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12 results on '"Sodum, Nalini"'

3. Effect of Aerobic Exercise and Time‐Restricted Feeding on Metabolic Markers and Circadian Rhythm in Mice Fed with the High‐Fat Diet

Author

Raza, Ghulam Shere, primary, Kaya, Yağmur, additional, Stenbäck, Ville, additional, Sharma, Ravikant, additional, Sodum, Nalini, additional, Mutt, Shivaprakash Jagalur, additional, Gagnon, Dominique D., additional, Tulppo, Mikko, additional, Järvelin, Marjo‐Riitta, additional, Herzig, Karl‐Heinz, additional, and Mäkelä, Kari A., additional

Published
2024
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4. Effect of Aerobic Exercise and Time-Restricted Feeding on Metabolic Markers and Circadian Rhythm in Mice Fed with the High-Fat Diet

Author

Raza, Ghulam Shere, Kaya, Yagmur, Stenback, Ville, Sharma, Ravikant, Sodum, Nalini, Jagalur Mutt, Shivaprakash, Gagnon, Dominique D., Tulppo, Mikko, Jarvelin, Marjo-Riitta, Herzig, Karl-Heinz, Makela, Kari A., Raza, Ghulam Shere, Kaya, Yagmur, Stenback, Ville, Sharma, Ravikant, Sodum, Nalini, Jagalur Mutt, Shivaprakash, Gagnon, Dominique D., Tulppo, Mikko, Jarvelin, Marjo-Riitta, Herzig, Karl-Heinz, and Makela, Kari A.

Abstract

Scope: Diet and exercise are significant players in obesity and metabolic diseases. Time-restricted feeding (tRF) has been shown to improve metabolic responses by regulating circadian clocks but whether it acts synergically with exercise remains unknown. It is hypothesized that forced exercise alone or combined with tRF alleviates obesity and its metabolic complications.Methods and resultsMale C57bl6 mice are fed with high-fat or a control diet for 12 weeks either ad libitum or tRF for 10 h during their active period. High-fat diet (HFD)-fed mice are divided into exercise (treadmill for 1 h at 12 m min(-1) alternate days for 9 weeks and 16 m min(-1) daily for the following 3 weeks) and non-exercise groups. tRF and tRF-Ex significantly decreased body weight, food intake, and plasma lipids, and improved glucose tolerance. However, exercise reduced only body weight and plasma lipids. tRF and tRF-Ex significantly downregulated Fasn, Hmgcr, and Srebp1c, while exercise only Hmgcr. HFD feeding disrupted clock genes, but exercise, tRF, and tRF-Ex coordinated the circadian clock genes Bmal1, Per2, and Rev-Erb alpha in the liver, adipose tissue, and skeletal muscles. Conclusion: HFD feeding disrupted clock genes in the peripheral organs while exercise, tRF, and their combination restored clock genes and improved metabolic consequences induced by high-fat diet feeding.

Published
2024
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9. In-vitro pharmacological evaluation of Sulforaphane from Brassica oleracea

Author

Sodum Nalini, Shaik Chand, and TS Mohamed

Subjects
Anti-arthritic activity, lcsh:R, lcsh:Medicine, Sulforaphane, Protein denaturation methods
Abstract

Objectives: Sulforaphane has numerous Pharmacological and therapeutic effects like anti-oxidant, anti-cancer, anti-diabetic, anti-arthritic, anti-ulcer, anti-viral. The present study was designed to evaluate the anti-arthritic activity of Sulforaphane by in-vitro screening methods. Methods: The anti-arthritic activity of Sulforaphane was investigated by protein denaturation assay by using Bovine serum albumin (BSA) and egg albumin. Sulforaphane used in various concentration (10, 50, 100, 250, 500 µg/ml) against both the methods and Diclofenac sodium was used as reference standard. Results: The anti-arthiritic activity sulforaphane was directly proportional to inhibition of denaturation of albumin. Sulforaphane shows concentration dependent inhibition activity in both bovine serum albumin and egg albumin assay. The maximum inhibition was observed in the concentration of 500 µg/ml with 92.8% inhibition for BSA and 96.3% for egg albumin respectively. Conclusion: Sulforaphane have significant anti-arthritic activity accessed by BSA denaturation and egg albumin denaturation assay. Based on present finding future direction also planned to conform the activity by using well established in-vivo methods.

Published
2019
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