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Inflammatory diseases including different types of rheumatics are a major cause of morbidity worldwide. This study addresses the global burden of inflammatory diseases, focusing on safer alternatives to synthetic anti-inflammatory drugs. Extracts from ethnomedicinal plants, Delonix elata, Hygrophila auriculata, and Drynaria quercifolia, were combined to enhance their anti-inflammatory properties. The ethanolic extract was obtained from the leaves of Delonix elata, seeds of Hygrophila auriculata, and rhizomes of Drynaria quercifolia, showing the existence of phenolics, flavonoids, and alkaloids in preliminary phytochemical screening. Two combinations, D (1:1:1) and E (10:5:1), were prepared. In vitro studies revealed that combination D shown maximum total antioxidant activity the strongest capacity to scavenge DPPH radicals. Antibacterial assays demonstrated varying zones of inhibition for E. coli and S. aureus among the combinations. Notably, combination D showed the largest zone of inhibition for E. coli, while sample C was most effective against S. aureus. Protein denaturation assay for anti-inflammatory activity highlighted combination D's remarkable inhibition of BSA denaturation (97.37% at 1mg/ml concentration). This research explores potential natural remedies and holistic healthcare solutions through the synergistic effects of plant extracts, aligning with traditional medicinal knowledge. [ABSTRACT FROM AUTHOR]

Although it was difficult to anticipate the time or location of an earthquake, it was feasible to estimate the probability of a subsequent failure. Using fragility curve analysis, six models with varying shear wall locations were utilized to forecast the chance of failure in this study. For each model, a nonlinear time history analysis was performed that considers 40 earthquakes. Later the fragility curve had been drawn based on the outcome of the study. In this work, uncertainty was taken into consideration, while framing fragility curves and its relationship to models and materials was examined. 280 nonlinear time history analyses had been done for this analysis. The response with the highest score in each analysis had been recorded. The fragility curve was formed between the PGA and the probability of exceedance. As a result, model FC-FIG. 7 performs effectively in the face of seismic force, having acceptable levels of damage including rapid occupancy, limit state, and collapse prevention. In this study, the probability of exceedance of each model was calculated for the PGA of 0.5. [ABSTRACT FROM AUTHOR]

Buildings’ responses to lateral forces have been the topic of a great deal of research work in recent years. Performing a comprehensive nonlinear analysis is required for Performance-Based Design. During earthquakes, nonlinear static analysis (pushover analysis) is frequently employed in performance-based design, where gravity loads are held constant and lateral forces are increased monotonically until the target displacement is reached. The capacity curve, derived from a pushover analysis, depicts the overall performance of the structure by illustrating the relationship between the base shear and the roof displacement. There has been a lot of research on structures with shear walls, but none of it has focused on finding the best possible spot. As part of these analyses, shear walls are placed at different locations of the structure. We analyzed 13 different models to determine the best location, and found out that model 6 performing well, when comparing with other models. As a result, PO-Fig. 7 is found out to be subjected to 76.89% greater shear resistance capacity than the no-shear-wall model. [ABSTRACT FROM AUTHOR]

An efficient protocol of plant regeneration through direct and indirect organogenesis in Swertia chirayita was developed. Explants cultured on Murashige and Skoog medium supplemented with 2,4-D (0.5 mg L) with combination of Kinetin (0.5 mg L) showed the highest frequency (84%) of callusing and 1.0mg L 6-benzyladenine (BA) in combination with (100 mg L) Adenine sulphate (Ads) + (0.1 mg L) Indole acetic acid (IAA) was excellent for maximum adventitious shoot (12.69 ± 1.30) formation in four week of culture. A maximum number of (7.14 ± 0.99) shoots were developed per leaf explants through direct organogenesis. The highest frequency of rooting (11.46 ± 1.56) was observed on MS medium augmented with IAA (1.0 mg L). Well-rooted shoots transferred to plastic pots containing a soilrite: sand mix and then moved to the greenhouse for further growth and development. Four major secondary metabolites were analyzed and quantified using high performance liquid chromatography. Amount of secondary metabolites was found significantly higher, in in vitro plantlets compared to in vivo plantlets and callus raised from S. chirayita. Higher heavy metal accumulation in in vitro as compared to in vivo plantlets correlates higher secondary metabolite production supporting that they play regulatory role in influencing the plant secondary metabolism. [ABSTRACT FROM AUTHOR]