9,485 results on '"Scordo, A"'
Search Results
2. Jen Scordo, Pat Egan out at 97.5 The Fanatic amid cutbacks at Beasley
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National Broadcasting Company Inc. NBC Sports ,The Fanatic (Novel) ,Television broadcasting industry ,Business ,General interest ,Business, regional - Abstract
Byline: Rob Tornoe May 8Layoffs have hit 97.5 The Fanatic again, part of nationwide cutbacks from parent-company Beasley Media Group. Among those impacted by cuts imposed by parent-company Beasley Media [...]
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- 2024
3. Jen Scordo out at 97.5 The Fanatic amid cutbacks at Beasley
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National Broadcasting Company Inc. NBC Sports -- Officials and employees ,The Fanatic (Novel) ,Television broadcasting industry -- Officials and employees ,Business ,General interest ,Business, regional - Abstract
Byline: Rob Tornoe May 8Layoffs have hit 97.5 The Fanatic again, part of nationwide cutbacks from parent-company Beasley Media Group. Among those impacted by cuts imposed by parent-company Beasley Media [...]
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- 2024
4. Federal Court of Australia Judgment: Scordo v Commonwealth Bank of Australia [2024] FCA 359
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Commonwealth Bank of Australia ,Forensic oratory ,Banks (Finance) ,Banking industry ,Judgments ,Banking industry ,News, opinion and commentary - Abstract
Canberra: Federal Court of Australia has issued the following judgment on (12 April 2024): FEDERAL COURT OF AUSTRALIA Scordo v Commonwealth Bank of Australia [2024] FCA 359 File number(s): VID [...]
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- 2024
5. Intermediate Mass Kaonic Atoms at DA$\Phi$NE
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Artibani, Francesco, Clozza, Francesco, Bazzi, Massimiliano, Capoccia, Cesidio, Clozza, Alberto, De Paolis, Luca, Dulski, Kamil, Guaraldo, Carlo, Iliescu, Mihai, Khreptak, Aleksander, Manti, Simone, Napolitano, Fabrizio, Doce, Oton Vazquez, Scordo, Alessandro, Sgaramella, Francesco, Sirghi, Florin, Spallone, Antonio, Cargnelli, Michael, Marton, Johann, Tuchler, Marlene, Zmeskal, Johannes, Bosnar, Damir, Friscic, Ivica, Bragadireanu, Mario, Borghi, Giacomo, Carminati, Marco, Deda, Griseld, Fiorini, Carlo, Del Grande, Raffaele, Iwasaki, Masahiko, Moskal, Pawel, Niedzwiecki, Szymon, Silarski, Michal, Skurzok, Magdalena, Ohnishi, Hiroaki, Toho, Kairo, Sirghi, Diana, Pischicchia, Kristian, and Curceanu, Catalina
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Nuclear Experiment - Abstract
The SIDDHARTA-2 collaboration aims to measure for the first time the shift and width induced on the $1s$ level of kaonic deuterium by the strong interaction. In the preliminary phase to the experiment, a test run using a Helium-4 target was performed to optimize the performance of the full experimental apparatus. This preliminary study highlighted the possibility to measure transition lines coming from intermediate mass kaonic atoms, such as kaonic carbon and kaonic aluminum. In order to measure transitions where strong interaction is manifesting at higher energies, out of the energy range of the SIDDHARTA-2 apparatus, the collaboration is testing a new detector system which exploits a novel compound semiconductor, the Cadmium Zinc Telluride. Tests are now running at DA$\Phi$NE to study the performance of this detector, exploring the possibility to build a dedicated setup., Comment: 10 pages, 3 figures, eQCD conference
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- 2024
6. First Linearity and Stability Characterization for CZT Detection System in a e$^+$e$^-$ Collider Environment
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Abbene, Leonardo, Artibani, Francesco, Bettelli, Manuele, Buttacavoli, Antonino, Principato, Fabio, Zappettini, Andrea, Bazzi, Massimiliano, Borghi, Giacomo, Bragadireanu, Mario, Cargnelli, Michael, Carminati, Marco, Clozza, Alberto, Clozza, Francesco, De Paolis, Luca, Del Grande, Raffaele, Dulski, Kamil, Fabbietti, Laura, Fiorini, Carlo, Guaraldo, Carlo, Iliescu, Mihail, Iwasaki, Masahiko, Khreptak, Aleksander, Manti, Simone, Marton, Johann, Moskal, Pawel, Napolitano, Fabrizio, Niedźwiecki, Szymon, Ohnishi, Hiroaki, Piscicchia, Kristian, Sada, Yuta, Sgaramella, Francesco, Sirghi, Diana Laura, Sirghi, Florin, Skurzok, Magdalena, Silarski, Michal, Spallone, Antonio, Toho, Kairo, Toscano, Lorenzo, Tüchler, Marlene, Doce, Oton Vasquez, Zmeskal, Johann, Curceanu, Catalina, and Scordo, Alessandro
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Physics - Instrumentation and Detectors - Abstract
The SIDDHARTA-2 collaboration built a new cadmium-zinc-telluride (CZT, CdZnTe)-based X-ray detection system, used for the first time in the DA$\Phi$NE electron-positron collider at INFN-LNF. The aim of this work is to show that these detectors present optimal long- and short-term linearity and stability to perform precise spectroscopic measurements in a collider environment. The spectra used as references for calibration are reported, and the results about the linearity and stability studies are presented. It is also discussed and showed what is the proper function to describe all the effects that alter the Gaussian shape in semiconductors, particularly evident in the CZT case. Good residuals and resolutions were obtained for all the calibrations. In a test run with the source and the collider beam on, it was demonstrated that the calibrations made with beam off are optimal also when the beam is on, and the actual systematics in a physics run were estimated. These promising results show the potentialities of this detector in the high rate environment of a particle collider, and pave the way for the use of CZT detectors in kaonic atoms researches and in accelerators, with applications for particle and nuclear physics., Comment: 15 pages, 9 figures, 3 tables
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- 2024
7. Ellis Island Oral History Project, Series EI, no. 0133: Interview of Rosario Scordo by Paul E. Sigrist, Jr., April 8, 1992.
8. Mini-Proceedings of the 'Fourth International Workshop on the Extension Project for the J-PARC Hadron Experimental Facility (HEF-ex 2024)'
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Achenbach, P., Aoki, K., Aoki, S., Curceanu, C., Diehl, S., Doi, T., Endo, M., Fujita, M., Fukuda, T., Garcia-Tecocoatzi, H., Geng, L. S., Gunji, T., Hanhart, C., Harada, M., Harada, T., Hayakawa, S., He, B. R., Hiyama, E., Honda, R., Ichikawa, Y., Isaka, M., Jido, D., Jinno, A., Kamada, K., Kamiya, Y., Kong, Y. K., Liu, Z. W., Lu, J. X., Miwa, K., Mizutani, K., Murakami, K., Muto, R., Murase, K., Nagao, S., Nanamura, T., Nanjo, H., Nara, Y., Ohnishi, A., Qiu, J. W., Sakaguchi, A., Sakuma, F., Santopinto, E., Scordo, A., Sekihara, T., Seong, C., Shevchenko, N. V., Stone, J. R., Strakovsky, I., Suzuki, K., Takahashi, H., Takizawa, M., Tamura, H., Tomida, N., Umeya, A., Doce, O. Vázquez, Yamagata-Sekihara, J., Yamamoto, T. O., Xiao, Y., Yin, Z., Yu, Z., and Zou, B. S.
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Nuclear Experiment ,High Energy Physics - Experiment ,High Energy Physics - Phenomenology ,Nuclear Theory - Abstract
The mini proceedings of the "Fourth International Workshop on the Extension Project for the J-PARC Hadron Experimental Facility (HEF-ex 2024) [https://kds.kek.jp/event/46965]" held at J-PARC, February 19-21, 2024, are presented. The workshop was devoted to discussing the physics case that connects both the present and the future Hadron Experimental Facility at J-PARC, covering a wide range of topics in flavor, hadron, and nuclear physics related to both experimental and theoretical activities being conducted at the facility.
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- 2024
9. Kaonic lead feasibility measurement at DA{\Phi}NE to solve the charged kaon mass discrepancy
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Bosnar, D., Abbene, L., Amsler, C., Artibani, F., Bazzi, M., Bragadireanu, M., Buttacavoli, A., Cargnelli, M., Carminati, M., Clozza, A., Clozza, F., Deda, G., De Paolis, L., Del Grande, R., Dulski, K., Fabbietti, L., Fiorini, C., Friščić, I., Guaraldo, C., Iliescu, M., Iwasaki, M., Khreptak, A., Makek, M., Manti, S., Marton, J., Moskal, P., Napolitano, F., Niedźwiecki, S., Ohnishi, H., Piscicchia, K., Scordo, A., Sgaramella, F., Sirghi, D., Sirghi, F., Skurzok, M., Silarski, M., Spallone, A., Toho, K., Tüchler, M., Doce, O. Vasquez, Zmeskal, J., and Curceanu, C.
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Physics - Instrumentation and Detectors ,Nuclear Experiment - Abstract
An HPGe detector equipped with a transistor reset preamplifier and readout with a CAEN DT5781 fast pulse digitizer was employed in the measurement of X-rays from kaonic lead at the DA$\Phi$NE $e^+e^-$ collider at the Laboratori Nazionali di Frascati of INFN. A thin scintillator in front of a lead target was used to select kaons impinging on it and to form the trigger for the HPGe detector. We present the results of the kaonic lead feasibility measurement, where we show that the resolution of the HPGe detector in regular beam conditions remains the same as that without the beam and that a satisfactory background reduction can be achieved. This measurement serves as a test bed for future dedicated kaonic X-rays measurements for the more precise determination of the charged kaon mass., Comment: 14 pages, 7 figures
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- 2024
10. Measurement of the mesonic decay branch of the $\bar{K}\!N\!N$ quasi-bound state
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Yamaga, T., Ajimura, S., Asano, H., Beer, G., Bhang, H., Bragadireanu, M., Buehler, P., Busso, L., Cargnelli, M., Choi, S., Curceanu, C., Enomoto, S., Fujioka, H., Fujiwara, Y., Fukuda, T., Guaraldo, C., Hashimoto, T., Hayano, R. S., Hiraiwa, T., Iio, M., Iliescu, M., Inoue, K., Ishiguro, Y., Ishikawa, T., Ishimoto, S., Itahashi, K., Iwai, M., Iwasaki, M., Kanno, K., Kato, K., Kato, Y., Kawasaki, S., Kienle, P., Kou, H., Ma, Y., Marton, J., Matsuda, Y., Mizoi, Y., Morra, O., Murayama, R., Nagae, T., Noumi, H., Ohnishi, H., Okada, S., Outa, H., Piscicchia, K., Sada, Y., Sakaguchi, A., Sakuma, F., Sato, M., Scordo, A., Sekimoto, M., Shi, H., Shirotori, K., Sirghi, D., Sirghi, F., Suzuki, S., Suzuki, T., Tanida, K., Tatsuno, H., Tokuda, M., Tomono, D., Toyoda, A., Tsukada, K., Doce, O. Vazquez, Widmann, E., Yamazaki, T., Yim, H., Zhang, Q., and Zmeskal, J.
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Nuclear Experiment ,Nuclear Theory - Abstract
We conducted measurements of $K^- + {^3{\rm He}} \to \pi \!Y \!N + N'$ reactions using a $1~{\rm GeV}/c$ $K^-$-beam, with the objective of understanding the broad decay width of $\bar{K} \!N \!N$ (approximately twice as broad as that of $\Lambda(1405)$ considered to be the $\bar{K} \!N$ quasi-bound state). We successfully reproduced distributions of the $\pi \! Y \! N$ invariant mass and momentum transfer for $\pi \! Y \! N$ using model fitting functions for $\bar{K} \!N \!N$ formation and quasi-free $\bar{K}$ absorption (${\rm QF}_{\bar{K}-{\rm abs}}$) processes. The model can describe the experimental data quite well, and four $\bar{K} \! N \! N \to \pi \! Y \! N $ cross-sections were obtained. The results indicate that mesonic decay is the dominant decay branch of $\bar{K} \! N \! N$. The results also suggest that $\Gamma_{\pi \Lambda N} \sim \Gamma_{\pi \Sigma N}$, which indicates that the $I_{\bar{K} \! N}=1$ absorption channel, in addition to the $I_{\bar{K} \! N}=0$ absorption channel, substantially contribute to the $\bar{K} \! N \! N$ decay, making the $\bar{K} \! N \! N$ state approximately twice as unstable as $\Lambda$(1405).
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- 2024
11. Biophotons: A Hard Problem
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De Paolis, L., Francini, R., Davoli, I., De Matteis, F., Scordo, A., Clozza, A., Grandi, M., Pace, E., Curceanu, C., Grigolini, P., and Benfatto, M.
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Physics - Biological Physics - Abstract
About a hundred years ago the Russian biologist A. Gurwitsch, based on his experiments with onion plants by measuring their growth rate, made the hypothesis that plants emitted a weak electromagnetic field which somehow influenced cell growth. This interesting observation remained fundamentally ignored by the scientific community and only in the 1950s the electromagnetic emission from some plants was measured using a photomultiplier used in single counting mode. Later, in the 80s several groups in the world started some extensive work to understand the origin and role of this ultra-weak emission, hereby called biophotons, coming from living organisms. Biophotons are an endogenous very small production of photons in the visible energy range in and from cells and organism, and this emission is characteristic of alive organisms. Today there is no doubt that biophotons really exist, this emission has in fact been measured by many groups and on many different living organisms, from humans to bacteria. On the contrary, the origin of biophotons and whether organisms use them in some way to exchange information is not yet well known; no model proposed since now is really capable of reproducing and interpreting the great variety of experimental data coming from the many different living systems measured so far. In this brief review we present our experimental work on biophotons coming from germinating seeds, the main experimental results and some methods we are using to analyze the data in order to open the door for interpretative models of this phenomenon and clarifying its function in the regulation and communication between cells and living organisms. We also discuss some ideas on how to increase the signal-to-noise ratio of the measured signal to have new experimental possibilities that allow the measurement and the characterization of currently unmeasurable quantities., Comment: 19 pages, 7 figures
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- 2024
12. ordinanza 2 aprile 1997; Pres. Scordo, Rel. Magliulo; W. Abate (Avv. Penta) c. T. Abate (Avv. Miranda, Coccio) e M. Abate
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- 1997
13. Washed Away: Incorporating Bank Erosion into Highway Risk Assessments
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Davidson, S. L., Marin-Esteve, B., Weatherly, H., Scordo, E., Holm, K., di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Cui, Zhen-Dong, Series Editor, Lu, Xinzheng, Series Editor, Rujikiatkamjorn, Cholachat, editor, Xue, Jianfeng, editor, and Indraratna, Buddhima, editor
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- 2025
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14. First measurement of kaonic helium-4 M-series transitions
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Sgaramella, F, Sirghi, D, Abbene, L, Artibani, F, Bazzi, M, Bosnar, D, Bragadireanu, M, Buttacavoli, A, Cargnelli, M, Carminati, M, Clozza, A, Clozza, F, Deda, G, Del Grande, R, De Paolis, L, Dulski, K, Fabbietti, L, Fiorini, C, Friscic, I, Guaraldo, C, Iliescu, M, Iwasaki, M, Khreptak, A, Manti, S, Marton, J, Miliucci, M, Moskal, P, Napolitano, F, Niedzwiecki, S, Ohnishi, H, Piscicchia, K, Principato, F, Scordo, A, Silarski, M, Sirghi, F, Skurzok, M, Spallone, A, Toho, K, Tuchler, M, Doce, O Vazquez, Yoshida, C, Zmeskal, J, and Curceanu, C
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Nuclear Experiment - Abstract
In this paper we present the results of a new kaonic helium-4 measurement with a 1.37 g/l gaseous target by the SIDDHARTA-2 experiment at the DA{\Phi}NE collider. We measured, for the first time, the energies and yields of three transitions belonging to the Mseries. Moreover, we improved by a factor about three, the statistical precision of the 2p level energy shift and width induced by the strong interaction, obtaining the most precise measurement for gaseous kaonic helium, and measured the yield of the L{\alpha} transition at the employed density, providing a new experimental input to investigate the density dependence of kaonic atoms transitions yield., Comment: 12 pages, 5 figures, 3 tables
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- 2023
15. CdZnTe detectors tested at the DA{\Phi}NE collider for future kaonic atoms measurements
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Scordo, A., Abbene, L., Artibani, F., Bazzi, M., Bettelli, M., Bosnar, D., Borghi, G., Bragadireanu, M., Buttacavoli, A., Cargnelli, M., Carminati, M., Clozza, A., Clozza, F., De Paolis, L., Deda, G., Del Grande, R., Fabbietti, L., Fiorini, C., Friščić, I., Guaraldo, C., Iliescu, M., Iwasaki, M., Khreptak, A., Manti, S., Marton, J., Moskal, P., Napolitano, F., Niedźwiecki, S., Ohnishi, H., Piscicchia, K., Principato, F., Sada, Y., Sgaramella, F., Shi, H., Silarski, M., Sirghi, D. L., Sirghi, F., Skurzok, M., Spallone, A., Toho, K., Tüchler, M., Yoshida, C., Zappettini, A., Zmeskal, J., and Curceanu, C.
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Physics - Instrumentation and Detectors ,Nuclear Experiment - Abstract
The SIDDHARTA-2 collaboration at the INFN Laboratories of Frascati (LNF) aims to perform groundbreaking measurements on kaonic atoms. In parallel and beyond the ongoing kaonic deuterium, presently running on the DA$\Phi$NE collider at LNF, we plan to install additional detectors to perform further kaonic atoms' studies, taking advantage of the unique low energy and low momentum spread $K^-$ beam delivered by the at-rest decay of the $\phi$ meson. CdZnTe devices are ideal for detecting transitions toward both the upper and lower levels of intermediate-mass kaonic atoms, like kaonic carbon and aluminium, which have an important impact on the strangeness sector of nuclear physics. We present the results obtained in a set of preliminary tests conducted on DA$\Phi$NE, in view of measurements foreseen in 2024, with the twofold aim to tune the timing window required to reject the extremely high electromagnetic background, and to quantify the readout electronics saturation effect due to the high rate, when placed close to the Interaction Region (IR). In the first test we used commercial devices and electronics, while for the second one both were customized at the IMEM-CNR of Parma and the University of Palermo. The results confirmed the possibility of finding and matching a proper timing window where to identify the signal events and proved better performances, in terms of energy resolution, of the custom system. In both cases, strong saturation effects were confirmed, accounting for a loss of almost 90\% of the events, which will be overcome by a dedicated shielding structure foreseen for the final experimental setup.
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- 2023
16. Detecting Iron Oxidation States in Liquids with the VOXES Bragg Spectrometer
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Manti, Simone, Miliucci, Marco, Scordo, Alessandro, Bedogni, Roberto, Clozza, Alberto, Iliescu, Mihail, Moskal, Gabriel, Piscicchia, Kristian, Porcelli, Alessio, Sirghi, Diana, Sirghi, Florin, and Curceanu, Catalina
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Physics - Applied Physics - Abstract
Determining the oxidation states of metals assumes great importance in various applications because a variation in the oxidation number can drastically influence the material properties. As an example, this becomes evident in edible liquids like wine and oil, where a change in the oxidation states of the contained metals can significantly modify both the overall quality and taste. To this end, here we present the MITIQO project, which aims to identify oxidation states of metals in edible liquids utilizing X-ray emission with Bragg spectroscopy. This is achieved using the VOXES crystal spectrometer, developed at INFN National Laboratories of Frascati (LNF), employing mosaic crystal (HAPG) in the Von Hamos configuration. This combination allow us to work with effective source sizes of up to a few millimeters and improves the typical low efficiency of Bragg spectroscopy, a crucial aspect when studying liquids with low metal concentration. Here we showcase the concept behind MITIQO, for a liquid solution containing oxidized iron. We performed several high-resolution emission spectra measurements, for the liquid and for different powdered samples containing oxidized and pure iron. By looking at the spectral features of the iron's K$\beta$ emission lineshape, we were able to obtain, for a liquid, a result consistent with the oxidized iron powders and successfully quantifying the effect of oxidation.
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- 2023
17. Colesevelam for lenalidomide associated diarrhea in patients with multiple myeloma
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Malin Hultcrantz, Hani Hassoun, Neha Korde, Kylee MacLachlan, Sham Mailankody, Dhwani Patel, Urvi A. Shah, Carlyn Rose Tan, David J. Chung, Oscar B. Lahoud, Heather J. Landau, Michael Scordo, Gunjan L. Shah, Sergio A. Giralt, Matthew J. Pianko, Miranda Burge, Kelly Barnett, Meghan Salcedo, Julia Caple, Linh Tran, Jenna Blaslov, Tala Shekarkhand, Selena Hamid, David Nemirovsky, Andriy Derkach, Oluwatobi Arisa, Cody J. Peer, William D. Figg, Saad Z. Usmani, Ola Landgren, and Alexander M. Lesokhin
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Published
- 2024
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18. Successful use of narsoplimab to treat allogeneic transplant-associated thrombotic microangiopathy while maintaining sirolimus
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Alhomoud, Mohammad, Scordo, Michael, and Perales, Miguel-Angel
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- 2024
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19. Colesevelam for lenalidomide associated diarrhea in patients with multiple myeloma
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Hultcrantz, Malin, Hassoun, Hani, Korde, Neha, MacLachlan, Kylee, Mailankody, Sham, Patel, Dhwani, Shah, Urvi A., Tan, Carlyn Rose, Chung, David J., Lahoud, Oscar B., Landau, Heather J., Scordo, Michael, Shah, Gunjan L., Giralt, Sergio A., Pianko, Matthew J., Burge, Miranda, Barnett, Kelly, Salcedo, Meghan, Caple, Julia, Tran, Linh, Blaslov, Jenna, Shekarkhand, Tala, Hamid, Selena, Nemirovsky, David, Derkach, Andriy, Arisa, Oluwatobi, Peer, Cody J., Figg, William D., Usmani, Saad Z., Landgren, Ola, and Lesokhin, Alexander M.
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- 2024
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20. Comparison of infectious complications with BCMA-directed therapies in multiple myeloma
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Nath, Karthik, Shekarkhand, Tala, Nemirovsky, David, Derkach, Andriy, Costa, Bruno Almeida, Nishimura, Noriko, Farzana, Tasmin, Rueda, Colin, Chung, David J., Landau, Heather J., Lahoud, Oscar B., Scordo, Michael, Shah, Gunjan L., Hassoun, Hani, Maclachlan, Kylee, Korde, Neha, Shah, Urvi A., Tan, Carlyn Rose, Hultcrantz, Malin, Giralt, Sergio A., Usmani, Saad Z., Shahid, Zainab, Mailankody, Sham, and Lesokhin, Alexander M.
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- 2024
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21. Prognostic impact of corticosteroid and tocilizumab use following chimeric antigen receptor T-cell therapy for multiple myeloma
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Costa, Bruno Almeida, Flynn, Jessica, Nishimura, Noriko, Devlin, Sean M., Farzana, Tasmin, Rajeeve, Sridevi, Chung, David J., Landau, Heather J., Lahoud, Oscar B., Scordo, Michael, Shah, Gunjan L., Hassoun, Hani, Maclachlan, Kylee, Hultcrantz, Malin, Korde, Neha, Lesokhin, Alexander M., Shah, Urvi A., Tan, Carlyn R., Giralt, Sergio A., Usmani, Saad Z., Nath, Karthik, and Mailankody, Sham
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- 2024
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22. Wildfire smoke reduces lake ecosystem metabolic rates unequally across a trophic gradient
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Smits, Adrianne P., Scordo, Facundo, Tang, Minmeng, Cortés, Alicia, Farruggia, Mary Jade, Culpepper, Joshua, Chandra, Sudeep, Jin, Yufang, Valbuena, Sergio A., Watanabe, Shohei, Schladow, Geoffrey, and Sadro, Steven
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- 2024
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23. Conventional and novel [18F]FDG PET/CT features as predictors of CAR-T cell therapy outcome in large B-cell lymphoma
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Leithner, Doris, Flynn, Jessica R., Devlin, Sean M., Mauguen, Audrey, Fei, Teng, Zeng, Shang, Zheng, Junting, Imber, Brandon S., Hubbeling, Harper, Mayerhoefer, Marius E., Bedmutha, Akshay, Luttwak, Efrat, Corona, Magdalena, Dahi, Parastoo B., Luna de Abia, Alejandro, Landego, Ivan, Lin, Richard J., Palomba, M. Lia, Scordo, Michael, Park, Jae H., Tomas, Ana Alarcon, Salles, Gilles, Lafontaine, Daniel, Michaud, Laure, Shah, Gunjan L., Perales, Miguel-Angel, Shouval, Roni, and Schöder, Heiko
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- 2024
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24. Habitat-specific metabolism and nutrient limitation within an oligotrophic Patagonian lake
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Scordo, Facundo, Seitz, Carina, Abasto, Benjamín, Spetter, Carla V., Piccolo, M. Cintia, Chandra, Sudeep, and Perillo, Gerardo M. E.
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- 2024
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25. Novel Machine Learning and Differentiable Programming Techniques applied to the VIP-2 Underground Experiment
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Napolitano, F, Bazzi, M, Bragadireanu, M, Cargnelli, M, Clozza, A, De Paolis, L, Del Grande, R, Fiorini, C, Guaraldo, C, Iliescu, M, Laubenstein, M, Manti, S, Marton, J, Miliucci, M, Piscicchia, K, Porcelli, A, Scordo, A, Sgaramella, F, Sirghi, D, Sirghi, F, Doce, O, Zmeskal, J, and Curceanu, C
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Physics - Instrumentation and Detectors ,Nuclear Experiment - Abstract
In this work, we present novel Machine Learning and Differentiable Programming enhanced calibration techniques used to improve the energy resolution of the Silicon Drift Detectors (SDDs) of the VIP-2 underground experiment at the Gran Sasso National Laboratory (LNGS). We achieve for the first time a Full Width at Half Maximum (FWHM) in VIP-2 below 180 eV at 8 keV, improving around 10 eV on the previous state-of-the-art. SDDs energy resolution is a key parameter in the VIP-2 experiment, which is dedicated to searches for physics beyond the standard quantum theory, targeting Pauli Exclusion Principle (PEP) violating atomic transitions. Additionally, we show that this method can correct for potential miscalibrations, requiring less fine-tuning with respect to standard methods., Comment: Submitted to Measurement Science and Technology
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- 2023
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26. Biophotons -- new experimental data and analysis
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Benfatto, M., Pace, E., Davoli, I., Lucci, Massimiliano, Francini, R., De Matteis, Fabio, Scordo, Alessandro, Clozza, Alberto, Grandi, Maurizio, Curceanu, C., and Grigolini, P.
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Physics - Biological Physics ,Quantitative Biology - Quantitative Methods - Abstract
Biophotons are an ultra-weak emission of photons in the visible energy range from living matter. In this work, we study the emission from germinating seeds using an experimental technique designed to detect light of extremely small intensity. The emission from lentil seeds and single bean was analyzed during the whole germination process in terms of both the different spectral components through low pass filters and the different count distributions in the various stages of the germination process. Although the shape of the emission spectrum appears to be very similar in the two samples used in our experiment, our analysis is able to highlight the differences present in the two cases. In this way, it was possible to correlate the various types of emissions to the degree of development of the seed during germination., Comment: 18 pages including references, 8 figures, this work has been presented to the DCP22 held in 2022 in Pisa
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- 2023
27. Measurements of high-n transitions in intermediate mass kaonic atoms by SIDDHARTA-2 at DA$\mathrm{\Phi}$NE
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Sgaramella, F., Tüchler, M., Amsler, C., Bazzi, M., Bosnar, D., Bragadireanu, M., Cargnelli, M., Carminati, M., Clozza, A., Deda, G., Del Grande, R., De Paolis, L., Fabbietti, L., Fiorini, C., Friščić, I., Guaraldo, C., Iliescu, M., Iwasaki, M., Khreptak, A., Manti, S., Marton, J., Miliucci, M., Moskal, P., Napolitano, F., Niedźwiecki, S., Ohnishi, H., Piscicchia, K., Sada, Y., Scordo, A., Shi, H., Silarski, M., Sirghi, D., Sirghi, F., Skurzok, M., Spallone, A., Toho, K., Doce, O. Vazquez, Widmann, E., Yoshida, C., Zmeskal, J., and Curceanu, C.
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Nuclear Experiment ,Physics - Instrumentation and Detectors - Abstract
The SIDDHARTA-2 experiment installed at the DA$\mathrm{\Phi}$NE collider of INFN-LNF performed, for the first time, measurements of high-n transitions in intermediate mass kaonic atoms during the data taking campaigns of 2021 and 2022. Kaonic carbon, oxygen, nitrogen and aluminium transitions, which occur in the setup materials, were measured by using the kaons stopped in the gaseous helium target cell with aluminium frames and Kapton walls, and are reported in this paper. These new kaonic atoms measurements add valuable input to the kaonic atoms transitions data base, which is used as a reference for theories and models of the low-energy strong interaction between antikaon and nuclei. Moreover, these results pave the way for future dedicated kaonic atoms measurements through the whole periodic table and to a new era for the antikaon-nuclei studies at low energy., Comment: 8 pages, 7 figures
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- 2023
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28. Hadron production and propagation in pion-induced reactions on nuclei
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Yassine, R. Abou, Adamczewski-Musch, J., Arnold, O., Atomssa, E. T., Becker, M., Behnke, C., Berger-chen, J. C., Blanco, A., Blume, C., Böhmer, M., Chlad, L., Chudoba, P., Ciepał, I., Deb, S., Deveaux, C., Dittert, D., Dreyer, J., Epple, E., Fabbietti, L., Fonte, P., Franco, C., Friese, J., Fröhlich, I., Förtsch, J., Galatyuk, T., Garzón, J. A., Gernhäuser, R., Greifenhagen, R., Grunwald, M., Gumberidze, M., Harabasz, S., Heinz, T., Hennino, T., Höhne, C., Hojeij, F., Holzmann, R., Idzik, M., Kämpfer, B., Kampert, K.-H., Kardan, B., Kedych, V., Koenig, I., Koenig, W., Kohls, M., Kolas, J., Kolb, B. W., Korcyl, G., Kornakov, G., Kotte, R., Krueger, W., Kugler, A., Kunz, T., Lalik, R., Lapidus, K., Linev, S., Linz, F., Lopes, L., Lorenz, M., Mahmoud, T., Maier, L., Malige, A., Markert, J., Maurus, S., Metag, V., Michel, J., Mihaylov, D. M., Mikhaylov, V., Molenda, A., Müntz, C., Münzer, R., Nabroth, M., Naumann, L., Nowakowski, K., Orliński, J., Otto, J. -H., Parpottas, Y., Parschau, M., Pauly, C., Pechenov, V., Pechenova, O., Piasecki, K., Pietraszko, J., Povar, T., Prościński, K., Prozorov, A., Przygoda, W., Pysz, K., Ramstein, B., Rathod, N., Rodriguez-Ramos, P., Rost, A., Rustamov, A., Salabura, P., Scheib, T., Schild, N., Schmidt-Sommerfeld, K., Schuldes, H., Schwab, E., Scozzi, F., Seck, F., Sellheim, P., Siebenson, J., Silva, L., Singh, U., Smyrski, J., Spataro, S., Spies, S., Stefaniak, M., Ströbele, H., Stroth, J., Sturm, C., Sumara, K., Svoboda, O., Szala, M., Tlusty, P., Traxler, M., Tsertos, H., Udrea, I. C., Vazquez-Doce, O., Wagner, V., Weber, A. A., Wendisch, C., Wiebusch, M. G., Wirth, J., Władyszewska, A., Zbroszczyk, H. P., Zherebtsova, E., Zielinski, M., Zumbruch, P., Curceanu, C., Piscicchia, K., and Scordo, A.
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- 2024
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29. An inexpensive method for the measurement of photosynthetically active radiation profiles in waterbodies
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Scordo, Facundo, Seitz, Carina, Suenaga, Erin K., Piccolo, M. Cintia, Chandra, Sudeep, Amodeo, Martín, and Perillo, Gerardo M. E.
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- 2024
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30. Precise lifetime measurement of $^4_\Lambda$H hypernucleus using in-flight $^4$He$(K^-, \pi^0)^4_\Lambda$H reaction
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Akaishi, T., Asano, H., Chen, X., Clozza, A., Curceanu, C., Del Grande, R., Guaraldo, C., Han, C., Hashimoto, T., Iliescu, M., Inoue, K., Ishimoto, S., Itahashi, K., Iwasaki, M., Ma, Y., Miliucci, M., Murayama, R., Noumi, H., Ohnishi, H., Okada, S., Outa, H., Piscicchia, K., Sakaguchi, A., Sakuma, F., Sato, M., Scordo, A., Shirotori, K., Sirghi, D., Sirghi, F., Suzuki, S., Tanida, K., Toda, T., Tokuda, M., Yamaga, T., Yuan, X., Zhang, P., Zhang, Y., and Zhang, H.
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Nuclear Experiment - Abstract
We present a new measurement of the $^4_\Lambda$H hypernuclear lifetime using in-flight $K^-$ + $^4$He $\rightarrow$ $^4_\Lambda$H + $\pi^0$ reaction at the J-PARC hadron facility. We demonstrate, for the first time, the effective selection of the hypernuclear bound state using only the $\gamma$-ray energy decayed from $\pi^0$. This opens the possibility for a systematic study of isospin partner hypernuclei through comparison with data from ($K^-$, $\pi^-$) reaction. As the first application of this method, our result for the $^4_\Lambda$H lifetime, $\tau(^4_\Lambda \mathrm{H}) = 206 \pm 8 (\mathrm{stat.}) \pm 12 (\mathrm{syst.})\ \mathrm{ps}$, is one of the most precise measurements to date. We are also preparing to measure the lifetime of the hypertriton ($^3_\Lambda$H) using the same setup in the near future.
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- 2023
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31. New opportunities for kaonic atoms measurements from CdZnTe detectors
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Abbene, L., Bettelli, M., Buttacavoli, A., Principato, F., Zappettini, A., Amsler, C., Bazzi, M., Bosnar, D., Bragadireanu, M., Cargnelli, M., Carminati, M., Clozza, A., Deda, G., De Paolis, L., Del Grande, R., Fabbietti, L., Fiorini, C., Friščić, I., Guaraldo, C., Iliescu, M., Iwasaki, M., Khreptak, A., Manti, S., Marton, J., Miliucci, M., Moskal, P., Napolitano, F., Niedźwiecki, S., Ohnishi, H., Piscicchia, K., Sada, Y., Sgaramella, F., Shi, H., Silarski, M., Sirghi, D. L., Sirghi, F., Skurzok, M., Spallone, A., Toho, K., Tüchler, M., Doce, O. Vazquez, Yoshida, C., Zmeskal, J., Scordo, A., and Curceanu, C.
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Physics - Instrumentation and Detectors - Abstract
We present the tests performed by the SIDDHARTA-2 collaboration at the DA{\Phi}NE collider with a quasi-hemispherical CdZnTe detector. The very good room-temperature energy resolution and efficiency in a wide energy range show that this detector technology is ideal for studying radiative transitions in intermediate and heavy-mass kaonic atoms. The CdZnTe detector was installed for the first time in an accelerator environment to perform tests on the background rejection capabilities, which were achieved by exploiting the SIDDHARTA-2 Luminosity Monitor. A spectrum with an $^{241}Am$ source has been acquired, with beams circulating in the main rings, and peak resolutions of 6% at 60 keV and of 2.2% at 511 keV have been achieved. The background suppression factor, which turned out to be of the order of $\simeq10^{5-6}$, opens the possibility to plan for future kaonic atom measurements with CdZnTe detectors.
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- 2023
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32. Hadron Production and Propagation in Pion-Induced Reactions on Nuclei
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Yassine, R. Abou, Adamczewski-Musch, J., Arnold, O., Atomssa, E. T., Becker, M., Behnke, C., Berger-Chen, J. C., Blanco, A., Blume, C., Böhmer, M., Chlad, L., Chudoba, P., Ciepał, I., Deveaux, C., Dittert, D., Dreyer, J., Epple, E., Fabbietti, L., Fonte, P., Franco, C., Friese, J., Fröhlich, I., Förtsc, J., Galatyuk, T., Garzón, J. A., Gernhäuser, R., Greifenhagen, R., Grunwald, M., Gumberidze, M., Harabasz, S., Heinz, T., Hennino, T., Höhne, C., Hojeij, F., Holzmann, R., Idzik, M., Kämpfer, B., Kampert, K-H., Kardan, B., Kedych, V., Koenig, I., Koenig, W., Kohls, M., Kolas, J., Kolb, B. W., Korcyl, G., Kornakov, G., Kotte, R., Krueger, W., Kugler, A., Kunz, T., Lalik, R., Lapidus, K., Linev, S., Linz, F., Lopes, L., Lorenz, M., Mahmoud, T., Maier, L., Malige, A., Markert, J., Maurus, S., Metag, V., Michel, J., Mihaylov, D. M., Mikhaylov, V., Molenda, A., Müntz, C., Münzer, R., Nabroth, M., Naumann, L., Nowakowski, K., Orliński, J., Otto, J. -H., Parpottas, Y., Parschau, M., Pauly, C., Pechenov, V., Pechenova, O., Piasecki, K., Pietraszko, J., Povar, T., Prozorov, A., Przygoda, W., Pysz, K., Ramstein, B., Rathod, N., Rodriguez-Ramos, P., Rost, A., Rustamov, A., Salabura, P., Scheib, T., Schild, N., Schmidt-Sommerfeld, K., Schuldes, H., Schwab, E., Scozzi, F., Seck, F., Sellheim, P., Siebenson, J., Silva, L., Singh, U., Smyrski, J., Spataro, S., Spies, S., Stefaniak, M., Ströbele, H., Stroth, J., Strzempek, P., Sturm, C., Sumara, K., Svoboda, O., Szala, M., Tlusty, P., Traxler, M., Tsertos, H., Vazquez-Doce, O., Wagner, V., Weber, A. A., Wendisch, C., Wiebusch, M. G., Wirth, J., Zbroszczyk, H. P., Zherebtsova, E., Zumbruch, P., Curceanu, C., Piscicchia, K., and Scordo, A.
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Nuclear Experiment - Abstract
Hadron production ($\pi^\pm$, proton, $\Lambda$, $K_S^0$, $K^\pm$) in $\pi^- + \mathrm{C}$ and $\pi^- + \mathrm{W}$ collisions is investigated at an incident pion beam momentum of $1.7~\mathrm{GeV}/c$. This comprehensive set of data measured with HADES at SIS18/GSI significantly extends the existing world data on hadron production in pion induced reactions and provides a new reference for models that are commonly used for the interpretation of heavy-ion collisions. The measured inclusive differential production cross-sections are compared with state-of-the-art transport model (GiBUU, SMASH) calculations. The (semi-) exclusive channel $\pi^- + A \rightarrow \Lambda + K_S^0 +X$, in which the kinematics of the strange hadrons are correlated, is also investigated and compared to a model calculation. Agreement and remaining tensions between data and the current version of the considered transport models are discussed.
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- 2023
33. Experimental test of Non-Commutative Quantum Gravity by VIP-2 Lead
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Piscicchia, Kristian, Addazi, Andrea, Marciano, Antonino, Bazzi, Massimiliano, Cargnelli, Michael, Clozza, Alberto, De Paolis, Luca, Del Grande, Raffaele, Guaraldo, Carlo, Iliescu, Mihail Antoniu, Laubenstein, Matthias, Marton, Johann, Miliucci, Marco, Napolitano, Fabrizio, Porcelli, Alessio, Scordo, Alessandro, Sirghi, Diana Laura, Sirghi, Florin, Doce, Oton Vazquez, Zmeskal, Johann, and Curceanu, Catalina
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High Energy Physics - Theory ,General Relativity and Quantum Cosmology ,High Energy Physics - Experiment ,High Energy Physics - Phenomenology - Abstract
Pauli Exclusion Principle (PEP) violations induced by space-time non-commutativity, a class of universality for several models of Quantum Gravity, are investigated by the VIP-2 Lead experiment at the Gran Sasso underground National Laboratory of INFN. The VIP-2 Lead experimental bound on the non-commutative space-time scale $\Lambda$ excludes $\theta$-Poincar\'e far above the Planck scale for non vanishing ``electric-like" components of $\theta_{\mu \nu}$, and up to $6.9 \cdot 10^{-2}$ Planck scales if they are null. Therefore, this new bound represents the tightest one so far provided by atomic transitions tests. This result strongly motivates high sensitivity underground X-ray measurements as critical tests of Quantum Gravity and of the very microscopic space-time structure., Comment: 13 pages, 2 figures. arXiv admin note: substantial text overlap with arXiv:2209.00074
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- 2022
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34. ASIC notice: International Motor Cars Pty. Ltd. (Formerly Known As 'Scordo Transport Services Pty. Ltd.') (Trading As 'International Motor Cars') (Subject to Deed of Company Arrangement): NOTICE OF MEETING OF CREDITORS Schedule 2 - Insolvency Practice Schedule (Corporations) s75-10(a) Insolvency Practice Rules (Corporations) 2016 s75-40(1)
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Corporations ,Transportation industry -- Finance ,Company financing ,News, opinion and commentary - Abstract
Canberra: Australian Securities and Investments Commission has issued the following notice: Corporations Act 2001 Schedule 2 - Insolvency Practice Schedule (Corporations) s75-10(a) Insolvency Practice Rules (Corporations) 2016 s75-40(1) NOTICE OF [...]
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- 2022
35. Evaluation of EMG patterns in children during assisted walking in the exoskeleton
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Margherita Villani, Priscilla Avaltroni, Giulia Scordo, Damiana Rubeca, Peter Kreynin, Ekaterina Bereziy, Denise Berger, Germana Cappellini, Francesca Sylos-Labini, Francesco Lacquaniti, and Yury Ivanenko
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children ,robotic exoskeleton ,assisted gait ,EMG patterns ,spinal locomotor output ,development ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
While exoskeleton technology is becoming more and more common for gait rehabilitation in children with neurological disorders, evaluation of gait performance still faces challenges and concerns. The reasoning behind evaluating the spinal locomotor output is that, while exoskeleton's guidance forces create the desired walking kinematics, they also affect sensorimotor interactions, which may lead to an abnormal spatiotemporal integration of activity in particular spinal segments and the risk of abnormalities in gait recovery. Therefore, traditional indicators based on kinematic or kinetic characteristics for optimizing exoskeleton controllers for gait rehabilitation may be supplemented by performance measures associated with the neural control mechanisms. The purpose of this study on a sample of children was to determine the basic features of lower limb muscle activity and to implement a method for assessing the neuromechanics of spinal locomotor output during exoskeleton-assisted gait. To this end, we assessed the effects of a robotic exoskeleton (ExoAtlet Bambini) on gait performance, by recording electromyographic activity of leg muscles and analyzing the corresponding spinal motor pool output. A slower walking setting (about 0.2 m/s) was chosen on the exoskeleton. The results showed that, even with slower walking, the level of muscle activation was roughly comparable during exoskeleton-assisted gait and normal walking. This suggests that, despite full assistance for leg movements, the child's locomotor controllers can interpret step-related afferent information promoting essential activity in leg muscles. This is most likely explained by the active nature of stepping in the exoskeleton (the child was not fully relaxed, experienced full foot loading and needed to maintain the upper trunk posture). In terms of the general muscle activity patterns, we identified notable variations for the proximal leg muscles, coactivation of the lumbar and sacral motor pools, and weak propulsion from the distal extensors at push-off. These changes led to the lack of characteristic lumbosacral oscillations of the center of motoneuron activity, normally associated with the pendulum mechanism of bipedal walking. This work shows promise as a useful technique for analyzing exoskeleton performance to help children develop their natural gait pattern and to guide system optimization in the future for inclusion into clinical care.
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- 2024
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36. Evaluating serum free light chain ratio as a biomarker in multiple myeloma
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Theresia Akhlaghi, Kylee Maclachlan, Neha Korde, Sham Mailankody, Alexander Lesokhin, Hani Hassoun, Sydney X Lu, Dhwani Patel, Urvi Shah, Carlyn Tan, Andriy Derkach, Oscar Lahoud, Heather J Landau, Gunjan L. Shah, Michael Scordo, David J Chung, Sergio A Giralt, Saad Z Usmani, Ola Landgren, and Malin Hultcrantz
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Abstract
Not available.
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- 2024
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37. Sezioni unite civili; sentenza 19 ottobre 1962, n. 3046; Pres. Tavolaro P. P., Est. Sparvieri, P. M. Pepe (concl. conf.); Com. Melito Porto Salvo (Avv. Sacca Luchesi) c. Scordo (Avv. Gazzoni) e Min. lavori pubblici (Avv. dello Stato Vitucci); Min. interno c. Scordo e Com. Melito Porto Salvo; Min. lavori pubblici c. Scordo e Com. Melito Porto Salvo
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- 1963
38. First Simultaneous K$^-$p $\rightarrow (\Sigma^0/\Lambda) \, \pi^0$ Cross Sections Measurements at 98 MeV/c
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Piscicchia, Kristian, Skurzok, Magdalena, Cargnelli, Michael, Del Grande, Raffaele, Fabbietti, Laura, Marton, Johann, Moskal, Pawel, Scordo, Alessandro, Ramos, Àngels, Sirghi, Diana Laura, Doce, Oton Vazquez, Zmeskal, Johann, Wycech, Slawomir, Branchini, Paolo, Ceradini, Filippo, Czerwinski, Eryk, De Lucia, Erika, Fiore, Salvatore, Kupsc, Andrzej, Mandaglio, Giuseppe, Martini, Matteo, Passeri, Antonio, Patera, Vincenzo, Del Rio, Elena Perez, Selce, Andrea, Silarski, Michał, and Curceanu, Catalina
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Nuclear Experiment ,High Energy Physics - Phenomenology - Abstract
We report the first simultaneous and independent measurements of the K$^{-}$p $\rightarrow \Sigma^0 \, \pi^{0}$ and K$^{-}$p $\rightarrow \Lambda \, \pi^{0}$ cross sections around 100 MeV/c kaon momentum. The kaon beam delivered by the DA$\Phi$NE collider was exploited to detect K$^-$ absorptions on Hydrogen atoms, populating the gas mixture of the KLOE drift chamber. The precision of the measurements ($\sigma_{K^- p \rightarrow \Sigma^0 \pi^0} = 42.8 \pm 1.5 (stat.) ^{+2.4}_{-2.0}(syst.) \ \mathrm{mb}$ and $\sigma_{K^- p \rightarrow \Lambda \pi^0} = 31.0 \pm 0.5 (stat.) ^{+1.2}_{-1.2}(syst.) \ \mathrm{mb}\,$) is the highest yet obtained in the low kaon momentum regime.
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- 2022
39. Pole position of $\Lambda(1405)$ measured in $d(K^-,n)\pi\Sigma$ reactions
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Collaboration, J-PARC E31, Aikawa, S., Ajimura, S., Akaishi, T., Asano, H., Beer, G., Berucci, C., Bragadireanu, M., Buehler, P., Busso, L., Cargnelli, M., Choi, S., Curceanu, C., Enomoto, S., Fujioka, H., Fujiwara, Y., Fukuda, T., Guaraldo, C., Hashimoto, T., Hayano, R. S., Hiraiwa, T., Iio, M., Iliescu, M., Inoue, K., Ishiguro, Y., Ishimoto, S., Ishikawa, T., Itahashi, K., Iwai, M., Iwasaki, M., Kanno, K., Kato, K., Kato, Y., Kawasaki, S., Kienle, P., Komatsu, Y., Kou, H., Ma, Y., Marton, J., Matsuda, Y., Mizoi, Y., Morra, O., Murayama, R., Nagae, T., Noumi, H., Ohnishi, H., Okada, S., Omar, Z., Outa, H., Piscicchia, K., Sada, Y., Sakaguchi, A., Sakuma, F., Sato, M., Scordo, A., Sekimoto, M., Shi, H., Shirotori, K., Sirghi, D., Sirghi, F., Suzuki, K., Suzuki, S., Suzuki, T., Tanida, K., Tatsuno, H., Tokiyasu, A. O., Tokuda, M., Tomono, D., Toyoda, A., Tsukada, K., Vazquez-Doce, O., Widmann, E., Yamaga, T., Yamazaki, T., Yim, H., Zhang, Q., and Zmeskal, J.
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Nuclear Experiment - Abstract
We measured a set of $\pi^\pm\Sigma^\mp$, $\pi^0\Sigma^0$, and $\pi^-\Sigma^0$ invariant mass spectra below and above the $\bar{K}N$ mass threshold in $K^-$-induced reactions on deuteron. We deduced the $S$-wave $\bar{K}N\rightarrow\pi\Sigma$ and $\bar{K}N\rightarrow\bar{K}N$ scattering amplitudes in the isospin 0 channel in the framework of a $\bar{K}N$ and $\pi\Sigma$ coupled channel. We find that a resonance pole corresponding to $\Lambda(1405)$ is located at 1417.7$^{+6.0}_{-7.4}$(fitting errors)$^{+1.1}_{-1.0}$(systematic errors) + $[-26.1^{+6.0}_{-7.9}$(fitting errors)$^{+1.7}_{-2.0}$(systematic errors)]$i$ MeV/$c^2$, closer to the $\bar{K}N$ mass threshold than the value determined by the Particle Data Group., Comment: 8 pages, 5 figures
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- 2022
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40. Genomic and immune signatures predict clinical outcome in newly diagnosed multiple myeloma treated with immunotherapy regimens
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Maura, Francesco, Boyle, Eileen M., Coffey, David, Maclachlan, Kylee, Gagler, Dylan, Diamond, Benjamin, Ghamlouch, Hussein, Blaney, Patrick, Ziccheddu, Bachisio, Cirrincione, Anthony, Chojnacka, Monika, Wang, Yubao, Siegel, Ariel, Hoffman, James E., Kazandjian, Dickran, Hassoun, Hani, Guzman, Emily, Mailankody, Sham, Shah, Urvi A., Tan, Carlyn, Hultcrantz, Malin, Scordo, Michael, Shah, Gunjan L., Landau, Heather, Chung, David J., Giralt, Sergio, Zhang, Yanming, Arbini, Arnaldo, Gao, Qi, Roshal, Mikhail, Dogan, Ahmet, Lesokhin, Alexander M., Davies, Faith E., Usmani, Saad Z., Korde, Neha, Morgan, Gareth J., and Landgren, Ola
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- 2023
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41. Prognostic impact of corticosteroid and tocilizumab use following chimeric antigen receptor T-cell therapy for multiple myeloma
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Bruno Almeida Costa, Jessica Flynn, Noriko Nishimura, Sean M. Devlin, Tasmin Farzana, Sridevi Rajeeve, David J. Chung, Heather J. Landau, Oscar B. Lahoud, Michael Scordo, Gunjan L. Shah, Hani Hassoun, Kylee Maclachlan, Malin Hultcrantz, Neha Korde, Alexander M. Lesokhin, Urvi A. Shah, Carlyn R. Tan, Sergio A. Giralt, Saad Z. Usmani, Karthik Nath, and Sham Mailankody
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Despite being the mainstay of management for cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS), there is limited data regarding the impact of tocilizumab (TCZ) and corticosteroids (CCS) on chimeric antigen receptor (CAR) T-cell efficacy in multiple myeloma (MM). The present study aims to evaluate the prognostic impact of these immunosuppressants in recipients of BCMA- or GPRC5D-directed CAR T cells for relapsed/refractory MM. Our retrospective cohort involved patients treated with commercial or investigational autologous CAR T-cell products at a single institution from March 2017–March 2023. The primary endpoint was progression-free survival (PFS). Secondary endpoints included overall response rate (ORR), complete response rate (CRR), and overall survival (OS). In total, 101 patients (91% treated with anti-BCMA CAR T cells and 9% treated with anti-GPRC5D CAR T cells) were analyzed. Within 30 days post-infusion, 34% received CCS and 49% received TCZ for CRS/ICANS management. At a median follow-up of 27.4 months, no significant difference in PFS was observed between CCS and non-CCS groups (log-rank p = 0.35) or between TCZ and non-TCZ groups (log-rank p = 0.69). ORR, CRR, and OS were also comparable between evaluated groups. In our multivariable model, administering CCS with/without TCZ for CRS/ICANS management did not independently influence PFS (HR, 0.74; 95% CI, 0.36–1.51). These findings suggest that, among patients with relapsed/refractory MM, the timely and appropriate use of CCS or TCZ for mitigating immune-mediated toxicities does not appear to impact the antitumor activity and long-term outcomes of CAR T-cell therapy.
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- 2024
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42. Comparison of infectious complications with BCMA-directed therapies in multiple myeloma
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Karthik Nath, Tala Shekarkhand, David Nemirovsky, Andriy Derkach, Bruno Almeida Costa, Noriko Nishimura, Tasmin Farzana, Colin Rueda, David J. Chung, Heather J. Landau, Oscar B. Lahoud, Michael Scordo, Gunjan L. Shah, Hani Hassoun, Kylee Maclachlan, Neha Korde, Urvi A. Shah, Carlyn Rose Tan, Malin Hultcrantz, Sergio A. Giralt, Saad Z. Usmani, Zainab Shahid, Sham Mailankody, and Alexander M. Lesokhin
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract B-cell-maturation-antigen (BCMA)-directed therapies are highly active for multiple myeloma, but infections are emerging as a major challenge. In this retrospective, single-center analysis we evaluated infectious complications after BCMA-targeted chimeric-antigen-receptor T-cell therapy (CAR-T), bispecific-antibodies (BsAb) and antibody-drug-conjugates (ADC). The primary endpoint was severe (grade ≥3) infection incidence. Amongst 256 patients, 92 received CAR-T, 55 BsAb and 109 ADC. The incidence of severe infections was higher with BsAb (40%) than CAR-T (26%) or ADC (8%), including grade 5 infections (7% vs 0% vs 0%, respectively). Comparing T-cell redirecting therapies, the incidence rate of severe infections was significantly lower with CAR-T compared to BsAb at 1-year (incidence-rate-ratio [IRR] = 0.43, 95%CI 0.25−0.76, P = 0.004). During periods of treatment-emergent hypogammaglobulinemia, BsAb recipients had higher infection rates (IRR:2.27, 1.31−3.98, P = 0.004) and time to severe infection (HR 2.04, 1.05–3.96, P = 0.036) than their CAR-T counterparts. During periods of non-neutropenia, CAR-T recipients had a lower risk (HR 0.44, 95%CI 0.21−0.93, P = 0.032) and incidence rate (IRR:0.32, 95% 0.17–0.59, P
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- 2024
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43. Wildfire smoke reduces lake ecosystem metabolic rates unequally across a trophic gradient
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Adrianne P. Smits, Facundo Scordo, Minmeng Tang, Alicia Cortés, Mary Jade Farruggia, Joshua Culpepper, Sudeep Chandra, Yufang Jin, Sergio A. Valbuena, Shohei Watanabe, Geoffrey Schladow, and Steven Sadro
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Geology ,QE1-996.5 ,Environmental sciences ,GE1-350 - Abstract
Abstract Wildfire smoke covers entire continents, depositing aerosols and reducing solar radiation fluxes to millions of freshwater ecosystems, yet little is known about impacts on lakes. Here, we quantified trends in the spatial extent of smoke cover in California, USA, and assessed responses of gross primary production and ecosystem respiration to smoke in 10 lakes spanning a gradient in water clarity and nutrient concentrations. From 2006 − 2022, the maximum extent of medium or high-density smoke occurring between June-October increased by 300,000 km2. In the three smokiest years (2018, 2020, 2021), lakes experienced 23 − 45 medium or high-density smoke days, characterized by 20% lower shortwave radiation fluxes and five-fold higher atmospheric fine particulate matter concentrations. Ecosystem respiration generally declined during smoke cover, especially in low-nutrient, cold lakes, whereas responses of primary production were more variable. Lake attributes and seasonal timing of wildfires will mediate the effects of smoke on lakes.
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- 2024
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44. Conventional and novel [18F]FDG PET/CT features as predictors of CAR-T cell therapy outcome in large B-cell lymphoma
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Doris Leithner, Jessica R. Flynn, Sean M. Devlin, Audrey Mauguen, Teng Fei, Shang Zeng, Junting Zheng, Brandon S. Imber, Harper Hubbeling, Marius E. Mayerhoefer, Akshay Bedmutha, Efrat Luttwak, Magdalena Corona, Parastoo B. Dahi, Alejandro Luna de Abia, Ivan Landego, Richard J. Lin, M. Lia Palomba, Michael Scordo, Jae H. Park, Ana Alarcon Tomas, Gilles Salles, Daniel Lafontaine, Laure Michaud, Gunjan L. Shah, Miguel-Angel Perales, Roni Shouval, and Heiko Schöder
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Lymphoma ,Positron emission tomography ,Biomarker ,Immunotherapy ,CAR-T ,Radiomics ,Diseases of the blood and blood-forming organs ,RC633-647.5 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Relapse and toxicity limit the effectiveness of chimeric antigen receptor T-cell (CAR-T) therapy for large B-cell lymphoma (LBCL), yet biomarkers that predict outcomes and toxicity are lacking. We examined radiomic features extracted from pre-CAR-T 18F-fluorodeoxyglucose positron emission tomography/computed tomography ([18F]FDG PET/CT) scans (n = 341) of 180 patients (121 male; median age, 66 years). Three conventional (maximum standardized uptake value [SUVmax], metabolic tumor volume [MTV], total lesion glycolysis [TLG]) and 116 novel radiomic features were assessed, along with inflammatory markers, toxicities, and outcomes. At both pre-apheresis and pre-infusion time points, conventional PET features of disease correlated with elevated inflammatory markers. At pre-infusion, MTV was associated with grade ≥ 2 cytokine release syndrome (odds ratio [OR] for 100 mL increase: 1.08 [95% confidence interval (CI), 1.01–1.20], P = 0.031), and SUVmax was associated with failure to achieve complete response (CR) (OR 1.72 [95% CI, 1.24–2.43], P
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- 2024
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45. VIP-2 with modulated current: pathfinder for enhanced Pauli exclusion principle violation studies
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Alessio Porcelli, Massimiliano Bazzi, Nicola Bortolotti, Mario Bragadireanu, Michael Cargnelli, Alberto Clozza, Luca De Paolis, Raffaele Del Grande, Carlo Guaraldo, Mihail Iliescu, Matthias Laubenstein, Simone Manti, Johann Marton, Marco Miliucci, Fabrizio Napolitano, Kristian Piscicchia, Alessandro Scordo, Francesco Sgaramella, Diana Laura Sirghi, Florin Sirghi, Oton Vazquez Doce, Johann Zmeskal, and Catalina Curceanu
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Astrophysics ,QB460-466 ,Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 - Abstract
Abstract Fermions are subject to the Pauli Exclusion Principle (PEP), which is grounded on the spin-statistics theorem and, hence, related to the very same structure of the underlying symmetries. The VIP-2 (VIolation of Pauli exclusion principle - 2) experiment has been performing extreme sensitivity tests of the PEP, up to its current and final configuration, exploiting several experimental setups designed to study different theoretical models of PEP violation, looking for a faint signal of physics Beyond the Standard Model.A current is introduced in the copper target to bring new electrons into the system and, hence, fulfill the requirements of the Messiah-Greenberg Super-Selection rule. The searched spin-statistics violating signal corresponds to X-rays emitted when the new electrons perform atomic transitions to the already filled fundamental level of copper. This work analyzes the set of the VIP-2 data corresponding to a test run of 68 days in a current modulated regime alternating no current with current data-taking in short periods (50 s each), instead the usual alternating months-long data-taking of each of these two phases. We propose an analysis method to improve the experiment’s sensitivity: a spectral analysis constraint with the Discrete Fourier Transformation of the data. Compared to the spectrum-only analysis, about a factor of 1.5 of improvement to the limit for the probability of PEP violation for electrons was obtained.
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- 2024
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46. Strongest atomic physics bounds on Non-Commutative Quantum Gravity Models
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Piscicchia, Kristian, Addazi, Andrea, Marciano, Antonino, Bazzi, Massimiliano, Cargnelli, Michael, Clozza, Alberto, De Paolis, Luca, Del Grande, Raffaele, Guaraldo, Carlo, Iliescu, Mihail Antoniu, Laubenstein, Matthias, Marton, Johann, Miliucci, Marco, Napolitano, Fabrizio, Porcelli, Alessio, Scordo, Alessandro, Sirghi, Diana Laura, Sirghi, Florin, Doce, Oton Vazquez, Zmeskal, Johann, and Curceanu, Catalina
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High Energy Physics - Theory ,General Relativity and Quantum Cosmology ,High Energy Physics - Phenomenology - Abstract
Investigations of possible violations of the Pauli Exclusion Principle represent critical tests of the microscopic space-time structure and properties. Space-time non-commutativity provides a class of universality for several Quantum Gravity models. In this context the VIP-2 Lead experiment sets the strongest bounds, searching for Pauli Exclusion Principle violating atomic-transitions in lead, excluding the $\theta$-Poincar\'e Non Commutative Quantum Gravity models far above the Planck scale for non-vanishing $\theta_{\mu \nu}$ ``electric-like'' components, and up to $6.9 \cdot 10^{-2}$ Planck scales if $\theta_{0i} = 0$., Comment: 7 pages, 2 figures
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- 2022
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47. Studies of the linearity and stability of Silicon Drift Detectors for kaonic atoms X-ray spectroscopy
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Khreptak, A., Amsler, C., Bazzi, M., Bosnar, D., Bragadireanu, M., Carminati, M., Cargnelli, M., Clozza, A., Deda, G., De Paolis, L., Del Grande, R., Fabbietti, L., Fiorini, C., Guaraldo, C., Iliescu, M., Iwasaki, M., Manti, S., Marton, J., Miliucci, M., Moskal, P., Napolitano, F., Niedźwiecki, S., Ohnishi, H., Piscicchia, K., Sada, Y., Scordo, A., Sgaramella, F., Shi, H., Silarski, M., Sirghi, D., Sirghi, F., Skurzok, M., Spallone, A., Toho, K., Tüchler, M., Doce, O. Vazquez, Zmeskal, J., Yoshida, C., and Curceanu, C.
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Physics - Instrumentation and Detectors ,Nuclear Experiment - Abstract
The SIDDHARTA-2 experiment at the DA$\Phi$NE collider aims to perform precision measurements of kaonic atoms X-ray spectroscopy for the investigation of the antikaon-nucleon strong interaction. To achieve this goal, novel large-area Silicon Drift Detectors (SDDs) have been developed. These devices have special geometry, field configuration and readout electronics that ensure excellent performance in terms of linearity and stability. The paper presents preliminary results for the linearity determination and stability monitoring of the SDDs system during the measurement of kaonic deuterium carried out in the summer of 2022.
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- 2022
48. First tests of the full SIDDHARTA-2 experimental apparatus with a 4 He gaseous target
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Scordo, A., Amsler, C., Bazzi, M., Bosnar, D., Bragadireanu, M., Cargnelli, M., Carminati, M., Clozza, A., Deda, G., De Paolis, L., Del Grande, R., Fabbietti, L., Fiorini, C., Guaraldo, C., Iliescu, M., Iwasaki, M., Khreptak, A., King, P., Sandri, P. Levi, Manti, S., Marton, J., Miliucci, M., Moskal, P., Napolitano, F., Niedźwiecki, S., Ohnishi, H., Piscicchia, K., Sada, Y., Sgaramella, F., Shi, H., Silarski, M., Sirghi, D. L., Sirghi, F., Skurzok, M., Spallone, A., Toho, K., Tüchler, M., Doce, O. Vazquez, Yoshida, C., Zmeskal, J., and Curceanu, C.
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Physics - Instrumentation and Detectors ,Nuclear Experiment - Abstract
In this paper, we present the first tests performed after the full installation of the SIDDHARTA-2 experimental apparatus on the Interaction Region of the DA{\Phi}NE collider at the INFN National Laboratories of Frascati. Before starting the first measurement of the kaonic deuterium 2p{\rightarrow}1s transition, accurate evaluation of the background rejection. mainly achieved with the Kaon Trigger system, was required. This run, performed in the period 04-26/05/2022 with a 4 He gaseous target, confirmed the 10^5 rejection factor obtained with a reduced version of the setup and different machine conditions in 2021. This important outcome motivated the filling of the target cell with deuterium and the starting of the measurement campaign of the kaonic deuterium 2p{\rightarrow}1s transition.
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- 2022
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49. VIP-2 with modulated current: pathfinder for enhanced Pauli exclusion principle violation studies
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Porcelli, Alessio, Bazzi, Massimiliano, Bortolotti, Nicola, Bragadireanu, Mario, Cargnelli, Michael, Clozza, Alberto, De Paolis, Luca, Del Grande, Raffaele, Guaraldo, Carlo, Iliescu, Mihail, Laubenstein, Matthias, Manti, Simone, Marton, Johann, Miliucci, Marco, Napolitano, Fabrizio, Piscicchia, Kristian, Scordo, Alessandro, Sgaramella, Francesco, Sirghi, Diana Laura, Sirghi, Florin, Doce, Oton Vazquez, Zmeskal, Johann, and Curceanu, Catalina
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- 2024
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50. Sustained Minimal Residual Disease Negativity in Multiple Myeloma is Associated with Stool Butyrate and Healthier Plant-Based Diets.
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Shah, Urvi A, Maclachlan, Kylee H, Derkach, Andriy, Salcedo, Meghan, Barnett, Kelly, Caple, Julia, Blaslov, Jenna, Tran, Linh, Ciardiello, Amanda, Burge, Miranda, Shekarkhand, Tala, Adintori, Peter, Cross, Justin, Pianko, Matthew J, Hosszu, Kinga, McAvoy, Devin, Mailankody, Sham, Korde, Neha, Hultcrantz, Malin, Hassoun, Hani, Tan, Carlyn R, Lu, Sydney X, Patel, Dhwani, Diamond, Benjamin, Shah, Gunjan, Scordo, Michael, Lahoud, Oscar, Chung, David J, Landau, Heather, Usmani, Saad Z, Giralt, Sergio, Taur, Ying, Landgren, C Ola, Block, Gladys, Block, Torin, Peled, Jonathan U, van den Brink, Marcel RM, and Lesokhin, Alexander M
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Nutrition ,Rare Diseases ,Complementary and Integrative Health ,Clinical Research ,Cancer ,Hematology ,Oral and gastrointestinal ,Good Health and Well Being ,Humans ,Multiple Myeloma ,Butyrates ,Neoplasm ,Residual ,Diet ,Healthy ,Diet ,Vegetarian ,Oncology and Carcinogenesis ,Oncology & Carcinogenesis - Abstract
PurposeSustained minimal residual disease (MRD) negativity is associated with long-term survival in multiple myeloma. The gut microbiome is affected by diet, and in turn can modulate host immunity, for example through production of short-chain fatty acids including butyrate. We hypothesized that dietary factors affect the microbiome (abundance of butyrate-producing bacteria or stool butyrate concentration) and may be associated with multiple myeloma outcomes.Experimental designWe examined the relationship of dietary factors (via a food frequency questionnaire), stool metabolites (via gas chromatography-mass spectrometry), and the stool microbiome (via 16S sequencing - α-diversity and relative abundance of butyrate-producing bacteria) with sustained MRD negativity (via flow cytometry at two timepoints 1 year apart) in myeloma patients on lenalidomide maintenance. The Healthy Eating Index 2015 score and flavonoid nutrient values were calculated from the food frequency questionnaire. The Wilcoxon rank sum test was used to evaluate associations with two-sided P < 0.05 considered significant.ResultsAt 3 months, higher stool butyrate concentration (P = 0.037), butyrate producers (P = 0.025), and α-diversity (P = 0.0035) were associated with sustained MRD negativity. Healthier dietary proteins, (from seafood and plants), correlated with butyrate at 3 months (P = 0.009) and sustained MRD negativity (P = 0.05). Consumption of dietary flavonoids, plant nutrients with antioxidant effects, correlated with stool butyrate concentration (anthocyanidins P = 0.01, flavones P = 0.01, and flavanols P = 0.02).ConclusionsThis is the first study to demonstrate an association between a plant-based dietary pattern, stool butyrate production, and sustained MRD negativity in multiple myeloma, providing rationale to evaluate a prospective dietary intervention.
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- 2022
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