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1. Induction of VEGF secretion from bone marrow stromal cell line (ST-2) by the dissolution products of mesoporous silica glass particles containing CuO and SrO

Author

Balasubramanian, Preethi, Salinas, Antonio J., Sanchez-Salcedo, Sandra, Detsch, Rainer, Vallet-Regi, Maria, and Boccaccini, Aldo R.

Subjects
Quantitative Biology - Tissues and Organs
Abstract

Certain biomaterials are capable of inducing the secretion of Vascular Endothelial Growth Factor (VEGF) from cells exposed to their biochemical influence, which plays a vital role in stimulating angiogenesis. Looking for this capacity, in this study three porous glasses were synthesized and characterized. The objective of this study was to determine the concentration of the glass particles that, being out of the cytotoxic range, could increase VEGF secretion. The viability of cultivated bone marrow stromal cells (ST-2) was assessed. The samples were examined with light microscopy (LM) after the histochemical staining for haematoxylin and eosin (HE). The biological activity of glasses was evaluated in terms of the influence of the Cu2+ and Sr2+ ions on the cells. The dissolution products of CuSr-1 and CuSr-2.5 produced the highest secretion of VEGF from ST-2 cells after 48 h of incubation. The combination of Cu2+ and Sr2+ lays the foundation for engineering a bioactive glass than can lead to vascularized, functional bone tissue when used in bone regeneration applications., Comment: 21 pages, 7 figures

Published
2021
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8. List of Contributors

Author

Acharya, Abhinav, primary, Ackun-Farmmer, Marian A., additional, Aggas, John R., additional, Andersen, Phillip J., additional, Anderson, James M., additional, Anseth, Kristi, additional, Archer, Paul A., additional, Ashammakhi, Nureddin, additional, Avila, Jose D., additional, Babensee, Julia E., additional, Badylak, Stephen f., additional, Baek, Kiheon, additional, Baker, Aaron B., additional, Bakht, Syeda Mahwish, additional, Bandyopadhyay, Amit, additional, Barchowsky, Aaron, additional, Bass, Garrett, additional, Becker, Matthew L., additional, Belleghem, Sarah Miho Van, additional, Benoit, Danielle S.W., additional, Biesiekierski, Arne, additional, Billiar, Kristen L., additional, Bose, Susmita, additional, Bowman, Christopher, additional, Boyce, Steven, additional, Brown, Bryan N., additional, Brown, Justin L., additional, Capadona, Jeffrey R., additional, Castner, David G., additional, Chang, Calvin, additional, Chang, Philip, additional, Chilkoti, Ashutosh, additional, Christman, Karen L., additional, Chung, Sangwon, additional, Coleman, Kelly P., additional, Conway, Dan, additional, Cook, Keith E., additional, Cooper, Stuart L., additional, Cosgriff-Hernandez, Elizabeth, additional, Coury, Arthur J., additional, Criscione, Joseph D., additional, Culver, Heidi, additional, Curtis, Jim, additional, Deng, Feiyang, additional, Dhavalikar, Prachi, additional, Diaz-Gomez, Luis, additional, Domingues, Rui M.A., additional, Duncan, Elaine, additional, Duran, Pamela, additional, Esbrit, Pedro, additional, Eskin, Suzanne G., additional, Esmail, Michael Y., additional, Ferracane, Jack L., additional, Fischbach, Claudia, additional, Fischman, Gary, additional, Fisher, John P., additional, Francolini, Iolanda, additional, Frey, Steven J., additional, Gaharwar, Akhilesh K., additional, García, Andrés J., additional, Gibson, Iain R., additional, Gilbert, Jeremy L., additional, Ginn, Brian, additional, Goldblatt, Zachary E., additional, Goldenberg, Seth J., additional, Gomes, Manuela E., additional, Gómez-Florit, Manuel, additional, Gonçalves, Inês C., additional, Gorbet, Maud B., additional, Grainger, David W., additional, Grody, Miles, additional, Guda, Teja, additional, Guelcher, Scott A., additional, Guiseppi-Elie, Anthony, additional, Hacking, S. Adam, additional, Hallab, Nadim James, additional, Hall-Stoodley, Luanne, additional, Hanson, Stephen R., additional, Han, Woojin M., additional, Harman, Melinda K., additional, Harrington, Roger, additional, Haschak, Martin J., additional, Heath, Daniel E., additional, Hicks, Emily Anne, additional, Hill, Ryan T., additional, Hoffman, Allan S., additional, Horbett, Thomas A., additional, Hubbell, Jeffrey A., additional, Ipek, Rasim, additional, Jacobs, Joshua J., additional, Jang, Young C., additional, Jiang, Shaoyi, additional, Johnson, Richard J., additional, Jones, Julian R., additional, Jo, Vickie Y., additional, Kane, Ravi S., additional, Kaplan, David L., additional, Kar, Ronit, additional, Keselowsky, Benjamin George, additional, Khademhosseini, Ali, additional, Kim, Yu Seon, additional, King, Martin W., additional, Kohane, Daniel S., additional, Kohn, David H., additional, Kuhn, Liisa T., additional, Kulkarni, Mangesh, additional, Kuo, Catherine K., additional, Lai, Angela, additional, Lambert, Bryron, additional, Lan, Ziyang, additional, Latour, Robert A., additional, Laurencin, Cato T., additional, Lawson, Bryan K., additional, Layland, Shannon Lee, additional, Lee, Jae Sung, additional, Lee-Parritz, David, additional, Lei, Ying, additional, Lemons, Jack E., additional, Levy, Robert J., additional, Lewerenz, Gregory M., additional, Lewis, Jamal S., additional, Liebscher, Simone, additional, Lin, Chien-Chi, additional, Livingston, Natalie K., additional, Li, Yang, additional, Li, Yuncang, additional, Lu, Helen, additional, Macdougall, Laura, additional, Mahadik, Bhushan, additional, Mamidwar, Sachin, additional, Manspeaker, Margaret P., additional, Mao, Hai-Quan, additional, Ma, Peter X., additional, Marcet, Tyler, additional, Martin, Jeffrey, additional, Martins, M. Cristina L., additional, McArthur, Sally L., additional, McGill, Meghan, additional, McIntire, Larry V., additional, Mei, Lei, additional, Mendes, Bárbara B., additional, Mikos, Antonios G., additional, Mitchell, Richard N., additional, Mitra, Indranath, additional, Muirhead, Ben, additional, Munir, Khurram, additional, Murphy, William L., additional, Nguyen, Phong K., additional, Nolfi, Alexis L., additional, Overby, Clyde, additional, Ozan, Sertan, additional, Padera, Robert F., additional, Pearce, Hannah A., additional, Peppas, Nicholas A., additional, Pereira, Andreia T., additional, Pfeifer, Carmem S., additional, Pinto, Artur M., additional, Raia, Nicole R., additional, Rankin, Edward A., additional, Ratner, Buddy D., additional, Regi, Maria Vallet, additional, Reis, Rui L., additional, Ritchie, Alastair Campbell, additional, Sakiyama-Elbert, Shelly E., additional, Salhadar, Karim, additional, Salinas, Antonio J., additional, Schenke-Layland, Katja, additional, Schoen, Frederick J., additional, Schutrum, Brittany E., additional, Sefton, Michael V., additional, Seidman, Michael A., additional, Shah, Darshan S., additional, Sheardown, Heather, additional, Shoffstall, Andrew J., additional, Simon, Carl G., additional, Simon, Josh, additional, Sims Jr., Kenneth R., additional, Slack, Steven M., additional, Slavin, Benjamin, additional, Snodderly, Kirstie Lane, additional, Stayton, Patrick S., additional, Steichen, Stephanie D., additional, Stoodley, Paul, additional, Swanson, W. Benton, additional, Tam, Hobey, additional, Tayab, Aftab, additional, Thomas, Susan N., additional, Traxel, Kellen D., additional, Tuan, Rocky S., additional, Tucker, Erik I., additional, Ukita, Rei, additional, Veith, Austin, additional, Vidal Yucha, Sarah E., additional, Viney, Christopher, additional, Vyavahare, Naren, additional, Wagner, William R., additional, Wang, Min, additional, Wang, Raymond M., additional, Warner, Petra, additional, Wen, Cuie, additional, West, Jennifer L., additional, Whitman, Matthew A., additional, Witte, Frank, additional, Wolf, Michael F., additional, Yao, Zhicheng, additional, Yaszemski, Michael, additional, Yaszemski, Michael J., additional, Yin, Lichen, additional, Zhang, Guigen, additional, Zhang, Peng, additional, Zhong, Zhiyuan, additional, and Ziats, Nicholas P., additional

Published
2020
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12. List of contributors

Author

Al-Maawi, Sarah, primary, Ambrosio, Luigi, additional, Best, Serena M., additional, Brown, Owen, additional, Chambers, Phil, additional, Chamorro, Natalia Pajares, additional, Chatzistavrou, Xanthippi, additional, Cifuentes Cuellar, SC, additional, De Santis, Roberto, additional, Delgado López, JM, additional, Dunne, Nicholas J., additional, Engel, Elisabeth, additional, Froehlich, Whit, additional, Fuchs, Robyn K., additional, Genitiempo, Maurizio, additional, Ghanaati, Shahram, additional, Ginebra, Maria-Pau, additional, González-Carrasco, JL, additional, Guarino, Vincenzo, additional, Höland, Wolfram, additional, Lacroix, Damien, additional, Lieblich Rodríguez, M, additional, Marsh, Adam C., additional, Mateos-Timoneda, MA, additional, McCarthy, Helen O., additional, Merolli, Antonio, additional, Montufar, Edgar B., additional, Palmquist, Anders, additional, Patrício, TMF, additional, Pawelec, Kendell M., additional, Ramírez Rodríguez, GB, additional, Rampf, Markus, additional, Rey-Vinolas, Sergi, additional, Salinas, Antonio J., additional, Shah, Furqan A., additional, Thompson, William R., additional, Trobos, Margarita, additional, Vallet-Regí, María, additional, Vercler, Christian, additional, Warden, Stuart J., additional, White, Ashley A., additional, and Zaborowska, Magdalena, additional

Published
2019
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14. New Photocrosslinked 3D Foamed Scaffolds Based on GelMA Copolymers: Potential Application in Bone Tissue Engineering

Author

Ministerio de Ciencia e Innovación (España), Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Instituto de Salud Carlos III, European Commission, European Research Council, Pablos, Jesús L., Jiménez-Holguín, Javier, Sánchez Salcedo, Sandra, Salinas, Antonio J., Corrales, Teresa, Vallet-Regí, María, Ministerio de Ciencia e Innovación (España), Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Instituto de Salud Carlos III, European Commission, European Research Council, Pablos, Jesús L., Jiménez-Holguín, Javier, Sánchez Salcedo, Sandra, Salinas, Antonio J., Corrales, Teresa, and Vallet-Regí, María

Abstract

The production of customized polymeric hydrogels in the form of 3D scaffolds with application in bone tissue engineering is currently a topic of great interest. Based on gelatin methacryloyl (GelMa) as one of the most popular used biomaterials, GelMa with two different methacryloylation degrees (DM) was obtained, to achieve crosslinked polymer networks by photoinitiated radical polymerization. In this work, we present the obtention of new 3D foamed scaffolds based on ternary copolymers of GelMa with vinylpyrrolidone (VP) and 2-hydroxyethylmethacrylate (HEMA). All biopolymers obtained in this work were characterized by infrared spectroscopy (FTIR) and thermogravimetric analysis (TGA), whose results confirm the presence of all copolymers in the crosslinked biomaterial. In addition, scanning electron microscopy (SEM) pictures were obtained verifying the presence of the porosity created by freeze-drying process. In addition, the variation in its swelling degree and its enzymatic degradation in vitro was analyzed as a function of the different copolymers obtained. This has allowed us to observe good control of the variation in these properties described above in a simple way by varying the composition of the different comonomers used. Finally, with these concepts in mind, biopolymers obtained were tested through assessment of several biological parameters such as cell viability and differentiation with MC3T3-E1 pre-osteoblastic cell line. Results obtained show that these biopolymers maintain good results in terms of cell viability and differentiation, along with tunable properties in terms of hydrophilic character, mechanical properties and enzymatic degradation.

Published
2023

19. A unified in vitro evaluation for apatite-forming ability of bioactive glasses and their variants

Author

Maçon, Anthony L. B., Kim, Taek B., Valliant, Esther M., Goetschius, Kathryn, Brow, Richard K., Day, Delbert E., Hoppe, Alexander, Boccaccini, Aldo R., Kim, Ill Yong, Ohtsuki, Chikara, Kokubo, Tadashi, Osaka, Akiyoshi, Vallet-Regí, Maria, Arcos, Daniel, Fraile, Leandro, Salinas, Antonio J., Teixeira, Alexandra V., Vueva, Yuliya, Almeida, Rui M., Miola, Marta, Vitale-Brovarone, Chiara, Verné, Enrica, Höland, Wolfram, and Jones, Julian R.

Published
2015
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31. Contributor contact details

Author

Planell, Josep A., primary, Navarro, Melba, additional, Fuchs, Robyn K., additional, Warden, Stuart J., additional, Turner, Charles H., additional, Baldini, Nicola, additional, Cenni, Elisabetta, additional, Lacroix, Damien, additional, White, Ashley A., additional, Best, Serena M., additional, González-Carrasco, José Luis, additional, Vallet-Regí, María, additional, Salinas, Antonio J., additional, Mateos-Timoneda, Miguel Angel, additional, De Santis, Roberto, additional, Guarino, Vincenzo, additional, Ambrosio, Luigi, additional, Ginebra, Maria-Pau, additional, Helary, G., additional, Migonney, Véronique, additional, Taylor, David, additional, Merolli, Antonio, additional, Leali, Paolo Tranquilli, additional, Santin, Matteo, additional, Palmquist, Anders, additional, Thomsen, Peter, additional, Brånemark, Rickard, additional, Engqvist, Håkan, additional, Lausmaa, Jukka, additional, Trommelmans, Leen, additional, Dierickx, Kris, additional, and Selling, Joseph, additional

Published
2009
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37. Osteogenic Effect of ZnO-Mesoporous Glasses Loaded with Osteostatin.

Author

Pérez, Rebeca, Sanchez-Salcedo, Sandra, Lozano, Daniel, Heras, Clara, Esbrit, Pedro, Vallet-Regí, María, and Salinas, Antonio J.

Subjects
OSTEOINDUCTION, BIOACTIVE glasses, C-terminal residues
Abstract

Mesoporous Bioactive Glasses (MBGs) are a family of bioceramics widely investigated for their putative clinical use as scaffolds for bone regeneration. Their outstanding textural properties allow for high bioactivity when compared with other bioactive materials. Moreover, their great pore volumes allow these glasses to be loaded with a wide range of biomolecules to stimulate new bone formation. In this study, an MBG with a composition, in mol%, of 80% SiO2-15% CaO-5% P2O5 (Blank, BL) was compared with two analogous glasses containing 4% and 5% of ZnO (4ZN and 5ZN) before and after impregnationwith osteostatin, a C-terminal peptide froma parathyroid hormone-related protein (PTHrP107-111). Zn2+> ions were included in the glass for their bone growth stimulator properties, whereas osteostatin was added for its osteogenic properties. Glasses were characterized, and their cytocompatibility investigated, in pre-osteoblastic MC3T3-E1 cell cultures. The simultaneous additions of osteostatin and Zn2+> ions provoked enhanced MC3T3-E1 cell viability and a higher differentiation capacity, compared with either raw BL or MBGs supplemented only with osteostatin or Zn2+>. These in vitro results show that osteostatin enhances the osteogenic effect of Zn2+>-enriched glasses, suggesting the potential of this combined approach in bone tissue engineering applications. [ABSTRACT FROM AUTHOR]

Published
2018
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38. Role of the Short Distance Order in Glass Reactivity.

Author

Vallet-Regi, María and Salinas, Antonio J.

Subjects
*BIOACTIVE glasses, *REACTIVITY (Chemistry), *NANOSTRUCTURED materials, *SOL-gel processes, *SIMULATION methods & models, *NUCLEAR magnetic resonance spectroscopy
Abstract

In 2005, our group described for the first time the structural characterization at the atomic scale of bioactive glasses and the influence of the glasses' nanostructure in their reactivity in simulated body fluids. In that study, two bioactive sol-gel glasses with composition 80%SiO2-20%CaO and 80%SiO2-17%CaO-3%P2O5 (in mol-%) were characterized by High-Resolution Transmission Electron Microscopy (HRTEM). Such characterization revealed unknown features of the glasses' structure at the local scale that allowed the understanding of their different in vitro behaviors as a consequence of the presence or absence of P2O5. Since then, the nanostructure of numerous bioactive glasses, including melt-prepared, sol-gel derived, and mesoporous glasses, was investigated by HRTEM, Nuclear Magnetic Resonance (NMR) spectroscopy, Molecular Dynamics (MD) simulations, and other experimental techniques. These studies have shown that although glasses are amorphous solids, a certain type of short distance order, which greatly influences the in vitro and in vivo reactivity, is always present. This paper reviews the most significant advances in the understanding of bioactive glasses that took place in the last years as a result of the growing knowledge of the glasses' nanostructure. [ABSTRACT FROM AUTHOR]

Published
2018
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39. Highly-Bioreactive Silica-Based Mesoporous Bioactive Glasses Enriched with Gallium(III).

Author

Sanchez-Salcedo, Sandra, Malavasi, Gianluca, Salinas, Antonio J., Lusvardi, Gigliola, Rigamonti, Luca, Menabue, Ledi, and Vallet-Regi, Maria

Subjects
SILICA, MESOPOROUS materials, BIOACTIVE compounds, GALLIUM, GLASS, BONE cells, ANTIBACTERIAL agents
Abstract

Beneficial effects in bone cell growth and antibacterial action are currently attributed to Ga3+ ions. Thus, they can be used to upgrade mesoporous bioactive glasses (MBGs), investigated for tissue engineering, whenever they released therapeutic amounts of gallium ions to the surrounding medium. Three gallium-enriched MBGs with composition (in mol %) xSiO2-yCaO-zP2O5-5Ga2O3, being x = 70, y = 15, z = 10 for Ga_1; x = 80, y = 12, z = 3 for Ga_2; and x = 80, y = 15, z = 0 for Ga_3, were investigated and compared with the gallium-free 80SiO2-15CaO-5P2O5 MBG (B). 29Si and 31P MAS NMR analyses indicated that Ga3+ acts as network modifier in the glass regions with higher polymerization degree and as network former in the zones with high concentration of classical modifiers (Ca2+ ions). Ga_1 and Ga_2 exhibited a quick in vitro bioactive response because they were coated by an apatite-like layer after 1 and 3 days in simulated body fluid. Although we have not conducted biological tests in this paper (cells or bacteria), Ga_1 released high but non-cytotoxic amounts of Ga3+ ions in Todd Hewitt Broth culture medium that were 140 times higher than the IC90 of Pseudomonas aeruginosa bacteria, demonstrating its potential for tissue engineering applications. [ABSTRACT FROM AUTHOR]

Published
2018
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47. Nanostructure and Bioactivity of Hybrid Aerogels

Author

Salinas, Antonio J., primary, Vallet-Regí, María, additional, Toledo-Fernández, José A., additional, Mendoza-Serna, Roberto, additional, Piñero, Manuel, additional, Esquivias, Luis, additional, Ramírez-Castellanos, Julio, additional, and González-Calbet, José M., additional

Published
2008
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