98 results on '"Quillen V"'
Search Results
2. Quillen v. Commonwealth. June 21, 1906. [54 S. E. 333.]
- Published
- 1906
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3. Additive transcriptomic variation associated with reproductive traits suggest local adaptation in a recently settled population of the Pacific oyster, Crassostrea gigas.
- Author
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Sussarellu R, Huvet A, Lapègue S, Quillen V, Lelong C, Cornette F, Jensen LF, Bierne N, and Boudry P
- Subjects
- Animals, Female, Gene Expression Profiling, Introduced Species, Male, Ostreidae metabolism, Ostreidae physiology, Phenotype, Reproduction physiology, Adaptation, Physiological genetics, Gonads metabolism, Ostreidae genetics, Reproduction genetics
- Abstract
Background: Originating from Northeast Asia, the Pacific oyster Crassostrea gigas has been introduced into a large number of countries for aquaculture purpose. Following introduction, the Pacific oyster has turned into an invasive species in an increasing number of coastal areas, notably recently in Northern Europe., Methods: To explore potential adaptation of reproductive traits in populations with different histories, we set up a common garden experiment based on the comparison of progenies from two populations of Pacific oyster sampled in France and Denmark and their hybrids. Sex ratio, condition index and microarray gene expression in gonads, were analyzed in each progeny (n = 60)., Results: A female-biased sex-ratio and a higher condition index were observed in the Danish progeny, possibly reflecting an evolutionary reproductive strategy to increase the potential success of natural recruitment in recently settled population. Using multifarious statistical approaches and accounting for sex differences we identified several transcripts differentially expressed between the Danish and French progenies, for which additive genetic basis is suspected (showing intermediate expression levels in hybrids, and therefore additivity). Candidate transcripts included mRNA coding for sperm quality and insulin metabolism, known to be implicated in coordinated control and success of reproduction., Conclusions: Observed differences suggest that adaptation of invasive populations might have occurred during expansion acting on reproductive traits, and in particular on a female-biased sex-ratio, gamete quality and fertility.
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- 2015
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4. Abundance of Vibrio aestuarianus, water temperature, and stocking density are associated with summer mortality of Pacific oysters in suspended culture.
- Author
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Cowan, M. W., Pearce, C. M., Green, T. J., Finston, T., Meyer, G. R., McAmmond, B., Van Hamme, J. D., Bottos, E. M., Marshall, R., Evans, W., Sutherland, T. F., and de la Bastide, P. Y.
- Subjects
PACIFIC oysters ,MARINE heatwaves ,OYSTER culture ,MIXED infections ,HIGH temperatures - Abstract
High mortality rates of cultured Pacific oysters (Crassostrea gigas) during the summer months have regularly occurred on oyster farms in British Columbia, Canada over the last 10 years, but little is known about the microbial and environmental conditions that contribute to such mortality events. The objective of the study was to determine correlative factors associated with the onset of a summer mortality event in oysters (mean ± SD shell height: 14.2 ± 0.5 mm) grown in suspended culture at four stocking densities (150, 300, 450, 600 oysters tray
−1 ) from May 11 to September 17, 2018. Variables examined included both biotic (oyster growth, mortality, reproductive development, and microbiome (approximately every week); Vibrio and harmful algal species abundance) and abiotic (temperature, salinity, turbidity, dissolved oxygen, pCO2 , pH, and aragonite saturation) ones. Both the absolute abundance of V. aestuarianus and the relative abundance of Vibrio spp. increased with observed oyster mortality and declining health. Mortality was highest on August 12 and associated with a prior period of elevated temperatures (i.e., increasing temperatures from early July to early August) and increased oyster growth/reproductive development. At that time, systemic mixed microbial infections and necrotic gill tissue in histological cross sections were observed in 19% of oysters that appeared healthy macroscopically. Cumulative percent mortalities per tray ranged from 34 to 75%, the highest-density trays having significantly less mortality and smaller shell width, shell length, and gonad length than lower-density trays. This study demonstrates the significant impact of summer mortality on Pacific oysters and highlights the biotic (host growth, reproductive development, and microbiome composition as well as Vibrio spp. abundance) and abiotic (water temperature) factors associated with the observed mortality in this region. [ABSTRACT FROM AUTHOR]- Published
- 2024
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5. Transcriptomic response to salinity variation in native and introduced mud-tidal gastropod Batillaria attramentaria.
- Author
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Patra, Ajit Kumar, Phuong-Thao Ho, and Yong-Jin Won
- Subjects
BIOLOGICAL evolution ,ABIOTIC stress ,GASTROPODA ,SALINITY ,TRANSCRIPTOMES ,GENE expression profiling - Abstract
The introduced Asian mud-tidal gastropod Batillaria attramentaria has been reported to quickly dominate its new habitat, Elkhorn Slough, USA, which has a different osmotic condition from its native habitat. This species has also been reported to have a substantial impact on the ecosystem of the new habitat. In this study, we compared the gene expression profiles in response to temporary salinity variation in native (Asian) and introduced (North American) snails and elucidated the genetic mechanism underlying such rapid adaptation of the introduced species. We examined the transcriptomes of four B. attramentaria populations, including three from the native habitats and one from the introduced habitat, in response to salinity variation. We found that 2,353, 2,505, 10,362, and 16,381 genes were differentially expressed due to their lineages (Kuroshio vs. Tsushima), origins (native vs. introduced), locations (Korea, Japan, or the USA), and salinity variations (stressful: 13, 23, and 43 PSU vs. optimal: 33 PSU), respectively. We found that GO-enriched differentially expressed genes involved in the detection of various abiotic and biotic stimuli through sensory perception and genes involved in response to abiotic stimulus and stress were upregulated when exposed to lower-salinity conditions in all locations. The results indicated that B. attramentaria has adapted well to varied salinity conditions and evolved after around 100 years of invasion in Elkhorn Slough. This study provides valuable transcriptomic data on salinity stress response genes in the tidal gastropod and contributes to the research on the adaptive evolution of coastal gastropods. [ABSTRACT FROM AUTHOR]
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- 2023
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6. WHEN BOUSFIELD LOCALIZATIONS AND HOMOTOPY IDEMPOTENT FUNCTORS MEET AGAIN.
- Author
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CARMONA, VICTOR
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MATHEMATICAL physics ,HOMOLOGICAL algebra ,HYPOTHESIS - Abstract
We generalize Bousfield-Friedlander's Theorem and Hirschhorn's Localization Theorem to settings where the hypotheses are not satisfied at the expense of obtaining semimodel categories instead of model categories. We use such results to answer, in the world of semimodel categories, an open problem posed by May-Ponto about the existence of Bousfield localizations for Hurewicz and mixed type model structures (on spaces and chain complexes). We also provide new applications that were not available before, e.g. stabilization of non-cofibrantly generated model structures or applications to mathematical physics. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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7. Transcriptional Profiling of Populations in the Clam Ruditapes decussatus Suggests Genetically Determined Differentiation in Gene Expression along Parallel Temperature Gradients and between Races of the Atlantic Ocean and West Mediterranean Sea.
- Author
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Saavedra, Carlos, Milan, Massimo, Leite, Ricardo B., Cordero, David, Patarnello, Tomaso, Cancela, M. Leonor, and Bargelloni, Luca
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GENE expression ,CLAMS ,RIBOSOMAL proteins ,GLOBAL warming ,OCEAN ,GENE expression profiling ,MARINE biology - Abstract
Ongoing ocean warming due to climate change poses new challenges for marine life and its exploitation. We have used transcriptomics to find genetically based responses to increased temperature in natural populations of the marine clam Ruditapes decussatus, which lives along parallel thermal gradients in southern Europe. Clams of the Atlantic and West Mediterranean races were collected in northern (cool) and a southern (warm) localities. The animals were kept in running seawater in the warm, southern Atlantic locality for a 15-week period. During this period, water temperature was raised to typical southern European summer values. After this period, an expression profile was obtained for a total of 34 clams and 11,025 probes by means of an oligonucleotide microarray. We found distinct transcriptional patterns for each population based on a total of 552 differentially expressed genes (DEGs), indicating innate differences which probably have a genetic basis. Race and latitude contributed significantly to gene expression differences, with very different sets of DEGs. A gene ontology analysis showed that races differed mainly in the genes involved in ribosomal function and protein biosynthesis, while genes related to glutathione metabolism and ATP synthesis in the mitochondria were the most outstanding with respect to north/south transcriptional differences. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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8. Effects of Two Toxin-Producing Harmful Algae, Alexandrium catenella and Dinophysis acuminata (Dinophyceae), on Activity and Mortality of Larval Shellfish.
- Author
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Pease, Sarah K. D., Brosnahan, Michael L., Sanderson, Marta P., and Smith, Juliette L.
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SHELLFISH ,PARALYTIC shellfish poisoning ,PARALYTIC shellfish toxins ,AMERICAN oyster ,SEAFOOD poisoning ,ALEXANDRIUM ,LARVAE - Abstract
Harmful algal bloom (HAB) species Alexandrium catenella and Dinophysis acuminata are associated with paralytic shellfish poisoning (PSP) and diarrhetic shellfish poisoning (DSP) in humans, respectively. While PSP and DSP have been studied extensively, less is known about the effects of these HAB species or their associated toxins on shellfish. This study investigated A. catenella and D. acuminata toxicity in a larval oyster (Crassostrea virginica) bioassay. Larval activity and mortality were examined through 96-h laboratory exposures to live HAB cells (10–1000 cells/mL), cell lysates (1000 cells/mL equivalents), and purified toxins (10,000 cells/mL equivalents). Exposure to 1000 cells/mL live or lysed D. acuminata caused larval mortality (21.9 ± 7.0%, 10.2 ± 4.0%, respectively) while exposure to any tested cell concentration of live A. catenella, but not lysate, caused swimming arrest and/or mortality in >50% of larvae. Exposure to high concentrations of saxitoxin (STX) or okadaic acid (OA), toxins traditionally associated with PSP and DSP, respectively, had no effect on larval activity or mortality. In contrast, pectenotoxin-2 (PTX2) caused rapid larval mortality (49.6 ± 5.8% by 48 h) and completely immobilized larval oysters. The results indicate that the toxic effects of A. catenella and D. acuminata on shellfish are not linked to the primary toxins associated with PSP and DSP in humans, and that PTX2 is acutely toxic to larval oysters. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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9. Enriched model categories and presheaf categories.
- Author
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Guillou, Bertrand J. and May, J. Peter
- Subjects
MODEL theory ,MATHEMATICAL equivalence - Abstract
We collect in one place a variety of known and folklore results in enriched model category theory and add a few new twists. The central theme is a general procedure for constructing a Quillen adjunction, often a Quillen equivalence, between a given V-model category and a category of enriched presheaves in V, where V is any good enriching category. For example, we rederive the result of Schwede and Shipley that reasonable stable model categories are Quillen equivalent to presheaf categories of spectra (alias categories of module spectra) under more general hypotheses. The technical improvements and modifications of general model categorical results given here are applied to equivariant contexts in the sequels [13, 14], where we indicate various directions of application. [ABSTRACT FROM AUTHOR]
- Published
- 2020
10. ENRICHED MODEL CATEGORIES IN EQUIVARIANT CONTEXTS.
- Author
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GUILLOU, BERTRAND, MAY, J. P., and RUBIN, JONATHAN
- Subjects
MODEL categories (Mathematics) ,HOPF algebras ,DISCRETE groups ,MODULES (Algebra) ,COMMUTATIVE rings - Abstract
We give a general framework of equivariant model category theory. Our groups G, called Hopf groups, are suitably defined group objects in any well-behaved symmetric monoidal category V . For any V, a discrete group G gives a Hopf group, denoted I[G]. When V is cartesian monoidal, the Hopf groups are just the group objects in V . When V is the category of modules over a commutative ring R, I[G] is the group ring R[G] and the general Hopf groups are the cocommutative Hopf algebras over R. We show how all of the usual constructs of equivariant homotopy theory, both categorical and model theoretic, generalize to Hopf groups for any V . This opens up some quite elementary unexplored mathematical territory, while systematizing more familiar terrain. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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11. Marine invasions enter the genomic era: three lessons from the past, and the way forward.
- Author
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VIARD, Frédérique, DAVID, Patrice, and DARLING, John A.
- Subjects
MARINE biological invasions ,GENOMICS ,INTRODUCED species ,BIOGEOGRAPHY ,BIODIVERSITY - Abstract
The expanding scale and increasing rate of marine biological invasions have been documented since the early 20th century. Besides their global ecological and economic impacts, nonindigenous species (NIS) also have attracted much attention as opportunities to explore important eco-evolutionary processes such as rapid adaptation, long-distance dispersal and range expansion, and secondary contacts between divergent evolutionary lineages. In this context, genetic tools have been extensively used in the past 20 years. Three important issues appear to have emerged from such studies. First, the study of NIS has revealed unexpected cryptic diversity in what had previously been assumed homogeneous entities. Second, there has been surprisingly little evidence of strong founder events accompanying marine introductions, a pattern possibly driven by large propagule loads. Third, the evolutionary processes leading to successful invasion have been difficult to ascertain due to faint genetic signals. Here we explore the potential of novel tools associated with high-throughput sequencing (HTS) to address these still pressing issues. Dramatic increase in the number of loci accessible via HTS has the potential to radically increase the power of analyses aimed at species delineation, exploring the population genomic consequences of range expansions, and examining evolutionary processes such as admixture, introgression, and adaptation. Nevertheless, the value of this new wealth of genomic data will ultimately depend on the ability to couple it with expanded "traditional" efforts, including exhaustive sampling of marine populations over large geographic scales, integrated taxonomic analyses, and population level exploration of quantitative trait differentiation through common-garden and other laboratory experiments. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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12. EMPLOYMENT DISCRIMINATION IN THE LEGAL PROFESSION: A QUESTION OF ETHICS?
- Author
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Long, Alex B.
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ANTI-discrimination laws ,LABOR laws ,LEGAL professions ,CIVIL rights ,LAWYERS - Abstract
In recent years, the ABA and local bar leaders have taken numerous steps to raise awareness about the need to increase diversity within the legal profession. In order to increase diversity, however, the legal profession must also seek to eliminate unlawful employment discrimination. In most workplaces, an employer's main concern with respect to discrimination is the possibility of a civil suit. In a surprising number of states, however, rules of professional conduct either explicitly prohibit employment discrimination on the part of lawyers or could be easily read to do so. Amending the rules of professional conduct in this manner is unlikely to have much of an impact when addressing employment discrimination and increasing diversity in the legal profession. These kinds of rules may, however, serve additional purposes that make their adoption worth considering. [ABSTRACT FROM AUTHOR]
- Published
- 2016
13. Untitled.
- Published
- 2016
14. Transfer of algebras over operads along Quillen adjunctions.
- Author
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Gutiérrez, Javier J.
- Subjects
MATHEMATICAL transformations ,OPERADS ,ADJUNCTION theory ,MATHEMATICAL models ,BLOWING up (Algebraic geometry) ,MATHEMATICAL category theory ,GEOMETRIC connections - Abstract
Let be a cofibrantly generated monoidal model category and ℳ be a monoidal -model category. If C is any set, then we denote by ℳC the product category of copies of ℳ indexed by C. Given a cofibrant C-coloured operad in , we give sufficient conditions for the fibrant replacement and cofibrant replacement functors in ℳC to preserve -algebra structures. In particular, we show how -algebra structures can be transferred along Quillen adjunctions of monoidal -model categories, and we apply this result to the Quillen adjunctions defined by enriched Bousfield localizations and colocalizations on ℳ. As an application, we prove that in the category of symmetric spectra the n-connective cover functor preserves A∞ and E∞ module spectra over connective ring spectra, for every n∈ℤ. [ABSTRACT FROM AUTHOR]
- Published
- 2012
15. Status of O6-methylguanine-DNA methyltransferase [MGMT] gene promoter methylation among patients with glioblastomas from India.
- Author
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Nehru, Gopal Arun, Pai, Rekha, Samuel, Prasanna, Chacko, Ari George, and Chacko, Geeta
- Subjects
GLIOBLASTOMA multiforme ,O6-Methylguanine-DNA Methyltransferase ,METHYLTRANSFERASES ,METHYLATION ,POLYMERASE chain reaction ,PATIENTS - Abstract
Background: O6-methylguanine DNA methyltransferase [MGMT] gene promoter methylation has emerged as a promising marker in determining resistance to temozolomide, used in the treatment of patients with glioblastomas. Aim: To determine the frequency of MGMT promoter methylation among patients with glioblastomas using methylation-specific polymerase chain reaction (MSP) and compare it to the results obtained by bisulfite sequencing of a subset of samples. Materials and Methods: DNA obtained from the frozen tissue of 27 samples of glioblastomas and three other gliomas, were analyzed for MGMT promoter methylation using a nested MSP assay. Sixteen samples were also subjected to bisulfite sequencing to determine the methylation status of 27 CpG sites within the sequenced region of the MGMT promoter. Data with respect to radiation, chemotherapy and survival outcome was also collected. Results: MGMT promoter methylation was seen in 67% of the cases included in the study using frozen tissues by MSP analysis, while 62% were methylated among glioblastomas alone. There was a 100% concordance between the results obtained by MSP analysis and bisulfite sequencing. Clinical outcome was known among 67% of cases and methylation was higher among those patients who had no recurrence, though it was not statistically significant [P=0.44]. Conclusion: The frequency of methylation seen in this study concurs with that reported earlier from the country. MSP was easy to perform and interpret. However, the utility of this testing system in a routine diagnostic setting is still being debated. [ABSTRACT FROM AUTHOR]
- Published
- 2012
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16. Shaken Baby Syndrome as Felony Murder in North Carolina.
- Author
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Vollrath, Derick R.
- Subjects
SHAKEN baby syndrome ,CHILD abuse laws ,FELONY murder ,CRIMINAL law ,JUDICIAL reform ,LEGISLATIVE reform ,PROSECUTION - Abstract
The article discusses North Carolina criminal law for the prosecution of Shaken Baby Syndrome deaths as first-degree murder. Information on the felony murder rule of North Carolina and its codification of the felonious child abuse' crimes is presented, and reflects that felony murder doctrine rule is indefensible in the context of Shaken Baby Syndrome. It suggests for legislative and judicial reform in the criminal law of North Carolina for treatment of Shaken Baby Syndrome cases.
- Published
- 2012
17. High thymidine kinase 1 (TK1) expression is a predictor of poor survival in patients with pT1 of lung adenocarcinoma.
- Author
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Xu, Yan, Shi, Qun-Li, Ma, Henghui, Zhou, Hangbo, Lu, Zhenfeng, Yu, Bo, Zhou, Xiaojun, Eriksson, Staffan, He, Ellen, and Skog, Sven
- Abstract
In this study, we explore the association of thymidine kinase 1 (TK1) expression in tumour tissues with clinical pathological parameters and prognosis in patients with pathological T1 (pT1) lung adenocarcinoma. The expression of TK1 was studied by immunohistochemistry techniques in 80 patients with surgically resected pT1 lung adenocarcinoma, retrospectively and at >10-year follow-up. Compared to patients with low TK1 expression [labelling index (LI) <25.0%], patients with high TK1 expression (LI ≥25.0%) showed significantly increased lymphatic/vascular permeation and lymph node involvement and higher stromal invasion grade and pathological stage, and a greater number of patients had a tumour size of 2.1 to 3.0 cm. The 5-year survival and the mortality during follow-up for patients with high TK1 expression were significantly worse than that of patients with low TK1 expression. The prognoses of the cases with grade 0, grade 1 and grade 2 stromal invasions were similar and were better than those of cases with grade 3. In patients with stromal invasion grade 3, the 5-year survival and the mortality during follow-up were significantly worse for patients with high TK1 compared to patients with low TK1 expression. Univariate analyses showed that stromal invasion and TK1 expression were significant prognostic factors, while in the multivariate analysis, TK1 expression and tumour stage were found to be independent prognostic factors, but not stromal invasion. This is the first study showing that TK1 expression in combination with stromal invasion is a more reliable prognostic factor than stromal invasion classification itself in patients with pT1 lung adenocarcinoma. TK1 expression enables a further classification of the patients and opens opportunities for improved treatment outcome. [ABSTRACT FROM AUTHOR]
- Published
- 2012
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18. Serological Thymidine Kinase 1 is a Biomarker for Early Detection of Tumours--A Health Screening Study on 35,365 People, Using a Sensitive Chemiluminescent Dot Blot Assay.
- Author
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Zhi Heng Chen, Shou Qing Huang, Yande Wang, Ai Zhen Yang, Jian Wen, Xiao Hong Xu, Yan Chen, Qu Bo Chen, Ying Hong Wang, He, Ellen, Ji Zhou, and Skog, Sven
- Subjects
THYMIDINE ,PROTEIN kinases ,TUMORS ,FATTY liver ,PROSTATE cancer - Abstract
Serological thymidine kinase 1 (STK1) is a reliable proliferation marker for prognosis, monitoring tumour therapy, and relapse. Here we investigated the use of STK1 in health screening for early detection of pre-malignant and malignant diseases. The investigation was based on 35,365 participants in four independent health screening studies in China between 2005-2011. All participants were clinically examined. The concentration of STK1 was determined by a sensitive chemiluminescent dot blot ECL assay. The ROCvalue of the STK1 assay was 0.96. At a cut-off STK1 value of 2.0 pM, the likelihood (+) value was 236.5, and the sensitivity and the specificity were 0.78 and 0.99, respectively. The relative number of city-dwelling people with elevated STK1 values (≥2.0 pM) was 0.8% (198/26,484), while the corresponding value for the group of oil-field workers was 5.8% (514/8,355). The latter group expressed significantly higher frequency of refractory anaemia, fatty liver, and obesity, compared to the city dwellers, but no cases of breast hyperplasia or prostate hyperplasia. Furthermore, people working in oil drilling/oil transportation showed higher STK1 values and higher frequency of pre-malignancies and benign diseases than people working in the oil-field administration. In the STK1 elevated group of the city-dwelling people, a statistically significantly higher number of people were found to have malignancies, pre-malignancies of all types, moderate/severe type of hyperplasia of breast or prostate, or refractory anaemia, or to be at high risk for hepatitis B, compared to people with normal STK1 values (<2.0 pM). No malignancies were found in the normal STK1 group. In the elevated STK1 group 85.4% showed diseases linked to a higher risk for pre-/early cancerous progression, compared to 52.4% of those with normal STK1 values. Among participants with elevated STK1 values, 8.8% developed new malignancies or progress in their pre-malignancies within 5 to 72 months, compared to 0.2% among people with normal STK1 values. People who showed elevated STK1 values were at about three to five times higher risk to develop malignancies compared to a calculated risk based on a cancer incidence rate of 0.2-0.3%. We conclude that serological TK1 protein concentration is a reliable marker for risk assessment of pre/early cancerous progression. [ABSTRACT FROM AUTHOR]
- Published
- 2011
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19. ON LEFT AND RIGHT MODEL CATEGORIES AND LEFT AND RIGHT BOUSFIELD LOCALIZATIONS.
- Author
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BARWICK, CLARK
- Subjects
MATHEMATICAL category theory ,LOCALIZATION (Mathematics) ,MILNOR fibration ,SHEAF theory ,EXISTENCE theorems ,HOMOTOPY theory - Abstract
We verify the existence of left Bousfield localizations and of enriched left Bousfield localizations, and we prove a collection of useful technical results characterizing certain fibrations of (enriched) left Bousfield localizations. We also use such Bousfield localizations to construct a number of new model categories, including models for the homotopy limit of right Quillen presheaves, for Postnikov towers in model categories, and for presheaves valued in a symmetric monoidal model category satisfying a homotopy-coherent descent condition. We then verify the existence of right Bousfield localizations of right model categories, and we apply this to construct a model of the homotopy limit of a left Quillen presheaf as a right model category. [ABSTRACT FROM AUTHOR]
- Published
- 2010
- Full Text
- View/download PDF
20. Short and long-term outcome of treatment with high-dose melphalan and stem cell transplantation for multiple myeloma-associated AL amyloidosis.
- Author
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Girnius, Saulius, Seldin, David, Skinner, Martha, Finn, Kathleen, Quillen, Karen, Doros, Gheorghe, and Sanchorawala, Vaishali
- Subjects
MELPHALAN ,CANCER chemotherapy ,STEM cell transplantation ,AMYLOIDOSIS ,MULTIPLE myeloma ,KAPLAN-Meier estimator - Abstract
High-dose melphalan chemotherapy and autologous peripheral blood stem cell transplantation (HDM/SCT) has been shown to result in a durable hematologic response and prolonged overall survival in systemic amyloid light-chain (AL) amyloidosis as well as multiple myeloma. However, little is known about the myeloma associated with AL amyloidosis (MM/AL). In this retrospective study, we evaluated 87 patients with MM/AL from 1994 to 2007. Sixteen of these patients underwent HDM/SCT at Boston University Medical Center. Three patients (19%) died from treatment-related mortality. The overall median survival for all 87 patients was 22 months by Kaplan-Meier estimates. However, this was improved to 54.5 months for those who received HDM/SCT compared to 21 months for those who did not receive HDM/SCT. A hematologic complete response was achieved by 25% (4/16) of patients at 6 months after HDM/SCT. Hematologic relapses occurred in 60% of patients at a median of 1 year after HDM/SCT. In conclusion, HDM/SCT can prolong overall survival in patients with MM/AL who are eligible to receive it. [ABSTRACT FROM AUTHOR]
- Published
- 2010
- Full Text
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21. HOMOTOPY THEORY OF PRESHEAVES OF Γ-SPACES.
- Author
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BERGSAKER, HÅKON SCHAD
- Subjects
HOMOTOPY theory ,PRESHEAVES ,SHEAF theory ,AXIOMS ,MODULES (Algebra) ,MATHEMATICAL analysis - Abstract
We consider the category of presheaves of Γ-spaces, or equivalently, of Γ-objects in simplicial presheaves. Our main result is the construction of stable model structures on this category parametrised by local model structures on simplicial presheaves. If a local model structure on simplicial presheaves is monoidal, then the corresponding stable model structure on presheaves of Γ-spaces is monoidal and satisfies the monoid axiom. This allows us to lift the stable model structures to categories of algebras and modules over a monoid. [ABSTRACT FROM AUTHOR]
- Published
- 2009
- Full Text
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22. RETALIATORY LITIGATION TACTICS: The Chilling Effects of "After-Acquired Evidence.".
- Author
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Hart, Melissa
- Published
- 2008
23. Transcriptome Profiling of the Pacific Oyster Crassostrea gigas Visceral Ganglia over a Reproduction Cycle Identifies Novel Regulatory Peptides.
- Author
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Réalis-Doyelle, Emilie, Schwartz, Julie, Cabau, Cédric, Le Franc, Lorane, Bernay, Benoit, Rivière, Guillaume, Klopp, Christophe, and Favrel, Pascal
- Abstract
The neuropeptides involved in the regulation of reproduction in the Pacific oyster (Crassostrea gigas) are quite diverse. To investigate this diversity, a transcriptomic survey of the visceral ganglia (VG) was carried out over an annual reproductive cycle. RNA-seq data from 26 samples corresponding to VG at different stages of reproduction were de novo assembled to generate a specific reference transcriptome of the oyster nervous system and used to identify differentially expressed transcripts. Transcriptome mining led to the identification of novel neuropeptide precursors (NPPs) related to the bilaterian Eclosion Hormone (EH), crustacean female sex hormone/Interleukin 17, Nesfatin, neuroparsin/IGFBP, prokineticins, and urotensin I; to the protostome GNQQN, pleurin, prohormones 3 and 4, prothoracotropic hormones (PTTH), and QSamide/PXXXamide; to the lophotrochozoan CCWamide, CLCCY, HFAamide, and LXRX; and to the mollusk-specific NPPs CCCGS, clionin, FYFY, GNamide, GRWRN, GSWN, GWE, IWMPxxGYxx, LXRYamide, RTLFamide, SLRFamide, and WGAGamide. Among the complete repertoire of NPPs, no sex-biased expression was observed. However, 25 NPPs displayed reproduction stage-specific expression, supporting their involvement in the control of gametogenesis or associated metabolisms. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
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24. Maryland Law Review
- Author
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Meyers, Lynn F., Meyers, Lynn F., Meyers, Lynn F., and Meyers, Lynn F.
- Published
- 1959
25. Potential Threat of Microplastic Pollution on Coastal-Marine Ecosystem– An Emerging Economic Setback and Question to Blue Economy?
- Author
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Dey, Uttiya, Chell, Sudeshna, Mondal, Mijanur, Das, Kousik, Raj, Deep, Pandey, Ghanshyam, Meraj, Gowhar, Kumar, Pankaj, Almazroui, Mansour, and Verma, Swati
- Published
- 2024
- Full Text
- View/download PDF
26. Shannon Pratt's The Lawyer's Business Valuation Handbook : Understanding Financial Statements, Appraisal Reports, and Expert Testimony, Third Edition
- Author
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Shannon Pratt, Roger J. Grabowski, FASA,, Alina V. Niculita, ASA, ARM-BV, CFA, MBA,, Shannon Pratt, Roger J. Grabowski, FASA,, and Alina V. Niculita, ASA, ARM-BV, CFA, MBA,
- Abstract
Highly technical and often difficult to understand, business valuations are a critical subject for lawyers in many areas, such as divorce, bankruptcy, corporate and tax law, and estate and financial planning. The authors of this book, who have over 40 years of combined experience in transactional matters and litigation, present and discuss key concepts in valuation. At the same time, they explain how to dig beneath the surface of expert opinions and show how to find the most pertinent facts, interpret the data, and evaluate the quality and comprehensiveness of evidence. This easy-to-use manual covers all aspects of determining the value of a business, including definitions of value; personal versus enterprise goodwill, valuing professional practices and small businesses, cross-examination, commonly used terminology and bodies of evidence, professional credentials and standards; and recognized and accepted valuation methods. Adding to the book's usefulness are'Questions to Ask'for most sections, extensive case citations throughout to courts'positions on many issues, and appendices that include a glossary, bibliography of business valuation databases, and other useful tools.
- Published
- 2025
27. Ecophysiology and Ocean Acidification in Marine Mollusks : From Molecule to Behavior
- Author
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Youji Wang and Youji Wang
- Abstract
Ecophysiology and Ocean Acidification in Marine Mollusks: From Molecule to Behavior provides an extensive overview of the latest research on the various ecophysiological effects of ocean acidification on marine mollusks. This book synthesizes historical information and recent findings on the effects of environmental change, ocean warming, and acidification on key mollusks and their life-history. It also discusses the underlying mechanisms underpinning the effects of ocean warming and acidification. Written by internationally recognized experts in the field of marine biology, this book systematically examines the effects of ocean acidification on the reproduction, growth and development, physiological metabolism, immunity, and behavior of marine mollusks. The book concludes by discussing the implications of current research, acknowledging data limitations in the field, and proposing future research directions, providing a better understanding of the potential impacts of ocean acidification on mollusks and the global aquaculture industry and inspiring new thinking for future research practices. It will be an indispensable resource for researchers, practitioners, undergraduate and graduate students, conservationists, and aquaculturists alike who are interested in marine environmental change, ecology, physiology, and marine biology. - Describes the causes and consequences of ocean acidification in the marine environment - Summarizes our modern understanding of the impact of ocean acidification on the physiology and behavior of marine mollusks - Discusses the limitations of existing studies - Proposes future research directions on ocean acidification and marine mollusks
- Published
- 2024
28. Business Valuation Case Law Yearbook, 2024 Edition
- Author
-
BVR Staff and BVR Staff
- Abstract
The legal coverage and in-depth analysis from the BVR legal team including an Introduction by Jim Alerding, BVR Legal Editor delivers lessons learned to help appraisers reach better and more defensible valuation conclusions. The 2024 yearbook illustrates how financial experts helped their side win (and lose) in the courtroom and includes 70 new cases that were added to BVLaw in 2023. The yearbook covers key court decisions involving business valuation during 2023. The cases are all related in some way to valuation, economic damages and lost profits, and other litigation. This publication also includes as exhibits some of the cases that the editorial team determined to be of high importance to the valuation and expert witness community during 2023. This must-have collection benefits both the generalist as well as the specialist.
- Published
- 2024
29. Problems in Contract Law : Cases and Materials
- Author
-
Charles L. Knapp, Nathan M. Crystal, Harry G. Prince, Danielle K. Hart, Joshua M. Silverstein, Charles L. Knapp, Nathan M. Crystal, Harry G. Prince, Danielle K. Hart, and Joshua M. Silverstein
- Subjects
- Contracts--United States
- Abstract
Problems in Contract Law: Cases and Materials, by Charles L. Knapp, Nathan M. Crystal, Harry G. Prince, Danielle K. Hart, and Joshua M. Silverstein, includes cases with notes and explanatory text, additional commentary, essay, and short-answer problems, and multiple-choice review questions for each chapter. The cases selected are a balance of traditional and contemporary that reflect the development and complexity of contract law. Explanatory notes and text place the classic and newer decisions in their larger legal context. Questions and problems provide opportunities to practice core legal skills and encourage students to explore the relationship between theory and practice. This successful book is well known for approaching contract law and theory from multiple perspectives and using a variety of contractual settings. Adaptable for instructors with different pedagogical philosophies, Problems in Contract Law can easily be used in teaching by traditional case analysis, through problem-based instruction, or using theoretical inquiry. The purchase of this ebook edition does not entitle you to receive access to the Connected eBook with Study Center on CasebookConnect. You will need to purchase a new print book to get access to the full experience, including: lifetime access to the online ebook with highlight, annotation, and search capabilities; practice questions from your favorite study aids; an outline tool and other helpful resources.New to the 10th Edition: Five new principal cases that reflect advances in or improved statements of contract law. One restored principal case (Oppenheimer & Co. v. Oppenheim, Appel, Dixon & Co.) that provides valuable perspectives on a fundamental area of contract law. Twelve new problems, including several shorter problems, to provide more review options for teachers and students and to add contemporary fact patterns. Eight new tables and flow charts to assist students with the conceptual structure of complicated legal subjects. Editing of note and text material to reduce length without affecting coverage and to capture new legal developments. Reorganization of text and comment material to focus comments primarily on historical developments, allowing professors greater flexibility in assigning or deleting comments. Student accessibility to deleted cases from prior editions through Casebook Connect, allowing professors the further flexibility of continuing to easily assign cases for which they have a particular preference. Professors and students will benefit from: The authors'emphasis on making the material accessible for both students taking and professors teaching the course - rejecting a hide-the-ball approach. The continued appeal to professors with various teaching methodologies: traditional, problem-oriented, theoretical, and practical. The comprehensive nature of the contents allows professors the flexibility to teach their students the basics or conduct a more in-depth analysis of a given topic. The continued mixture of classic and contemporary cases. Review questions at the end of each chapter that are primarily designed for students to perform self-assessments of their grasp of the material. Answers with explanations are included in an appendix within the book.
- Published
- 2023
30. The Diverse World of PDEs
- Author
-
I. S. Krasil′shchik, A. B. Sossinsky, A. M. Verbovetsky, I. S. Krasil′shchik, A. B. Sossinsky, and A. M. Verbovetsky
- Subjects
- Differential equations, Partial--Congresses, Differential equations, Nonlinear--Congresses, Geometry, Differential--Congresses, Homology theory--Congresses, Commutative algebra, Algebraic geometry, Ordinary differential equations, Partial differential equations, Functional analysis, Differential geometry
- Abstract
This volume contains the proceedings of the Alexandre Vinogradov Memorial Conference on Diffieties, Cohomological Physics, and Other Animals, held from December 13–17, 2021, at Independent University of Moscow and Moscow State University, Moscow, Russia. The papers reflect the modern interplay between partial differential equations and various aspects of algebra and computer science. The topics discussed are: relations between integrability and differential rings, supermanifolds, differential calculus over graded algebras, noncommutative generalizations of PDEs, quantum vector fields, generalized Nijenhuis torsion, cohomological approach to the geometry of differential equations, the argument shift method, Frölicher structures in the formal Kadomtsev–Petviashvili hierarchy, and computer-based determination of optimal systems of Lie subalgebras. The companion volume (Contemporary Mathematics, Volume 788) is devoted to Geometry and Mathematical Physics.
- Published
- 2023
31. Das Recht des Grundstückskaufs : Eine rechtsvergleichende Untersuchung
- Author
-
Bernd von Hoffmann and Bernd von Hoffmann
- Subjects
- Vendors and purchasers
- Published
- 2022
32. Die fehlerhafte Konstruktionsentscheidung. : Eine Untersuchung zur Auslegung von § 3 ProdHaftG unter Berücksichtigung des US-amerikanischen Rechts.
- Author
-
Katharina Kollmann and Katharina Kollmann
- Abstract
Die Auslegung des § 3 ProdHaftG gehört nach wie vor zu den umstrittensten Fragen des Produkthaftungsrechts. Dies zeigt sich besonders bei der Schadensverursachung durch Produkte, deren Sicherheitsrisiken der Hersteller in Kauf genommen hat, um andere - wünschenswerte - Produkteigenschaften zu ermöglichen. Nachdem keine »absolute« Produktsicherheit gefordert ist, setzt eine deliktische Haftung des Herstellers für eine fehlerhafte Konstruktionsentscheidung voraus, daß die Rechtsordnung einen Standard formuliert, nach dem im Einzelfall das erlaubte von dem verbotenen Risiko durch richterliche Wertung geschieden werden kann. In den Vereinigten Staaten, dem »Mutterland des Produkthaftungsrechts«, das auch für die Ausgestaltung des § 3 ProdHaftG sowie für die im Rahmen von § 823 Abs. 1 BGB entwickelten Standards maßgebliche Impulse gesetzt hat, wurden zur Bestimmung der Fehlerhaftigkeit von Konstruktionen zwei Modelle entwickelt, nämlich zum einen der consumer expectation Test, der durch die Vertreter der ökonomischen Theorie des Rechts eine wesentliche Fortschreibung für das deutsche Recht erfahren hat, und zum anderen die Kosten-Nutzen-Analyse, die Eingang in das Restatement (Third) of Torts gefunden hat. Die Verfasserin untersucht anhand eines Rechtsvergleichs, inwieweit die Erkenntnisse der amerikanischen Diskussion für das deutsche Recht nutzbar gemacht werden können. Nachdem die genannten Modelle auch zur Auslegung des § 3 ProdHaftG herangezogen werden können, wird anhand des Instrumentariums der ökonomischen Theorie des Rechts geprüft, welcher Ansatz zur Bewertung bewußter Konstruktionsentscheidungen herangezogen werden sollte. Im Ergebnis spricht sich Katharina Kollmann für verstärkte Aufklärung des Verbrauchers auf Basis des informationellen Fehlerbegriffs aus.
- Published
- 2021
33. A patient with persistent wheezing, sinusitis, elevated IgE, and eosinophilia
- Author
-
Robinson, Jeff, Ahmed, Zulfiqar, Siddiqui, Afzal, Roy, Thomas, Berk, Steven, Smith, John Kelly, and Krishnaswamy, Guha
- Published
- 1999
- Full Text
- View/download PDF
34. Examples & Explanations for Family Law
- Author
-
Robert E. Oliphant, Nancy Ver Steegh, Robert E. Oliphant, and Nancy Ver Steegh
- Subjects
- Domestic relations--United States--Outlines, syllabi, etc
- Abstract
A favorite classroom prep tool of successful students that is often recommended by professors, the Examples & Explanations (E&E) series provides an alternative perspective to help you understand your casebook and in-class lectures. Each E&E offers hypothetical questions complemented by detailed explanations that allow you to test your knowledge of the topics in your courses and compare your own analysis.Here's why you need an E&E to help you study throughout the semester:Clear explanations of each class topic, in a conversational, funny style.Features hypotheticals similar to those presented in class, with corresponding analysis so you can use them during the semester to test your understanding, and again at exam time to help you review.It offers coverage that works with ALL the major casebooks, and suits any class on a given topic.The Examples & Explanations series has been ranked the most popular study aid among law students because it is equally as helpful from the first day of class through the final exam.
- Published
- 2019
35. Problems in Contract Law : Cases and Materials
- Author
-
Charles L. Knapp, Nathan M. Crystal, Harry G. Prince, Charles L. Knapp, Nathan M. Crystal, and Harry G. Prince
- Subjects
- Casebooks (Law), Contracts--United States
- Abstract
In Problems in Contract Law: Cases and Materials, Ninth Edition, by Charles L. Knapp, Nathan M. Crystal, and Harry G. Prince, a balance of traditional and contemporary cases reflect the development and complexity of contract law. Explanatory notes and text place classic and contemporary cases in their larger legal context, while questions and problem exercises bridge theory and practice. Adaptable for instructors with different teaching techniques, this successful book includes various perspectives and contractual settings, and offers a highly intelligent, contemporary treatment of contract law. It can easily be used in teaching by traditional case analysis, through problem-based instruction, or using theoretical inquiry.New to the Ninth Edition:Seven new cases that reflect advances in or improved statements of contract lawTwo restored cases (Kirksey v. Kirksey and Hill v. Jones) that provide valuable perspectives on fundamental areas of contract lawEight new problems (including seven net additions and one replacement) to provide more review options for teachers and students and to add contemporary fact patternsA new, two-color design featuring interesting photographs illustrating people and places discussed in some of the casesEditing of note and text material to reduce length without affecting coverageReorganization of text and comment material to focus comments primarily on historical developments, allowing professors flexibility in assigning or deleting commentsStudent accessibility to deleted cases from prior editions through Connected Casebook, allowing professors the further flexibility of continuing to easily assign cases for which they have a particular preferenceProfessors and students will benefit from:Flexible application for professors with various teaching methodologies: traditional, problem, theoretical, and practicalA mixture of classic and contemporary casesThe authors'emphasis on accessibility of the material—rejecting a hide-the-ball approachReview questions at the end of each chapter that are primarily designed for students to perform self-assessments of their grasp of the material. Answers with explanations are included in an appendix within the book.
- Published
- 2019
36. Whitman, Burkhart, Freyermuth, and Rule's Law of Property, 4th (Hornbook Series)
- Author
-
Whitman, Dale A., Burkhart, Ann M., Freyermuth, R. Wilson, Rule, Troy A., Whitman, Dale A., Burkhart, Ann M., Freyermuth, R. Wilson, and Rule, Troy A.
- Subjects
- Real property--United States
- Abstract
'[This book covers] property laws surveys estates in land--present, future, and concurrent, comparable interests in personalty, landlord and tenant law, and rights against neighbors and other third persons. Also examines easements and profits, running covenants, governmental controls on land use, land contracts, conveyances, titles, and recording systems. Contains footnote citations to leading court decisions for easy location of primary authority.'--
- Published
- 2019
37. Litigating the Aviation Case, Fourth Edition
- Author
-
Andrew J. Harakas and Andrew J. Harakas
- Abstract
Aviation law is a constantly evolving area of practice, continuing to change in response to the many challenges facing the industry as a whole. Litigating these cases is notoriously complex and challenging, requiring extensive expertise with aviation and engineering principles coupled with detailed legal analysis. A long-trusted resource, this updated edition of Litigating the Aviation Case provides current information and strategic guidance on all aspects of aviation litigation.An overview and analysis of the current legal issues in aviation litigation by the most prominent names in the aviation legal community, this new edition offers important updates and insights on traditional issues as well as in-depth discussion of the new issues that have arisen recently, many of which are in response to the multijurisdictional nature of aviation. The book's authors examine new legal issues as well as twists on traditional litigation matters, including:JurisdictionForum non conveniensPreemptionThe Montreal ConventionUnruly passengersPreservation of evidenceInsurance coverageDamagesThe impact of trade sanctions and Medicare on litigation, and moreLitigating the Aviation Case provides a solid base of knowledge for the aviation novice as well as the seasoned practitioner with updates on existing issues and identification of the new issues facing the aviation litigator to ensure effective advocacy. It also offers strategic guidance on the full array of aviation litigation issues, including:Locating recognized sub-specialistsMaximizing the effectiveness of evidencePresenting effective opening and closing statementsCross-examining witnessesDeveloping winning trial strategies
- Published
- 2019
38. Annette von Droste-Hülshoff Handbuch
- Author
-
Cornelia Blasberg, Jochen Grywatsch, Cornelia Blasberg, and Jochen Grywatsch
- Subjects
- LITERARY CRITICISM / European / German
- Abstract
Annette von Droste-Hülshoff (1797–1848) gilt heute als bedeutendste deutschsprachige Autorin des 19. Jahrhunderts. Teile ihres Werks, wie die Judenbuche, der lyrische Zyklus der Haidebilder und einzelne exponierte Gedichte, waren und sind kontinuierlich Gegenstand der wissenschaftlichen Forschung und der öffentlichen Wahrnehmung. Daneben existieren größere Werkkomplexe, denen bisher nur wenig Aufmerksamkeit zuteil geworden ist. Das Droste-Handbuch hat sich die Neu-Entdeckung des komplexen Oeuvres zur Aufgabe gemacht. Es erschließt das literarische, das musikalische und das Briefwerk von Annette von Droste-Hülshoff durch zahlreiche Einzeltextanalysen und Überblicksartikel in bislang nicht vorhandener Vollständigkeit. Dabei liegt der Fokus darauf, die ästhetische Prägnanz und Modernität der Texte herauszuarbeiten, vor dem Hintergrund der Forschung zu diskutieren und neue Bezugsfelder der Interpretation zu den Marktverhältnissen, den ästhetischen Debatten zwischen Romantik und Vormärz und den zeitgenössischen Wissenschaften aufzutun. Erstmals wird ein umfassendes Kompendium für die wissenschaftliche Auseinandersetzung mit dem Gesamtwerk Drostes vorgelegt.
- Published
- 2018
39. Krise und Gemeinschaft. Stefan Georges 'Der Stern des Bundes'
- Author
-
Christophe Fricker and Christophe Fricker
- Abstract
Stefan Georges Gedichtband'Der Stern des Bundes'ist eines der provokativsten und ungewöhnlichsten Werke in deutscher Sprache. Am Vorabend des Ersten Weltkriegs entfaltet George hier soziale, religiöse, poetologische, persönliche, philosophische und sogar wirtschaftliche Fragen.'Der Stern des Bundes'galt als Voraussage kommender Katastrophen, als Warnung, als Anregung zu friedlicher und intimer Gemeinschaftsbildung im Angesicht großer Krisen und als Bekräftigung eines hoffnungsvollen Blicks auf eine gemeinsam erfahrene Welt. Krise und Gemeinschaft versammelt Einführungs- und Überblicksartikel, Beiträge zu wichtigen Worten aus dem Stern und Interpretationen zentraler Gedichte. Es richtet sich besonders auch an Leserinnen und Leser, denen der'Stern'noch fremd ist.
- Published
- 2017
40. Property : Concise Edition
- Author
-
Jesse Dukeminier, James E. Krier, Gregory S. Alexander, Michael Schill, Lior Jacob Strahilevitz, Jesse Dukeminier, James E. Krier, Gregory S. Alexander, Michael Schill, and Lior Jacob Strahilevitz
- Subjects
- Casebooks (Law), Property--United States
- Abstract
A concise edition of the legendary casebook, Property: Concise Edition, 2E is perfectly suited for use in a four-credit course. Jesse Dukeminier's trademark wit, passion, and human interest perspective has made Property, now in its Eighth Edition, one of the best—and best loved—casebooks of all time. A unique blend of authority and good humor, you'll find a moveable feast of visual interest, compelling cases, and timely coverage of contemporary issues.The purchase of this Kindle edition does not entitle you to receive access to the online e-book, practice questions from your favorite study aids, and outline tool available through CasebookConnect.
- Published
- 2017
41. Model Subdivision Regulations
- Author
-
Robert H. Freilich, Michael M. Shultz, Robert H. Freilich, and Michael M. Shultz
- Subjects
- Model ordinances--United States, Land subdivision--Law and legislation--United States
- Abstract
A major revision of a classic planning text. This book contains a complete model subdivision ordinance for city and county governments as well as more than 100 pages of legal commentary. The model regulations are generally compatible with all state statutes and work in urban, suburban, and rural settings. They show how communities can finance capital facilities, balance new development with existing surroundings, avoid exposure to the legal pitfalls of takings and substantive due process claims, and much more. Two new chapters cover public facilities impact fees and land readjustment. The chapter on impact fees includes a section on regulatory takings law that looks at how prominent U.S. Supreme Court cases have affected property rights, development, and regulation. Each section of the model regulations is followed by insightful commentary that supports, annotates, and documents the text. The authors explore the rationale for using various regulations, basing their arguments on existing statutory authority, case law, and federal constitutional requirements. The commentary identifies and explains changes from the original model regulations. Whether you're drafting new regulations or considering amendments to existing ones, you'll find Model Subdivision Regulations to be an invaluable reference.
- Published
- 2017
42. Administration of Government Contracts
- Author
-
John Cibinic Jr, James F. Nagle, Ralph C. Nash Jr, John Cibinic Jr, James F. Nagle, and Ralph C. Nash Jr
- Subjects
- Government purchasing--Law and legislation--United States, Public contracts--United States
- Abstract
Learn expert strategies for reducing conflicts and managing government contracts. Successful contract administration ensures that both parties fulfill their contractual obligations — and adapt to changing circumstances when necessary. No matter which side of the contract you're on — government official or vendor — a firm grasp of contract procedures and legal requirements is essential for sound management and dispute resolution. Administration of Government Contracts, from The George Washington University Law School Government Contracts Program and CCH, provides expert guidance on all phases of the contract administration process. You will learn the best way to: Interpret contract terms accurately Handle differing site conditions Renegotiate terms to reflect changes Make price adjustments Resolve disputes without litigation Ensure prompt, full payment Terminate contracts Comprehensive coverage and analysis of federal procurement legislation clarifies complex rules! Federal procurement legislation and court decisions have changed the way you can handle delays, determine payment policies and resolve disputes. This edition explains the rules resulting from the Federal Acquisition Streamlining Act, the Competition in Contracting Act, the Prompt Payment Act and other key changes. Written by the pre-eminent authorities in government contracting, the unbiased analysis of important case law and decisions provides an overview of the current legal environment and helps you put everything in perspective. Handy tools help you access vital information quickly Find authoritative information in seconds with these helpful aids: Detailed table of contents and subject index help you search for specific guidance on key issues by subject area or alphabetically List of acronyms defines important government contracting terms Legal citations for more than 3,400 court, BCA and Comptroller General decisions will save you hours of research time Table of authorities guides you to information about key parts of the CFR, DAR, DFARS and FAR throughout the text
- Published
- 2016
43. BVR's Business Valuation in Divorce Case Law Compendium, Third Edition
- Author
-
BVR Staff and BVR Staff
- Subjects
- Divorce settlements--United States--Digests, Business enterprises--Valuation--Law and legislation--United States--Digests, Equitable distribution of marital property--United States--Digests
- Abstract
Divorce is a state law matter. Since different states have different statutes and case law pertaining to marital distribution, it can be difficult for attorneys and experts alike to keep up with key valuation developments. BVR's new Business Valuation in Divorce Case Law Compendium, Third Edition is an indispensable tool for every divorce professional who wants to stay ahead of the game. Now updated with the most recent court cases featuring divorce cases with a business valuation component, this must-have compendium contains 340+ divorce cases that grapple with key business valuation issues. It is organized into seven key topical sections so you can find the information you need quickly and easily. The new edition includes in-depth coverage from our acclaimed legal analysts as well as top business valuation experts, who report on disputes ranging from personal versus professional goodwill, discounts, tax affecting, and more. This one-of-a-kind legal resource saves hours of research with comprehensive coverage on the best (and worst) practices that attorneys and experts used in making their case in courts throughout the country. Highlights of the compendium include: - Save hours of research time with the most current analysis of the business valuation issues that often arise in divorce cases. Quickly learn how courts across the U.S. view business valuation methods and approaches in divorce cases with analysis of 340+ cases - Easily navigate each state's position on goodwill in divorce. This compendium provides an easy-to-use reference chart (Jurisprudence in Divorce) as a guide to the complicated topic of how goodwill is viewed on a state-by-state basis - Don't miss key strategies that can help you be a more effective financial expert. Get in-depth analysis from BVR's expert legal team on which techniques financial experts have employed that have either stood up or failed in court - Tap into the knowledge of top business valuation experts. In addition to case law analysis, this compendium offers advice from top business valuation experts on valuing goodwill in divorce, double dipping, tax affecting and discounts
- Published
- 2016
44. The Delaware State Constitution
- Author
-
Randy J. Holland and Randy J. Holland
- Subjects
- Constitutional law--Delaware, Constitutions--Delaware, Constitutional history--Delaware
- Abstract
The Delaware State Constitution is the first state constitution drafted by a convention composed of popularly elected representatives, and it is rich with history and tradition. The Delaware Bill of Rights has remained almost exactly the same since 1792, and it has enacted specific provisions whereby its three branches of government operate differently from the federal system. The Delaware State Constitution provides an outstanding constitutional and historical account of the state's basic governing charter. In it, Judge Randy Holland begins with an overview of Delaware's constitutional history. He then provides an in-depth, section-by-section analysis of the entire constitution, detailing important changes that have been made over the years. Justice Holland's learned treatment, along with the list of cases, index, and bibliography, makes this guide indispensable for students, scholars, and practitioners of Delaware's constitution. This second edition includes all amendments to the Delaware Constitution since 2002 and all significant court decisions interpreting any provision in the Delaware Constitution that have been issued since 2002. The Oxford Commentaries on the State Constitutions of the United States is an important series that reflects a renewed international interest in constitutional history and provides expert insight into each of the 50 state constitutions. Each volume in this innovative series contains a historical overview of the state's constitutional development, a section-by-section analysis of its current constitution, and a comprehensive guide to further research. Under the expert editorship of Professor G. Alan Tarr, Director of the Center on State Constitutional Studies at Rutgers University, this series essential reference tools for understanding state constitutional law. Books in the series can be purchased individually or as part of a complete set, giving readers unmatched access to these important political documents.
- Published
- 2016
45. Analyzing Complex Appraisals for Business Professionals
- Author
-
Shannon P. Pratt, John Lifflander, Shannon P. Pratt, and John Lifflander
- Abstract
The essential guide to business and real estate appraisals for non-appraiser professionals In Analyzing Complex Appraisals for Business Professionals, renowned business and real estate valuation authorities Shannon P. Pratt and John Lifflander provide the ultimate crash course for evaluating a wide range of properties and enterprises. This guide to understanding, interpreting, and evaluating residential, commercial, business, and industrial appraisals, gives any business professional straightforward, practical steps to achieve sound financial reasoning in the face of numerous valuation intricacies and problem areas. Using a similar approach to Pratt's previous international bestselling books, the authors'detailed instructions and invaluable insider's advice make even the most sophisticated techniques accessible to bankers, attorneys, loan officers, accountants, real estate brokers, and other professionals. The authors introduce a strategic overview of the basics aspects of USPAP (Uniform Standards of Professional Appraisal Practice), and then build on that background. Each segment of the book includes a discussion of the applicable appraisal theory, which is then followed by an explanation of the most common methodologies for that particular discipline and a set of examples of its application. Analogies with general concepts are also applied to specific appraisal subjects. The ability to evaluate a wide range of properties and enterprises―from land and homes to commercial and industrial facilities to valuations of businesses ―is more imperative today than ever before. Find out why, and the best practices to do so, with Analyzing Complex Appraisals for Business Professionals.
- Published
- 2015
46. Contracts, 7th (Hornbook Series)
- Author
-
Joseph Perillo and Joseph Perillo
- Subjects
- Contracts--United States
- Abstract
The author provides a detailed treatment of the basic rules, principles, and issues in contracts. Topics covered include offer and acceptance, parol evidence and interpretation, consideration, promissory estoppel, contracts under seal, capacity of parties, conditions, performance, and breach. The author also discusses damages, avoidance and reformation, third-party beneficiaries, assignments, and the statute of frauds. The discharge of contracts and illegal bargains are also the subject of separate chapters.
- Published
- 2014
47. The Rehabilitation Specialist's Handbook
- Author
-
Roy, Serge H, Wolf, Steven L, Scalzitti, David A, Roy, Serge H, Wolf, Steven L, and Scalzitti, David A
- Subjects
- Physical therapy, Physical therapy--Handbooks, manuals, etc, Rehabilitation--Handbooks, manuals, etc
- Abstract
The 4th Edition of the gold standard of rehabilitation resources is now in full color and thoroughly revised and updated to reflect the art and science of practice today! A compendium of frequently used, but rarely memorized information organized for easy reference, it covers an extraordinary breadth of topics—from the full range of basic scientific information (neuroanatomy and clinical neurology, osteology and clinical orthopedics, general anatomy, cardiac and pulmonary anatomy) to the treatments and methods used in modern rehabilitation practice.
- Published
- 2013
48. Graduate Medical Education Directory
- Author
-
American Medical Association and American Medical Association
- Subjects
- Medicine--Specialties and specialists--Certification--United States--Directories, Medicine--Study and teaching (Graduate)--United States--Directories, Residents (Medicine)--United States--Directories
- Abstract
Newly revised by the American Medical Association (AMA), the Graduate Medical Education Directory (or the'Green Book') contains extensive information on more than 9,000 Accreditation Council for Graduate Medical Education-accredited programs in the United States, including residency, fellowship,and combined programs, plus residency application and career-planning resources This is the only reference that delivers complete and current information for planning a medical career.
- Published
- 2013
49. BVR's Guide to Personal V. Enterprise Goodwill, Fifth Edition
- Author
-
BVR and BVR
- Subjects
- Goodwill (Commerce)--Valuation--United States
- Abstract
BVR's Guide to Personal v. Enterprise Goodwill delivers firsthand knowledge and the most current issues in goodwill with expertise from Mark Dietrich, Ron Seigneur, Kevin Yeanoplos, Jay Fishman, Shannon Pratt, David Wood, Noah Gordon, and more. Save valuable research time with the one resource that every BV professional needs to have in their business valuation library. Highlights of the new edition include: - The most current thought leadership with new and updated articles on personal and enterprise goodwill from leading experts, including: -'Personal Goodwill: Three Recent Taxpayer Defeats Affirm Existence of a Sometimes Forgotten Asset'(by Michael F. Lynch, David J. Beausejour, and David B. Casten) -'Apportioning Goodwill in Divorce: A Discussion'(by Jim Alerding and Andrew Soshnick, Esq.) - The most important court cases regarding goodwill, including court cases digests of critical decisions (full text of court cases available with online version) - Easy-to-use summary data including a newly updated article with aggregate summary data from the Goodwill Registry on medical and dental practices (published by The Health Care Group).
- Published
- 2012
50. The Delaware State Constitution
- Author
-
Randy Holland and Randy Holland
- Subjects
- Constitutional law--Delaware, Constitutions--Delaware, Constitutional history--Delaware
- Abstract
The Delaware state constitution is the first state constitution drafted by a convention composed of popularly elected representatives, and it is rich with history and tradition. The Delaware Bill of Rights has remained almost exactly the same since 1792, and it has enacted specific provisions whereby its three branches of government operate differently from the federal system. The Delaware State Constitution provides an outstanding constitutional and historical account of the state's basic governing charter. In it, Judge Randy Holland begins with an overview of Delaware's constitutional history. He then provides an in-depth, section-by-section analysis of the entire constitution, detailing important changes that have been made over the years. Justice Holland's learned treatment, along with the list of cases, index, and bibliography, makes this guide indispensable for students, scholars, and practitioners of Delaware's constitution. Previously published by Greenwood, this title has been brought back in to circulation by Oxford University Press with new verve. Re-printed with standardization of content organization in order to facilitate research across the series, this title, as with all titles in the series, is set to join the dynamic revision cycle of The Oxford Commentaries on the State Constitutions of the United States. The Oxford Commentaries on the State Constitutions of the United States is an important series that reflects a renewed international interest in constitutional history and provides expert insight into each of the 50 state constitutions. Each volume in this innovative series contains a historical overview of the state's constitutional development, a section-by-section analysis of its current constitution, and a comprehensive guide to further research. Under the expert editorship of Professor G. Alan Tarr, Director of the Center on State Constitutional Studies at Rutgers University, this series provides essential reference tools for understanding state constitutional law. Books in the series can be purchased individually or as part of a complete set, giving readers unmatched access to these important political documents.
- Published
- 2011
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