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Aim. To assess the efficacy and safety of lenvatinib and pembrolizumab for the treatment of mismatch repair-proficient endometrial cancer (EC) in routine clinical practice in Russia.Materials and methods. This multicenter, retrospective, cohort study included patients with recurrent and metastatic EC from 37 cancer centers in Russia treated between May 2020 and April 2023. Patients with histologically verified EC without microsatellite instability who received ≥1 course of pembrolizumab/lenvatinib therapy were included in the study. The primary endpoint was progression-free survival; the clinical characteristics of the patients were additionally analyzed, the objective response rate and the toxicity profile of therapy were assessed.Results. The study included 100 patients. Median age was 65 (30–83) years. The most common histologic tumor subtype was endometrioid adenocarcinoma (68 %); serous adenocarcinoma was diagnosed in 22 % of cases, other types of tumor – 10 % of cases. All patients had pMMR/microsatellite-stable tumors. The median progression-free survival was 7.75 months (95 % confidence interval 0.7–33.8), and a partial response to therapy was observed in 24 % of patients. Almost half of the patients (44 %) required dose reduction due to adverse events. The most common adverse events included fatigue (n = 26; 26 %), hypertension (n = 20; 20 %), and hypothyroidism (n = 14; 14 %).Conclusion. This study confirms the clinical efficacy of lenvatinib and pembrolizumab in patients with recurrent and metastatic EC without mismatch repair system deficiency (pMMR-tumors) in routine clinical practice.

The tritium thermal activation method is discussed based on the formation of atomic tritium via dissociation of tritium molecules on a tungsten wire heated by an electric current. An analysis was made of the development of ideas about the processes occurring in the system and methods for optimizing the conditions for obtaining labeled compounds, ensuring required values of specific radioactivity and intramolecular distribution and minimum amount of by-products.This approach allows introduction of tritium not only into individual compounds, but also into complex mixtures of molecules, providing a uniform distribution of the label over the components. On the other hand, selective introduction of tritium into sterically accessible fragments of supramolecular complexes may give information on structural organization of complexes. The tritium probe method as a systematic approach is considered, including preparation of tritium-labeled compounds, determination of the formation conditions of intermolecular complexes with their help, determination of composition of complexes and, using treatment with tritium atoms and distribution of tritium over the components, determination of structural parameters of complexes. The use of tritium thermal activation method, together with computer simulation and modern instrumental research methods, makes it possible to obtain unique information about the composition and structure of complex multicomponent systems. [ABSTRACT FROM AUTHOR]