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In the present investigation, spray drying independent operating conditions such as the inlet air temperature (A-IAT 130, 150 and 170 °C), outlet air temperature (B-OAT 60, 70 and 80 °C), needle speed (C-NS 3S, 4S, 5S), maltodextrin concentration (D-MD 10, 15, 20 %), pump speed (E-PS 5, 10, 15 mL/min) and water/grape pomace ratio (F-W/GP ratio 10, 15, 20) were optimized to develop the spray-dried grape pomace powder (SDGPP) with maximum yield. The impact of these conditions on total phenolic contents (TPC), total flavonoid contents (TFC), and antioxidant activity (DPPH· values) of SDGPP samples were analyzed. The independent spray drying factors (IAT, OAT, NS, MD, PS, and W/GP ratio) impart a strong direct effect (p ≤ 0.05) on powder yield, TPC, TFC, and DPPH· values. The interaction effects (A × B, A × C, A × D, A × E, A × F, B × C, B × D, B × E, B × F, C × D, C × E, C × F, D × E, D × F, and E × F) of independent variables were noted non-significant (p ≥ 0.05) for response values. After validation of the model and verification of results, the independents' variables were found in the range of 170 °C (IAT), 80 °C (OAT), 4S (NS), 15 % (MD), 10 mL/min (PS) and 15 (W/GP ratio) for yield (64.7 ± 1.18 %), TPC (7.66 ± 0.53 mg GAE/g), TFC (3.19 ± 0.30 mg CE/g) and DPPH· 140.3 ± 1.59 (100 µL/mL), respectively. The decrease in TPC, TFC, and DPPH· values of SDGPP samples was noted during 60 days of storage at 25 ± 2 °C and 65 ± 5 % RH (p ≤ 0.05) but not greater than unprocessed samples. It could be concluded that the protection of phenolic contents and retention of antioxidant activity of dried powders can be achieved at optimized spray drying conditions for discerning food and byproduct processing industries. [Display omitted] • Spray drying of phenolics rich grape pomace is a promising method for encapsulation. • Interaction for spray drying independent factors was optimized for pomace powder. • The quality of raw and spray-dried grape pomace was evaluated during storage. [ABSTRACT FROM AUTHOR]

[Display omitted] Mesoporous aluminosilicates Al-SBA-15 with large pore sizes and suitable acid properties are promising substitutes to zeolites for catalytic cracking of bulky hydrocarbons without molecular diffusion limitation. The conventional processes to synthesize Al-SBA-15 are time-consuming and often suffer from low "framework" Al contents. Herein, Al-SBA-15 microspheres are synthesized using the rapid and scalable microfluidic jet spray drying technique. They possess uniform particle sizes (45–60 μm), variable surface morphologies, high surface areas (264–340 m2/g), uniform mesopores (3.8–4.9 nm) and rich acid sites (126–812 μmol/g) and high acid strength. Their physicochemical properties are compared with the counterparts synthesized using traditional hydrothermal and evaporation-induced self-assembly methods. The spray drying technique results in a higher incorporation of aluminum (Al) atoms into the silica "framework" compared to the other two methods. The catalytic cracking efficiencies of 1,3,5-triisopropylbenzene (TIPB) on the Al-SBA-15 materials synthesized using the three different methods and nanosized ZSM-5 are compared. The optimal spray-dried Al-SBA-15 exhibits the best performance with 100 % TIPB conversion, excellent selectivity (about 75 %) towards the formation of deeply cracked products (benzene and propylene) and high stability. The catalytic performances of the spray-dried Al-SBA-15 with varying Si/Al ratios are also compared. The reasons for the different performances of the different materials are discussed, where the mesopores, high acid density and strength are observed to play the most critical role. This work might provide a basis for the synthesis of mesoporous rich metal-substituted silica materials for different catalytic applications. [ABSTRACT FROM AUTHOR]

Jasmine rice leaves extract contains a high number of beneficial flavonoids that have antioxidative, anticancer, and anti-inflammatory properties. The extract has a short shelf-life due to high water activity. The powder form of the extract is convenient to handle and has a longer shelf-life. This study demonstrates an optimization of the microencapsulation process for protecting flavonoids from jasmine rice leaves extract by varying coating materials (maltodextrin, gum Arabic and chitosan) and spray drying conditions that are resulting in high yield and bioactivity. Physical and bio-chemical properties of jasmine rice extract microcapsules from different drying conditions (150–190 °C) also examined and compared to lead to the selection of a suitable coating material and spray drying condition. The results revealed the high potential of using gum Arabic to coat rice leaves extract at a 1:7.5 ratio under spray drying at 190 °C for the best retaining of bioactive compounds, and antioxidant activity. [ABSTRACT FROM AUTHOR]

This study investigates the encapsulation of Tenebrio molitor hydrolysate exhibiting DPP-IV inhibitory activity by spray-drying and electrospraying techniques. First, we optimized the feed formulation and processing conditions required to obtain nano-microcapsules by electrospraying when using Arabic gum as an encapsulating agent and pullulan and Tween 20 as additives. The optimum formulation was also dried by spray-drying, where the removal of the additives was also assayed. Morphology analysis reveals that electrosprayed capsules have a smaller size (1.2 ± 0.5 µm vs. 12.4 ± 8.7 µm) and greater uniformity compared to those obtained by spray-drying. Regarding the surface nitrogen content and DPP-IV inhibitory activity, our results show no significant difference between the electrosprayed capsules and spray-dried capsules containing additives (IC50 of ~1.5 mg protein/mL). Therefore, it was concluded that adding additives during spray-drying allows for a similar encapsulation efficiency and reduced degradation during processing, as achieved by electrospraying technique but providing higher productivity. On the other hand, spray-dried capsules without additives displayed a higher surface nitrogen content percentage, which was mainly due to the absence of Tween 20 in the feed formulation. Consequently, these capsules presented a higher IC50 value (IC50 of 1.99 ± 0.03 mg protein/mL) due to the potential degradation of surface-exposed peptides. [ABSTRACT FROM AUTHOR]

BACKGROUND: Human milk fat analog emulsion (HMFAE) is an emulsion that mimics the composition and structure of human milk (HM) fat globules. The application of HMFAE in infant formula requires a series of milk powder processing steps, such as pasteurization and spray drying. However, the effect of milk powder processing on fat digestion of HMFAE is still unclear. In this study, the influence of pasteurization and spray drying on the lipolysis behavior of HMFAE was studied and compared with HM using a simulated infant in vitro digestion model. RESULTS: Pasteurization and spray drying increased the flocculation and aggregation of lipid droplets in HMFAE during digestion. Spray drying destroyed the lipid droplet structure of HMFAE, and partial milk fat globule membrane‐covered lipid droplets turned into protein‐covered lipid droplets, which aggravated lipid–protein aggregation during gastric digestion and hindered fat digestion in the small intestine. The final lipolysis degree was in the order HM (64.55%) > HMFAE (63.41%) > pasteurized HMFAE (61.75%) > spray‐dried HMFAE (60.57%). After complete gastrointestinal digestion, there were no significant differences in free fatty acid and sn‐2 monoacylglycerol profile among the HMFAE, pasteurized HMFAE, and spray‐dried HMFAE. CONCLUSION: Milk powder processing can reduce lipolysis by altering the lipid droplet structure of HMFAE and the degree of lipid droplet aggregation during digestion. © 2024 Society of Chemical Industry. [ABSTRACT FROM AUTHOR]

To ensure the high quality of biopharmaceutical products, it is imperative to implement specialized unit operations that effectively safeguard the structural integrity of large molecules. While lyophilization has long been a reliable process, spray drying has recently garnered attention for its particle engineering capabilities for the pulmonary route of administration. However, maintaining the integrity of biologics during spray drying remains a challenge. To address this issue, we explored a novel dehydration system based on aerosol-assisted room-temperature drying of biological formulations recently developed at Princeton University, called Rapid Room-Temperature Aerosol Dehydration. We compared the quality attributes of the bulk powder of biopharmaceutical products manufactured using this drying technology with that of traditional spray drying. For all the fragment antigen-binding formulations tested, in terms of protein degradation and aerosol performance, we were able to achieve a better product quality using this drying technology compared to the spray drying technique. We also highlight areas for improvement in future prototypes and prospective commercial versions of the system. Overall, the offered dehydration system holds potential for improving the quality and diversity of biopharmaceutical products and may pave the way for more efficient and effective production methods in the biopharma industry. [ABSTRACT FROM AUTHOR]

High-quality baijiu yeast – modified Sporidiobolus johnsonii A (MSJA) suffers from the problem of weak vitality, thus failing to combine high efficiency and high survival rate drying. Therefore, in this study, we firstly designed a real-time sampling experiment of MSJA spray drying process, and based on this, we established a New CFD model (N-CFD model) that can accurately simulate the variation of the spray drying process of microorganisms such as MSJA. Then, a new spray drying air inlet mechanism of "high-temperature cyclone in the center L-type guide plate + medium-temperature laminar flow in the peripheral holes and slots" was invented. Finally, the parametric scanning simulation was carried out to optimize the flow angle θ of the L-type guide plate using the N-CFD model. The results show that, firstly, the N-CFD model can accurately simulate the temperature distribution (P1 = 0.05) and the motion of drying particles in the drying tower. Secondly, the optimized new air inlet mechanism with the L-type guide plate flow angle θ = 47° can even out the temperature and particle distribution in the drying tower, which meets the "two-stage theory of spray drying." Finally, under the premise of ensuring the drying efficiency, the survival rate of MSJA spray drying was increased from 42.6% to 82.24%, which achieved the objectives of low sticking wall, high efficiency and high survival rate of spray drying MSJA. [ABSTRACT FROM AUTHOR]

The objective of this investigation was to evaluate the influence of two carrier agents, Nopal and Aloe Vera mucilage on the physicochemical properties and stability of blackberry and raspberry powders obtained by spray drying. A pilot scale spray dryer with a feed flow of 20 L/h and an atomization speed of 28,000 rpm was used. The inlet and outlet air temperatures were from 180 to 80 °C, respectively. Yield, moisture content, water activity, hygroscopicity index, solubility time, volumetric density, stability diagrams, micrographs, and particle temperature were evaluated. The highest yields for blackberry extract were 75% with a concentration of 2.5% (w/v) Nopal mucilage, while raspberry extract yielded 65% with a concentration of 5% (w/v) Nopal mucilage. The increase in the concentration of the carrier agent presented an increase in the values of humidity, water activity, volumetric density, and solubility when Nopal mucilage was used as a carrier agent in both blackberry and raspberry extracts. Furthermore, when Aloe Vera mucilage was used as a carrier agent, these same values decreased with increasing concentration. The storage conditions of the powders obtained should be stored at temperatures below 20°C and water activities below 0.4. In addition, the stability diagrams show the particle conditions that should not be exceeded during spray drying. [ABSTRACT FROM AUTHOR]

Lactobacillus delbrueckii subsp. bulgaricus and Lactiplantibacillus plantarum are two lactic acid bacteria (LAB) widely used in the food industry. The objective of this work was to assess the resistance of these bacteria to freeze- and spray-drying and study the mechanisms involved in their loss of activity. The culturability and acidifying activity were measured to determine the specific acidifying activity, while membrane integrity was studied by flow cytometry. The glass transitions temperature and the water activity of the dried bacterial suspensions were also determined. Fourier transform infrared (FTIR) micro-spectroscopy was used to study the biochemical composition of cells in an aqueous environment. All experiments were performed after freezing, drying and storage at 4, 23 and 37 °C. The results showed that Lb. bulgaricus CFL1 was sensitive to osmotic, mechanical, and thermal stresses, while Lpb. plantarum WCFS1 tolerated better the first two types of stress but was more sensitive to thermal stress. Moreover, FTIR results suggested that the sensitivity of Lb. bulgaricus CFL1 to freeze-drying could be attributed to membrane and cell wall degradation, whereas changes in nucleic acids and proteins would be responsible of heat inactivation of both strains associated with spray-drying. According to the activation energy values (47–85 kJ/mol), the functionality loss during storage is a chemically limited reaction. Still, the physical properties of the glassy matrix played a fundamental role in the rates of loss of activity and showed that a glass transition temperature 40 °C above the storage temperature is needed to reach good preservation during storage. Key points: • Specific FTIR bands are proposed as markers of osmotic, mechanic and thermal stress • Lb. bulgaricus CFL1 was sensitive to all three stresses, Lpb. plantarum WCFS1 to thermal stress only • Activation energy revealed chemically limited reactions ruled the activity loss in storage [ABSTRACT FROM AUTHOR]

This study assessed the effect of whey protein isolate (WPI) and its coconut oil complexes (CO-WPI) on the viability of Limosilactobacillus reuteri KUB-AC5 during spray drying and storage. Varied CO concentrations (0%, 4%, and 8%, w/w) and spray drying temperatures (110 °C and 130 °C) influenced secondary structures, free sulfhydryl groups, disulfide bonds, and DPPH• and ABTS•+ scavenging activities of WPI. Throughout the spray drying and storage processes, CO-WPI effectively reduced lipid peroxidation in the probiotic membranes, as detected by advanced 1H-nuclear magnetic resonance, compared to WPI alone. Microencapsulation in 4CO-WPI at 110 °C provided the highest cell viability during drying (1.34 × 1011 CFU g−1), coupled with the highest cholesterol assimilation (58.43%). After 12 months at 4 °C, viability remained high (5.57 × 1010 CFU g−1). This study demonstrated CO-WPI's potential in reducing oxidative damage and improving probiotic survival, highlighting its efficacy as a microencapsulant in spray drying. [ABSTRACT FROM AUTHOR]

Biotechnological and pharmaceutical processes based on bacteria require an inoculum with high long-term viability. In order to provide a stabilized bacterial culture for biodegradation of ammonia and ammonium, the model species Kocuria rhizophila DSM 348 was spray-dried using different protective agents. Providing a medium with 200 g/L skimmed milk powder (SMP) and 12.5 g/L monosodium L-glutamate (MSG) resulted in a survival rate of 99.1% ± 3.6% immediately after spray drying, whereas 200 g/L trehalose and 12.5 g/L MSG led to a lower viability (34.7% ± 5.9%). A reference medium with phosphates (7 g/L KH2PO4 + 7 g/L K2HPO4) accomplished a survival rate of 9.8% ± 2.9%. Long-term experiments confirmed high viability of spray-dried bacteria after 52 weeks at 4 °C with less than 1 log-reduction compared to the first day of storage, resulting in powders with at least 1010 CFU/g. [ABSTRACT FROM AUTHOR]

Background. Amoxicillin trihydrate possesses poor solubility, compressibility, and flow behavior. Amorphous solid dispersion prepared by spray drying could solve all three problems at the same time. Objective. To prepare amorphous solid dispersion after screening of polymers by solvent casting method using a spray drying method. Methods. The solvent casting method was used to screen polymers, PVP/VA S-630, PVP K30, Soluplus, PEG 4000, HPMC AS, and HPMC HP55, in 1 : 1 and 2 : 3 ratios and followed by spray drying after polymer selection. Results. The dissolution performance of the formulation improved with time. The optimum feed rate and feed concentration were found to have an impact on the flow properties and particle size of spray-dried formulations, and they were selected as independent variables in a 32 full factorial statistical design. The ANOVA and regression analysis suggest that the developed regression model has a significant overall fit to the data and can explain a substantial proportion of the variability in the dissolution at 10 minutes. The optimized batch was selected based on the decisive factors of minimum and maximum values of response variables. Overall, the optimized batch demonstrated improved characteristics in terms of percentage yield (32.81%), dissolution at 10 min (49.70%), and angle of repose at 31.42°. Conclusion. This study provides valuable insights into optimizing formulation strategies for preserving the amorphous state of drugs and contributes to the development of stable pharmaceutical formulations. [ABSTRACT FROM AUTHOR]

In this study, a new micro delivery system based on an anionic methacrylate copolymer, able to improve the biological response of myo-inositol by daily oral administration, was manufactured by spray-drying. It has an ideal dose form for oral administration, with an experimental drug loading (DL)% of 14% and a regulated particle size of less than 15 µm. The new formulation features an improvement on traditional formulations used as a chronic therapy for the treatment of polycystic ovary syndrome. The microparticles' release profile was studied and ex vivo porcine intestinal mucosa permeation experiments were performed to predict potential improvements in oral absorption. Batch n. 3, with the higher Eudragit/MI weight ratio (ratio = 6), showed the best-modified release profiles of the active ingredient, ensuring the lowest myo-inositol loss in an acidic environment. The in vivo evaluation of the myo-inositol micro delivery system was carried out in a rat animal model to demonstrate that the bioavailability of myo-inositol was increased when compared to the administration of the same dosage of the pure active ingredient. The AUC and Cmax of the loaded active molecule in the micro delivery system was improved by a minimum of 1.5 times when compared with the pure substance, administered with same dosage and route. Finally, the increase of myo-inositol levels in the ovary follicles was assessed to confirm that a daily administration of the new formulation improves myo-inositol concentration at the site of action, resulting in an improvement of about 1.25 times for the single administration and 1.66 times after 7 days of repeated administration when compared to pure MI. [ABSTRACT FROM AUTHOR]

Spray drying (SD) and freeze drying (FD) represent common methods utilized across various industries to achieve powdered final products. Electrostatic spray drying (ESD) is an emerging alternative as a continuous process to dry sensitive products without degradation, challenging the established drying techniques. This study aims to explore the efficacy of this process (ESD) in preserving the integrity of active components like oils, lactic acid bacteria (LAB), and enzymes. Additionally, a life cycle assessment (LCA) of these three drying technologies was conducted for a comprehensive evaluation. In oil encapsulation, the study showed that oxidation was significantly influenced by the formulation and the drying processes employed, where higher encapsulation efficiency resulted in lower degradation. This was observed, for instance, in the saponin composition dried with ESD. For LAB encapsulation, the results demonstrated higher preservation using FD and ESD. However, the impact of climate change using FD is twice superior to the ESD process. Finally, for enzyme application, β-gal activity was retained maximally while encapsulating using skim milk or maltodextrin. Specifically, regardless of drying technique, maltodextrin exhibited a maximum retention of β-gal activity, exceeding 30%. In all the case studies, ESD proved to excel in encapsulating thermosensitive actives, highlighting superior retention of native viability and properties compared to SD. Additionally, ESD generated results comparable to those achieved with FD. Therefore, ESD appears to be a promising method for high powder quality and a more sustainable process than FD and SD. [Display omitted] • Introduction of ESD compared to SD & FD was performed. • Effects of formulation and scales were studied. • LCA was conducted to evaluate powder production scenarios. • ESD was the most efficient to encapsulate thermosensitive active. [ABSTRACT FROM AUTHOR]

In the frame of this work, the experimental analysis of the reconstitution properties, sorption isotherms and the Fourier-transform infrared spectroscopy (FTIR) spectra of maltodextrin powder was carried out. Before the analysis the substance was dried by standard spray drying method or flame spray drying (FSD). During the analyses, the influence of the applied FSD parameters on the analyzed properties was also estimated. The powders dried using the standard spray dryer were characterized by a better wettability parameter, which was related to a high bulk density. A shorter solubility time was obtained for powders dried by the FSD method, which may be explained by the larger particle diameters. Analyzing maltodextrin powders dried with the FSD, a significant influence of the atomization pressure and particle size on the wettability parameter was found. Application of FSD method does not affect the sorption characteristics of maltodextrin and does not change significantly the chemical structure of the material, since characteristic peaks of FTIR spectra were preserved after the FSD. [ABSTRACT FROM AUTHOR]

The objective of this paper was to evaluate the effect of spray drying (SD), spray freeze‐drying (SFD), freeze‐drying (FD), and microwave freeze‐drying (MFD) on the characteristics of fish oil (FO) microcapsules. The physicochemical properties, morphology, fatty acid composition, and stability of the microcapsules were analyzed. The encapsulation efficiencies of microcapsules dried by SD, SFD, FD, and MFD were 86.98%, 77.79%, 63.29%, and 57.89%, respectively. SD microcapsules exhibited superior properties in terms of effective loading capacity, color, and flowability. Conversely, SFD microcapsules demonstrated improved solubility. Microencapsulation positively affected the thermal stability of FO, but the content of unsaturated fatty acids decreased. The findings from the storage experiment indicated that the oxidative stability of SD fish oil microcapsules was marginally lower compared to microcapsules produced through three alternative drying techniques, all of which were based on the FD concept. The comparison of various drying methods and their effects on the quality of FO microcapsules offers valuable insights that can serve as a foundation for the industrial production of high‐quality microcapsules. [ABSTRACT FROM AUTHOR]

The development of an inhalation powder (IP) for cancer therapy is desired to improve the therapeutic response and patient compliance. The latest studies highlighted that statins, a class of drugs used in hypercholesterolemia, can have anticancer and antiinflammatory properties. Therefore, the aim of the study was to develop an IP containing liposomes loaded with simvastatin using spray drying technology, as well as to investigate the influence of formulation factors on the quality attributes of the IP by means of experimental design. Results highlighted that the composition of liposomes, namely type of phospholipid and cholesterol concentration, highly influences the quality attributes of IP, and the use of optimal concentrations of excipients, i.e. D-mannitol and L-leucine, is essential to preserve the characteristics of liposomes throughout the spray drying process. The in vitro characterization of the optimal IP formulation revealed that the total percentage of released drug is higher from the IP formulation compared to the powder of active substance (53.38 vs. 42.76%) over a period of six hours, and 39.67% of dry particles have a size less than 5 µm, making them suitable for inhalation. As a conclusion, spray drying technology can be effectively used in the development and preparation of IP containing liposomes. [ABSTRACT FROM AUTHOR]

A simple and scalable approach to fabricate monodispersed Si 3 N 4 hollow microspheres (Si 3 N 4 HMs) with uniform spherical structures is proposed in this study. This approach involves spray drying of Si 3 N 4 precursor, followed by carbothermal reduction nitridation. The homogeneous Si 3 N 4 precursor was first obtained by mixing phenolic resins and silicon resins, which are carbon and silicon sources, respectively. The spray drying process was then tuned by regulating the viscosity of the precursor by adding polyvinyl butyral in an appropriate ratio. Next, the hollow precursor microspheres were pyrolyzed at 1500 °C for 6 h, while ensuring that the shells of the obtained Si 3 N 4 HMs remained intact. Porous Si 3 N 4 ceramics with different contents of Si 3 N 4 HMs were then prepared using the gel-casting method. It was observed that the densities and dielectric constants of the porous Si 3 N 4 ceramics decreased with an increasing Si 3 N 4 HMs content. Thus, the proposed approach can be used for the synthesis of Si 3 N 4 HMs, that can be further processed into ceramic materials with both low densities and dielectric constants. [ABSTRACT FROM AUTHOR]

Spray drying is a process that involves instantaneous conversion of a liquid or slurry into a free‐flowing powder in the presence of hot air or nitrogen gas current in a drying chamber. The technique is usually used to encapsulate active molecules like essential oils, plant extracts, fragrances, flavours and enzymes within a wall material. The encapsulation provides chemical and physical stability to the actives by converting them into free‐flowing powders which prevents their susceptibility to external atmospheric conditions like temperature, humidity, UV exposure and chemical oxidation. Spray drying encapsulation has an edge over other encapsulation techniques because it is fast, simple, efficient and economically feasible. The article focuses on encapsulating various essential oils within natural polymers and emulsifiers by spray drying methods to form stable microcapsules. The review also provides information on different types of spray drying equipment and process parameters like the type of atomiszer and nozzles, inlet–outlet temperature and type of cyclones. All the process parameters and materials are found to influence the physicochemical properties of the microencapsulates of essential oils. The review also discusses the effects of process parameters and materials on the encapsulation efficiency, moisture content, bulk and tapped density, agglomeration properties and thermal stability of the microencapsulates. Thus, the consolidated review will provide an overview of various optimization parameters and governing factors for obtaining microencapsulates of essential oils. [ABSTRACT FROM AUTHOR]

The process of drying probiotic bacteria to enhance their storage stability is important for the food industry. This study aimed to assess the efficacy of various drying techniques and food-grade protectants in preserving the viability of Bifidobacterium animalis subsp. lactis KMP H9-01 during drying and under prolonged storage conditions. Among the four protectants tested (skim milk, trehalose, sucrose, and maltodextrin), trehalose and skim milk at 5% (w/v) were selected for freeze- and spray-drying, each conducted at different temperatures. This evaluation encompasses survivability and the observation of the shelf life of probiotic powders. The results demonstrated that spray-drying at 160 °C/80 °C, with either skim milk or trehalose as a protectant, yielded the highest viable cell counts (>log 7 CFU/g) even after 6 months of storage at room temperature in the range of 25–30 °C, regardless of the use of vacuum and nonvacuum packaging. Notably, the calculated inactivation rate values (KRT) demonstrated remarkable stability, ranging from 5.36 × 10−2 to 5.82 × 10−2 day−1. Furthermore, the decimal reduction time (DRT) values predicted that a 90% reduction in probiotic cell number would require approximately 1.3 to 1.4 months at room temperature. [ABSTRACT FROM AUTHOR]

BACKGROUND: Sour cherry juice concentrate powder can serve as a modern, easy‐to‐handle, phenolics‐rich merchandise; however, its transformation into powdered form requires the addition of carriers. In line with the latest trends in food technology, this study valorizes the use of dairy by‐products (whey protein concentrate, whey, buttermilk, and mixes with maltodextrin) as carriers. A new multiple approach for higher drying yield, phenolics retention (phenolic acids, flavonols and anthocyanins) and antioxidant capacity of powders were tested as an effect of simultaneous decrease of drying temperature due to the drying air dehumidification and lower carrier content. RESULTS: Dairy‐based carriers were effective for spray drying of sour cherry‐juice concentrate. The drying yield was increased and retention of phenolics was higher when compared with maltodextrin. The application of dehumidified air, which enabled the drying temperature to be reduced, affected drying yield positively, and also affected particle morphology and retention of phenolics (the phenolic content was approximately 30% higher than with spray drying). CONCLUSIONS: The study proved that it is possible to apply dairy‐based by‐products to produce sour cherry juice concentrate powders profitably, lowering the spray‐drying temperature and changing the carrier content. Dehumidified air spray drying can be recommended for the production of fruit juice concentrate powders with improved physicochemical properties. © 2023 Society of Chemical Industry. [ABSTRACT FROM AUTHOR]

Essential oils (EOs) have many beneficial qualities, including antimicrobial, antioxidant, antiviral, and antifungal activities, along with good aroma, which have played a significant role in pharmaceutical, textile, and food industries. However, their high volatility and sensibility to external factors, as well as susceptibility to deterioration caused by environmental and storage conditions, or even common processing, and consequently limited water solubility, makes it difficult to incorporate them into aqueous food matrices and limits their industrial application. Spray-drying encapsulation has been proposed as a solution and a challenging research field to retard oil oxidation, extend EO's shelf life, improve their physicochemical stability, achieve controlled release, suggest novel uses, and therefore boost their added value. The objective of this review is to discuss various used wall materials, infeed emulsion properties, the main formulation and process variables affecting the physicochemical properties and release characteristics of the EOs-loaded particles obtained by spray-drying, the stability of EOs during storage, and the applications of encapsulated EOs powders in foods and nutrition, pharmaceuticals, and textile industries. The current review also summarizes recent advances in spray drying approaches for improving encapsulation efficiency, flavor retention, controlled release, and applicability of encapsulated EOs, thereby expanding their use and functionalities. [ABSTRACT FROM AUTHOR]

Jinicuil seed starch (JSS) was partially characterized and then evaluated as wall material. JSS showed higher content of proteins, lipids, and resistant starch than commercial corn starch (CCS). JSS granules presented both oval-spherical shapes and heterogeneous sizes (~1–40 µm) and exhibited a crystallinity lower than CCS with an A-type X-ray diffraction pattern. Both gelatinization peak and final viscosity values in the pasting profile were higher in JSS than in CCS. At 90 °C, the water solubility was 22% and the swelling power was 17 g g−1. Under refrigeration and freeze-thaw, the JSS gel showed high stability. JSS showed a significant presence of protein and small particles; therefore, it was evaluated as wall material in spray drying. The results showed the formation of spherical aggregates and encapsulation efficiencies of L-ascorbic acid of 14.97–81.84%, with process yields of 19.96–27.64%, under the conditions evaluated. JSS has a potential application in the food industry but also as wall material for microencapsulation by spray drying. [ABSTRACT FROM AUTHOR]

This study investigated the influence of gas-injected nanobubbles on the morphology of particles during spray drying under various experimental conditions. The nanoparticle tracking system was used to measure the generation, size, and concentration of nanobubbles. Experiments were conducted at different temperatures (160°C–260°C) and feed rates (0.2–0.26 g/s) to examine the effect of nanobubbles on spray drying and present diverse results. The deionized (DI) water with generated nanobubbles had a particle concentration of 1.8 × 108 particles/mL and a mean particle size of 242.6 nm, which was ∼3.31 × 107 particles/mL higher untreated DI water. The maltodextrin solution containing nanobubbles also showed a significant increase in particle generation, with a concentration of 1.62 × 109 particles/mL. The viscosity of the maltodextrin solution containing nanobubbles decreased by ∼18%, from 9.3 mPa·s to 7.5 mPa·s. Overall, the size of the generated particles was similar regardless of nanobubble treatment, but there was a tendency for particle size to increase under specific temperature (260°C) and feed flow rate (0.32 g/s) conditions. Furthermore, it was observed that the Hausner ratio significantly varied with increasing temperature and feed flow rate, and these results were explained through scanning electron microscopy images. These findings confirm that the gas nanobubbles mixed in the feed can exert diverse effects on the spray drying system and powder characteristics depending on the operating conditions. This study suggests that nanobubbles can contribute to a more efficient process in spray drying and can influence the morphological characteristics of particles depending on the spray drying conditions. [ABSTRACT FROM AUTHOR]

This work aimed to reduce the loss of thermally unstable nutrients during the powder production process using closed-loop spray drying using an innovative carrier, coconut husk powder. β-carotene was selected as the subject of this study because it decomposes easily, but it is essential for the human body. The use of coconut husk powder as the carrier achieved an excellent powder recovery rate (RR) and β-carotene concentration compared with whey protein isolate, maltodextrin, cellulose, pectin, casein, and other commonly used carriers. The optimal outlet air temperature for spray drying was also found to be 50-55 °C. Coconut husk powder showed an excellent powder recovery rate (84%) and concentration (0.32 mg/g), which is high compared with the other carriers, because of its multi-layered spherical structure. The coconut powder also increased the stability of β-carotene. After being exposed to a temperature of 85 °C for 6 h, coconut husk powder was more resistant to high temperatures than maltodextrin. [ABSTRACT FROM AUTHOR]

Summary: Preserving food products from oxidation improves their quality and stability. This study compares the effects of storage on L‐theanine, caffeine, moisture content and antioxidant activity of spray‐dried and freeze‐dried white tea infusions. The antioxidant activities of both dried infusions were restored over a 60‐day storage. On Day 60, the L‐theanine and caffeine levels of the freeze‐dried samples were respectively 1.45 ± 0.03 mg mL−1 and 2.23 ± 0.04 mg mL−1 compared with 1.16 ± 0.03 mg mL−1 and 1.97 ± 0.01 mg mL−1 on Day 0. In the spray‐dried samples, the L‐theanine was 0.32 ± 0.01 mg mL−1 on Day 60 and 0.36 ± 0.02 mg mL−1 on Day 0, while caffeine remained unchanged. Regarding undried/control samples, L‐theanine and caffeine declined from respectively 0.29 ± 0.0004 mg mL−1 and 0.33 ± 0.01 mg mL−1 on Day 0 to 0.2 ± 0.001 mg mL−1 and 0.26 ± 0.02 mg mL−1 on Day 60, associated with a decrease in DPPH activity from 75.87% (Day 0) to 15.34% (Day 60). Freeze‐drying and spray‐drying tea infusions yielded functional products with stable antioxidant activity and moisture. Both drying techniques are reliable for preserving tea preparations. [ABSTRACT FROM AUTHOR]

Summary: The present study aimed to comparatively analyse the functional properties of the spray drying particles prepared from the noble scallop (Chlamys nobilis) mantle protein‐pectin hydrated mixtures. And the microstructural characteristics of the particles were assessed by Fourier transform infrared, scanning electronic microscopy, and SDS‐PAGE to detect critical changes. The results showed that the solubility of enzymatically extracted protein was significantly improved by spray drying after pectin hydration (AP‐LMP and AP‐HMP), from 76.77% (AP) to 97.87% (AP‐LMP) and 97.13% (AP‐HMP), respectively. And the spray drying water‐extracted protein (HP) after pectin hydration (HP‐LMP and HP ‐HMP) exhibited a greater emulsifying property, from 103.10 m2/g (HP) to 145.55 ± 0.92 m2/g (HP‐LMP) and 200.29 ± 1.16 m2/g (HP‐HMP). The spray drying after pectin hydration had successfully enhanced emulsifying and rheological properties when compared with AP and HP. The results of SDS‐PAGE showed more protein participated in the formation of macromolecule and FT‐IR spectra demonstrated the formation of protein‐pectin spray drying particles facilitated not only by electrostatic interactions but also by covalent binding via Maillard reaction, made a closely compatible protein structure verified by the improvement of fluorescence intensity. This work is expected to provide a theoretical basic data for the development and application of scallop mantle extracted proteins. [ABSTRACT FROM AUTHOR]

Plant-based beverages (PBs) are currently gaining interest among consumers who are seeking alternative sustainable options to traditional dairy drinks. The study aimed to obtain powdered plant beverages without the addition of carriers by spray drying method to implement them in the future as an alternative to the liquid form of dairy drinks. Some of the most well-known commercial beverages sources like soy, almond, rice and oat were analyzed in this work. The effect of different treatments (concentration, addition of oat fiber) and two approaches od spray drying (conventional high temperature spray drying—SD, and dehumidified air spray drying at low temperature—DASD) were presented. Moreover, moisture content, water activity, particle morphology and size of obtained powders were analyzed. It was possible to obtain PBs without the addition of carriers, although the drying yield of four basic beverages was low (16.1–37.4%). The treatments and change in spray drying approach enhanced the drying yield, especially for the concentrated beverage dried using DASD (59.2%). Additionally, Fourier Transform Infrared (FTIR) spectroscopy was applied to evaluate the differences in chemical composition of powdered PBs. FTIR analysis revealed differences in the range of the absorption frequency of amide I, amide II (1700–1500 cm−1) and carbohydrate region (1200–900 cm−1). Principal component analysis (PCA) was carried out to study the relationship between spray dried plant beverages samples based on the fingerprint region of FTIR spectra, as well as the physical characteristics. Additionally, hierarchical cluster analysis (HCA) was employed to explore the clustering of the powders. [ABSTRACT FROM AUTHOR]

A fast, simple and cost-effective technique has been used to produce spray-drying porous particles of salbutamol sulfate (SS) for inhalation drug delivery. The particles were produced using water as solvent and ammonium bicarbonate as pore-forming agent. A full factorial experimental design (24) with a central point was used to evaluate the influence of process parameters (drying air inlet temperature, atomization air volume flowrate, feed volume flowrate and the pore-forming agent concentration) on process yield, moisture content, densities and particle size. In addition, particle morphology, in-vitro aerosolization properties, stability and cytotoxicity of selected samples were studied. Within the experimental design parameters window, it was shown that the highest inlet temperature and pore-forming agent concentration were the factors that more affected the process yield and tap density values. Particles with the lowest tap densities values exhibited porous morphology. In addition, the pore-forming agent concentration proved to be the most significant variable affecting particle size. The highest pore-forming agent concentration, the largest particle size. The porous particles exhibit remarkable aerosolization performance, surpassing the performance of previously reported SS porous particles and a commercial formulation. These powders showed a high process yield and the absence of ammonium bicarbonate in the final product, as confirmed by FT-IR. Furthermore, the powders presented good stability even over long periods of time and did not exhibit cytotoxicity on the murine alveolar macrophage cell line RAW 264.7. [ABSTRACT FROM AUTHOR]

Spray-drying and freeze-drying are indispensable techniques for microencapsulating biologically active compounds, crucial for enhancing their bioavailability and stability while protecting them from environmental degradation. This study evaluates the effectiveness of these methods in encapsulating Citrus x paradisi L. (grapefruit) peel extract, focusing on sustainable recovery from waste peels. Key objectives included identifying optimal wall materials and assessing each encapsulation technique's impact on microencapsulation. The investigation highlighted that the choice of wall material composition significantly affects the microencapsulation's efficiency and morphological characteristics. A wall material mixture of 17 g maltodextrin, 0.5 g carboxymethylcellulose, and 2.5 g β-cyclodextrin was optimal for spray drying. This combination resulted in a sample with a wettability time of 1170 (s), a high encapsulation efficiency of 91.41%, a solubility of 60.21%, and a low moisture content of 5.1 ± 0.255%. These properties indicate that spray-drying, particularly with this specific wall material composition, offers a durable structure and can be conducive to prolonged release. Conversely, varying the precise compositions used in the freeze-drying process yielded different results: quick wettability at 132.6 (s), a solubility profile of 61.58%, a moisture content of 5.07%, and a high encapsulation efficiency of 78.38%. The use of the lyophilization technique with this latter wall material formula resulted in a more porous structure, which may facilitate a more immediate release of encapsulated compounds and lower encapsulation efficiency. [ABSTRACT FROM AUTHOR]

Results of the experiments on drying of skin-forming material sprayed with two nozzles in counter-current pilot spray dryer are presented in the article. Phase Doppler Anemometry (PDA) measurements were conducted above, between, and below two nozzles spraying upward and downward which allowed us to track changes of particle size distribution (PSD) and particle velocities in the tower for different nozzle configurations. The analysis of PSD shows that for two nozzles pointing downwards, the drying zone was observed under the lower nozzle whereas the agglomeration zone develops between nozzles. For the upward orientation of the lower nozzle, a zone of simultaneous drying and agglomeration forms between the nozzles. Analysis of product moisture content, PSD, and bulk density showed the effect of nozzle configuration on product properties. [ABSTRACT FROM AUTHOR]

Spray drying of sugar-rich foods causes problems, related mainly to low glass transition temperature, which is manifested by high stickiness, lower drying efficiency, and yield. Thus, a number of research papers have been published recently on this topic. This study summarizes the obtained results and indicates possible future directions. The most popular method to overcome the stickiness problem is still the application of carriers. However, in addition to conventional carriers like maltodextrin and gum Arabic, novel carriers are also being tested. The carriers with additional health-promoting properties are the most interesting group. In the material-science approach the application of proteins as anti-stickiness agents can also be mentioned. Moreover, the raw materials can be modified by membrane techniques to reduce sugar content and increase glass transition temperature. In the process-based approach, the main efforts are mostly focused on decreasing of drying temperature. Currently, the use of dehumidified air has been successfully verified as a possible way to reduce drying temperature. The reduction of stickiness achieved by this method allows to minimize the amounts of carriers added into the feed before spray drying. [ABSTRACT FROM AUTHOR]

Summary: Converting craft beer to a powder form allows the concentration of phenolic and volatile compounds. In this study, craft beer was brewed in laboratory brewing equipment and converted to a powder using freeze‐drying and spray‐drying processes. When the freeze‐dried powder was dissolved in water, its physicochemical properties were identical to those of craft beer. Freeze‐drying effectively encapsulated the bioactive compounds in craft beer, with an encapsulation rate of 99.6%, which was 27.6% higher than that of spray‐drying. Headspace solid‐phase microextraction coupled to gas chromatography–mass spectrometry analysis revealed that the esters were effectively retained after freeze‐drying and had the highest retention of 90% for ethyl hexanoate, whereas spray‐drying resulted in the loss of most of the esters. Spray‐dried particles were all spherical, whereas lyophilized particles were irregularly shaped. The particle size ranged from 6.28 to 12.15 μm for spray‐dried powders and from 14.19 to 50.97 μm for lyophilized powders. The findings indicate that both encapsulation methods are effective for the preparation of craft beer powder. However, freeze‐drying can encapsulate the bioactive and volatile compounds in craft beer more effectively than spray‐drying and aid in the better retention of craft beer characteristics. [ABSTRACT FROM AUTHOR]

Cystic fibrosis is the most common autosomal recessive disease that shortens life expectancy. According to studies, approximately 60 to 70% of adult patients are infected with P. aeruginosa. The current work explores the possibility of preparing microparticles using the spray-drying and freeze-drying methods and comparing the results obtained. A combination of ivacaftor and ciprofloxacin was loaded in microparticles of bovine serum albumin with Lleucine by the spray drying and freeze drying approaches to generate microparticles that could be delivered via a dry powder inhaler. The spray-dried microparticles had a particle size of 1.6 ± 0.04 µm with a polydispersity ratio of 0.33. They had a zeta potential of -27.3 ± 1.1 mV. The mass median aerodynamic diameter of the spray-dried microparticles was 3.74 ± 0.08 µm. The freeze-dried microparticles had a particle size of 0.8175 ± 5.6 µm with a polydispersity ratio of 0.33. They had a zeta potential of -23.3 ± 1.1 mV. The mass median aerodynamic diameter of the microparticles was 3.75 ± 0.07 µm. The microparticles produced by the spray-drying process were found to have better aerosol performance. [ABSTRACT FROM AUTHOR]

This study aimed to characterize and microencapsulate soybean seed coats phenolic compounds by spray‐drying, evaluating physicochemical properties and storage stability. Different extraction methodologies were used to obtain crude extract (SCE), ethyl acetate fraction, water fraction, and bound phenolic extract. Extraction yield, total phenolic and flavonoid contents, and antioxidant capacity were determined. HPLC–electrospray ionization source‐MS/MS analysis was performed on SCE. Microencapsulation by spray‐drying of SCE incorporating 10%, 20%, and 30% maltodextrin (MD) was carried out. Drying yield (DY), encapsulation efficiency (EE), moisture, morphology and particle size, dry, and aqueous storage stability were evaluated on the microcapsules. SCE had 7.79 g/100 g polyphenolic compounds (mainly isoflavones and phenolic acids) with antioxidant activity. Purification process by solvent partitioning allowed an increase of phenolic content and antioxidant activity. Microcapsules with 30% MD exhibited the highest DY, EE, and stability. Microencapsulated polyphenolic compounds from soybean seed coats can be used as functional ingredients in food products. Practical Application: Soybean seed coat is a usually discarded agro‐industrial by‐product, which presents antioxidant compounds of interest to human health. These compounds are prone to oxidation due to their chemical structure; therefore, microencapsulation is a viable and reproducible solution to overcome stability‐related limitations. Microencapsulation of soybean seed coats polyphenols is an alternative which protects and extends the stability of phenolic compounds that could be potentially incorporated into food products as a natural additive with antioxidant properties. [ABSTRACT FROM AUTHOR]

Spray drying is a widely used technique for production of milk powder. This is a high level energy consumption process. There are scanty published studies on single-stage spray drying plant for skim milk powder production. In this study, thermodynamic analyses, i.e., energy and exergy analyses and exergoeconomic analysis of single stage spray drying unit has been executed for skim milk powder production. The analyzed parameters are specific exergy destruction ratio, exergy efficiency, relative irreversibility factor, energy improvement potential, exergy improvement potential, specific energy destruction ratio, energy efficiency, and relative energy destruction ratio. The energy and exergy equations were used for computation of these parameters. The energy efficiency and exergy efficiency of plant were computed as 89.63 and 49.19%, respectively. The energy and exergy improvement potential were maximum for drying chamber followed by booster pump, which indicated that there was vast scope in the technical improvement for drying chamber. Highest cost of processing was obtained for drying chamber (percentage relative cost difference: 59.84%) followed by cyclone separator (percentage relative cost difference: 48.98%). Based on these analyses, improvement of high improvement potential components of the spray drying plant may be carried out. [ABSTRACT FROM AUTHOR]

Spray drying of milk is a highly energy intensive process. In this study, thermodynamic and exergoeconomic analyses of two-stage spray drying plant have been executed. This plant was analyzed on the basis of various parameters such as energy efficiency, exergy efficiency, energy improvement potential, exergy improvement potential, etc. The energy and exergy efficiency of the plant were 72.90 and 35.15%, respectively. The maximum energy improvement potential was for drying whereas maximum exergy improvement potential was for homogenizer. It indicates huge scope in the technical improvement for drying chamber and homogenizer of the plant. The highest cost of processing was for cyclone separator (percentage relative cost difference: 44%) followed by drying chamber (percentage relative cost difference: 40.71%). Highest energy destroyed was calculated for drying chamber (195.83 kJ/kg) followed by VFBD (87.62 kJ/kg). Lowest energy efficiency was calculated for VFBD (34.64%) followed by drying chamber (50.04%). Highest energy improvement potential was estimated for drying chamber (97.86 kJ/kg). Highest relative energy destruction ratio was calculated for drying chamber (52.04%) followed by VFBD (23.30%). Highest energetic factor was calculated for drying chamber (28.22%) followed by homogenizer (16.71%). Based on these analyses, it was realized that performance of the spray drying plant may be substantially improved by some design improvement of drying chamber and homogenizer only. [ABSTRACT FROM AUTHOR]

The current study investigates the formation of microencapsulated geraniol powder, with the exopolysaccharide EPS-K1B3 produced by Halomonas caseinilytica K1, as wall material, using spray-drying. Evaluation of the antimicrobial activity of the functional emulsions, prepared at either pH 5 or pH 7, was carried out against Gram-positive (Listeria innocua (ATCC 33090)) and Gram-negative (Escherichia coli (DSM682)) bacterial strains. Results showed prolonged antimicrobial efficacy until 30 days of incubation for geraniol microcapsules compared to wet geraniol emulsions, which could confirm the ability of the spray-drying process to protect encapsulated geraniol for a longer period. The highest antimicrobial efficacy of geraniol microcapsules was observed against L. innocua at pH 5. Therefore, the influence of pH on the functional property of geraniol microcapsules could be highlighted beside the targeted bacterial strain. [ABSTRACT FROM AUTHOR]

Fruits and vegetables are food products with a great nutritional contribution although they are very perishable, so alternatives are sought for their greater durability. Spray drying is currently one of the most used methods in the food industry for dehydrating these foods. Tomato powder has a promising and potential market, as it is a product with good commercial value and easy handling. This review addresses the fundamental principles of spray drying of tomato derivatives, the main factors that influence this process and the characteristics of the dried product. As well as bibliometric data from studies related to the drying of tomato derivatives, are also analyzed. Parameters such as the number of publications per year, journals, affiliations, countries, authors and type of scientific document were taken into account. [ABSTRACT FROM AUTHOR]

Spray drying systems with heat recovery have gained prominence in recent times due to the energy crises and changing weather conditions. These systems are widely used in various industries, including chemical, food, fertilizer, and pharmaceutical, but their energy-intensive nature calls for efficient operation and heat retrieval. This review article discusses the current developments in heat recovery methods, including direct, indirect, and hybrid systems, as well as improvements in dryer efficiency and thermal optimization techniques. Pinch and exergy evaluations are extensively investigated as they play a crucial role in heat integration design and analysis. Recovering heat from the exhaust stream of spray dryers poses challenges due to fouling caused by fines in the exit stream and the selection of analysis methods. Exploring non-conventional energy sources like solar and geothermal energy shows potential for drying operations, but further research is needed for design and control. The adoption of recovery options has led to a 35% improvement in energy efficiency and around 74% energy savings in specific cases. [ABSTRACT FROM AUTHOR]

In this study, Dunaliella salina and Porphyridium cruentum biomass were encapsulated by using a spray-dryer (SD) and combined D-optimal method. The independent variables were SD inlet temperature (170–190 °C), maltodextrin (25–75%, w/w, in dm), and microalgae biomass (25–75%, w/w, in dm). Prior to spray drying, P. cruentum and D. salina were cultivated in a pilot scale tubular photobioreactor and than harvested using a conical plate centrifuge. Significant models were determined for the effects of independent variables on total carotenoids, chlorophyll-a, crude protein, moisture contents and encapsulation yield (EY), water activity, average particle size, wettability, hygroscopicity, L* and C* properties for both microalgae species (p <.05). Due to the low EY (11.1–33.1%), we recommend encapsulation and drying of P. cruentum biomass with alternative methods to SD. The extracellular, as well as the cell wall and storage polysaccharides released into the culture medium of these microalgae are possible reasons for the low EY. [ABSTRACT FROM AUTHOR]

Amorphous solid dispersions (ASDs) enable formulations to improve the solubility of poorly soluble active pharmaceutical ingredients (APIs). The amorphous state is reached through the disruption of the crystalline lattice of an API resulting in an increased apparent solubility with faster disintegration. Nevertheless, this form is characterized by a high-energy state which is prone to re-crystallization. To ensure a stable ASD, excipients, e.g., polymers that form a matrix in which an API is dispersed, are used. The applicable polymer range is usually linked to their solubility in the respective solvent, therefore limiting the use of hydrophilic polymers. In this work, we show the applicability of the hydrophilic polymer, polyvinyl alcohol (PVA), in spray-dried solid dispersions. Using a three-fluid nozzle approach, this polymer can be used to generate ASDs with a targeted dissolution profile that is characterized by a prominent spring and desired parachute effect showing both supersaturation and crystallization inhibition. For this purpose, the polymer was tested in formulations containing the weakly basic drug, ketoconazole, and the acidic drug, indomethacin, both classified as Biopharmaceutics Classification System (BSC) class II drugs, as well as the weakly basic drug ritonavir classified as BCS IV. Furthermore, ritonavir was used to show the enhanced drug-loading capacity of PVA derived from the advantageous viscosity profile that makes the polymer an interesting candidate for spray drying applications. [ABSTRACT FROM AUTHOR]

Protein denaturation during spray drying is critical for high-quality food powders. This study investigated the influence of particle size on protein denaturation using phycocyanin as a marker. The effect of particle size was investigated at three different air outlet temperatures, with the inlet air temperature held constant. For each temperature combination, different nozzles were utilized to obtain varying particle sizes. Denaturation increased with higher outlet air temperature and larger particle size, up to a size of 40 μm. This increase in denaturation with particle size was attributed to faster drying rates and the absence of denaturation once particles are dry. Particle size had a similar magnitude of effect as outlet air temperature. For larger particles, a plateau in denaturation was observed due to a prolonged constant drying rate regime. It can be assumed that conditions that retain phycocyanin are also suited for the retention for less thermolabile proteins. [ABSTRACT FROM AUTHOR]

The relationship between the properties of wall material and spray-dried microcapsules was investigated. Soybean oil was encapsulated with various concentrations of maltodextrin (10 and 20% w / w) and sugar beet pectin (0.5, 1, 2, 3, and 4% w / w) solution via spray drying with a three-fluid nozzle (3FN). The rheological properties of the wall material solution were characterized using a controlled strain rheometer before spray drying and were found to fit the power-law model. The rheological properties of a wall material within the range of the samples tested had a limited impact on the morphology of the microcapsules. Most spray-dried samples had a wrinkled surface with some microcapsules having a spherical shape with a hollow core. As the consistency index of the wall material solution increased, the particle size distribution of microcapsules became wider. The surface oil content of the microcapsules was between 1.3 and 3.4%, generally increasing as the consistency index of the wall material solution increased. The encapsulation efficiency (EE) was between 74.7 and 91.2%. When compared with the sample produced with a two-fluid nozzle (2FN), 3FN microcapsules were larger and had higher effective EE and higher oil loading than 2FN microcapsules. This study revealed that oil could be encapsulated by wall materials, without the preparation of an emulsion, with a 3FN, which will save time and energy for the encapsulation process. [ABSTRACT FROM AUTHOR]

Polysaccharide/silica hybrid microcapsules were prepared using ionic gelation followed by spray-drying. Chitosan and alginate were used as biopolymer matrices, and in situ prepared silica was used as a structuring additive. The prepared microparticles were used in two very different applications: the encapsulation of hydrophilic molecules, and as a support for palladium nanoparticles used as catalysts for a model organic reaction, namely the reduction of p-nitrophenol by sodium borhydride. In the first application, erioglaucine disodium salt, taken as a model hydrophilic substance, was encapsulated in situ during the preparation of the microparticles. The results indicate that the presence of silica nanostructures, integrated within the polymer matrix, affect the morphology and the stability of the particles, retarding the release of the encapsulated substance. In the second application, chloropalladate was complexed on the surface of chitosan microparticles, and palladium(II) was subsequently reduced to palladium(0) to obtain heterogeneous catalysts with an excellent performance. [ABSTRACT FROM AUTHOR]

Enzyme-treated cellulose nanofibrils (CNFs) were produced via a lab-scale mass colloider using bleached kraft pulp (BKP) to evaluate their processability and power requirements during refining and spray-drying operations. To evaluate the energy efficiency in the CNF refining process, the net energy consumption, degree of polymerization (DP), and viscosity were determined. Less energy was consumed to attain a given fines level by using the endoglucanase enzymes. The DP and viscosity were also decreased using the enzymes. The morphological properties of the enzyme-pretreated spray-dried CNF powders (SDCNFs) were measured. Subsequently, the enzyme-pretreated SDCNFs were added to a PP matrix with MAPP as a coupling agent. The mixture was then compounded through a co-rotating twin-screw extruder to determine whether the enzyme treatment of the CNFs affects the mechanical properties of the composites. Compared to earlier studies on enhancing PMCs with SDCNF powders, this research investigates the use of enzyme-pretreated SDCNF powders. It was confirmed that the strength properties of PP increased by adding SDCNFs, and the strength properties were maintained after adding enzyme-pretreated SDCNFs. [ABSTRACT FROM AUTHOR]

While using saccharides as stabilizers for therapeutic protein drying is common, the mechanisms underlying the stabilization during drying remain largely unexplored. Herein, we investigated the effect of different saccharides, trehalose dihydrate (TD), dextran (DEX), and hydroxypropyl β-cyclodextrins (low substitution—HP and high substitution—HPB), on the relative activities of the enzymes trypsin and catalase during miniaturized drying (MD) or spray drying (SD). For trypsin, the presence of saccharides, especially HP, was beneficial, as it significantly improved the enzyme activity following MD. The HPB preserved trypsin's activity during MD and SD. Adding saccharides during MD did not show a notable improvement in catalase activities. Increasing TD was beneficial during the SD of catalase, as indicated by significantly increased activity. Molecular docking and molecular dynamics simulations oftrypsin with HP or HPB revealed the influence of their substitution on the binding affinity for the enzyme. A higher affinity of HP to bind trypsin and itself was observed during simulations. Experimentally, activity reduction was mainly observed during MD, attributable to the higher droplet temperature during MD than during SD. The activities from the experiments and aggregation propensity from molecular modeling helped elucidate the impact of the size of protein and saccharides on preserving the activity during drying. [ABSTRACT FROM AUTHOR]

The aim of this study was to relate the composition of the W/O emulsion used as a starting fluid in the spray-drying process to the quality of the dry polymer particles obtained in terms of physical–chemical properties, compatibility and drug release performance. Four W/O emulsions containing vancomycin hydrochloride (VAN), an encapsulating PLGA polymer and Poloxamer® 407, chitosan and/or sorbitan monooleate as stabilisers were spray-dried using an ultrasonic atomising nozzle. The microparticles obtained were micron-sized, with a volume mean diameter between 43.2 ± 0.3 and 64.0 ± 12.6 µm, and spherical with a mostly smooth, non-porous surface and with high drug loading (between 14.5 ± 0.6 and 17.1 ± 1.9% w/w). All formulations showed a prolonged and biphasic VAN release profile, with diffusion being the primary release mechanism. Microparticles prepared from the emulsions with Poloxamer® 407 and sorbitan monooleate released VAN rapidly and completely within one day. The release of VAN from microparticles prepared from the emulsion without additives or with chitosan in the inner aqueous phase was significantly decreased; after four days, a cumulative release of 65% and 61%, respectively, was achieved. Microparticles with encapsulated chitosan had the largest mean particle diameter and the slowest release of VAN. [ABSTRACT FROM AUTHOR]

Summary: The searching of alternative products that help reduce sugar consumption is a recurring objective due to the high number of overweight people in the world. The spray drying process of natural strawberry juice (SWJ) was evaluated using Agave angustifolia fructans as an encapsulating agent. Five fructan concentrations and three drying conditions were evaluated. The microcapsules obtained were characterised by anthocyanins content (UVvis), moisture percentage, hygroscopicity, colour, Tg, morphology (light scattering and SEM) and FTIR. Considering a recovery yield above 50%, the inlet/outlet temperatures of 180/90–95 °C and 15% of fructans were the conditions to obtain the powders with a hygroscopicity of 31%, anthocyanin retention of 84% and the highest Tg (54 °C). FTIR spectra and SEM evidenced that fructans can act as a homogeneous encapsulating matrix of SWJ. Therefore A. angustifolia fructans can be an alternative of low‐caloric power for the encapsulation of SWJ through spray. [ABSTRACT FROM AUTHOR]

The ultrasonic-assisted spray dryer, also known as a nano spray dryer and predominantly used on a lab scale in the pharmaceutical and food industries, enables the production of nanometer-sized particles. In this study, the nano spray dryer was applied to cellulosic materials, such as cellulose nanofibrils (CNFs) and cellulose nanocrystals (CNCs). CNC suspensions were successfully dried, while the CNF suspensions could not be dried, attributable to their longer fibril lengths. The nano spray drying process was performed under different drying conditions, including nebulizer hole sizes, solid concentrations, and gas flow rates. It was confirmed that the individual particle size of nano spray-dried CNCs (nano SDCNCs) decreased as the nebulizer hole sizes and solid contents of the suspensions decreased. The production rate of the nano spray dryer increased with higher solid contents and lower gas flow rates. The resulting nano SDCNCs were added to a polyvinyl alcohol (PVA) matrix as a reinforcing material to evaluate their reinforcement behavior in a plastic matrix using solvent casting. After incorporating the 20 wt.% nano SDCNCs into the PVA matrix, the tensile strength and tensile modulus elasticity of the neat PVA nanocomposite film increased by 22% and 32%, respectively, while preserving the transparency of the films. [ABSTRACT FROM AUTHOR]