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4. Efficacy, safety, adherence and persistence of PCSK9 inhibitors in clinical practice: A single country, multicenter, observational study (AT-TARGET-IT)

Author

Gargiulo, P, Basile, C, Cesaro, A, Marzano, F, Buonocore, D, Asile, G, Abbate, V, Vicidomini, F, Paolillo, S, Spaccarotella, C, Catalano, A, Spirito, G, Merlini, P, Maloberti, A, Iannuzzo, G, Ciccone, M, Zito, A, Paloscia, L, D'Alleva, A, Varbella, F, Corleto, A, Brunetti, N, Corbo, M, Calabro, P, Indolfi, C, Perrone-Filardi, P, Gargiulo P., Basile C., Cesaro A., Marzano F., Buonocore D., Asile G., Abbate V., Vicidomini F., Paolillo S., Spaccarotella C. A. M., Catalano A., Spirito G., Merlini P. A., Maloberti A., Iannuzzo G., Ciccone M. M., Zito A. P., Paloscia L., D'Alleva A., Varbella F., Corleto A., Brunetti N. D., Corbo M. D., Calabro P., Indolfi C., Perrone-Filardi P., Gargiulo, P, Basile, C, Cesaro, A, Marzano, F, Buonocore, D, Asile, G, Abbate, V, Vicidomini, F, Paolillo, S, Spaccarotella, C, Catalano, A, Spirito, G, Merlini, P, Maloberti, A, Iannuzzo, G, Ciccone, M, Zito, A, Paloscia, L, D'Alleva, A, Varbella, F, Corleto, A, Brunetti, N, Corbo, M, Calabro, P, Indolfi, C, Perrone-Filardi, P, Gargiulo P., Basile C., Cesaro A., Marzano F., Buonocore D., Asile G., Abbate V., Vicidomini F., Paolillo S., Spaccarotella C. A. M., Catalano A., Spirito G., Merlini P. A., Maloberti A., Iannuzzo G., Ciccone M. M., Zito A. P., Paloscia L., D'Alleva A., Varbella F., Corleto A., Brunetti N. D., Corbo M. D., Calabro P., Indolfi C., and Perrone-Filardi P.

Abstract

Background and aims: Proprotein Convertase Subtilisin/Kexin type 9 inhibitors (PCSK9i) are recommended in patients at high and very-high cardiovascular (CV) risk, with documented atherosclerotic CV disease (ASCVD), and for very-high risk patients with familial hypercholesterolaemia not achieving LDL-cholesterol (LDL-C) goal while receiving maximally tolerated dose of lipid-lowering therapy (LLT). However, single country real-life data, reporting the use of PCSK9i in clinical practice, are limited. Therefore, we designed AT-TARGET-IT, an Italian, multicenter, observational registry on the use of PCSK9i in clinical practice. Methods: All data were recorded at the time of the first prescription and at the latest observation preceding inclusion in the study. Results: 798 patients were enrolled. The median reduction in LDL-C levels was 64.9%. After stratification for CV risk, 63.8% achieved LDL-C target; of them, 83.3% took LLTs at PCSK9i initiation and 16.7% did not. 760 patients (95.2%) showed high adherence to therapy, 13 (1.6%) partial adherence, and 25 (3.1%) poor adherence. At 6 months, 99.7% of patients enrolled in the study remained on therapy; there were 519 and 423 patients in the study with a follow-up of at least 12 and 18 months, respectively. Persistence in these groups was 98.1% and 97.5%, respectively. Overall, 3.5% of patients discontinued therapy. No differences in efficacy, adherence, and persistence were found between alirocumab and evolocumab. Conclusions: PCSK9i are safe and effective in clinical practice, leading to very high adherence and persistence to therapy, and achievement of recommended LDL-C target in most patients, especially when used as combination therapy.

Published
2023

5. VST - VLT Survey Telescope Integration Status

Author

Belfiore, C., Brescia, M., Capaccioli, M., Caputi, O., Castiello, G., Cortecchia, F., Ferragina, L., Fierro, D., Fiume, V., Mancini, D., Mancini, G., Marra, G., Marty, L., Mazzola, G., Parisi, L., Pellone, L., Perrotta, F., Porzio, V., Schipani, P., Sciarretta, G., Spirito, G., Valentino, M., and Sedmak, G.

Subjects
Astrophysics
Abstract

The VLT Survey Telescope (VST) is a 2.6m aperture, wide field, UV to I facility, to be installed at the European Southern Observatory (ESO) on the Cerro Paranal Chile. VST was primarily intended to complement the observing capabilities of VLT with wide-angle imaging for detecting and pre-characterising sources for further observations with the VLT., Comment: 2 pages, 2 figures, conference

Published
2005

6. The VST telescope control software in the ESO VLT environment

Author

Schipani, P., Brescia, M., Mancini, D., Marty, L., and Spirito, G.

Subjects
Astrophysics
Abstract

The VST (VLT Survey Telescope) is a 2.6 m Alt-Az telescope to be installed at Mount Paranal in Chile, in the European Southern Observatory (ESO) site. The VST is a wide-field imaging facility planned to supply databases for the ESO Very Large Telescope (VLT) science and carry out stand-alone observations in the UV to I spectral range. This paper will focus mainly on control software aspects, describing the VST software architecture in the context of the whole ESO VLT control concept. The general architecture and the main components of the control software will be described., Comment: 3 pages, 2 figures, ICALEPCS 2001 Conference, PSN#THAP051

Published
2001

7. Novel SYNGAP1 Variant in an Adult Individual Affected by Intellectual Disability and Epilepsy: A Cold Case Solved through Whole-Exome Sequencing.

Author

Rosti G, Boeri S, Divizia MT, Pisciotta L, Mancardi MM, Lerone M, Cerminara M, Servetti M, Spirito G, Vozzi D, Fontana M, Gustincich S, Nobili L, Zara F, and Puliti A

Abstract

Introduction: Nowadays, whole-exome sequencing (WES) analysis is an essential part in the diagnostic pathway of individuals with complex phenotypes when routine exams, such as array-CGH and gene panels, have proved inconclusive. However, data on the diagnostic rate of WES analysis in adult individuals, negative to first-tier tests, are lacking. This is because initiatives with the aim of diagnosing rare diseases focus mainly on pediatric unsolved cases., Case Presentation: We hereby present a 45-year-old woman with severe intellectual disability, previous psychomotor developmental delay, behavioral disorders, stereotypies, nonconvulsive epilepsy, and dysmorphisms. The proband first came to our attention when she was 4 years old (in 1982); since then, she has undergone several clinical and instrumental assessments, without reaching a genetic diagnosis. At last, through WES analysis, a novel de novo variant in SYNGAP1 was found. The clinical characteristics associated with SYNGAP1 are similar to those presented by the proband., Conclusion: The variant is predicted to be deleterious and is most probably the cause of the proband's phenotype. The perseverance of the clinicians and the family allowed us to reach a diagnosis in a woman with a more than 30-year history of clinical evaluations, instrumental assessments, and genetic tests. This diagnosis was of significant relevance in genetic counseling for family members and the proband herself., Competing Interests: The authors have no conflicts of interest to declare., (Copyright © 2023 by S. Karger AG, Basel.)

Published
2023
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8. Exploratory analysis of L1 retrotransposons expression in autism.

Author

Spirito G, Filosi M, Domenici E, Mangoni D, Gustincich S, and Sanges R

Subjects
Humans, Retroelements genetics, Brain, Up-Regulation, Autistic Disorder genetics, Autism Spectrum Disorder genetics
Abstract

Background: Autism spectrum disorder (ASD) is a set of highly heterogeneous neurodevelopmental diseases whose genetic etiology is not completely understood. Several investigations have relied on transcriptome analysis from peripheral tissues to dissect ASD into homogenous molecular phenotypes. Recently, analysis of changes in gene expression from postmortem brain tissues has identified sets of genes that are involved in pathways previously associated with ASD etiology. In addition to protein-coding transcripts, the human transcriptome is composed by a large set of non-coding RNAs and transposable elements (TEs). Advancements in sequencing technologies have proven that TEs can be transcribed in a regulated fashion, and their dysregulation might have a role in brain diseases., Methods: We exploited published datasets comprising RNA-seq data from (1) postmortem brain of ASD subjects, (2) in vitro cell cultures where ten different ASD-relevant genes were knocked out and (3) blood of discordant siblings. We measured the expression levels of evolutionarily young full-length transposable L1 elements and characterized the genomic location of deregulated L1s assessing their potential impact on the transcription of ASD-relevant genes. We analyzed every sample independently, avoiding to pool together the disease subjects to unmask the heterogeneity of the molecular phenotypes., Results: We detected a strong upregulation of intronic full-length L1s in a subset of postmortem brain samples and in in vitro differentiated neurons from iPSC knocked out for ATRX. L1 upregulation correlated with an high number of deregulated genes and retained introns. In the anterior cingulate cortex of one subject, a small number of significantly upregulated L1s overlapped with ASD-relevant genes that were significantly downregulated, suggesting the possible existence of a negative effect of L1 transcription on host transcripts., Limitations: Our analyses must be considered exploratory and will need to be validated in bigger cohorts. The main limitation is given by the small sample size and by the lack of replicates for postmortem brain samples. Measuring the transcription of locus-specific TEs is complicated by the repetitive nature of their sequence, which reduces the accuracy in mapping sequencing reads to the correct genomic locus., Conclusions: L1 upregulation in ASD appears to be limited to a subset of subjects that are also characterized by a general deregulation of the expression of canonical genes and an increase in intron retention. In some samples from the anterior cingulate cortex, L1s upregulation seems to directly impair the expression of some ASD-relevant genes by a still unknown mechanism. L1s upregulation may therefore identify a group of ASD subjects with common molecular features and helps stratifying individuals for novel strategies of therapeutic intervention., (© 2023. The Author(s).)

Published
2023
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9. Efficacy, safety, adherence and persistence of PCSK9 inhibitors in clinical practice: A single country, multicenter, observational study (AT-TARGET-IT).

Author

Gargiulo P, Basile C, Cesaro A, Marzano F, Buonocore D, Asile G, Abbate V, Vicidomini F, Paolillo S, Spaccarotella CAM, Catalano A, Spirito G, Merlini PA, Maloberti A, Iannuzzo G, Ciccone MM, Zito AP, Paloscia L, D'Alleva A, Varbella F, Corleto A, Brunetti ND, Corbo MD, Calabrò P, Indolfi C, and Perrone-Filardi P

Subjects
Humans, PCSK9 Inhibitors, Cholesterol, LDL, Proprotein Convertase 9, Antibodies, Monoclonal adverse effects, Anticholesteremic Agents adverse effects, Hydroxymethylglutaryl-CoA Reductase Inhibitors therapeutic use
Abstract

Background and Aims: Proprotein Convertase Subtilisin/Kexin type 9 inhibitors (PCSK9i) are recommended in patients at high and very-high cardiovascular (CV) risk, with documented atherosclerotic CV disease (ASCVD), and for very-high risk patients with familial hypercholesterolaemia not achieving LDL-cholesterol (LDL-C) goal while receiving maximally tolerated dose of lipid-lowering therapy (LLT). However, single country real-life data, reporting the use of PCSK9i in clinical practice, are limited. Therefore, we designed AT-TARGET-IT, an Italian, multicenter, observational registry on the use of PCSK9i in clinical practice., Methods: All data were recorded at the time of the first prescription and at the latest observation preceding inclusion in the study., Results: 798 patients were enrolled. The median reduction in LDL-C levels was 64.9%. After stratification for CV risk, 63.8% achieved LDL-C target; of them, 83.3% took LLTs at PCSK9i initiation and 16.7% did not. 760 patients (95.2%) showed high adherence to therapy, 13 (1.6%) partial adherence, and 25 (3.1%) poor adherence. At 6 months, 99.7% of patients enrolled in the study remained on therapy; there were 519 and 423 patients in the study with a follow-up of at least 12 and 18 months, respectively. Persistence in these groups was 98.1% and 97.5%, respectively. Overall, 3.5% of patients discontinued therapy. No differences in efficacy, adherence, and persistence were found between alirocumab and evolocumab., Conclusions: PCSK9i are safe and effective in clinical practice, leading to very high adherence and persistence to therapy, and achievement of recommended LDL-C target in most patients, especially when used as combination therapy., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)

Published
2023
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10. Transposons Acting as Competitive Endogenous RNAs: In-Silico Evidence from Datasets Characterised by L1 Overexpression.

Author

Esposito M, Gualandi N, Spirito G, Ansaloni F, Gustincich S, and Sanges R

Abstract

LINE L1 are transposable elements that can replicate within the genome by passing through RNA intermediates. The vast majority of these element copies in the human genome are inactive and just between 100 and 150 copies are still able to mobilize. During evolution, they could have been positively selected for beneficial cellular functions. Nonetheless, L1 deregulation can be detrimental to the cell, causing diseases such as cancer. The activity of miRNAs represents a fundamental mechanism for controlling transcript levels in somatic cells. These are a class of small non-coding RNAs that cause degradation or translational inhibition of their target transcripts. Beyond this, competitive endogenous RNAs (ceRNAs), mostly made by circular and non-coding RNAs, have been seen to compete for the binding of the same set of miRNAs targeting protein coding genes. In this study, we have investigated whether autonomously transcribed L1s may act as ceRNAs by analyzing public dataset in-silico. We observed that genes sharing miRNA target sites with L1 have a tendency to be upregulated when L1 are overexpressed, suggesting the possibility that L1 might act as ceRNAs. This finding will help in the interpretation of transcriptomic responses in contexts characterized by the specific activation of transposons.

Published
2022
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11. Glomerular filtration rate: A prognostic marker in atrial fibrillation—A subanalysis of the AntiThrombotic Agents Atrial Fibrillation

Author

Proietti, Riccardo, Gonzini, Lucio, Pizzimenti, Giovanni, Ledda, Antonietta, Sanna, Pietro, Alturki, Ahmed, Russo, Vincenzo, Lencioni, Mauro, Siciliano, R., Boffa, M., Bazzanini, F., Di Nucci, G., Fonti, S., De Franceschi, T., Davio, P., Alagna, G., Cipollini, F., Arma, P., Gunnellini, M. G., Dottori, M., Paulillo, D., Giudice, M., Sicuro, M., Lenti, S., Iannelli, G., Notarstefano, P., Galiotto, M., Apolloni, Enzo, Molini, G., Massarelli, L., Di Iorio, P., Scandurra, F., Candelmo, F., Iodice, P., Laureano, R., Perlangeli, S., Praticò, A., Lucchesi, Q., Conese, V., Scalera, G., Palma, F., De Antoni, M. E., Beltramello, G., Carbonella, M., Capone, A., Bianchi, V., Zerella, F., Masina, M., Boggian, G., Pancaldi, L. G., Brucato, A. L., Scialfa, S., Ferrari, P., Gavazzi, A., Santoro, E., Bertinieri, G., Caragnano, V., Zaccaroni, S., Marchetti, G., Urbinati, S., Belmonte, G., Giannoni, C., Panuccio, D., Pedone, V., Colletta, M., Di Pasquale, G., Cemin, R., Paffoni, P. R. C., Pezzotti, Chiara, Capretti, M., Lamari, A. L., Maugeri, S., Moretti, R., Ganga, R., Mascia, P., Caddori, A., Cusumano, S., Alletto, M., DE VINCENZO, Ciro, Musacchio, E., Stendardo, A., Cantarella, SALVATORE ALFREDO, Ferrari, V., Bassano, F., PERRONE CAPANO, Carla, Piccinni, G. C., Catanzaro, M., Vinciguerra, A., Lusiani, L., De Caro, G., Scarcia, M., Scarcia, Aurora, Losi, E., Gaddi, O., Lo Sciuto, A., Cascio Ingurgio, N., Vignai, E., Romano, M., Borzì, V., Bellanuova, I. A., Felis, S., Gulizia, M. M., Francese, G. M., Artale, S., Mazzuca, S., Perticone, F., Tirotta, D., Talini, E., Ventrella, F., Iosa, G., Cuccurullo, O., Bertello, P. D., Benemio, G., Garognoli, O., Arcelli, G., Prosciutti, L., De Matthaeis, G., Quattrini, C., Calcagno, S., Canestrini, S., Franco, A., Pastorelli, R., Acquati, F., Botto, G. L., Sitta, N., Migliacci, R., Cosmi, F., Tarquini, B., Chiappetta, P., Sprovieri, M. F., Macrì, G., Bertolazzi, S., Spotti, Alessia, Pirelli, S., Marasco, M. F., Elia, Martina, Gambino, G. M., Fenoglio, L., Gelmini, G. P., Ziacchi, V., Rigon, N., Petix, N. R., Zipoli, A., Caiolo, A., Marino, E., Scattolin, G., Gerini, S., Parisi, G., Tavernese, G., Conti, Alessandro, Ferrante, Federico, Morettini, A., Alterini, B., Rocchi, Federico, Nozzoli, C., Goedecke, L., Seravalle, C., Cuomo, A., Panettieri, I., Pellegrino, P., Di Biase, M., Savarese, G., Patriarchi, F., Bondì, Giuseppina, Rossini, Elena, Nello, S., Ranieri, A. T., Gelonesi, F. N., Costantini, M., Dugnani, M., Ria, L., Mussardo, V., Zanini, G., Morgante, O., Fazio, G., Lo, G., Castello, C., Moroni, L. A., Costa, S., Domenicucci, S., Venzano, C., Loiacono, L., Ortuso, R., Esposito, L., Cuzzucrea, D. G., Fiammengo, F., Selva, E., Gestra, R., Alessandri, M., Nuzzi, G., Porrino, L., Parise, P., Capponi, E. A., Mandorla, S., Politi, Caterina, Olivieri, Claudia, Gurioli, L., Agostinelli, P., Striuli, R., Petrarca, Massimo, Corsini, Francesca, Orlandini, F., Badolati, S., Colarusso, D., Vertullo, V., Pelaggi, P., Campagna, G., Haupt, E., Parente, F., Milanese, G., Magliari, F., Morando, G., Guarise, P., Mazzone, A., Palumbo, G., Lambelet, P., Camaiti, A., Pasquinelli, P., Frediani, L., Vituliano, A., Brunelleschi, G., Lisi, C., La Torre, P. P. A., Villella, A., Rimoldi, A., Russo, V., Di Summa, F., Reggiani, A., Raimondo, F. C., Disalvo, D., Borrello, V. M., Magnante, A., Stellitano, E., Procopio, L., Franculli, F., Serafini, Filippo, Tondo, C., Fiorentini, C., Manfredini, R., Robbiolo, L., Pizzimenti, G., VASQUEZ LOPEZ, LUIDER FERNEY, Piangiamore, A., Tosi, P., Donà, G., Bacchiega, E., Malavasi, V., Modena, M. G., Divella, C., Marengo, C., Montanari, P., Manicardi, V., Abate, L., Cuccuini, A., Magni, S., Vincenti, A., Spinelli, M., Mortara, A., Specchia, G., Silvestri, N., Silvestri, Oriana, Piscopo, G., Muscherà, R., Gallucci, F., Cannavale, A., Bresciani, A., Perrone Filardi, P., Fontanella, Andrea, Iannuzzo, D., Lucà, S., Zuccoli, A., Rinaldi, P., Ferri, G., Barbieri, E., Grasselli, S., Rossi, A., Agosti, S., Sanna, GIAN PAOLO, Casu, G., Orecchioni, G., Da Silva Carvalho, P. C., POZZI MUCELLI, Roberto, Salvati, Fabio, Bendini, M. G., Giordano, G., Pellegrini, F., Pighini, G., Tremolada, F., Zanin, L., Ledda, A., Floresta, A. M., Enia, F., Nicolosi, G., Ingrillì, F., D'Angelo, A., Musacchio, D., Savastano, Silvia, Magnani, Leonardo, Capitelli, M., Cioni, Giovanni, Aloisi, B., De Finis, A., Vacri, A., Costantini, V., Guercini, F., Zingarini, G., Nardoni, M. C., Teghini, L., Panigada, G., Di Marco, S., Vergoni, W., Paonessa, K., Artom, A., Bigliardi, M., Riccardi, R., Riva, L., Marandino, A., Barsotti, L., Ginocchio, G., Marchese, Dario, Tintori, G., Annese, M., Breschi, R., Manini, M., Scopelliti, Giulia, Pastore, A., Spirito, G., Amato, A., Del Bianco, F., Ongari, M., Fiorencis, R., Querci, F., Martone, V. D., Molero, U., Fiusti, R., Giovannini, T., D'Arienzo, E., Cellamare, G., Placci, A., Gulli, G., Ruggeri, A., Pulitanò, G., Iori, I., Ingianni, N., Saporito, D., Marconi, GIAN MARIA, Grossi, Alice, Grosseto, D., Ciamei, M., Mete, F., Russo, F., Bianchi, C., Costantino, S., Manfellotto, D., Risa, M. P., Azzolini, P., Conversano, L., Santini, M., Macchiusi, A., Francia, P., Pietrantonio, F., Biscione, F., Magliano, G., Fedele, Francesca, Salituri, S., Salituri, F., Zamboni, S., Rossetti, C., Roncon, Leonora, Delucchi, M., De Benedictis, M., Vitolo, A., Anselmi, Michela, Celino, T., Moretti, V., Cuccurullo, M., Castelli, G., Martino, G., Pierandrei, G., Carella, A. M., Tonizzo, M., Nassi, R., Tarducci, R., Fronticelli Baldelli, M., Commisso, B., Lazzarini, D., Matarazzo, M. M., Novati, P., Petacchi, R., Maninchedda, P., Melandri, F., Bellesi, P., Sacchetti, C., Grandi, M., Cattana, A., Tassara, R., Menardo, G., Aykut, V., Chesi, G., Reverzani, A., Galgano, Angela, Bartone, B., Stornello, M., Muscio, G., Gemmiti, M. P., Alfonsi, F., Fontana, D., Astarita, C., Gaspardo, G., La Brocca, A., Rillo, M., Pascente, T., Pirozzi, M. R., Addis, L., De Siati, P., Beato, E., Iannaccone, V., Barabani, M., Castronuovo, M., Battaia, L., Biscottini, B., Boccali, A., Marengo, S., Dallerba, R., Diana, A., Coser, Alessandra, Pauletto, P., Calzolari, V., Olivari, Z., De Masi De Luca, G., Accogli, M., Gerloni, R., Cattin, Laura, Vitali Serdoz, L., Sinagra, G., Bulfoni, A., DE BIASIO, Melissa, Proclemer, A., Miserocchi, F., Marazzi, R., SALERNO URIARTE, JORGE ANTONIO, Levantesi, G., Olivetti, P., Capuano, A., Bertoncelli, M. C., Molinaro, N., Anastasio, L., Teti, G., Vescovo, G. A., Muriago, M., Incao, F., Lettica, G. V., Nieswandt, V., Osti, R., Tafi, A., Proietti, Riccardo, Gonzini, Lucio, Pizzimenti, Giovanni, Ledda, Antonietta, Sanna, Pietro, Alturki, Ahmed, Russo, Vincenzo, Lencioni, Mauro, Siciliano, R., Boffa, M., Bazzanini, F., Di Nucci, G., Fonti, S., De Franceschi, T., Davio, P., Alagna, G., Cipollini, F., Arma, P., Gunnellini, M. G., Dottori, M., Paulillo, D., Giudice, M., Sicuro, M., Lenti, S., Iannelli, G., Notarstefano, P., Galiotto, M., Apolloni, E., Molini, G., Massarelli, L., Di Iorio, P., Scandurra, F., Candelmo, F., Iodice, P., Laureano, R., Perlangeli, S., Praticò, A., Lucchesi, Q., Conese, V., Scalera, G., Palma, F., De Antoni, M. E., Beltramello, G., Carbonella, M., Capone, A., Bianchi, V., Zerella, F., Masina, M., Boggian, G., Pancaldi, L. G., Brucato, A. L., Scialfa, S., Ferrari, P., Gavazzi, A., Santoro, E., Bertinieri, G., Caragnano, V., Zaccaroni, S., Marchetti, G., Urbinati, S., Belmonte, G., Giannoni, C., Panuccio, D., Pedone, V., Colletta, M., Di Pasquale, G., Cemin, R., Paffoni, P. R. C., Pezzotti, C., Capretti, M., Lamari, A. L., Maugeri, S., Moretti, R., Ganga, R., Mascia, P., Caddori, A., Cusumano, S., Alletto, M., De Vincenzo, C., Musacchio, E., Stendardo, A., Cantarella, S. A., Ferrari, V., Bassano, F., Perrone, C., Piccinni, G. C., Catanzaro, M., Vinciguerra, A., Lusiani, L., De Caro, G., Scarcia, M., Scarcia, A., Losi, E., Gaddi, O., Lo Sciuto, A., Cascio Ingurgio, N., Vignai, E., Romano, M., Borzì, V., Bellanuova, I. A., Felis, S., Gulizia, M. M., Francese, G. M., Artale, S., Mazzuca, S., Perticone, F., Tirotta, D., Talini, E., Ventrella, F., Iosa, G., Cuccurullo, O., Bertello, P. D., Benemio, G., Garognoli, O., Arcelli, G., Prosciutti, L., De Matthaeis, G., Quattrini, C., Calcagno, S., Canestrini, S., Franco, A., Pastorelli, R., Acquati, F., Botto, G. L., Sitta, N., Migliacci, R., Cosmi, F., Tarquini, B., Chiappetta, P., Sprovieri, M. F., Macrì, G., Bertolazzi, S., Spotti, A., Pirelli, S., Marasco, M. F., Elia, M., Gambino, G. M., Fenoglio, L., Gelmini, G. P., Ziacchi, V., Rigon, N., Petix, N. R., Zipoli, A., Caiolo, A., Marino, E., Scattolin, G., Gerini, S., Parisi, G., Tavernese, G., Conti, A., Ferrante, F., Morettini, A., Alterini, B., Rocchi, F., Nozzoli, C., Goedecke, L., Seravalle, C., Cuomo, A., Panettieri, I., Pellegrino, P., Di Biase, M., Savarese, G., Patriarchi, F., Bondi, G., Rossini, E., Nello, S., Ranieri, A. T., Gelonesi, F. N., Costantini, M., Dugnani, M., Ria, L., Mussardo, V., Zanini, G., Morgante, O., Fazio, G., Lo, G., Castello, C., Moroni, L. A., Costa, S., Domenicucci, S., Venzano, C., Loiacono, L., Ortuso, R., Esposito, L., Cuzzucrea, D. G., Fiammengo, F., Selva, E., Gestra, R., Alessandri, M., Nuzzi, G., Porrino, L., Parise, P., Capponi, E. A., Mandorla, S., Politi, C., Olivieri, C., Gurioli, L., Agostinelli, P., Striuli, R., Petrarca, M., Corsini, F., Orlandini, F., Badolati, S., Colarusso, D., Vertullo, V., Pelaggi, P., Campagna, G., Haupt, E., Parente, F., Milanese, G., Magliari, F., Morando, G., Guarise, P., Mazzone, A., Palumbo, G., Lambelet, P., Camaiti, A., Pasquinelli, P., Frediani, L., Vituliano, A., Brunelleschi, G., Lisi, C., La Torre, P. P. A., Villella, A., Rimoldi, A., Russo, V., Di Summa, F., Reggiani, A., Raimondo, F. C., Disalvo, D., Borrello, V. M., Magnante, A., Stellitano, E., Procopio, L., Franculli, F., Serafini, F., Tondo, C., Fiorentini, C., Manfredini, R., Robbiolo, L., Pizzimenti, G., Vasquez, L., Piangiamore, A., Tosi, P., Donà, G., Bacchiega, E., Malavasi, V., Modena, M. G., Divella, C., Marengo, C., Montanari, P., Manicardi, V., Abate, L., Cuccuini, A., Magni, S., Vincenti, A., Spinelli, M., Mortara, A., Specchia, G., Silvestri, N., Silvestri, O., Piscopo, G., Muscherà, R., Gallucci, F., Cannavale, A., Bresciani, A., Perrone Filardi, P., Fontanella, A., Iannuzzo, D., Lucà, S., Zuccoli, A., Rinaldi, P., Ferri, G., Barbieri, E., Grasselli, S., Rossi, A., Agosti, S., Sanna, P., Casu, G., Orecchioni, G., Da Silva Carvalho, P. C., Pozzi, R., Salvati, F., Bendini, M. G., Giordano, G., Pellegrini, F., Pighini, G., Tremolada, F., Zanin, L., Ledda, A., Floresta, A. M., Enia, F., Nicolosi, G., Ingrillì, F., D'Angelo, A., Musacchio, D., Savastano, S., Magnani, L., Capitelli, M., Cioni, G., Aloisi, B., De Finis, A., Vacri, A., Costantini, V., Guercini, F., Zingarini, G., Nardoni, M. C., Teghini, L., Panigada, G., Di Marco, S., Vergoni, W., Paonessa, K., Artom, A., Bigliardi, M., Riccardi, R., Riva, L., Marandino, A., Barsotti, L., Ginocchio, G., Marchese, D., Tintori, G., Annese, M., Breschi, R., Manini, M., Scopelliti, G., Pastore, A., Spirito, G., Amato, A., Del Bianco, F., Ongari, M., Fiorencis, R., Querci, F., Martone, V. D., Molero, U., Fiusti, R., Giovannini, T., D'Arienzo, E., Cellamare, G., Placci, A., Gulli, G., Ruggeri, A., Pulitanò, G., Iori, I., Ingianni, N., Saporito, D., Marconi, M., Grossi, A., Grosseto, D., Ciamei, M., Mete, F., Russo, F., Bianchi, C., Costantino, S., Manfellotto, D., Risa, M. P., Azzolini, P., Conversano, L., Santini, M., Macchiusi, A., Francia, P., Pietrantonio, F., Biscione, F., Magliano, G., Fedele, F., Salituri, S., Salituri, F., Zamboni, S., Rossetti, C., Roncon, L., Delucchi, M., De Benedictis, M., Vitolo, A., Anselmi, M., Celino, T., Moretti, V., Cuccurullo, M., Castelli, G., Martino, G., Pierandrei, G., Carella, A. M., Tonizzo, M., Nassi, R., Tarducci, R., Fronticelli Baldelli, M., Commisso, B., Lazzarini, D., Matarazzo, M. M., Novati, P., Petacchi, R., Maninchedda, P., Melandri, F., Bellesi, P., Sacchetti, C., Grandi, M., Cattana, A., Tassara, R., Menardo, G., Aykut, V., Chesi, G., Reverzani, A., Galgano, A., Bartone, B., Stornello, M., Muscio, G., Gemmiti, M. P., Alfonsi, F., Fontana, D., Astarita, C., Gaspardo, G., La Brocca, A., Rillo, M., Pascente, T., Pirozzi, M. R., Addis, L., De Siati, P., Beato, E., Iannaccone, V., Barabani, M., Castronuovo, M., Battaia, L., Biscottini, B., Boccali, A., Marengo, S., Dallerba, R., Diana, A., Coser, A., Pauletto, P., Calzolari, V., Olivari, Z., De Masi De Luca, G., Accogli, M., Gerloni, R., Cattin, L., Vitali Serdoz, L., Sinagra, G., Bulfoni, A., De Biasio, M., Proclemer, A., Miserocchi, F., Marazzi, R., Salerno Uriarte, J. A., Levantesi, G., Olivetti, P., Capuano, A., Bertoncelli, M. C., Molinaro, N., Anastasio, L., Teti, G., Vescovo, G. A., Muriago, M., Incao, F., Lettica, G. V., Nieswandt, V., Osti, R., and Tafi, A.

Subjects
Male, medicine.medical_specialty, Time Factors, Clinical Investigations, Renal function, 030204 cardiovascular system & hematology, Risk Assessment, 03 medical and health sciences, 0302 clinical medicine, Fibrinolytic Agents, Risk Factors, atrial fibrillation, glomerular filtration rate, mortality, Cardiology and Cardiovascular Medicine, Internal medicine, Antithrombotic, medicine, Humans, In patient, 030212 general & internal medicine, Renal Insufficiency, Cardiovascular mortality, Aged, Retrospective Studies, business.industry, Incidence, Atrial fibrillation, General Medicine, medicine.disease, Prognosis, Survival Rate, Italy, Hospital admission, Atrial Fibrillation, Female, Follow-Up Studies, Glomerular Filtration Rate, Morbidity, Cardiology, business
Abstract

OBJECTIVE: An increased cardiovascular mortality and morbidity has been widely reported in patients with atrial fibrillation (AF). In this study, a subanalysis of the AntiThrombotic Agents Atrial Fibrillation (ATA‐AF) is performed with the aim to evaluate estimated glomerular filtration rate (eGFR) as an independent prognostic marker of cardiovascular mortality and morbidity in patients with AF. METHODS AND RESULTS: The ATA‐AF study enrolled 7148 patients with AF, in 360 Italian centers. The eGFR was calculated from data reported in patient notes or hospital database. This post‐hoc analysis included 1097 AF patients with eGFR data available and 1‐year clinical follow‐up. The endpoint was assessed as cardiovascular mortality and/or hospital admission for cardiovascular causes at follow‐up. Patients were also divided in two groups according to the eGFR (

Published
2018

12. Transposable element activation promotes neurodegeneration in a Drosophila model of Huntington's disease.

Author

Casale AM, Liguori F, Ansaloni F, Cappucci U, Finaurini S, Spirito G, Persichetti F, Sanges R, Gustincich S, and Piacentini L

Abstract

Huntington's disease (HD) is an autosomal dominant disorder with progressive motor dysfunction and cognitive decline. The disease is caused by a CAG repeat expansion in the IT15 gene, which elongates a polyglutamine stretch of the HD protein, Huntingtin. No therapeutic treatments are available, and new pharmacological targets are needed. Retrotransposons are transposable elements (TEs) that represent 40% and 30% of the human and Drosophila genomes and replicate through an RNA intermediate. Mounting evidence suggests that mammalian TEs are active during neurogenesis and may be involved in diseases of the nervous system. Here we show that TE expression and mobilization are increased in a Drosophila melanogaster HD model. By inhibiting TE mobilization with Reverse Transcriptase inhibitors, polyQ-dependent eye neurodegeneration and genome instability in larval brains are rescued and fly lifespan is increased. These results suggest that TE activation may be involved in polyQ-induced neurotoxicity and a potential pharmacological target., Competing Interests: The authors declare no competing interests., (© 2021 The Author(s).)

Published
2021
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13. Natural SINEUP RNAs in Autism Spectrum Disorders: RAB11B-AS1 Dysregulation in a Neuronal CHD8 Suppression Model Leads to RAB11B Protein Increase.

Author

Zarantonello G, Arnoldi M, Filosi M, Tebaldi T, Spirito G, Barbieri A, Gustincich S, Sanges R, Domenici E, Di Leva F, and Biagioli M

Abstract

CHD8 represents one of the highest confidence genetic risk factors implied in Autism Spectrum Disorders, with most mutations leading to CHD8 haploinsufficiency and the insurgence of specific phenotypes, such as macrocephaly, facial dysmorphisms, intellectual disability, and gastrointestinal complaints. While extensive studies have been conducted on the possible consequences of CHD8 suppression and protein coding RNAs dysregulation during neuronal development, the effects of transcriptional changes of long non-coding RNAs (lncRNAs) remain unclear. In this study, we focused on a peculiar class of natural antisense lncRNAs, SINEUPs, that enhance translation of a target mRNA through the activity of two RNA domains, an embedded transposable element sequence and an antisense region. By looking at dysregulated transcripts following CHD8 knock down (KD), we first identified RAB11B-AS1 as a potential SINEUP RNA for its domain configuration. Then we demonstrated that such lncRNA is able to increase endogenous RAB11B protein amounts without affecting its transcriptional levels. RAB11B has a pivotal role in vesicular trafficking, and mutations on this gene correlate with intellectual disability and microcephaly. Thus, our study discloses an additional layer of molecular regulation which is altered by CHD8 suppression. This represents the first experimental confirmation that naturally occurring SINEUP could be involved in ASD pathogenesis and underscores the importance of dysregulation of functional lncRNAs in neurodevelopment., Competing Interests: SG declares competing financial interests as cofounder and member of TranSINE Therapeutics. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Zarantonello, Arnoldi, Filosi, Tebaldi, Spirito, Barbieri, Gustincich, Sanges, Domenici, Di Leva and Biagioli.)

Published
2021
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14. Type I interferon activation in RAS-associated autoimmune leukoproliferative disease (RALD).

Author

Papa R, Rusmini M, Schena F, Traggiai E, Coccia MC, Caorsi R, Arrigo S, Pasetti F, Signa S, Barone P, Santamaria G, Spirito G, Sanges R, Vozzi D, Cavalli A, Gustincich S, Ravelli A, Gattorno M, Ceccherini I, and Volpi S

Subjects
Adult, Autoimmune Lymphoproliferative Syndrome complications, Humans, Liver Diseases immunology, Mutation, Autoimmune Lymphoproliferative Syndrome genetics, Autoimmune Lymphoproliferative Syndrome immunology, GTP Phosphohydrolases genetics, Interferon Type I immunology, Liver Diseases genetics, Membrane Proteins genetics
Abstract

RAS-associated autoimmune leukoproliferative disease (RALD) is a rare immune dysregulation syndrome caused by somatic gain-of-function mutations of either NRAS or KRAS gene in hematopoietic cells. We describe a 27-year-old patient presenting at 5 months of age with recurrent infections and generalized lymphadenopathy who developed a complex multi-organ autoimmune syndrome with hypogammaglobulinemia, partially controlled with oral steroids, hydroxichloroquine, mofetil mycophenolate and IVIG prophylaxis. Activation of type I interferon pathway was observed in peripheral blood. Since 18 years of age, the patient developed regenerative nodular hyperplasia of the liver evolving into hepatopulmonary syndrome. Whole exome sequencing analysis of the peripheral blood DNA showed the NRAS p.Gly13Asp mutation validated as somatic. Our report highlights the possibility of detecting somatic NRAS gene mutations in patients with inflammatory immune dysregulation and type I interferon activation., (Copyright © 2021 Elsevier Inc. All rights reserved.)

Published
2021
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15. Case Report: Whole Exome Sequencing Revealed Disease-Causing Variants in Two Genes in a Patient With Autism Spectrum Disorder, Intellectual Disability, Hyperactivity, Sleep and Gastrointestinal Disturbances.

Author

Cerminara M, Spirito G, Pisciotta L, Squillario M, Servetti M, Divizia MT, Lerone M, Berloco B, Boeri S, Nobili L, Vozzi D, Sanges R, Gustincich S, and Puliti A

Abstract

Autism Spectrum Disorder (ASD) refers to a broad range of conditions characterized by difficulties in communication, social interaction and behavior, and may be accompanied by other medical or psychiatric conditions. Patients with ASD and comorbidities are often difficult to diagnose because of the tendency to consider the multiple symptoms as the presentation of a complicated syndromic form. This view influences variant filtering which might ignore causative variants for specific clinical features shown by the patient. Here we report on a male child diagnosed with ASD, showing cognitive and motor impairments, stereotypies, hyperactivity, sleep, and gastrointestinal disturbances. The analysis of whole exome sequencing (WES) data with bioinformatic tools for oligogenic diseases helped us to identify two major previously unreported pathogenetic variants: a maternally inherited missense variant (p.R4122H) in HUWE1 , an ubiquitin protein ligase associated to X-linked intellectual disability and ASD; and a de novo stop variant (p.Q259X) in TPH2 , encoding the tryptophan hydroxylase 2 enzyme involved in serotonin synthesis and associated with susceptibility to attention deficit-hyperactivity disorder (ADHD). TPH2 , expressed in central and peripheral nervous tissues, modulates various physiological functions, including gut motility and sleep. To the best of our knowledge, this is the first case presenting with ASD, cognitive impairment, sleep, and gastrointestinal disturbances linked to both HUWE1 and TPH2 genes. Our findings could contribute to the existing knowledge on clinical and genetic diagnosis of patients with ASD presentation with comorbidities., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Cerminara, Spirito, Pisciotta, Squillario, Servetti, Divizia, Lerone, Berloco, Boeri, Nobili, Vozzi, Sanges, Gustincich and Puliti.)

Published
2021
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16. Sun acute n-acetyl cysteine infusion normalizes prooxidant insulin effects and enhances muscle and liver mitochondrial function as well as whole-body insulin sensivity in rat

Author

GORTAN CAPPELLARI, GIANLUCA, SEMOLIC, ANNA MARIA, CHENDI, ENRICO, ZANETTI, MICHELA, BARAZZONI, ROCCO, Spirito, G., GORTAN CAPPELLARI, Gianluca, Semolic, ANNA MARIA, Spirito, G., Chendi, Enrico, Zanetti, Michela, and Barazzoni, Rocco

Subjects
INSULIN SENSITIVITY, MITOCHONDRIAL FUNCTION, INSULIN SENSITIVITY, MITOCHONDRIAL FUNCTION
Published
2013

18. Organizzazione dell’UOMI per aree di assistenza dalla prevenzione all’assistenza per settori in un’ottica di presa in carico partecipata dell’utente

Author

TRIASSI, MARIA, SCHIAVONE L, AMBROSIO F, GIORDANO V, GRANATA A, SAVOIA F, PELUSO C, PIZZA A, SPIRITO G, SPAGNUOLO D, NOCERINO A, MORETTA S, QUARTUCCI F, LONGANELLA W, RINALDI A, FIORETTI A, VOZA N, GAUDIOSI M., Triassi, Maria, Schiavone, L, Ambrosio, F, Giordano, V, Granata, A, Savoia, F, Peluso, C, Pizza, A, Spirito, G, Spagnuolo, D, Nocerino, A, Moretta, S, Quartucci, F, Longanella, W, Rinaldi, A, Fioretti, A, Voza, N, and Gaudiosi, M.

Subjects
presa in carico
Published
2012

19. La distribuzione dei farmaci del PHT : scelte strategiche per la verifica dell’appropriatezza ed il controllo delle spesa

Author

TRIASSI, MARIA, MAROTTA P, QUARTUCCI F, GIORDANO V, PIZZA A, RINALDI A, AMBROSIO F, NOCERINO A, SPIRITO G, MORETTA S, GRANATA A, PENNACCHIO F, SAVOIA F, PASSARO M, PALLADINO R, RAIOLA E, TORRE G, SPAGNUOLO D, FIORETTI A, BELLOPEDE R., Triassi, Maria, Marotta, P, Quartucci, F, Giordano, V, Pizza, A, Rinaldi, A, Ambrosio, F, Nocerino, A, Spirito, G, Moretta, S, Granata, A, Pennacchio, F, Savoia, F, Passaro, M, Palladino, R, Raiola, E, Torre, G, Spagnuolo, D, Fioretti, A, and Bellopede, R.

Published
2012

20. Riorganizzazione del percorso diagnostico di laboratorio della funzionalità tiroidea

Author

TRIASSI, MARIA, TELESCA S, GAUDIOSI M, PENNACCHIO F, GIORDANO V, GRANATA A, SAVOIA F, RAIOLA E, VOZA N, FIORETTI A, PELUSO C, PIZZA A, SPIRITO G, AMBROSIO F, NOCERINO A, MORETTA S, QUARTUCCI F, TORRE G, LONGANELLA W, GERMANO A., Triassi, Maria, Telesca, S, Gaudiosi, M, Pennacchio, F, Giordano, V, Granata, A, Savoia, F, Raiola, E, Voza, N, Fioretti, A, Peluso, C, Pizza, A, Spirito, G, Ambrosio, F, Nocerino, A, Moretta, S, Quartucci, F, Torre, G, Longanella, W, and Germano, A.

Subjects
funzionalità tiroidea
Published
2012

21. Il ruolo strategico dell’elisoccorso nella pianificazione secondo la logica hub & spoke

Author

TRIASSI, MARIA, MINNITI D, PALLADINO R, PELUSO C, PIZZA A, SPIRITO G, AMBROSIO F, TORRE G, GIORDANO V, GRANATA A, SAVOIA F, LONGANELLA W, MORETTA S, FIORETTI A, PASSARO M, RAIOLA E, SPAGNUOLO D, GAUDIOSI M., Triassi, Maria, Minniti, D, Palladino, R, Peluso, C, Pizza, A, Spirito, G, Ambrosio, F, Torre, G, Giordano, V, Granata, A, Savoia, F, Longanella, W, Moretta, S, Fioretti, A, Passaro, M, Raiola, E, Spagnuolo, D, and Gaudiosi, M.

Subjects
hub & spoke
Published
2012

22. Le malattie rare in eta' pediatrica. Organizzare un percorso di presa in carico gestionale– assistenziale in un UOMI di ASL territoriale

Author

TRIASSI, MARIA, FORMISANO G, SPAGNUOLO D, VOZA N, GIORDANO G, GIORDANO V, GRANATA A, SAVOIA F, GAUDIOSI M, FIORETTI A, QUARTUCCI F, PELUSO C, PIZZA A, MORETTA S, NOCERINO A, SPIRITO G, AMBROSIO F, BELLOPEDE R, TRIASSI M., Triassi, Maria, Formisano, G, Spagnuolo, D, Voza, N, Giordano, G, Giordano, V, Granata, A, Savoia, F, Gaudiosi, M, Fioretti, A, Quartucci, F, Peluso, C, Pizza, A, Moretta, S, Nocerino, A, Spirito, G, Ambrosio, F, Bellopede, R, and Triassi, M.

Published
2012

23. I percorsi assistenziali in una U.O.C. di terapia subintensiva respiratoria di un’azienda ospedaliera

Author

TRIASSI, MARIA, CARDONE M, SPIRITO G, PIZZA A, PELUSO C, AMBROSIO F, BELLOPEDE R, NOCERINO A, QUARTUCCI F, MORETTA S, GIORDANO V, GRANATA A, SAVOIA F, PENNACCHIO F, PALLADINO R, PASSARO M, GAUDIOSI M, TORRE G., Triassi, Maria, Cardone, M, Spirito, G, Pizza, A, Peluso, C, Ambrosio, F, Bellopede, R, Nocerino, A, Quartucci, F, Moretta, S, Giordano, V, Granata, A, Savoia, F, Pennacchio, F, Palladino, R, Passaro, M, Gaudiosi, M, and Torre, G.

Published
2012

24. Dai sistemi informativi alla gestione dei percorsi assistenziali per HIV dedicati agli extracomunitari

Author

TRIASSI, MARIA, FERRARO G, RAIOLA E, TORRE G, SPIRITO G, GIORDANO V, GRANATA A, PENNACCHIO F, PASSARO M, VOZA N, SPAGNUOLO D, BELLOPEDE R, SAVOIA F, BUSIELLO F, PALLADINO R, GAUDIOSI M, FIORETTI A., Triassi, Maria, Ferraro, G, Raiola, E, Torre, G, Spirito, G, Giordano, V, Granata, A, Pennacchio, F, Passaro, M, Voza, N, Spagnuolo, D, Bellopede, R, Savoia, F, Busiello, F, Palladino, R, Gaudiosi, M, and Fioretti, A.

Subjects
HIV
Published
2012

25. Inserimento del personale neo-assunto nelle dinamiche complesse delle attività di nursing in terapia intensiva

Author

TRIASSI, MARIA, TASSARO G, VOZA N, PASSARO M, SPAGNUOLO D, TORRE G, GAUDIOSI M, PENNACCHIO F, RAIOLA E, GIORDANO V, GRANATA A, SAVOIA F, PALLADINO R, PELUSO C, PIZZA A, MORETTA S, QUARTUCCI F, AMBROSIO F, NOCERINO A, SPIRITO G., Triassi, Maria, Tassaro, G, Voza, N, Passaro, M, Spagnuolo, D, Torre, G, Gaudiosi, M, Pennacchio, F, Raiola, E, Giordano, V, Granata, A, Savoia, F, Palladino, R, Peluso, C, Pizza, A, Moretta, S, Quartucci, F, Ambrosio, F, Nocerino, A, and Spirito, G.

Published
2012

26. Rete integrata secondo criteri hub & spoke per lo sviluppo delle attività sanitarie e socio/sanitarie tra AASSLL territoriali campane ed IRCCS oncologico di riferimento destinate ai pazienti affetti da patologie urologiche

Author

TRIASSI, MARIA, STRIANO S, PENNACCHIO F, PELUSO C, PIZZA A, SPIRITO G, GIORDANO V, AMBROSIO F, BELLOPEDE R, NOCERINO A, MORETTA S, GRANATA A, SAVOIA F, PALLADINO R, PASSARO M, FIORETTI A, QUARTUCCI F, TORRE G., Triassi, Maria, Striano, S, Pennacchio, F, Peluso, C, Pizza, A, Spirito, G, Giordano, V, Ambrosio, F, Bellopede, R, Nocerino, A, Moretta, S, Granata, A, Savoia, F, Palladino, R, Passaro, M, Fioretti, A, Quartucci, F, and Torre, G.

Subjects
hub & spoke
Published
2012

27. Accesso dei presidi ambulatoriali di recupero e rieducazione funzionale alla rete delle strutture sanitarie accreditate in regione Campania

Author

TRIASSI, MARIA, CICCONE A, GRANATA A, GIORDANO V, SAVOIA F, PASSARO M, VOZA N, GIORDANO G, SPIRITO G, AMBROSIO F, NOCERINO A, MORETTA S, QUARTUCCI F, GAUDIOSI M, TORRE G, PALLADINO R, GERMANO A, PIZZA A., Triassi, Maria, Ciccone, A, Granata, A, Giordano, V, Savoia, F, Passaro, M, Voza, N, Giordano, G, Spirito, G, Ambrosio, F, Nocerino, A, Moretta, S, Quartucci, F, Gaudiosi, M, Torre, G, Palladino, R, Germano, A, and Pizza, A.

Subjects
presidi ambulatoriali
Published
2012

28. Caratteristiche assistenziali, organizzativo- gestionali e livelli di eccellenza erogati in ambito ginecologico

Author

TRIASSI, MARIA, MELITO V, TORRE G, PELUSO C, PIZZA A, GIORDANO V, GRANATA A, SAVOIA F, SPIRITO G, AMBROSIO F, NOCERINO A, MORETTA S, QUARTUCCI F, GAUDIOSI M, SPAGNUOLO D, VOZA N, PASSARO M, PENNACCHIO F, RAIOLA E, RUSSO R., Triassi, Maria, Melito, V, Torre, G, Peluso, C, Pizza, A, Giordano, V, Granata, A, Savoia, F, Spirito, G, Ambrosio, F, Nocerino, A, Moretta, S, Quartucci, F, Gaudiosi, M, Spagnuolo, D, Voza, N, Passaro, M, Pennacchio, F, Raiola, E, and Russo, R.

Subjects
livelli di eccellenza, ginecologia
Published
2012

29. Il modello organizzativo della centrale 118 secondo le logiche dei percorsi assistenziali ad integrazione assistenziale complessa

Author

TRIASSI, MARIA, BORSELLI R, BELLOPEDE R, GIORDANO V, GRANATA A, SAVOIA F, PALLADINO R, PELUSO C, PIZZA A, SPIRITO G, AMBROSIO F, NOCERINO A, MORETTA S, QUARTUCCI F, VOZA N, ONZA C, PASSARO M, SPAGNUOLO D., Triassi, Maria, Borselli, R, Bellopede, R, Giordano, V, Granata, A, Savoia, F, Palladino, R, Peluso, C, Pizza, A, Spirito, G, Ambrosio, F, Nocerino, A, Moretta, S, Quartucci, F, Voza, N, Onza, C, Passaro, M, and Spagnuolo, D.

Subjects
percorsi assistenziali
Published
2012

30. La centralizzazione delle attività’ di vigilanza ospedaliera e l’organizzazione di livelli uniformi di verifiche e controlli in una ASL multipresidiale

Author

TRIASSI, MARIA, PENNACCHIO F, SALVATORE C, GIORDANO V, SAVOIA F, GRANATA A, PIZZA A, SPIRITO G, NOCERINO A, MORETTA S, PELUSO C, PALLADINO R, BELLOPEDE R, PASSARO M, RAIOLA E, QUARTUCCI F, FIORETTI A, AMBROSIO F., Triassi, Maria, Pennacchio, F, Salvatore, C, Giordano, V, Savoia, F, Granata, A, Pizza, A, Spirito, G, Nocerino, A, Moretta, S, Peluso, C, Palladino, R, Bellopede, R, Passaro, M, Raiola, E, Quartucci, F, Fioretti, A, and Ambrosio, F.

Published
2012

31. Definire percorsi assistenziali post ricovero in ostetricia e ginecologia nell’ ottica dell’ appropriatezza assistenziale ed organizzativa

Author

TRIASSI, MARIA, CRESCENZO P, MORETTA S, GIORDANO V, GRANATA A, SAVOIA F, PELUSO C, PIZZA A, SPIRITO G, AMBROSIO F, NOCERINO A, QUARTUCCI F, PASSARO M, PALLADINO R, BELLOPEDE R, SPAGNUOLO D, BUSIELLO F, TORRE G, PENNACCHIO F., Triassi, Maria, Crescenzo, P, Moretta, S, Giordano, V, Granata, A, Savoia, F, Peluso, C, Pizza, A, Spirito, G, Ambrosio, F, Nocerino, A, Quartucci, F, Passaro, M, Palladino, R, Bellopede, R, Spagnuolo, D, Busiello, F, Torre, G, and Pennacchio, F.

Published
2012

32. Riorganizzazione del sistema informativo della filiera del farmaco in una azienda ospedaliera

Author

TRIASSI, MARIA, DI CARLUCCIO F, NOCERINO A, PELUSO C, GIORDANO V, PIZZA A, SPIRITO G, MORETTA S, QUARTUCCI F, SAVOIA F, GRANATA A, FIORETTI A, AMBROSIO F, DE LIGUORI P, PALLADINO R, RAIOLA E, PENNACCHIO F, GAUDIOSI M., Triassi, Maria, DI CARLUCCIO, F, Nocerino, A, Peluso, C, Giordano, V, Pizza, A, Spirito, G, Moretta, S, Quartucci, F, Savoia, F, Granata, A, Fioretti, A, Ambrosio, F, DE LIGUORI, P, Palladino, R, Raiola, E, Pennacchio, F, and Gaudiosi, M.

Subjects
filiera del farmaco
Published
2012

33. La Neurochirurgia dei tumori cerebrali in Campania: analisi di attività e progetto di management sanitario

Author

TRIASSI, MARIA, SCHONAUER E, ARTUSO F, BUONOMO M, GIORDANO V, BERNARDO A, QUARTUCCI F, SPIRITO G, IANNUZZO MT, MORETTO S, GRANATA A, DIANA MV, FORMICOLA M, DE LUCA L, AVITABILE F, MASCOLO D, NOCERINO A, DE LIGUORI P, PASSARO M, DE MARCO G, SAVOIA F, PELUSO C, BOTTA E, CACACE G, DE LUCA, PIZZA A, FABBROCINI M, MAUTONE P, AMBROSIO F, BUSIELLO F., Triassi, Maria, Schonauer, E, Artuso, F, Buonomo, M, Giordano, V, Bernardo, A, Quartucci, F, Spirito, G, Iannuzzo, Mt, Moretto, S, Granata, A, Diana, Mv, Formicola, M, DE LUCA, L, Avitabile, F, Mascolo, D, Nocerino, A, DE LIGUORI, P, Passaro, M, DE MARCO, G, Savoia, F, Peluso, C, Botta, E, Cacace, G, De, Luca, Pizza, A, Fabbrocini, M, Mautone, P, Ambrosio, F, and Busiello, F.

Published
2010

34. Percorso assistenziale per gli utenti geriatrici con frattura di femore ed organizzazione delle attività ospedaliere. L’integrazione dei profili assistenziali della presa in carico alla domiciliazione dell’utente secondo il dettato organizzativo e legislativo

Author

TRIASSI, MARIA, DI MARO G, GIORDANO V, BERNARDO A, SPIRITO G, QUARTUCCI F, IANNUZZO MT, BUONOMO M, ARTUSO F, GRIMALDI MC, MORETTO S, GRANATA A, DIANA MV, DE MARCO G, FORMICOLA M, DE LUCA L, NOCERINO A, DE LIGUORI P, MASCOLO D, PASSARO M, SAVOIA F, PELUSO C, PIZZA A, BOTTA E, CACACE G, MAUTONE P, AMBROSIO F, MANNA A, ACAMPORA E, GIORDANO G., Triassi, Maria, DI MARO, G, Giordano, V, Bernardo, A, Spirito, G, Quartucci, F, Iannuzzo, Mt, Buonomo, M, Artuso, F, Grimaldi, Mc, Moretto, S, Granata, A, Diana, Mv, DE MARCO, G, Formicola, M, DE LUCA, L, Nocerino, A, DE LIGUORI, P, Mascolo, D, Passaro, M, Savoia, F, Peluso, C, Pizza, A, Botta, E, Cacace, G, Mautone, P, Ambrosio, F, Manna, A, Acampora, E, and Giordano, G.

Published
2010

35. La rimodulazione delle attività sanitarie in un distretto sanitario di base. Finalizzare l’organizzazione delle attività per una reale integrazione ospedale territorio. Il valore degli indicatori di attività e i determinanti epidemiologici per intercettare i bisogni di salute

Author

TRIASSI, MARIA, QUARTUCCI F, GIORDANO V, BERNARDO A, BUONOMO M, SPIRITO G, NOCERINO A, ARTUSO F, DE LIGUORI P, MORETTO S, GRANATA A, DIANA MV, FORMICOLA M, MASCOLO D, PASSARO M, SAVOIA F, DE MARCO G, PELUSO C, BOTTA E, CACACE G, FABBROCINI M, PIZZA A, DE LUCA L, MAUTONE P, AMBROSIO F, MANNA A, ACAMPORA E, BUSIELLO F., Triassi, Maria, Quartucci, F, Giordano, V, Bernardo, A, Buonomo, M, Spirito, G, Nocerino, A, Artuso, F, DE LIGUORI, P, Moretto, S, Granata, A, Diana, Mv, Formicola, M, Mascolo, D, Passaro, M, Savoia, F, DE MARCO, G, Peluso, C, Botta, E, Cacace, G, Fabbrocini, M, Pizza, A, DE LUCA, L, Mautone, P, Ambrosio, F, Manna, A, Acampora, E, and Busiello, F.

Published
2010

36. L’assistenza nelle cure domiciliari: dalla comunicazione all’educazione dei caregiver, nel rispetto della normativa e dei livelli professionali specifici

Author

TRIASSI, MARIA, PELUSO C, GIORDANO V, BERNARDO A, BUONOMO M, SPIRITO G, NOCERINO A, ARTUSO F, QUARTUCCI F, MORETTO S, GRANATA A, DIANA MV, FORMICOLA M, MASCOLO D, PASSARO M, AVITABILE F, SAVOIA F, DE MARCO G, DE LUCA L, DE LIGUORI P, PIZZA A, BOTTA E, CACACE G, FABBROCINI M, MAUTONE P, AMBROSIO F, MANNA A, ACAMPORA E, BUSIELLO F., Triassi, Maria, Peluso, C, Giordano, V, Bernardo, A, Buonomo, M, Spirito, G, Nocerino, A, Artuso, F, Quartucci, F, Moretto, S, Granata, A, Diana, Mv, Formicola, M, Mascolo, D, Passaro, M, Avitabile, F, Savoia, F, DE MARCO, G, DE LUCA, L, DE LIGUORI, P, Pizza, A, Botta, E, Cacace, G, Fabbrocini, M, Mautone, P, Ambrosio, F, Manna, A, Acampora, E, and Busiello, F.

Published
2010

37. Il 'governo' del blocco operatorio in ospedale: dalla valutazione della performance alla gestione del rischio

Author

TRIASSI, MARIA, IANNUZZO MT, GIORDANO V, BERNARDO A, BUONOMO M, SPIRITO G, QUARTUCCI F, NOCERINO A, PIZZA A, ARTUSO F, MORETTO S, GRANATA A, DIANA MV, AVITABILE F, FORMICOLA M, MASCOLO D, PASSARO M, SAVOIA F, DE LIGUORI P, PELUSO C, BOTTA E, CACACE G, MAUTONE P, AMBROSIO F, MANNA A, ACAMPORA E, DE LUCA L, GIORDANO G., Triassi, Maria, Iannuzzo, Mt, Giordano, V, Bernardo, A, Buonomo, M, Spirito, G, Quartucci, F, Nocerino, A, Pizza, A, Artuso, F, Moretto, S, Granata, A, Diana, Mv, Avitabile, F, Formicola, M, Mascolo, D, Passaro, M, Savoia, F, DE LIGUORI, P, Peluso, C, Botta, E, Cacace, G, Mautone, P, Ambrosio, F, Manna, A, Acampora, E, DE LUCA, L, and Giordano, G.

Published
2010

38. Ipotesi di modello gestionale della sorveglianza sanitaria negli ex esposti all’amianto in una ASL territoriale

Author

TRIASSI, MARIA, ARTUSO F, BUONOCORE M, GIORDANO V, BERNARDO A, QUARTUCCI F, SPIRITO G, NOCERINO A, IANNUZZO MT, MORETTO S, GRANATA A, DIANA MV, FORMICOLA M, DE MARCO D, PASSARO M, SAVOIA F, PELUSO C, PIZZA A, BOTTA E, CACACE G, FABBROCINI M, MAUTONE P, AMBROSIO F, GIORDANO G, DE LUCA L., Triassi, Maria, Artuso, F, Buonocore, M, Giordano, V, Bernardo, A, Quartucci, F, Spirito, G, Nocerino, A, Iannuzzo, Mt, Moretto, S, Granata, A, Diana, Mv, Formicola, M, DE MARCO, D, Passaro, M, Savoia, F, Peluso, C, Pizza, A, Botta, E, Cacace, G, Fabbrocini, M, Mautone, P, Ambrosio, F, Giordano, G, and DE LUCA, L.

Published
2010

39. Emergenza Ictus: costituzione di una rete di stroke unit adeguate alle esigenze assistenziali e conforme agli aspetti giuridico normativi nella Regione Campania

Author

TRIASSI, MARIA, MARASCO G, GIORDANO V, BERNARDO A, BUONOMO M, SPIRITO G, NOCERINO A, QUARTUCCI F, ARTUSO F, GRIMALDI MC, FABBROCINI M, MORETTO S, GRANATA A, DIANA MV, FORMICOLA M, DE LUCA L, DE LIGUORI P, DE MARCO G, MASCOLO D, PASSARO M, SAVOIA F, PELUSO C, PIZZA A, BOTTA E, CACACE G, MAUTONE P, AMBROSIO F, MANNA A, ACAMPORA E, BUSIELLO, Triassi, Maria, Marasco, G, Giordano, V, Bernardo, A, Buonomo, M, Spirito, G, Nocerino, A, Quartucci, F, Artuso, F, Grimaldi, Mc, Fabbrocini, M, Moretto, S, Granata, A, Diana, Mv, Formicola, M, DE LUCA, L, DE LIGUORI, P, DE MARCO, G, Mascolo, D, Passaro, M, Savoia, F, Peluso, C, Pizza, A, Botta, E, Cacace, G, Mautone, P, Ambrosio, F, Manna, A, Acampora, E, and Busiello

Published
2010

40. La direzione infermieristica e tecnica nelle aziende sanitarie: fondamenti organizzativi e giuridici

Author

TRIASSI, MARIA, DE LEO G, GIORDANO V, BERNARDO A, SPIRITO G, BUONOMO M, QUARTUCCI F, NOCERINO A, IANNUZZO MT, ARTUSO F, MORETTO S, GRANATA A, DIANA MV, FORMICOLA M, DE MARCO G, DE LUCA L, DE LIGUORI P, MASCOLO D, PASSARO M, SAVOIA F, GRIMALDI MC, PELUSO C, PIZZA A, BOTTA E, CACACE G, MAUTONE P, AMBROSIO F, FABBROCINI M, BUSIELLO F., Triassi, Maria, DE LEO, G, Giordano, V, Bernardo, A, Spirito, G, Buonomo, M, Quartucci, F, Nocerino, A, Iannuzzo, Mt, Artuso, F, Moretto, S, Granata, A, Diana, Mv, Formicola, M, DE MARCO, G, DE LUCA, L, DE LIGUORI, P, Mascolo, D, Passaro, M, Savoia, F, Grimaldi, Mc, Peluso, C, Pizza, A, Botta, E, Cacace, G, Mautone, P, Ambrosio, F, Fabbrocini, M, and Busiello, F.

Published
2010

41. La gestione del rischio clinico nell’unità di gastroenterologia ed endoscopia digestiva

Author

TRIASSI, MARIA, DE LUCA L, GIORDANO V, BERNARDO A, BUONOMO M, SPIRITO G, QUARTUCCI F, ARTUSO F, MORETTO S, GRANATA A, DIANA MV, FORMICOLA M, MASCOLO D, TORRE G, DE MARCO G, NOCERINO A, DE LIGUORI P, PASSARO M, PIZZA A, SAVOIA F, PELUSO C, BOTTA E, CACACE G, MAUTONE P, FABBROCINI M, AMBROSIO F, GIORDANO G., Triassi, Maria, DE LUCA, L, Giordano, V, Bernardo, A, Buonomo, M, Spirito, G, Quartucci, F, Artuso, F, Moretto, S, Granata, A, Diana, Mv, Formicola, M, Mascolo, D, Torre, G, DE MARCO, G, Nocerino, A, DE LIGUORI, P, Passaro, M, Pizza, A, Savoia, F, Peluso, C, Botta, E, Cacace, G, Mautone, P, Fabbrocini, M, Ambrosio, F, and Giordano, G.

Published
2010

42. Organizzazione percorsi assistenziali multilivello in cardiologia. La gestione dell’IMA con st sopra o sottoslivellato, con percorsoi definiti pre ricovero, intraospedalieri e post dimissione: impatto nell’organizzazione e nei fondamenti giuridici del rischio clinico

Author

TRIASSI, MARIA, DEDIVITIIS M, GIORDANO V, BERNARDO A, SPIRITO G, QUARTUCCI F, BUONOMO M, IANNUZZO MT, ARTUSO F, MORETTO S, GRANATA A, DIANA MV, FORMICOLA M, AVITABILE F, DE MARCO G, MASCOLO D, PASSARO M, SAVOIA F, DE LIGUORI P, NOCERINO A, PELUSO C, PIZZA A, BOTTA E, CACACE G, MAUTONE P, AMBROSIO F, BUSIELLO F, DE LUCA L., Triassi, Maria, Dedivitiis, M, Giordano, V, Bernardo, A, Spirito, G, Quartucci, F, Buonomo, M, Iannuzzo, Mt, Artuso, F, Moretto, S, Granata, A, Diana, Mv, Formicola, M, Avitabile, F, DE MARCO, G, Mascolo, D, Passaro, M, Savoia, F, DE LIGUORI, P, Nocerino, A, Peluso, C, Pizza, A, Botta, E, Cacace, G, Mautone, P, Ambrosio, F, Busiello, F, and DE LUCA, L.

Published
2010

43. Modelli organizzativo gestionali del blocco operatorio, definizione di specifici setting assistenziali integrati nell’ottica della teoria prestazionale applicata in sanità

Author

TRIASSI, MARIA, BUONOMO M, GIORDANO V, BERNARDO A, QUARTUCCI F, SPIRITO G, IANNUZZO MT, NOCERINO A, ARTUSO F, MORETTO S, GRANATA A, DIANA MV, FORMICOLA M, MASCOLO D, PASSARO M, SAVOIA F, PELUSO C, PIZZA A, BOTTA E, CACACE G, FABBROCINI M, MAUTONE P, AMBROSIO F, DE MARCO G, MANNA A, ACAMPORA E, GIORDANO G, DE LUCA L., Triassi, Maria, Buonomo, M, Giordano, V, Bernardo, A, Quartucci, F, Spirito, G, Iannuzzo, Mt, Nocerino, A, Artuso, F, Moretto, S, Granata, A, Diana, Mv, Formicola, M, Mascolo, D, Passaro, M, Savoia, F, Peluso, C, Pizza, A, Botta, E, Cacace, G, Fabbrocini, M, Mautone, P, Ambrosio, F, DE MARCO, G, Manna, A, Acampora, E, Giordano, G, and DE LUCA, L.

Published
2010

44. Impact of polymorphic transposable elements on transcription in lymphoblastoid cell lines from public data.

Author

Spirito G, Mangoni D, Sanges R, and Gustincich S

Subjects
Alu Elements genetics, Animals, Behavior, Cell Line, Genome, Human, Humans, Immunity genetics, Minisatellite Repeats genetics, DNA Transposable Elements genetics, Databases, Genetic, Lymphocytes metabolism, Polymorphism, Genetic, Quantitative Trait Loci genetics, Transcription, Genetic
Abstract

Background: Transposable elements (TEs) are DNA sequences able to mobilize themselves and to increase their copy-number in the host genome. In the past, they have been considered mainly selfish DNA without evident functions. Nevertheless, currently they are believed to have been extensively involved in the evolution of primate genomes, especially from a regulatory perspective. Due to their recent activity they are also one of the primary sources of structural variants (SVs) in the human genome. By taking advantage of sequencing technologies and bioinformatics tools, recent surveys uncovered specific TE structural variants (TEVs) that gave rise to polymorphisms in human populations. When combined with RNA-seq data this information provides the opportunity to study the potential impact of TEs on gene expression in human., Results: In this work, we assessed the effects of the presence of specific TEs in cis on the expression of flanking genes by producing associations between polymorphic TEs and flanking gene expression levels in human lymphoblastoid cell lines. By using public data from the 1000 Genome Project and the Geuvadis consortium, we exploited an expression quantitative trait loci (eQTL) approach integrated with additional bioinformatics data mining analyses. We uncovered human loci enriched for common, less common and rare TEVs and identified 323 significant TEV-cis-eQTL associations. SINE-R/VNTR/Alus (SVAs) resulted the TE class with the strongest effects on gene expression. We also unveiled differential functional enrichments on genes associated to TEVs, genes associated to TEV-cis-eQTLs and genes associated to the genomic regions mostly enriched in TEV-cis-eQTLs highlighting, at multiple levels, the impact of TEVs on the host genome. Finally, we also identified polymorphic TEs putatively embedded in transcriptional units, proposing a novel mechanism in which TEVs may mediate individual-specific traits., Conclusion: We contributed to unveiling the effect of polymorphic TEs on transcription in lymphoblastoid cell lines.

Published
2019
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45. L’accreditamento istituzionale in nefrologia: leva organizzativa per definire modelli applicativi sperimentali in un UOC di Nefrologia di P.O. di ASL territoriale

Author

NAPPI F, GIORDANO V, BERNARDO A, NOCERINO A, SPIRITO G, FABBROCINI M, DELLA VECCHIA A, CUCCARO P, MOLESE A, DI RESTA M, REA T, MASCOLO D, AVITABILE F, MATARANTE E, BOTTA E, CACACE G, CAPPUCCIO A, DE MARCO G, TRIASSI, MARIA, Nappi, F, Giordano, V, Bernardo, A, Nocerino, A, Spirito, G, Fabbrocini, M, DELLA VECCHIA, A, Cuccaro, P, Molese, A, DI RESTA, M, Rea, T, Mascolo, D, Avitabile, F, Matarante, E, Botta, E, Cacace, G, Cappuccio, A, DE MARCO, G, and Triassi, Maria

Published
2009

46. 'Progetto Pharma - Uni - Hospital'. Integrare le funzioni di una U.O.C. Farmacia ospedaliera secondo logiche di pharmaceutical governance mediante una piattaforma unica di servizi per una tracciabilità del farmaco in un’ottica di rete integrata

Author

FUCILE AM, GIORDANO V, BERNARDO A, NOCERINO A, SPIRITO G, DELLA VECCHIA A, MOLESE A, CUCCARO P, DI RESTA M, MASCOLO D, AVITABILE F, MATARANTE E, BOTTA E, CACACE G, CAPPUCCIO A, DE MARCO G, TRIASSI, MARIA, Fucile, Am, Giordano, V, Bernardo, A, Nocerino, A, Spirito, G, DELLA VECCHIA, A, Molese, A, Cuccaro, P, DI RESTA, M, Mascolo, D, Avitabile, F, Matarante, E, Botta, E, Cacace, G, Cappuccio, A, DE MARCO, G, and Triassi, Maria

Subjects
Progetto Pharma
Published
2009

47. Ipotesi organizzativa di un day service per il trattamento delle varici degli arti inferiori

Author

ABATE LV, GIORDANO V, FABBROCINI M, BERNARDO A, NOCERINO A, SPIRITO G, MOLESE A, DELLA VECCHIA A, REA T, CUCCARO P, BOTTA E, CACACE G, CAPPUCCIO A, DE MARCO G, DI RESTA M, MASCOLO D, AVITABILE F, MATARANTE E, TRIASSI, MARIA, Abate, Lv, Giordano, V, Fabbrocini, M, Bernardo, A, Nocerino, A, Spirito, G, Molese, A, DELLA VECCHIA, A, Rea, T, Cuccaro, P, Botta, E, Cacace, G, Cappuccio, A, DE MARCO, G, DI RESTA, M, Mascolo, D, Avitabile, F, Matarante, E, and Triassi, Maria

Published
2009

48. Dall’appropriatezza organizzativa al recupero dei livelli di efficienza nelle attività integrate di Day Surgery in un IRCCS

Author

DEL GIUDICE M, GIORDANO V, FABBROCINI M, BERNARDO A, NOCERINO A, DELLA VECCHIA A, SPIRITO G, GIORDANO G, MANNA A, CUCCARO P, DI RESTA M, MASCOLO D, AVITABILE F, MATARANTE E, BOTTA E, CACACE G, CAPPUCCIO A, DE MARCO G, TRIASSI, MARIA, DEL GIUDICE, M, Giordano, V, Fabbrocini, M, Bernardo, A, Nocerino, A, DELLA VECCHIA, A, Spirito, G, Giordano, G, Manna, A, Cuccaro, P, DI RESTA, M, Mascolo, D, Avitabile, F, Matarante, E, Botta, E, Cacace, G, Cappuccio, A, DE MARCO, G, and Triassi, Maria

Published
2009

49. L’osservazione breve pediatrica: modalità organizzative, caratteristiche gestionali, finalità tendenti all’appropriatezza clinica nell’ottica della razionalizzazione delle attività aziendali e della corretta allocazione di utente e risorse

Author

D’AVINO P, GIORDANO V, BERNARDO A, NOCERINO A, SPIRITO G, DELLA VECCHIA A, MANNA A, CUCCARO P, DI RESTA M, MASCOLO D, AVITABILE F, MATARANTE E, BOTTA E, CACACE G, CAPPUCCIO A, DE MARCO G, TRIASSI, MARIA, D’Avino, P, Giordano, V, Bernardo, A, Nocerino, A, Spirito, G, DELLA VECCHIA, A, Manna, A, Cuccaro, P, DI RESTA, M, Mascolo, D, Avitabile, F, Matarante, E, Botta, E, Cacace, G, Cappuccio, A, DE MARCO, G, and Triassi, Maria

Published
2009

50. La filiera assistenziale in U.O.M.I: il 'consultorio' fra strutture aziendali e integrazione assistenziale. Impatto sull’organizzazione aziendale e sul tessuto socio sanitario di riferimento

Author

AMBROSIO F, GIORDANO V, SPIRITO G, DELLA VECCHIA A, FABBROCINI M, MANNA A, RICCO CS, BERNARDO A, NOCERINO A, CUCCARO P, GIORDANO G, REA T, DI RESTA M, MASCOLO D, AVITABILE F, MATARANTE E, BOTTA E, CACACE G, CAPPUCCIO A, DE MARCO G, TRIASSI, MARIA, Ambrosio, F, Giordano, V, Spirito, G, DELLA VECCHIA, A, Fabbrocini, M, Manna, A, Ricco, C, Bernardo, A, Nocerino, A, Cuccaro, P, Giordano, G, Rea, T, DI RESTA, M, Mascolo, D, Avitabile, F, Matarante, E, Botta, E, Cacace, G, Cappuccio, A, DE MARCO, G, and Triassi, Maria

Published
2009

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