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The goal of this study was to investigate the development of mental lexicon organization among typical and dyslexic native Arabic readers. The participants included 271 students, divided into dyslexic readers, age-matched typical readers, and typical readers 2 years younger. The lexical status of root and pattern morphemes was examined using two priming paradigms: masked priming and the cross-modal immediate repetition task. We conducted two visual lexical decision tasks (Experiment 1 for verb pattern, Experiment 3 for verb roots), and two auditory decision tasks (Experiment 2 for verb pattern, Experiment 4 for verb roots). In the visual tasks, the participants were asked to decide whether a visual stimulus was a real word or not by pressing the laptop keyboard's "yes" or "no" button. The auditory experiments were conducted similarly to the visual experiments, except that the stimuli were auditory, to clarify the locus of the morphological deficit observed in the visual test of the dyslexic students, should there be such failures. Analysis of Experiment 1 showed that verb patterns are not lexical entities with a role in organizing the mental lexicon among typical and dyslexic readers of different ages. However, Experiment 3 indicated that roots do indeed constitute lexical entities with a role in organizing the mental lexicon among normal and dyslexic readers of different ages. In Experiment 2, the auditory-morpho priming effect in the word pattern test was stronger among dyslexic and young readers than among more skilled readers, and contributed to speeding up lexical decisions more than its quality, among all research groups. In Experiment 4, the auditory-morpho priming effect in the root test was stronger than the visual effect among all participants, and contributed to hastening lexical decisions and improving the quality of the answers (success percentage). The results showed that roots contribute to the reading process. However, their contribution is different among dyslexic readers. Its construction is slower and different from that of typical readers, whereas word patterns have no lexical representation among the three reader groups that are likely to facilitate lexical decisions. The results are discussed with reference to the latest research literature on morpheme type (root or pattern)., (© 2021. The International Dyslexia Association.)

Background: There are few studies on death education models for nursing students in China. It is of great significance to construct a model of nursing students' death education combined with clinical practice. This study aims to evaluate the effect of death education on nursing students based on the Peace of Mind Tea House. Methods: The randomized controlled trial commenced from February 7 to March 18, 2021,featuring a two-month intercession at a hospital situated in Xiamen, China. The research subjects were chosen using a convenient sampling approach with nursing students from the hospital's internship program. Ninety-two participants were enrolled, with 46 in each group. Thirteen participants were lost to follow-up, corresponding to 14% of the total study population. The samples were then allocated randomly into either the intervention group or the control group. In addition to their hospital internship, the intervention group participated in six death education courses that focused on cognitive, emotional, and motor skills as well as the "Peace of Mind Tea House" program. Control participants will undergo regular internships. Before and two weeks after the course, both groups were evaluated for death anxiety, attitude towards death, and the meaning of life to assess the intervention's effectiveness. Results: In the fear of death item of the Death Attitude Scale and the meaning of life section, the post-test score minus the pre-test score of the intervention group were 2.50 ± 3.90 (p = 0.011), and 8.90 ± 11.07 (p = 0.035), respectively. During the communication and sharing session of the reassurance card activity, 41 participants (95.3%) found the activity meaningful. Conclusion: Our data analysis demonstrates that nursing students have accepted and acknowledged the Peace of Mind Tea House-based education on death, which positively impacted their attitudes towards deathand the meaning of life. The content of death education should be integrated with traditional culture, and a new model of death education should be constructed with the Heart to Heart cards as its core. This research presents proof of the efficacy of implementing appropriate death education for nursing students, and provides a successful intervention plan to alleviate their future death anxiety and develop a positive outlook on death. Trial registration: This study was approved by the Ethical Committee of Xiamen University School of Medicine (No. XDYX202304K21)(Date:18/01/2021). Written consent to participate was obtained from all the students. [ABSTRACT FROM AUTHOR]

Methods for ex vivo purging of neoplastic cells from harvested marrow are being developed to increase the efficacy of autologous transplantation. One approach is selective photosensitization, using sensitizing compounds and light radiation. Pyrene-containing fatty acids and lipids are potent photosensitizers, e.g. 12-(1-pyrene)dodecanoic acid (P12), is taken up preferentially by leukemic cells and undergo photoexcitation when exposed to long wave ultra-violet light, resulting in selective killing of leukemic cells. These compounds are incorporated into the neutral- and phospho-lipids of the cells. The presence of intracellular pyrene-linked lipids might present a potential hazard in applying these agents for clinical use. We have, therefore, studied a series of other pyrene-linked compounds with the objective of finding a non-metabolizable photosensitizing agent that can be easily removed from the cells. In the present paper we report the results with pyrene butanol (P4-OH), a pyrene linked short-chain alcohol. When compared to P12, P4-OH was found to be taken up by cells most rapidly and reached saturation within minutes. It did not undergo any metabolism and washing the cells with serum-containing salt solutions removed practically all the P4-OH. This compound was found to be an efficient photosensitizer (in terms of concentrations and time of incubation with the cells) and selective to leukemic cells--it caused a 99% reduction in leukemic clonogenic cells under conditions that normal hemopoietic progenitors remained almost intact. These properties make P4-OH a potential photosensitizer for clinical application.

Vesicular stomatitis virus (VSV) was incubated with pyrene dodecanoic acid (P12), a fluorescent derivative of a medium-chain length fatty acid, and subjected to irradiation with a long wavelength ultra-violet light source at 366 nm (UVA). This inactivated the virus, resulting in a drastic decrease of its infectivity. The virus inactivation was proportional to the concentration of the pyrene-fatty acid, the length of exposure of the virus to P12 and the irradiation dose.

The application of metal mordants is usually necessary in dyeing of wool with natural dyes to improve the dye exhaustion and fastness properties. The majority of metal salts generally used as mordants are considered as toxic and it is important to find replacements for them. Plant sources with high content of tannins are good candidates as bio‐mordant or colourant to overcome this drawback. In this study, the waste fallen leaves of pomegranate tree were used as a source of natural dye for the eco‐friendly dyeing of wool fabric without the use of metal mordants. The dyeing process variables including dye concentration, dyebath pH, and temperature were optimised using response surface methodology to obtain the highest colour strength. The colour strength was increased by increasing the natural dye powder up to 100%owf while the optimum pH and dyebath temperature were 4 and 100°C, respectively. The sample dyed under the optimal condition exhibited good fastness properties against washing and light. This study approved the potential of Punica granatum fallen leaves for the dyeing of wool without any mordant, while high fastness properties were obtained. [ABSTRACT FROM AUTHOR]

The effluent load from textile industries has forced traders and industrialists to use sustainable tools that not only save energy, money, and labor but also make the process cleaner. The purpose of this study is to improve the dyeing of proteinous fabrics using Acid Violet 49 dye under microwave radiation. Aqueous and acidic dye solutions were prepared and treated with MW radiations for up to 10 min. MW treated and untreated dye solutions were used to color treated and untreated fabrics to observe color yield. It has been found that dyeing of irradiated silk at 65 °C for 35 min, using 55 mL of irradiated dye solution containing 1 g/100 mL salt, has given excellent results. Whereas good color characteristics are obtained if irradiated wool fabric is dyed at 85 °C for 55 min, using 55 mL irradiated dye solution using 1 g/100 mL salt. Physicochemical analysis reveals that MW rays have physically modified the fabric without altering its chemistry. ISO standard methods employed for colorfastness show that under optimal conditions, the color developed is fast; statistical analysis shows that the dyeing process has given significant results. It is concluded that MW rays have excellent potential to improve acidic dyeing of proteinous fabric under mild conditions which show that the utilization of MW rays is a cost-, time-, and energy-effective process. [ABSTRACT FROM AUTHOR]

The Agrobacterium rhizogenes-mediated transformation of plants for hairy root induction epitomizes an attractive biotechnological strategy for enhancing the production of bioactive compounds from medicinal plants. The Curcuma longa L. (turmeric) belonging to Zingiberaceae family is a prevalent crop grown in India and other Southeast Asian countries. The three curcuminoids, viz. curcumin (CUR), demethoxycurcumin (DMC), and bisdemethoxycurcumin (BDMC), are the key bioactive components attributing to its pharmacological activity. The Curcuma longa hairy root lines were established from shoot base explants of in vitro grown plants using the A. rhizogenes strains A4, A4T, and 8196. The acetosyringone augmentation in bacterial culture and co-cultivation media proved to be advantageous for effective induction of hairy roots. The hairy root lines induced with A4 strain displayed maximum biomass growth after 25 days of inoculation, followed by 8196 and A4T. The transgenic nature of hairy roots was validated by the presence of rol A and mas1 gene. The maximum curcuminoid production was observed with hairy roots induced with A4 strain. The influence of methyl jasmonate (MJ) elicitor treatment was evaluated on growth and curcuminoid production using A4-induced hairy root lines. The MJ had very little influence on growth of hairy roots; however, higher concentrations of MJ (200 µM) evoked a significant response after 48 h for enhancing the production of all the three curcuminoids. The CUR content was 2.5-fold; DMC twofold; and BDMC 1.96-fold higher than unelicited hairy roots. Our results establish that the hairy roots of C. longa could be a stable potential source for pharmaceutically useful curcuminoids as an alternative to field-grown plants. [ABSTRACT FROM AUTHOR]

The ability to add value to waste materials from industrial operations has come to the attention of the wood processing industry, with reports, for example, of extracts from the bark tree conveying colour and UV protection to textile fibres. The objective of the present work was to expand our developments in this arena by using Copaifera langsdorffii Desf. bark extract as a natural dye for textile dyeing. A complete 2³-statistical experimental design and the central point was elaborated. The results showed that the optimal dyeing conditions were 98 °C, for 60 min, using undiluted bark extract. The dyed fabric was analysed by a spectrophotometer using the CIELAB system for evaluation of the colour strength. The results showed a K/S value of 5.78, and the dyed fabric had good colour fastness to rubbing and washing. [ABSTRACT FROM AUTHOR]

Stevia rebaudiana Bertoni is a perennial shrub native to South America. The study evaluated the safety profile of the leaf extract of stevia in Sprague-Dawley rats. Both acute and chronic toxicity studies were performed. Twenty-four (24) male Sprague-Dawley rats were divided into four groups of six animals in each group. Stevia was administered for 28 days via oral gavage to the rats at doses of 125, 500 and 2000 mg/kg body weight respectively and the control group was administered distilled water. Acute oral toxicity study was performed in Swiss albino mice of either sex for a 72h period and no death was recorded. In the chronic study, stevia extract demonstrated no adverse effects on body weights, absolute organ weights and relative organ weight ratio in the treated rats at any doses. Evaluation of the haematological and biochemical parameters demonstrated no toxic effect in the treated rats. Besides, stevia extract significantly decreased the serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), cholesterol, triglyceride and low-density lipoprotein (LDL) levels compared to the control animals. The results demonstrated a significant *(p< 0.05) decrease in hemoglobin (Hb) level at 2000 mg/kg and red blood cell (RBC) count at 500 mg/kg doses of stevia respectively, though the changes did not follow dose dependent manner. Present study reported the non-toxic nature of stevia extracts on chronic oral administration. The LD50 values of the stevia extracts were considered to be more than 5000 mg/kg body weight (BW) as no toxicity was observed up to 5000 mg/kg BW in treated animals. [ABSTRACT FROM AUTHOR]

Environmentally friendly products are the need of the hour, particularly in this pandemic situation because synthetic products need such toxic chemicals for their formulation and finishing which are carcinogenic for the globe. The current study is the utilization of waste black tea leaf (BT)–based tannin brown natural colorant for silk dyeing using microwave treatment. Dye (tannin) has been isolated in various media before and after microwave treatment up to 6 min and applied at various conditions. It has been found that 30 mL of aqueous extract of 3.0 pH obtained from 6.0 g of powder containing 3.0 g/100 mL of salt as an exhausting agent after microwave treatment for 5 min, when employed at 55 °C for 45 min, has given good color yield onto silk. Iron (3%) and acacia extract (2%) as pre-chemical and bio mordant, iron (2%) and pomegranate extract (2%) as post chemical and bio-mordant, and Al (3 %) and pomegranate extract (3%) as meta chemical and bio-mordant have given new shades with good to excellent fastness ratings. It is inferred that waste black tea leaves (BTs) in an aqueous medium have an excellent potential to serve as a source of natural tannin brown dye for the coloration of surface-modified silk fabrics under the influence of cost, energy, and time-effective microwave treatment. Additionally, the utilization of a low amount of sustainable chemical and bio-mordants has valorized the dyeing of silk by developing soothing and sustainable shades with good fastness properties. [ABSTRACT FROM AUTHOR]

Medication errors can endanger the health and safety of patients and need to be managed appropriately. This study aimed at developing a new and comprehensive method for estimating the probability of medication errors in hospitals. An extensive literature review was conducted to identify factors affecting medication errors. Success Likelihood Index Methodology was employed for calculating the probability of medication errors. For weighting and rating of factors, the Fuzzy multiple attributive group decision making methodology and Fuzzy analytical hierarchical process were used, respectively. A case study in an emergency department was conducted using the framework. A total number of 17 factors affecting medication error were identified. Workload, patient safety climate, and fatigue were the most important ones. The case study showed that subtasks requiring nurses to read the handwritten of other nurses and physicians are more prone to human error. As there is no specific method for assessing the risk of medication errors, the framework developed in this study can be very useful in this regard. The developed technique was very easy to administer. [ABSTRACT FROM AUTHOR]

Decoctions of ambang (Xymalos monospora) leaves are claimed to have therapeutic potentials but they are seasonal and highly perishable because of its high moisture content. To improve on the use of this plant, drying studies were carried out on its leaves in an effort to produce a green tea. Green tea was produced under 3 different drying conditions including shade, sun and electric drying. The effects of drying method and temperature (50, 60 and 70 °C) on the kinetics, proximate composition and total phenolic content of the teas were analyzed. Drying method had a significant effect on the drying kinetics and quality of the green tea produced. Drying occurred entirely in the falling rate period suggesting that the principal mechanism of drying was by diffusion. Kinetics of the drying processed were modeled successfully by the Page and Modified Page equations. Activation energy for the drying process as determined using K-values from the modified page equation was 27.89 kJ/mol. Significant differences were observed in the quality parameters of teas produced. Protein, carbohydrate and total phenolic content were also dependent on the type of solvent used for extraction. The green tea produced at 60 °C had most of its properties comparable to the commercial green tea used as a reference in the study. It is recommended that to produce good quality tea from ambang leaves, drying should be done at 60 °C for 6 h to obtain a tea with the following composition; moisture content (6.56 ± 0.01), total polyphenols (8.29 ± 0.08), Proteins (2.99 ± 0.13), ash (8.40 ± 0.15) and fiber content (20.43 ± 2.60). [ABSTRACT FROM AUTHOR]