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Cosmos bipinnatus has been used widely in traditional medicines. Here, we sequenced and assembled the complete chloroplast genome of C. bipinnatus . This genome is 150,356 bp in size with a pair of inverted repeats (IRs) of 25,082 bp, a large single-copy (LSC) region of 83,003 bp, and a small single-copy region (SSC) of 18,397 bp. It contains 112 unique genes, including 80 protein-coding, 4 rRNA, and 28 tRNA genes. The phylogenomic analysis showed the C. bipinnatus and species belonging to the Madieae, Millerieae, Heliantheae, and Eupatorieae tribes were clustered together. The availability of chloroplast genome provided valuable information for future conservation, taxonomy, evolution, and differentiation studies of C. bipinnatus., Competing Interests: No potential conflict of interest was reported by the authors., (© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.)

We have measured the angular autocorrelation function of near-infrared galaxies in SERVS + DeepDrill, the Spitzer Extragalactic Representative Volume Survey and its follow-up survey of the Deep Drilling Fields, in three large fields totalling over 20 deg2 on the sky, observed in two bands centred on 3.6 and 4.5 μ m. We performed this analysis on the full sample as well as on sources selected by [3.6]–[4.5] colour in order to probe clustering for different redshift regimes. We estimated the spatial correlation strength as well, using the redshift distribution from S-COSMOS with the same source selection. The strongest clustering was found for our bluest subsample, with 〈 z 〉 ∼ 0.7, which has the narrowest redshift distribution of all our subsamples. We compare these estimates to previous results from the literature, but also to estimates derived from mock samples, selected in the same way as the observational data, using deep light-cones generated from the SHARK semi-analytical model of galaxy formation. For all simulated (sub)samples, we find a slightly steeper slope than for the corresponding observed ones, but the spatial clustering length is comparable in most cases. [ABSTRACT FROM AUTHOR]

Skin protection against ultraviolet (UV) radiation has long been crucial due to its role in photoaging, sunburn, and wrinkles. This study focuses on developing a bio-based sunscreen from Calendula arvensis capitula extract. Various extraction methods (maceration, sonication, and infusion) and solvents (EtOH, EtOH-H2O, and H2O) were explored in order to identify the most effective extract for use in a sunscreen formulation. Each extract was analyzed for its phenolic content, as well as antioxidant activities (assessed through DPPH, CAT, and FRAP assays). Enzyme inhibition assays for tyrosinase, elastase, and collagenase highlighted the low IC50 values of the hydroethanolic extract. Furthermore, the in vitro sun protection factor (SPF) against UVB radiation was measured using ultraviolet spectrophotometry. A phytochemical analysis showed phenolic levels between 8 and 27 mg GAE/g, flavonoid concentrations of 7–13 mg QE/g, and tannin levels of 1.15–1.68 mg/mL, alongside moderate antioxidant activity. The ethanol maceration extract reduced the interfacial tension to 2.15 mN/m in 600 s, outperforming the conventional emulsifier polysorbate 20. The sonicated hydroethanolic extract demonstrated remarkable SPF efficacy (SPF = 193.65 ± 0.02), far exceeding that of the standard zinc oxide (SPF = 11.88 ± 0.03). The proposed formulations meet the COSMOS standards, suggesting their potential for certification as biological products. Further clinical and in vivo studies are necessary to confirm their safety and commercial viability. [ABSTRACT FROM AUTHOR]

Coastal change is a complex combination of multi-scale processes (e.g., wave-driven cross-shore and longshore transport; dune, bluff, and cliff erosion; overwash; fluvial and inlet sediment supply; and sea-level-driven recession). Historical sea-level-driven coastal recession on open ocean coasts is often outpaced by wave-driven change. However, future sea-level-driven coastal recession is expected to increase significantly in tandem with accelerating rates of global sea-level rise. Few models of coastal sediment transport can resolve the multitude of coastal-change processes at a given beach, and fewer still are computationally efficient enough to achieve large-scale, long-term simulations, while accounting for historical behavior and uncertainties in future climate. Here, we show that a scalable, data-assimilated shoreline-change model can achieve realistic simulations of long-term coastal change and uncertainty across large coastal regions. As part of the modeling case study of the U.S. South Atlantic Coast (Miami, Florida to Delaware Bay) presented here, we apply historical, satellite-derived observations of shoreline position combined with daily hindcasted and projected wave and sea-level conditions to estimate long-term coastal change by 2100. We find that 63 to 94% of the shorelines on the U.S. South Atlantic Coast are projected to retreat past the present-day extent of sandy beach under 1.0 to 2.0 m of sea-level rise, respectively, without large-scale interventions. [ABSTRACT FROM AUTHOR]

Precision cut lung slices (PCLS) are complex three-dimensional (3-D) lung tissue models, which preserve the native microenvironment, including cell diversity and cell-matrix interactions. They are an innovative ex vivo platform that allows studying disease as well as the effects of therapeutic agents or regulatory molecules [e.g., microRNA (miRNA)]. The aim of our study was to develop a protocol to transfect PCLS with miRNA using lipid nanoparticles (LNPs) to enable higher throughput screening of miRNA, obviating the need for custom stabilization and internalization approaches. PCLS of 4 mm diameter were generated using agarose-filled rodent lungs and a vibratome. TYE665-labeled scrambled miRNA was used to evaluate transfection efficacy of six different commercially available LNPs. Transfection efficacy was visualized using live high-content fluorescence microscopy, followed by higher-resolution confocal fluorescence microscopy in fixed PCLS. Metabolic activity and cellular damage were assessed using water-soluble tetrazolium salt (WST-1) and lactate dehydrogenase (LDH) release. Using a live staining kit containing a cell membrane impermeant nuclear dye, RedDot2, we established that cellular membranes in PCLS are permeable in the initial 24 h of slicing but diminished thereafter. Therefore, all transfection experiments occurred at least 24 h after slicing. All six commercially available LNPs enabled transfection without inducing significant cytotoxicity or impaired metabolic function. However, RNAiMAX and INTERFERin led to increases in transfection efficacy as compared with other LNPs, with detection possible as low as 25 nM. Therefore, LNP-based transfection of miRNA is possible and can be visualized in live or fixed PCLS, enabling future higher throughput studies using diverse miRNAs. NEW & NOTEWORTHY: RNA-based therapeutics hold significant promise for disease treatment; however, limited research exists on miRNA transfection specifically within PCLS. miRNA transfection has thus far required custom functionalization for stabilization and internalization. We aimed to optimize a transfection protocol for rapid screening approaches of miRNA sequences. We show that transfecting miRNA in PCLS is possible using lipid nanoparticles. In addition, we show that 25 nM of TYE665-miRNA is sufficient for detection in a high-content imaging system. [ABSTRACT FROM AUTHOR]

In this work, we study the time-dependent behavior of quantum correlations of a system of an inverted oscillator governed by out-of-equilibrium dynamics using the well-known Schwinger–Keldysh formalism in the presence of quantum mechanical quench. Considering a generalized structure of a time-dependent Hamiltonian for an inverted oscillator system, we use the invariant operator method to obtain its eigenstate and continuous energy eigenvalues. Using the expression for the eigenstate, we further derive the most general expression for the generating function as well as the out-of-time-ordered correlators (OTOCs) for the given system using this formalism. Further, considering the time-dependent coupling and frequency of the quantum inverted oscillator characterized by quench parameters, we comment on the dynamical behavior, specifically the early, intermediate and late time-dependent features of the OTOC for the quenched quantum inverted oscillator. Next, we study a specific case, where the system of an inverted oscillator exhibits chaotic behavior by computing the quantum Lyapunov exponent from the time-dependent behavior of OTOCs in the presence of the given quench profile. [ABSTRACT FROM AUTHOR]

UVCANDELS is a Hubble Space Telescope Cycle-26 Treasury Program awarded 164 orbits of primary ultraviolet (UV) F275W imaging and coordinated parallel optical F435W imaging in four CANDELS fields—GOODS-N, GOODS-S, EGS, and COSMOS—covering a total area of ∼426 arcmin2. This is ∼2.7 times larger than the area covered by previous deep-field space UV data combined, reaching a depth of about 27 and 28 ABmag (5 σ in 0."2 apertures) for F275W and F435W, respectively. Along with new photometric catalogs, we present an analysis of the rest-frame UV luminosity function (LF), relying on our UV-optimized aperture photometry method, yielding a factor of 1.5 increase over H-isophot aperture photometry in the signal-to-noise ratios of galaxies in our F275W imaging. Using well-tested photometric redshift measurements, we identify 5810 galaxies at redshifts 0.6 < z < 1, down to an absolute magnitude of M UV = −14.2. In order to minimize the effect of uncertainties in estimating the completeness function, especially at the faint end, we restrict our analysis to sources above 30% completeness, which provides a final sample of 4726 galaxies at −21.5 < M UV < −15.5. We performed a maximum likelihood estimate to derive the best-fit parameters of the UV LF. We report a best-fit faint-end slope of α = − 1.359 − 0.041 + 0.041 at z ∼ 0.8. Creating subsamples at z ∼ 0.7 and z ∼ 0.9, we observe a possible evolution of α with redshift. The unobscured UV luminosity density at M UV < −10 is derived as ρ U V = 1.339 − 0.030 + 0.027 (× 10 26 e r g s − 1 H z − 1 M p c − 3) using our best-fit LF parameters. The new F275W and F435 photometric catalogs from UVCANDELS have been made publicly available on the Barbara A. Mikulski Archive for Space Telescopes. [ABSTRACT FROM AUTHOR]

Multimorbidity refers to the presence of two or more chronic diseases and is associated with adverse outcomes for patients. Factors such as an ageing population have contributed to a rise in prevalence of multimorbidity globally; however, multimorbidity is often neglected in clinical guidelines. This is largely because patients with multimorbidity are systematically excluded from clinical trials. Accordingly, there is an urgent need to develop novel biomarkers and methods of prognostication for this cohort of patients. The hallmarks of ageing are now thought to potentiate the pathogenesis of multimorbidity. MicroRNAs are small, regulatory, noncoding RNAs which have been implicated in the pathogenesis and prognostication of numerous chronic diseases; there is a substantial body of evidence now implicating microRNA dysregulation with the different hallmarks of ageing in the aetiology of chronic diseases. This article proposes using the hallmarks of ageing as a framework to develop a panel of microRNAs to assess the prognostic burden of multimorbidity. This putative molecular morbidity score would have many potential applications, including assessing the efficacy of clinical interventions, informing clinical decision making and facilitating wider inclusion of patients with multimorbidity in clinical trials. [ABSTRACT FROM AUTHOR]

While comprehensive knowledge networks can be instrumental in finding solutions to complex problems or supporting the development of detailed simulation models, their large number of nodes and edges can become a hindrance. When the representation of a network becomes opaque, they stop fulfilling their role as a shared representation of a system between participants and modelers; hence, participants are less engaged in the model-building process. Combating the information overload created by large conceptual models is not merely a matter of changing formats: shifting from an unwieldy diagram to enormous amounts of text does not promote engagement. Rather, we posit that participants need an environment that provides details on demand and where interactions with a model rely primarily on a familiar format (i.e., text). In this study, we developed a visual analytics environment where linked visualizations allow participants to interact with large conceptual models, as shown in a case study with hundreds of nodes and almost a thousand relationships. Our environment leverages several advances in generative AI to automatically transform (i) a conceptual model into detailed paragraphs, (ii) detailed text into an executive summary of a model, (iii) prompts about the model into a safe version that avoids sensitive topics, and (iv) a description of the model into a complementary illustration. By releasing our work open source along with a video of our case study, we encourage other modelers to use this approach with their participants. Their feedback and future usability studies are key to respond to the needs of participants by improving our environment given individual preferences, models, and application domains. [ABSTRACT FROM AUTHOR]

Large-scale outflows driven by supermassive black holes are thought to have a fundamental role in suppressing star formation in massive galaxies. However, direct observational evidence for this hypothesis is still lacking, particularly in the young universe where star-formation quenching is remarkably rapid1–3, thus requiring effective removal of gas4 as opposed to slow gas heating5,6. Although outflows of ionized gas are frequently detected in massive distant galaxies7, the amount of ejected mass is too small to be able to suppress star formation8,9. Gas ejection is expected to be more efficient in the neutral and molecular phases10, but at high redshift these have only been observed in starbursts and quasars11,12. Here we report JWST spectroscopy of a massive galaxy experiencing rapid quenching at a redshift of 2.445. We detect a weak outflow of ionized gas and a powerful outflow of neutral gas, with a mass outflow rate that is sufficient to quench the star formation. Neither X-ray nor radio activity is detected; however, the presence of a supermassive black hole is suggested by the properties of the ionized gas emission lines. We thus conclude that supermassive black holes are able to rapidly suppress star formation in massive galaxies by efficiently ejecting neutral gas.JWST observations of a massive galaxy at a redshift of 2.45 show a powerful outflow of neutral gas, with a mass outflow rate that is sufficient to shut down star formation. [ABSTRACT FROM AUTHOR]

This document provides information about various educational resources and activities related to space and astronomy. It mentions a scale model of time activity, unit conversions, and proportional reasoning modules for students. It also discusses the use of image scaling in astronomy, as well as specific activities related to topics such as water on Mars, Pluto's size, and asteroid dynamics. [Extracted from the article]

The Atlantic meridional overturning circulation (AMOC) has caused significant climate changes over the past 90 000 years. Prior work has hypothesized that these millennial-scale climate variations effected past and contemporary biodiversity, but the effects are understudied. Moreover, few biogeographic models have accounted for uncertainties in palaeoclimatic simulations of millennial-scale variability. We examine whether refuges from millennial-scale climate oscillations have left detectable legacies in the patterns of contemporary species richness in eastern North America. We analyse 13 palaeoclimate estimates from climate simulations and proxy-based reconstructions as predictors for the contemporary richness of amphibians, passerine birds, mammals, reptiles and trees. Results suggest that past climate changes owing to AMOC variations have left weak but detectable imprints on the contemporary richness of mammals and trees. High temperature stability, precipitation increase, and an apparent climate fulcrum in the southeastern United States across millennial-scale climate oscillations aligns with high biodiversity in the region. These findings support the hypothesis that the southeastern United States may have acted as a biodiversity refuge. However, for some taxa, the strength and direction of palaeoclimate-richness relationships varies among different palaeoclimate estimates, pointing to the importance of palaeoclimatic ensembles and the need for caution when basing biogeographic interpretations on individual palaeoclimate simulations. This article is part of the theme issue 'Ecological novelty and planetary stewardship: biodiversity dynamics in a transforming biosphere'. [ABSTRACT FROM AUTHOR]

Prolonged exposure to environments with high concentrations of crystalline silica (CS) can lead to silicosis. Macrophages play a crucial role in the pathogenesis of silicosis. In the process of silicosis, silica (SiO 2 ) invades alveolar macrophages (AMs) and induces mitophagy which usually exists in three states: normal, excessive, and/or deficiency. Different mitophagy states lead to corresponding toxic responses, including successful macrophage repair, injury, necrosis, apoptosis, and even pulmonary fibrosis. This is a complex process accompanied by various cytokines. Unfortunately, the details have not been fully systematically summarized. Therefore, it is necessary to elucidate the role of macrophage mitophagy in SiO 2 -induced pulmonary fibrosis by systematic analysis on the literature reports. In this review, we first summarized the current data on the macrophage mitophagy in the development of SiO 2 -induced pulmonary fibrosis. Then, we introduce the molecular mechanism on how SiO 2 -induced mitophagy causes pulmonary fibrosis. Finally, we focus on introducing new therapies based on newly developed mitophagy-inducing strategies. We conclude that macrophage mitophagy plays a multifaceted role in the progression of SiO 2 -induced pulmonary fibrosis, and reprogramming the macrophage mitophagy state accordingly may be a potential means of preventing and treating pulmonary fibrosis., (© 2024 John Wiley & Sons Ltd.)

In this work, we present a quintessential interpretation of having a blue-tilted tensor power spectrum for canonical single-field slow-roll inflation to explain the recently observed Pulsar Timing Array (NANOGrav 15-year and EPTA) signal of Gravitational Waves (GW). We formulate the complete semi-classical description of cosmological perturbation theory in terms of scalar and tensor modes using the Non-Bunch Davies initial condition. We found that the existence of the blue tilt (n t) within the favoured range 1.2 < n t < 2.5 can be explained in terms of a newly derived consistency relation. Further, we compute a new field excursion formula using the Non-Bunch Davies initial condition, that validates the requirement of Effective Field Theory in the sub-Planckian regime, | Δ ϕ | ≪ M pl for the allowed value of the tensor-to-scalar ratio, r < 0.06 from CMB observations. In our study, we refer to this result as Anti Lyth bound as it violates the well-known Lyth bound originally derived for Bunch Davies initial condition. Further, we study the behaviour of the spectral density of GW and the associated abundance with the frequency, which shows that within the frequency domain 10 - 9 Hz < f < 10 - 7 Hz the outcome obtained from our analysis is completely consistent with the Pulsar Timing Array (NANOGrav 15-year and EPTA) signal. Also, we found that the behaviour of GW spectra satisfies the CMB constraints at the low frequency, f ∗ ∼ 7.7 × 10 - 17 Hz corresponding to the pivots scale wave number, k ∗ ∼ 0.05 Mpc - 1. Finally, the sharp falling behaviour of the GW spectra within the frequency domain 10 - 7 Hz < f < 1 Hz validates our theory in the comparatively high-frequency regime as well. [ABSTRACT FROM AUTHOR]

Idiopathic pulmonary fibrosis (IPF) is an age-related lung interstitial disease that occurs predominantly in people over 65 years of age and for which there is a lack of effective therapeutic agents. It has demonstrated that mesenchymal stem cells (MSCs) including alveolar epithelial cells (AECs) can perform repair functions. However, MSCs lose their repair functions due to their distinctive aging characteristics, eventually leading to the progression of IPF. Recent breakthroughs have revealed that the degree of autophagic activity influences the renewal and aging of MSCs and determines the prognosis of IPF. Autophagy is a lysosome-dependent pathway that mediates the degradation and recycling of intracellular material and is an efficient way to renew the nonnuclear (cytoplasmic) part of eukaryotic cells, which is essential for maintaining cellular homeostasis and is a potential target for regulating MSCs function. Therefore, this review focuses on the changes in autophagic activity of MSCs, clarifies the relationship between autophagy and health status of MSCs and the effect of autophagic activity on MSCs senescence and IPF, providing a theoretical basis for promoting the clinical application of MSCs. [ABSTRACT FROM AUTHOR]

Construction work sites and the surrounding built environments are notable contributors to atmosphere dust particulate matter (PM) emissions. PM produced in construction processes contain a range of chemically hazardous substances, posing significant health risks (HR) to individuals. As such, the evaluation of occupational HR in construction has become a focal point of interest internationally. Initiated in the early 2000s, there has been a growing demand within the construction research community for the creation of a unified PM database that encapsulates a wide array of construction activities. Previous studies have endeavored to establish a PM database for various construction contexts, yet they have fallen short in thoroughly addressing the diversity of construction materials and the levels of toxic substances (TS) within the PM. This research introduced a comprehensive PM and TS dataset and conducted a case study to measure the HR associated with diverse construction processes. This was accomplished by implementing a semi-automated Building Information Modeling (BIM) version 2020-based plugin, which streamlines the assessment of occupational HR in construction projects. This system provides construction supervisors with a tool to visually assess the HR of daily operations, thereby facilitating the adoption of preemptive measures to protect the health of construction workers. [ABSTRACT FROM AUTHOR]

The paper presents the pathogenic mycobiota associated with ornamental deciduous trees and shrubs as well as flowering plants grown in the green spaces of the city of Bucharest. The observations were carried out in 2020-2023 in the Herastrau Park, the Bazilescu Park, the Dendrological Park and the Botanical Garden on the USAMVcampus and adjoining streets. Ornamental plants are attacked by various pathogenic species of fungi from Ascomycota and Basidiomycota phyla. During the study, symptoms produced by 47 species of fungal pathogens, belonging to the phylum Ascomycota, included in 11 orders (Erysiphales, Rhytismatales, Glomerellales, Helotiales, Diaporthales, Capnodiales, Taphrinales, Mycosphaerellales, Venturiales, Myringiales, Pleosporales) were observed. From the Basidiomycota phylum, 10 species belonging to 4 orders (Pucciniales, Agaricales, Entylomatales, Polyporales) were identified. Fungal species were identified based on symptoms induced in plants and on morphological characteristics of pathogens. [ABSTRACT FROM AUTHOR]

Recent studies which select active galactic nucleus (AGN) in the mid-infrared (IR) part of the spectrum find that obscured AGNs reside in more massive dark matter haloes compared to unobscured ones. In contrast, X-ray AGN surveys do not find a difference in the dark matter haloes of these two populations. We visit anew this issue by examining the clustering properties of a large X-ray sample distributed over five deep fields. These are the CDF-N, CDF-S, ECDF-S, COSMOS, and AEGIS Chandra fields spanning the redshift interval 0.6 < |$z$| < 1.4. In particular, we present the clustering properties of 736 and 720 unobscured and obscured X-ray-selected AGNs (0.5–8 keV) with column densities higher and lower than |$\rm \mathit{ N}_H=10^{22}\,cm^{-2}$|⁠, respectively. We perform a spatial correlation function analysis for the two samples, and we find a weak (2σ) difference in the clustering of obscured sources (⁠|$\rm \mathit{ r}_o= 7.0 \pm 0.6$| h −1Mpc) compared to that of unobscured sources (⁠|$\rm \mathit{ r}_o= 5.4 \pm 0.6$| h −1Mpc) using a fixed slope of γ = 1.8. Furthermore, we compare our findings with recent results that base the obscured and unobscured AGN classification on the optical/IR colour (⁠|$R-[4.5]=6.1$|⁠). We find that the optical/IR criterion fails to identify a purely AGN sample. In particular, reddened AGNs with |$R-[4.5]\gt 6.1$| are divided almost equally between X-ray obscured and unobscured AGNs. Derivation of the spectral energy distributions reveals that in many cases the host galaxy contaminates the mid-IR bands thus affecting the optical/mid-IR obscured AGN classification. [ABSTRACT FROM AUTHOR]

Pulmonary fibrosis results from a plethora of abnormal pathogenetic events. In idiopathic pulmonary fibrosis (IPF), inhalational, environmental, or occupational exposures in genetically and epigenetically predisposed individuals trigger recurrent cycles of alveolar epithelial cell injury, activation of coagulation pathways, chemoattraction, and differentiation of monocytes into monocytederived alveolar macrophages (Mo-AMs). When these events happen intermittently and repeatedly throughout the individual's life cycle, the wound repair process becomes aberrant leading to bronchiolization of distal air spaces, fibroblast accumulation, extracellular matrix deposition, and loss of the alveolar-capillary architecture. The role of immune dysregulation in IPF pathogenesis and progression has been underscored in the past mainly after the disappointing results of immunosuppressant use in IPF patients; however, recent reports highlighting the prognostic and mechanistic roles of monocytes and Mo-AMs revived the interest in immune dysregulation in IPF. In this review, we will discuss the role of these cells in the onset and progression of IPF, as well as potential targeted therapies. [ABSTRACT FROM AUTHOR]