transcription repertoires, disease loci, protein products and their interactions become moreprecisely defined. Djinn Lite offers an accessible interface to help accumulate, enrich, and individualise sequence annotations relating to a gene, its transcripts and translations. The mechanism of transcript definition and creation, and subsequent navigation and exploration of features, are very intuitive and demand only a short learning curve. Ultimately, Djinn Lite can form the basis for providing valuable clues to plan new experiments, providing storage of sequences and annotations for dedication to customised projects. The application is appropriate for Windows 98-ME-2000-XP-2003 operating systems.

Published
2006
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20. Telomere sequence content can be used to determine ALT activity in tumours

Author

Lee, Michael, primary, Teber, Erdahl T, additional, Holmes, Oliver, additional, Nones, Katia, additional, Patch, Ann-Marie, additional, Dagg, Rebecca A, additional, Lau, Loretta M S, additional, Lee, Joyce H, additional, Napier, Christine E, additional, Arthur, Jonathan W, additional, Grimmond, Sean M, additional, Hayward, Nicholas K, additional, Johansson, Peter A, additional, Mann, Graham J, additional, Scolyer, Richard A, additional, Wilmott, James S, additional, Reddel, Roger R, additional, Pearson, John V, additional, Waddell, Nicola, additional, and Pickett, Hilda A, additional

Published
2018
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22. A Signature of Attention-Elicited Electrocortical Activity Distinguishes Response From Non-Response to the Non-Stimulant Atomoxetine in Children and Adolescents With ADHD

Author

Griffiths, Kristi R., primary, Jurigova, Barbora G., additional, Leikauf, John E., additional, Palmer, Donna, additional, Clarke, Simon D., additional, Tsang, Tracey W., additional, Teber, Erdahl T., additional, Kohn, Michael R., additional, and Williams, Leanne M., additional

Published
2017
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23. Extensive Proliferation of Human Cancer Cells with Ever-Shorter Telomeres

Author

Dagg, Rebecca A., primary, Pickett, Hilda A., additional, Neumann, Axel A., additional, Napier, Christine E., additional, Henson, Jeremy D., additional, Teber, Erdahl T., additional, Arthur, Jonathan W., additional, Reynolds, C. Patrick, additional, Murray, Jayne, additional, Haber, Michelle, additional, Sobinoff, Alexander P., additional, Lau, Loretta M.S., additional, and Reddel, Roger R., additional

Published
2017
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24. Limiting Thymic Precursor Supply Increases the Risk of Lymphoid Malignancy in Murine X-Linked Severe Combined Immunodeficiency

Author

Ginn, Samantha L., primary, Hallwirth, Claus V., additional, Liao, Sophia H.Y., additional, Teber, Erdahl T., additional, Arthur, Jonathan W., additional, Wu, Jianmin, additional, Lee, Hong Ching, additional, Tay, Szun S., additional, Hu, Min, additional, Reddel, Roger R., additional, McCormack, Matthew P., additional, Thrasher, Adrian J., additional, Cavazzana, Marina, additional, Alexander, Stephen I., additional, and Alexander, Ian E., additional

Published
2017
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27. The Transcriptional and Functional Properties of Mouse Epiblast Stem Cells Resemble the Anterior Primitive Streak

Author

Kojima, Yoji, primary, Kaufman-Francis, Keren, additional, Studdert, Joshua B., additional, Steiner, Kirsten A., additional, Power, Melinda D., additional, Loebel, David A.F., additional, Jones, Vanessa, additional, Hor, Angelyn, additional, de Alencastro, Gustavo, additional, Logan, Grant J., additional, Teber, Erdahl T., additional, Tam, Oliver H., additional, Stutz, Michael D., additional, Alexander, Ian E., additional, Pickett, Hilda A., additional, and Tam, Patrick P.L., additional

Published
2014
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28. Dietary intake of cholesterol is positively associated and use of cholesterol-lowering medication is negatively associated with prevalent age-related hearing loss

Author

Gopinath, Bamini, Flood, Victoria M, Teber, Erdahl, McMahon, Catherine M, Mitchell, Paul, Gopinath, Bamini, Flood, Victoria M, Teber, Erdahl, McMahon, Catherine M, and Mitchell, Paul

Abstract

We aimed to assess associations between dietary intake of fats (saturated and monounsaturated fats and cholesterol) and certain food groups (butter, margarine, and nuts) with the prevalence, incidence, and progression of age-related hearing loss. We also aimed to investigate the link between serum lipids and cholesterol-lowering medication (statins) and hearing loss. The Blue Mountains Hearing Study is a population-based survey of age-related hearing loss. Hearing loss was measured in 2956 participants (aged ≥50 y) and was defined as the pure-tone average (PTA) of frequencies 0.5, 1.0, 2.0, and 4.0 kHz > 25 dB hearing level (PTA0.5–4kHz). Dietary data were collected using a semiquantitative FFQ. After multivariable adjustment, the likelihood of prevalent hearing loss increased from the lowest (reference) to the highest quartile of dietary cholesterol intake (P-trend = 0.04). Among persons self-reporting statin use (n = 274), a 48% reduced odds of prevalent hearing loss was observed after multivariable adjustment [OR = 0.52 (95% CI = 0.29–0.93)]. Participants in the second and 3rd quartiles of dietary monounsaturated fat intake compared with those in the first quartile (reference) had a significantly reduced risk of hearing loss progression 5 y later [multivariable-adjusted OR = 0.39 (95% CI = 0.21–0.71)] and [OR = 0.51 (95% CI = 0.29–0.91)], respectively. Our results suggest that a diet high in cholesterol could have adverse influences on hearing, whereas treatment with statins and consumption of monounsaturated fats may have a beneficial influence.

Published
2011

29. Comparison of automated candidate gene prediction systems using genes implicated in type 2 diabetes by genome-wide association studies

Author

Teber, Erdahl T., Liu, Jason Y., Ballouz, Sara, Fatkin, Diane, Wouters, Merridee A., Teber, Erdahl T., Liu, Jason Y., Ballouz, Sara, Fatkin, Diane, and Wouters, Merridee A.

Abstract

Background Automated candidate gene prediction systems allow geneticists to hone in on disease genes more rapidly by identifying the most probable candidate genes linked to the disease phenotypes under investigation. Here we assessed the ability of eight different candidate gene prediction systems to predict disease genes in intervals previously associated with type 2 diabetes by benchmarking their performance against genes implicated by recent genome-wide association studies. Results Using a search space of 9556 genes, all but one of the systems pruned the genome in favour of genes associated with moderate to highly significant SNPs. Of the 11 genes associated with highly significant SNPs identified by the genome-wide association studies, eight were flagged as likely candidates by at least one of the prediction systems. A list of candidates produced by a previous consensus approach did not match any of the genes implicated by 706 moderate to highly significant SNPs flagged by the genome-wide association studies. We prioritized genes associated with medium significance SNPs. Conclusion The study appraises the relative success of several candidate gene prediction systems against independent genetic data. Even when confronted with challengingly large intervals, the candidate gene prediction systems can successfully select likely disease genes. Furthermore, they can be used to filter statistically less-well-supported genetic data to select more likely candidates. We suggest consensus approaches fail because they penalize novel predictions made from independent underlying databases. To realize their full potential further work needs to be done on prioritization and annotation of genes.

Published
2009

44. The use of soluble protein structures in modeling helical proteins in a layered membrane

Author

Lee, Hong Wing, Lee, Hong Ching, Lee, Lawrence K., Teber, Erdahl T., and Bret Church, W.

Abstract

Major advances have been made in the prediction of soluble protein structures, led by the knowledge-based modeling methods that extract useful structural trends from known protein structures and incorporate them into scoring functions. The same cannot be reported for the class of transmembrane proteins, primarily due to the lack of high-resolution structural data for transmembrane proteins, which render many of the knowledge-based method unreliable or invalid. We have developed a method that harnesses the vast structural knowledge available in soluble protein data for use in the modeling of transmembrane proteins. At the core of the method, a set of transmembrane protein decoy sets that allow us to filter and train features recognized from soluble proteins for transmembrane protein modeling into a set of scoring functions. We have demonstrated that structures of soluble proteins can provide significant insight into transmembrane protein structures. A complementary novel two-stage modeling/selection process that mimics the two-stage helical membrane protein folding was developed. Combined with the scoring function, the method was successfully applied to model 5 transmembrane proteins. The root mean square deviations of the predicted models ranged from 5.0 to 8.8 Å to the native structures.

Published
2014
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46. Telomerase promotes formation of a telomere protective complex in cancer cells

Author

Alexander P. Sobinoff, Ashley Harman, Jonathan W. Arthur, Tracy M. Bryan, Omesha N. Perera, Anthony J. Cesare, Karen L. MacKenzie, Michelle F. Maritz, Hilda A. Pickett, Sile F. Yang, Erdahl Teber, Perera, Omesha N, Sobinoff, Alexander P, Teber, Erdahl T, Harman, Ashley, Maritz, Michelle F, Yang, Sile F, Pickett, Hilda A, Cesare, Anthony J, Arthur, Jonathan W, MacKenzie, Karen L, and Bryan, Tracy M

Subjects
Telomerase, Cell cycle checkpoint, DNA damage, Inhibitor of Apoptosis Proteins, 03 medical and health sciences, 0302 clinical medicine, Cell Line, Tumor, Neoplasms, Humans, HSP70 Heat-Shock Proteins, telomeric DNA, Telomerase reverse transcriptase, neoplasms, Research Articles, Cancer, 030304 developmental biology, 0303 health sciences, Multidisciplinary, Cell growth, Chemistry, SciAdv r-articles, Cell Biology, Telomere, Cell biology, enzymes and coenzymes (carbohydrates), cell proliferation, Gene Expression Regulation, Cell culture, 030220 oncology & carcinogenesis, embryonic structures, Cancer cell, cancer cells, biological phenomena, cell phenomena, and immunity, Research Article, DNA Damage
Abstract

The telomerase protein hTERT has a noncanonical role in promoting telomere protection by heat shock protein 70., Telomerase is a ribonucleoprotein complex that catalyzes addition of telomeric DNA repeats to maintain telomeres in replicating cells. Here, we demonstrate that the telomerase protein hTERT performs an additional role at telomeres that is independent of telomerase catalytic activity yet essential for telomere integrity and cell proliferation. Short-term depletion of endogenous hTERT reduced the levels of heat shock protein 70 (Hsp70-1) and the telomere protective protein Apollo at telomeres, and induced telomere deprotection and cell cycle arrest, in the absence of telomere shortening. Short-term expression of hTERT promoted colocalization of Hsp70-1 with telomeres and Apollo and reduced numbers of deprotected telomeres, in a manner independent of telomerase catalytic activity. These data reveal a previously unidentified noncanonical function of hTERT that promotes formation of a telomere protective complex containing Hsp70-1 and Apollo and is essential for sustained proliferation of telomerase-positive cancer cells, likely contributing to the known cancer-promoting effects of both hTERT and Hsp70-1.

Published
2019

47. Active Ageing and Solidarity Between Generations in Europe : First Results From SHARE After the Economic Crisis

Author

Axel Börsch-Supan, Martina Brandt, Howard Litwin, Guglielmo Weber, Axel Börsch-Supan, Martina Brandt, Howard Litwin, and Guglielmo Weber

Subjects
Population aging--Social aspects--Europe, Population aging--Economic aspects--Europe
Abstract

SHARE is an international survey designed to answer the societal challenges that face us due to rapid population ageing. How do Europeans age? Under which circumstances do older people and their families live, how healthy and active are they, and how did the crisis affect them? The authors of this multidisciplinary book have taken a first step toward answering these questions based on the recent SHARE data including a new social networks module.

Published
2013

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