173 results on '"Sasaki, Atsuo T"'
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2. Beyond Warburg: LDHA activates RAC for tumour growth
3. IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma
4. A high dose KRP203 induces cytoplasmic vacuoles associated with altered phosphoinositide segregation and endosome expansion
5. Schlafen 11 predicts response to platinum-based chemotherapy in gastric cancers
6. Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways
7. TGF-β-dependent reprogramming of amino acid metabolism induces epithelial–mesenchymal transition in non-small cell lung cancers
8. Targeting Energy Metabolism to Overcome Therapeutic Resistance of Glioblastoma and Tumor-associated Edema
9. Integration of Molecular Analysis, Cutting-edge Mouse Genetic Models and Proton Therapy to Improve Outcomes for Glioma Patients
10. Emerging Roles of Wild-type and Mutant IDH1 in Growth, Metabolism and Therapeutics of Glioma
11. Multimodal action of KRP203 on phosphoinositide kinases in vitro and in cells
12. Functional molecular evolution of a GTP sensing kinase: PI5P4Kβ.
13. Localized Ras Signaling at the Leading Edge Regulates PI3K, Cell Polarity, and Directional Cell Movement
14. Drug discovery targeting GTP metabolism for cancer and infectious diseases using X-ray crystallography and cryo-EM
15. Data from Characterization of KRAS Rearrangements in Metastatic Prostate Cancer
16. Supplementary Methods and Data (posted 7/5/2011) from Characterization of KRAS Rearrangements in Metastatic Prostate Cancer
17. Supplementary Methods, Figures, Tables, and References from Characterization of KRAS Rearrangements in Metastatic Prostate Cancer
18. Multimodal action of KRP203 on phosphoinositide kinases in vitro and in cells
19. Homogeneous luminescent quantitation of cellular guanosine and adenosine triphosphates (GTP and ATP) using QT-LucGTP&ATP assay.
20. IMPDH inhibition activates TLR‐VCAM1 pathway and suppresses the development of MLL‐fusion leukemia
21. Epigenetic upregulation of Schlafen11 renders WNT- and SHH-activated medulloblastomas sensitive to cisplatin
22. The GTP responsiveness of PI5P4Kβ evolved from a compromised trade-off between activity and specificity
23. Method for Assaying the Lipid Kinase Phosphatidylinositol-5-phosphate 4-kinase α in Quantitative High-Throughput Screening (qHTS) Bioluminescent Format
24. Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses
25. A Fluorescent Reporter of AMPK Activity and Cellular Energy Stress
26. G Protein-Independent Ras/PI3K/F-Actin Circuit Regulates Basic Cell Motility
27. IMPDH inhibition activates TLR‐VCAM1 pathway and suppresses the development of MLL‐fusion leukemia.
28. SI-MOIRAI: A new method to identify and quantify the metabolic fate of nucleotides
29. Divergent Mechanisms Activating RAS and Small GTPases Through Post-translational Modification
30. Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis
31. Mycophenolate Mofetil Hepatotoxicity Associated With Mitochondrial Abnormality in Liver Transplant Recipients and Mice
32. Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer
33. Reuse of Molecules for Glioblastoma Therapy
34. Spatiotemporal Regulation of Ras-GTPases During Chemotaxis
35. Selenite targets eIF4E-binding protein-1 to inhibit translation initiation and induce the assembly of non-canonical stress granules
36. Finding the Way: Directional Sensing and Cell Polarization through Ras Signalling
37. Metabolic Compartmentalization at the Leading Edge of Metastatic Cancer Cells
38. GTP metabolic reprogramming by IMPDH2: unlocking cancer cells’ fuelling mechanism
39. Activity-specificity trade-off gives PI5P4Kβ a nucleotide preference to function as a GTP-sensing kinase
40. Structure–Activity Relationship Study of Covalent Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors
41. Correction: Identification of lysine methylation in the core GTPase domain by GoMADScan
42. Identification of lysine methylation in the core GTPase domain by GoMADScan
43. Dynamic compartmentalization of purine nucleotide metabolic enzymes at leading edge in highly motile renal cell carcinoma
44. Depletion of phosphatidylinositol 4-phosphate at the Golgi translocates K-Ras to mitochondria
45. In-vitro evaluation of MPA-loaded electrospun coaxial fiber membranes for local treatment of glioblastoma tumor cells
46. R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling
47. Pharmacologic Targeting of S6K1 in PTEN-Deficient Neoplasia
48. Inhibition of Impdh As an Effective Treatment for MLL-Fusion Leukemia
49. Structural reverse genetics study of the PI5P4Kβ-nucleotide complexes reveals the presence of the GTP bioenergetic system in mammalian cells
50. Use of Multiple Cryoprotectants to Improve Diffraction Quality from Protein Crystals
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